Blood analyzer

Abstract

The present invention provides a blood analyzer, which comprises: a sampling distribution module, which comprises a sampling device for collecting a blood sample and a sample separation device, the sampling device comprises a sampling needle and a first power device, the first power device is used for driving the sampling needle to collect the blood sample, and the sample separation device is used for separating the blood sample from the sampling needle; and the sample separating device is used for distributing the collected blood samples to different detection modules. The isolation air column is arranged between the sampling needle and the diluent, so that the blood sample is diluted as little as possible, and the measurement precision is improved.

Description

[0001] This application is a divisional application of the application with the application date of July 30, 2021, the application number of 202110878480.1, and the invention name of "Blood analyzer". TECHNICAL FIELD

[0002] The present application relates to the technical field of medical equipment, more specifically, to a blood analyzer. BACKGROUND

[0003] In the blood in vivo, due to the flow of blood and the mutual repulsion of the negative charges on the surface of red blood cells, the red blood cells are in a dispersed suspended state. When the blood is ex vivo, the red blood cells will sink due to gravity when at rest. When in a pathological state, the types and contents of proteins in the blood plasma will change, which will change the balance of charges in the blood, reduce the negative charges on the surface of red blood cells, and thus accelerate the formation of red blood cells into a coin shape and accelerate the sedimentation. Therefore, the rate of red blood cell sedimentation within 1 hour, i.e., the erythrocyte sedimentation rate (ESR), can be detected to assist in the evaluation of the disease.

[0004] In the application scenario of blood in clinical examination, blood routine is also an essential test index. Therefore, an all-in-one machine is needed that can detect ESR and blood routine to meet the clinical needs of blood detection items. The sampling module of the all-in-one machine separately distributes blood to the blood routine detection module and the blood sedimentation detection module (ESR detection module). The current structure design of the ESR detection module and the sampling module in the all-in-one machine is not reasonable, which makes the blood sample distributed to the ESR module easily diluted by the diluent or lost greatly in the connecting pipeline, resulting in insufficient measurement accuracy. SUMMARY

[0005] Therefore, the present application provides a blood analyzer to solve the problem of insufficient measurement accuracy of blood sedimentation detection. The technical solution is as follows:

[0006] The blood analyzer comprises: a sampling and distribution module, a blood sedimentation detection module, a blood routine detection module, and a liquid path support module; the sampling and distribution module comprises a sampling device and a sample distribution device, the sampling device comprises a sampling needle and a first power device, the first power device is used to drive the sampling needle to collect a blood sample, and the sample distribution device is used to distribute the collected blood sample to different detection modules; the blood sedimentation detection module comprises a detection pipeline and an optical detection device, the detection pipeline provides a detection place for the blood sample, and the optical detection device is used to irradiate the blood sample in the detection pipeline with light and detect the absorption or scattering degree of the light by the blood sample in the detection pipeline, so as to obtain the erythrocyte sedimentation rate of the blood sample; the blood routine detection module comprises a blood routine detection pool and a blood routine detection device, the blood routine detection pool provides a detection place for the blood sample, and the blood routine detection device is used to perform blood routine detection on the blood sample in the blood routine detection pool; the liquid path support module is used to provide liquid path support for the sampling and distribution module, the blood sedimentation detection module, and the blood routine detection module; the sampling device further comprises a sample suction pipeline connected to the sampling needle and the first power device; the liquid path support module is connected to the sample suction pipeline, at least part of the sample suction pipeline is filled with a dilution liquid, and an isolation air column is arranged between the blood sample and the dilution liquid after the sampling needle collects the blood sample.

[0007] Optionally, the volume of the isolation air column is greater than or equal to 5 μL and less than or equal to 20 μL.

[0008] Optionally, the volume of the isolation air column is greater than or equal to 10 μL and less than or equal to 15 μL.

[0009] Optionally, the detection pipeline is part of the sample suction pipeline, and the optical detection device is arranged on both sides of the sample suction pipeline; the sample distribution device is connected to the sample suction pipeline, and the sample distribution device sucks at least part of the blood sample close to the isolation air column to the detection pipeline after the sampling of the sampling needle is completed.

