Traditional Chinese medicine composition with effects of promoting qi circulation, relieving pain, warming yang, activating blood, warming yang and promoting coronary circulation

Abstract

The invention discloses a traditional Chinese medicine composition with the effects of promoting qi circulation, relieving pain, warming yang, activating blood and promoting coronary circulation. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 40-80 parts of peach kernel, 40-80 parts of safflower, 58-86 parts of rhizoma pinellinae praeparata, 72-108 parts of tangerine, 72-108 parts of vinegar-processed rhizoma corydalis, 72-108 parts of angelica sinensis, 72-108 parts of salvia miltiorrhiza, 40-80 parts of rhizoma cyperi, 72-108 parts of poria cocos, 120-180 parts of radix astragali preparata and 29-43 parts of radix glycyrrhizae preparata. Clinical results show that the composition has a remarkable curative effect on internal carotid plaque formation (traditional Chinese medicine symptoms) and is high in total effective rate.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine technology, and specifically relates to a traditional Chinese medicine composition with the effects of promoting qi circulation and relieving pain, warming yang and activating blood circulation, and warming yang and unblocking meridians. Background Technology

[0002] Atherosclerotic plaque formation is a crucial pathological basis for cardiovascular and cerebrovascular diseases, especially since plaque detachment in the internal carotid artery can easily trigger serious events such as cerebral infarction. Traditional Chinese medicine theory often categorizes this as "abdominal masses" or "blood stasis," with the pathogenesis primarily involving deficiency of Yang Qi, phlegm and blood stasis, and obstruction of the meridians. Treatment should focus on warming Yang, promoting blood circulation, resolving stasis and masses, and relieving pain by unblocking the meridians.

[0003] Currently, in clinical practice, besides Western medicine, traditional Chinese medicine decoctions are widely used to treat such diseases. While decoctions offer flexibility and can be adjusted according to the patient's condition, they have several significant drawbacks: First, the process of self-preparation is cumbersome, requiring multiple steps such as soaking, pre-decocting, adding ingredients later, boiling, and filtering. Requirements for the equipment, heat, and time are crucial, which is difficult for ordinary patients to master, easily leading to loss of efficacy or improper preparation, and compromising quality. Second, hospital-prepared decoctions are often packaged in large, heavy liquid bags, making them extremely inconvenient to carry and requiring refrigeration and heating before consumption, which is very inconvenient for patients on business trips, traveling, or working. Third, the bitter taste and large volume of decoctions result in a poor patient experience, leading to decreased medication adherence and directly affecting treatment efficacy.

[0004] Therefore, providing a traditional Chinese medicine preparation that is effective, of stable quality, easy to carry and take, and with high patient compliance to meet clinical needs has become an urgent problem to be solved in this field. Summary of the Invention

[0005] The purpose of this invention is to overcome the shortcomings of the prior art and provide a traditional Chinese medicine composition with the effects of promoting qi circulation and relieving pain, warming yang and activating blood circulation, and warming yang and unblocking meridians.

[0006] To achieve the above objectives, the present invention adopts the following technical solution:

[0007] A traditional Chinese medicine composition with the effects of promoting qi circulation and relieving pain, warming yang and activating blood circulation, and warming yang and unblocking meridians is made from the following raw materials in parts by weight: 40-80 parts of peach kernel, 40-80 parts of safflower, 58-86 parts of prepared pinellia, 72-108 parts of tangerine peel, 72-108 parts of vinegar-processed corydalis, 72-108 parts of angelica, 72-108 parts of salvia miltiorrhiza, 40-80 parts of cyperus rotundus, 72-108 parts of poria cocos, 120-180 parts of prepared astragalus membranaceus, and 29-43 parts of prepared licorice.

[0008] Preferably, the traditional Chinese medicine composition is made from the following raw materials in parts by weight: 60 parts peach kernel, 60 parts safflower, 72 parts prepared pinellia, 90 parts tangerine peel, 90 parts vinegar-processed corydalis, 90 parts angelica, 90 parts salvia miltiorrhiza, 60 parts cyperus rotundus, 90 parts poria cocos, 150 parts prepared astragalus membranaceus, and 36 parts prepared licorice.

