Antibacterial peptide, preparation method and application thereof, and antibacterial drug
By preparing an antimicrobial peptide with the amino acid sequence NH2-RRWRIVLIRARK-CONH2, the problem of drug resistance in dermatophyte infections has been solved, providing a long-acting and stable antimicrobial drug that can effectively treat dermatophyte infections and improve patients' quality of life.
CN120842320APending Publication Date: 2025-10-28HENAN UNIVERSITY OF TECHNOLOGY
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Patent Information
- Application Number
- CN202510781112.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-06-12
- Publication Date
- 2025-10-28
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Figure CN120842320A_ABST
Abstract
The invention discloses an antibacterial peptide, a preparation method and application thereof and an antibacterial drug, and relates to the technical field of antibacterial peptides, the amino acid sequence of the antibacterial peptide is NH2-RRWRIVLIRARK-CONH2, and the preparation method is a polypeptide solid-phase synthesis method. The antibacterial peptide is wide in acid-base stability range from pH 2 to pH 9; the temperature stability range is wide and ranges from-20 DEG C to 50 DEG C; 95% ethanol resistance is realized; the shelf life is stable and exceeds 6 months. According to the antibacterial peptide provided by the invention, the trichophyton mentagrophytes are killed by inhibiting spore germination of the trichophyton mentagrophytes and causing hypha breakage, the trichophyton mentagrophytes do not generate drug resistance to the antibacterial peptide, the 1% concentration of the antibacterial peptide has an obvious treatment effect on a guinea pig model infected by the trichophyton mentagrophytes, and the antibacterial peptide has a good application prospect as a novel candidate drug for treating trichophyton mentagrophytes infection.
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