[0010] Optionally, the volume distance between the detection pipeline and the needle tip of the sampling needle is greater than a preset volume distance and less than or equal to 200 μL, and the preset volume distance is the sum of a preset maximum sample suction amount and the volume of the isolation air column.

[0011] Optionally, the blood sedimentation detection module further comprises a heater, the heater is used to heat the blood sample in the detection pipeline, and the distance between the heater and the needle tip of the sampling needle is greater than the preset volume distance and less than or equal to 200 μL, and the preset volume distance is the sum of a preset maximum sample suction amount and the volume of the isolation air column.

[0012] Optionally, the blood analyzer further comprises a controller, the controller controls the sample distribution device to first distribute a first part of the blood sample close to the needle tip of the sampling needle to the blood routine detection pool, and then distribute a second part of the blood sample close to the isolation air column to the blood sedimentation detection module.

[0013] Optionally, the detection pipeline is connected to the sample pipeline; the sample separation device is connected to the detection pipeline, and after the sampling of the sampling needle is completed, the sample separation device sucks at least part of the blood sample close to the isolation gas column to the detection pipeline.

[0014] Optionally, the volume distance between the detection pipeline and the needle tip of the sampling needle is greater than the preset volume distance and less than or equal to 200 μL, and the preset volume distance is the sum of the preset maximum sample suction amount and the volume of the isolation gas column.

[0015] Optionally, the blood routine detection pool is connected to the sample pipeline, and the sample separation device is connected to the blood routine detection pool, and after the sampling of the sampling needle is completed, the sample separation device sucks at least part of the blood sample close to the isolation gas column to the blood routine detection pool; the volume distance between the blood routine detection pool and the needle tip of the sampling needle is greater than the preset volume distance and less than or equal to 200 μL, and the preset volume distance is the sum of the preset maximum sample suction amount and the volume of the isolation gas column.

[0016] Compared with the prior art, the present application has the following beneficial effects:

[0017] The blood analyzer provided by the present application sets an isolation gas column between the sampling needle and the diluent, so that the blood sample is diluted as little as possible, thereby improving the measurement accuracy. BRIEF DESCRIPTION OF DRAWINGS

[0018] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the following will briefly introduce the drawings needed to be used in the embodiments or the prior art description. Obviously, the drawings in the following description are only embodiments of the present application, and for those skilled in the art, other drawings can also be obtained without creative labor on the basis of the provided drawings.

[0019] Figure 1 A schematic diagram of a blood analyzer of an embodiment is shown;

[0020] Figure 2 A schematic diagram of part of the structure of a blood analyzer of an embodiment is shown;

[0021] Figure 3 A schematic diagram of a blood analyzer of an embodiment is shown, in which the instrument is in the sample suction process;

[0022] Figure 4 A schematic diagram of a blood analyzer of an embodiment is shown, in which the instrument is in the blood routine blood separation process;

[0023] Figure 5 A schematic diagram of a blood analyzer of an embodiment is shown, in which the instrument is in the blood sedimentation detection process;

[0024] Figure 6A schematic diagram showing a partial structure of a blood analyzer according to one embodiment is shown;

[0025] Figure 7 A schematic diagram of a partial structure of a blood analyzer according to one embodiment is shown. Detailed Implementation

[0026] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0027] The present invention will now be described in further detail with reference to specific embodiments and accompanying drawings. Similar elements in different embodiments are referred to by associated similar element reference numerals. In the following embodiments, many details are described to facilitate a better understanding of this application. However, those skilled in the art will readily recognize that some features may be omitted in different situations, or may be replaced by other elements, materials, or methods. In some cases, certain operations related to this application are not shown or described in the specification. This is to avoid obscuring the core parts of this application with excessive description. For those skilled in the art, detailed description of these related operations is not necessary; they can fully understand the related operations based on the description in the specification and general technical knowledge in the art.