[0009] Preferably, the dosage form of the traditional Chinese medicine composition is granules.

[0010] Preferably, the method for preparing the granules includes the following steps:

[0011] (1) Weigh the prescribed amount of raw materials and soak them in water;

[0012] (2) Boil twice. For the first boil, add 8-12 times the amount of water and boil for 1-2 hours. For the second boil, add 6-10 times the amount of water and boil for 1-2 hours.

[0013] (3) Combine the decoctions, filter them, and concentrate the filtrate under reduced pressure to a clear extract with a relative density of 1.15 to 1.35;

[0014] (4) Centrifuge the clear paste, add excipients, make into granules, dry, granulate, and package.

[0015] Preferably, in step (2), 10 times the amount of water is added for the first time and simmered for 1.5 hours, and 8 times the amount of water is added for the second time and simmered for 1.5 hours.

[0016] Preferably, in step (3), the pressure of vacuum concentration is -0.03 to -0.07 MPa, and the relative density is measured at 65°C.

[0017] Preferably, in step (4), the excipient is dextrin; and the drying temperature is 70±5℃.

[0018] The traditional Chinese medicine composition is used to prepare a drug for treating carotid artery plaque formation.

[0019] The herbal composition of this invention is based on the TCM principles of "warming yang and promoting blood circulation, resolving phlegm and dissipating nodules, and regulating qi and unblocking meridians," and is formulated strictly according to the principles of principal, assistant, adjuvant, and guide herbs. The properties, flavors, meridian tropisms, and effects of each herb in the formula are described below:

[0020] Principal herbs (peach kernel and safflower): Together they are the principal herbs, mainly responsible for promoting blood circulation, removing blood stasis, clearing the channels, and dispersing nodules.

[0021] Peach kernel: Bitter and sweet in taste, neutral in nature; enters the heart, liver, and large intestine meridians. Its functions include promoting blood circulation, removing blood stasis, and moistening the intestines to relieve constipation. This herb effectively removes blood stasis from the meridians, making it a key medicine for treating masses and lumps.

[0022] Safflower: pungent in taste and warm in nature; enters the heart and liver meridians. Its functions include promoting blood circulation, regulating menstruation, dispersing blood stasis, and relieving pain. Its light and ascending nature allows it to circulate through the meridians, enhancing the blood-activating and stasis-removing effects of peach kernel.

[0023] Assistant herbs (Salvia miltiorrhiza, Angelica sinensis, vinegar-processed Corydalis yanhusuo, Cyperus rotundus, Citrus reticulata peel, processed Pinellia ternata): These herbs assist the principal herbs in nourishing and activating blood, promoting qi circulation, relieving pain, drying dampness, and resolving phlegm.

[0024] Danshen (Salvia miltiorrhiza): Bitter in taste, slightly cold in nature; enters the heart and liver meridians. Its functions include promoting blood circulation and removing blood stasis, regulating menstruation and relieving pain, and clearing the heart and relieving irritability. There is a saying that "one dose of Danshen decoction has the same effect as Siwu Decoction," as it nourishes and invigorates blood, removing blood stasis without harming the body's vital energy.

[0025] Angelica sinensis: sweet and pungent in taste, warm in nature; enters the liver, heart, and spleen meridians. Its functions include nourishing and invigorating blood, regulating menstruation and relieving pain, and moistening the intestines to promote bowel movements. This herb is considered a sacred medicine for blood, as it both nourishes and invigorates blood, thus combining blood-invigorating with blood-nourishing effects.

[0026] Vinegar-processed Corydalis: pungent and bitter in taste, warm in nature; enters the liver and spleen meridians. Its functions include promoting blood circulation, regulating qi, and relieving pain. After being processed with vinegar, its qi-regulating and pain-relieving effects are further enhanced, making it an excellent medicine for promoting blood circulation, regulating qi, and relieving pain, specifically treating various pains throughout the body.