[0028] Furthermore, the features, operations, or characteristics described in the specification can be combined in any suitable manner to form various embodiments. At the same time, the steps or actions in the method description can be rearranged or adjusted in a manner obvious to those skilled in the art. Therefore, the various orders in the specification and drawings are only for the clear description of a particular embodiment and do not imply a necessary order, unless otherwise stated that a particular order must be followed.

[0029] The serial numbers assigned to components in this document, such as "first" and "second," are used only to distinguish the described objects and have no sequential or technical meaning. The terms "connection" and "linkage" used in this application, unless otherwise specified, include both direct and indirect connections (linkages).

[0030] like Figures 1 to 3 As shown, one embodiment of this application provides a blood analyzer 100, including a sampling distribution module 10, an erythrocyte sedimentation rate (ESR) detection module 20, a complete blood count (CBC) detection module 30, a fluid flow support module 40, and a controller 50. The blood analyzer 100 may also include a protein detection module or other detection modules for detecting specific proteins.

[0031] The sampling and dispensing module 10 is used to collect blood samples from the sample container 200 and dispense the blood samples to the plurality of detection modules. Specifically, the sampling and dispensing module 10 comprises a sampling device and a dispensing device, the sampling device comprises a sampling needle 11 and a first power device 12, the first power device 12 is used to drive the sampling needle 11 to collect blood samples; the dispensing device is used to dispense the collected blood samples to different detection modules. The dispensing device can be implemented in various ways according to the structure of the detection module, for example, by a power source to dispense the blood samples to different detection modules, or by sucking the blood samples from the sampling needle 11 to the detection pool or detection pipeline 21 of the detection module. Specifically, the first power device 12 is used to provide negative pressure to draw the blood samples of the sample container 200 into the sampling needle 11. The first power device 12 can be a pump, a syringe or other power pressure source, for example, a positive and negative air pressure source.

[0032] It should be noted that the sampling device and the dispensing device in the sampling and dispensing module 10 can comprise the same structure or different structures, for example, the sampling device comprises the sampling needle 11 and the first power device 12, when collecting blood samples, the first power device 12 provides negative pressure to draw the blood samples of the sample container 200 into the sampling needle 11; the dispensing device also comprises the sampling needle 11 and the first power device 12, when dispensing blood samples, the first power device 12 provides negative pressure to suck the blood samples into the blood sedimentation detection module 20; the dispensing device can also comprise a power device providing positive pressure or negative pressure to dispense the blood samples to the blood routine detection module 30.

[0033] The blood sedimentation detection module 20 comprises a detection tube 21 and an optical detection device 22. The detection tube 21 is used to provide a detection site for the blood sample. The optical detection device 22 is arranged correspondingly to the detection tube 21, and is used to irradiate the blood sample in the detection tube 21 with light and detect the absorption or scattering degree of the light by the blood sample in the detection tube 21, so as to obtain the erythrocyte sedimentation rate of the blood sample. The optical detection device 22 comprises a light source 221 and a photoelectric converter 222, and the light absorption or light scattering measurement of the blood sample in the detection tube 21 is realized by the light source 221 and the photoelectric converter 222. The blood sedimentation detection module 20 further comprises a heater 23 and a temperature sensor 24, and the temperature control of the detection tube 21 is realized by the heater 23 and the temperature sensor 24. The blood sedimentation detection module 20 can further comprise a tube fixing block for fixing the detection tube 21. In addition, the detection tube 21 and the optical detection device 22 can also be arranged separately, that is, the detection tube can not be fixed at the optical detection device 22, and the detection tube 21 moves with the sampling needle at least in one movement direction, that is, the detection tube 21 and the sampling needle 11 are arranged stationary at least in one movement direction. In one mode, when the sampling needle 11 moves at the sample container 200 to collect the blood sample, the detection tube 21 communicates with the sampling needle 11 and moves with the sampling needle 11; then the sampling needle dispenses the blood sample, and the first power device 12 provides negative pressure to suck the blood sample to the detection tube 21 located at the optical detection device for detection (since the sampling needle 11 is connected to the tube, in fact, when the sampling needle moves, the tube also moves in the optical detection device 22, therefore, after the sampling needle finishes sampling, the tube segment that transports the blood sample to the optical detection device 22 is the detection tube). In another mode, a certain segment of the tube connected with the sampling needle 11 can be arranged as the detection tube, for example, a segment of the tube close to the sampling needle is arranged as the detection tube, so that after the sampling needle 11 finishes collecting the blood sample, the first power device 12 provides negative pressure to suck the blood sample to the detection tube, and then the sampling needle 11 moves to bring the detection tube to the optical detection device 22 for detection.