[0027] Cyperus rotundus: pungent, slightly bitter, and slightly sweet in taste; neutral in nature; enters the liver, spleen, and triple burner meridians. Its functions include soothing the liver and relieving depression, regulating qi and relieving chest tightness, regulating menstruation and relieving pain. This herb is the "general manager of qi-related diseases," able to circulate through the triple burner, relieving stagnant qi, and promoting blood circulation as qi flows smoothly.

[0028] Orange peel: pungent and bitter in taste, warm in nature; enters the lung and spleen meridians. Its functions include regulating qi and relieving chest congestion, drying dampness and resolving phlegm. It is more warming and drying than dried tangerine peel, and is particularly effective in removing phlegm and dampness, and in resolving phlegm and nodules.

[0029] Pinellia ternata (processed): pungent in taste and warm in nature; enters the spleen, stomach, and lung meridians. Its functions include drying dampness and resolving phlegm, relieving nausea and vomiting, and dissipating lumps and nodules. This herb is pungent, warm, and drying, making it a key medicine for drying dampness and resolving phlegm, and for warming and transforming cold phlegm. Combined with Citrus reticulata peel, it achieves the same effect of drying dampness and resolving phlegm.

[0030] Adjuvant herbs (processed Astragalus membranaceus and Poria cocos): These herbs are used together to warm the Yang, replenish Qi, strengthen the spleen, eliminate dampness, and support the body's vital energy.

[0031] Astragalus membranaceus (processed): Sweet in taste and warm in nature; enters the lung and spleen meridians. Its functions include tonifying qi and raising yang, consolidating the exterior and stopping sweating, promoting diuresis and reducing swelling, generating fluids and nourishing blood, and promoting circulation and relieving pain. This formula utilizes its warming and tonifying qi power; sufficient qi can promote blood circulation and warm the meridians, making it the core of warming yang and unblocking the meridians.

[0032] Poria cocos: sweet and bland in taste, neutral in nature; enters the heart, lung, spleen, and kidney meridians. Its functions include promoting diuresis and eliminating dampness, strengthening the spleen, and calming the mind. This herb can strengthen the spleen and eliminate dampness, preventing the source of phlegm production and thus preventing the internal generation of phlegm and dampness.

[0033] Guiding herb (roasted licorice): It acts as a guiding herb to harmonize the effects of other herbs.

[0034] Prepared licorice root: sweet in taste and neutral in nature; it enters the heart, lung, spleen, and stomach meridians. Its functions include tonifying the spleen and stomach, replenishing qi and restoring the pulse, and harmonizing the effects of other herbs. In this formula, it can both assist astragalus in replenishing qi and moderate the harshness of the other herbs, harmonizing their flavors and ensuring the overall effect of the formula.

[0035] The principle behind the formula's overall composition: The combined effects of these herbs work synergistically to promote qi circulation, relieve pain, warm yang, invigorate blood, and unblock the meridians. Peach kernel and safflower break up blood stasis; salvia miltiorrhiza and angelica sinensis nourish and invigorate blood; corydalis yanhusuo and cyperus rotundus promote qi circulation to aid blood flow; tangerine peel and prepared pinellia ternata dry dampness and resolve phlegm to eliminate phlegm accumulation; roasted astragalus membranaceus warms yang and tonifies qi to aid blood circulation; poria cocos strengthens the spleen and eliminates dampness to eradicate the source of phlegm; and roasted licorice root harmonizes the effects of all the herbs. The entire formula combines tonification and purgation, invigorating blood without harming it, promoting qi circulation without depleting it, resolving phlegm without promoting dampness, and warming yang without being overly drying. It closely addresses the pathogenesis of "deficiency of yang qi and mutual binding of phlegm and blood stasis," making it a precise formula for "masses" such as carotid artery plaque formation.

[0036] The beneficial effects of this invention are as follows:

[0037] 1. Definitely effective and scientifically formulated: The composition of this invention uses peach kernel and safflower to invigorate blood and remove blood stasis as the principal ingredients; salvia miltiorrhiza and angelica sinensis to nourish and invigorate blood; vinegar-processed corydalis yanhusuo and cyperus rotundus to regulate qi and relieve pain; tangerine peel and prepared pinellia ternata to dry dampness and resolve phlegm as the assistant ingredients; roasted astragalus membranaceus to warm yang and tonify qi, and poria cocos to strengthen the spleen and eliminate dampness as the adjuvant ingredients; roasted licorice root to harmonize the other ingredients as the guiding ingredient. The entire formula works synergistically to regulate qi and relieve pain, warm yang and invigorate blood, and warm yang and unblock the meridians, significantly addressing the pathogenesis of "deficiency of yang qi and mutual binding of phlegm and blood stasis." Clinical observation data from hundreds of cases show that its overall effective rate in treating carotid artery plaque formation is relatively high.

[0038] 2. Advanced dosage form and convenient use: The traditional Chinese medicine composition of this invention is in granule form, overcoming all the disadvantages of decoctions. Granules are stable, easy to store and transport, and convenient to carry. They can be taken simply by dissolving them in warm water, greatly improving the convenience and compliance of patients.

[0039] 3. Controllable quality and stable process: Through optimized modern pharmaceutical processes such as extraction, concentration, and drying, the effective components in the prescription are extracted and preserved to the greatest extent, ensuring the stability and consistency of efficacy. Furthermore, this invention establishes a method for determining the content of hesperidin as an indicator component (see separate application), providing a solid guarantee for product quality control and ensuring the stable and reliable efficacy of each batch of product.

[0040] 4. High bioavailability: Granules are extracted and purified, making the active ingredients easier for the human body to absorb, and their bioavailability may be higher than that of traditional decoctions. Detailed Implementation

[0041] The present invention will be further described in detail below with reference to embodiments, but the implementation of the present invention is not limited thereto.

[0042] Example 1

[0043] Preparation of granules of traditional Chinese medicine composition

[0044] Weigh out 60g of peach kernel, 60g of safflower, 72g of prepared pinellia, 90g of tangerine peel, 90g of vinegar-processed corydalis, 90g of angelica, 90g of salvia miltiorrhiza, 60g of cyperus rotundus, 90g of poria cocos, 150g of prepared astragalus membranaceus, and 36g of prepared licorice root. Soak these eleven herbs in water for 30 minutes, then decoct twice. For the first decoction, add 10 times the amount of water and decoct for 1.5 hours. For the second decoction, add 8 times the amount of water and decoct for 1.5 hours. Combine the decoctions, filter, and concentrate the filtrate under reduced pressure at -0.05 MPa to a clear extract with a relative density of 1.25 at 65°C. Centrifuge the extract, add an appropriate amount of dextrin, mix well, granulate using a 16-mesh sieve, dry at 70°C, and then granulate again using a 16-mesh sieve to produce 1000g of granules (equivalent to the total raw herb weight). Divide the granules into 100 bags (10g per bag).

[0045] Example 2

[0046] Preparation of granules of traditional Chinese medicine composition:

[0047] Weigh out 50g of peach kernel, 70g of safflower, 65g of prepared pinellia, 100g of tangerine peel, 85g of vinegar-processed corydalis, 95g of angelica, 80g of salvia miltiorrhiza, 50g of cyperus rotundus, 100g of poria cocos, 130g of prepared astragalus membranaceus, and 40g of prepared licorice. The preparation method is the same as in Example 1, and the final product is made into granules.

[0048] Example 3

[0049] Preparation of granules of traditional Chinese medicine composition:

[0050] Weigh out 70g of peach kernel, 50g of safflower, 80g of prepared pinellia, 80g of tangerine peel, 100g of vinegar-processed corydalis, 80g of angelica, 100g of salvia miltiorrhiza, 70g of cyperus rotundus, 80g of poria cocos, 170g of prepared astragalus membranaceus, and 32g of prepared licorice. The preparation method is the same as in Example 1, and the final product is made into granules.

[0051] Comparative example: Traditional decoction

[0052] Weigh the medicinal materials according to the prescription ratio of Example 1, and hand them over to the hospital's decoction room to decoct them according to the conventional decoction method (add water and decoct twice, then combine the decoctions), and then package them into bags of decoction.

[0053] Clinical efficacy verification

[0054] A clinical observation was conducted on 100 patients with carotid artery plaque formation (diagnosed as "zhengji" in Traditional Chinese Medicine). The patients were treated with granules prepared according to Example 1 of this invention (10g / dose, twice daily). Results showed that 2 cases were cured, 29 cases showed significant improvement, 51 cases showed improvement, and 18 cases showed no improvement, with a total effective rate of 82%. This was significantly higher than patient adherence to traditional decoctions, and the efficacy was stable and reliable. See Table 1.

[0055] Table 1

[0056]

[0057]

[0058]

[0059] In summary, the traditional Chinese medicine composition granules provided by this invention not only fully preserve the efficacy of the original decoction, but also achieve significant progress in dosage form, portability, user experience, and quality control, and have good clinical application prospects and market value.

[0060] The above description is only a preferred embodiment of the present invention. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the principle of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. A traditional Chinese medicine composition with the effects of promoting qi circulation and relieving pain, warming yang and activating blood circulation, and warming yang and unblocking meridians, characterized in that, It is made from the following raw materials in parts by weight: 40-80 parts peach kernel, 40-80 parts safflower, 58-86 parts prepared pinellia, 72-108 parts tangerine peel, 72-108 parts vinegar-processed corydalis, 72-108 parts angelica, 72-108 parts salvia miltiorrhiza, 40-80 parts cyperus rotundus, 72-108 parts poria cocos, 120-180 parts prepared astragalus membranaceus, and 29-43 parts prepared licorice.

2. The traditional Chinese medicine composition according to claim 1, characterized in that, It is made from the following raw materials in parts by weight: 60 parts peach kernel, 60 parts safflower, 72 parts prepared pinellia, 90 parts tangerine peel, 90 parts vinegar-processed corydalis, 90 parts angelica, 90 parts salvia miltiorrhiza, 60 parts cyperus rotundus, 90 parts poria cocos, 150 parts prepared astragalus membranaceus, and 36 parts prepared licorice.

3. The traditional Chinese medicine composition according to claim 1 or 2, characterized in that, The dosage form of the traditional Chinese medicine composition is granules.

4. The traditional Chinese medicine composition according to claim 3, characterized in that, The method for preparing the granules includes the following steps: (1) Weigh the prescribed amount of raw materials and soak them in water; (2) Boil twice. For the first boil, add 8-12 times the amount of water and boil for 1-2 hours. For the second boil, add 6-10 times the amount of water and boil for 1-2 hours. (3) Combine the decoctions, filter them, and concentrate the filtrate under reduced pressure to a clear extract with a relative density of 1.15 to 1.35; (4) Centrifuge the clear paste, add excipients, make into granules, dry, granulate, and package.

5. The traditional Chinese medicine composition according to claim 4, characterized in that, In step (2), add 10 times the amount of water for the first time and simmer for 1.5 hours. Add 8 times the amount of water for the second time and simmer for 1.5 hours.

6. The traditional Chinese medicine composition according to claim 4, characterized in that, In step (3), the pressure of vacuum concentration is -0.03 to -0.07 MPa, and the relative density is measured at 65°C.

7. The traditional Chinese medicine composition according to claim 4, characterized in that, In step (4), the excipient is dextrin; the drying temperature is 70±5℃.

8. The traditional Chinese medicine composition according to claim 1 or 2, characterized in that, The traditional Chinese medicine composition is used to prepare a drug for treating carotid artery plaque formation.

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