[0034] The blood routine detection module 30 comprises a blood routine detection pool 31 and a blood routine detection device (not shown in the figure). The blood routine detection pool 31 is used to provide a detection site for the blood sample, and the blood routine detection device performs blood routine detection on the blood sample in the blood routine detection pool 31.

[0035] The liquid path support module 40 is configured to provide liquid path support for the sampling and dispensing module 10, the blood sedimentation detection module 20 and the blood routine detection module 30. The liquid path support can include fluid driving, reagent filling, liquid path cleaning, waste liquid discharge and other functional support. For example, the liquid path support module 40 can provide cleaning liquid to the sampling and dispensing module 10, the blood sedimentation detection module 20 and the blood routine detection module 30 respectively, so as to clean the sampling needle 11, the detection pipeline 21 and the blood routine detection cell 31 respectively, thereby avoiding contamination of the blood sample to be detected and inaccurate detection results. In addition, the liquid path support module 40 can be connected to the sampling needle 11 through a pipeline, and the liquid path support module 40 keeps the pipeline full of dilution liquid, so that the sampling, sampling and other processes are faster and more reliable.

[0036] The controller 50 is communicatively connected to the sampling and dispensing module 10, the blood sedimentation detection module 20 and the blood routine detection module 30, and the liquid path support module 40 to process information and control the operation of each module.

[0037] The sampling device further comprises a sampling pipeline 13 connected to the sampling needle 11 and the first power device 12; the liquid path support module 40 is connected to the sampling pipeline 13, and at least part of the sampling pipeline 13 is filled with dilution liquid. After the sampling needle 11 collects the blood sample, an isolation air column 60 is arranged between the blood sample and the dilution liquid. Specifically, after the sampling needle 11 collects the blood sample, the blood sample is filled in the sampling needle 11 or in the sampling needle 11 and the sampling pipeline 13, and an isolation air column 60 is arranged between the blood sample and the dilution liquid, so as to isolate the blood sample from the dilution liquid, thereby preventing the blood sample from being diluted. As an optional embodiment, before sampling, the liquid path support module 40 fills the dilution liquid in part of the sampling pipeline 13, and fills the gas in the part of the sampling pipeline 13 close to the sampling needle 11 and in the sampling needle 11. After sampling, the isolation air column 60 is formed between the blood sample and the dilution liquid. As another optional embodiment, before sampling, the liquid path support module 40 fills the dilution liquid in the sampling pipeline 13, and fills the gas in the sampling needle 11. After sampling, the isolation air column 60 is formed between the blood sample and the dilution liquid. As another optional embodiment, before sampling, the liquid path support module 40 fills the dilution liquid in the sampling pipeline 13 and the sampling needle 11. Before the sampling needle 11 sucks the blood sample, the sampling needle 11 first sucks a preset volume or a certain amount of gas. After sampling, the isolation air column 60 is formed between the blood sample and the dilution liquid. The gas can be air or other gas that is difficult to dissolve in the dilution liquid and the blood sample.

[0038] Preferably, the volume of the isolation gas column 60 is greater than or equal to 5 μL and less than or equal to 20 μL. Within this range, the isolation gas column 60 can effectively isolate the blood sample from the diluent while maintaining a suitable length for the aspiration tubing 13, ensuring rapid aspiration and dispensing. Further, the volume of the isolation gas column 60 is greater than or equal to 10 μL and less than or equal to 15 μL; within this range, the isolation gas column 60 provides even better isolation between the diluent and the blood sample.

[0039] In this embodiment, as Figure 2 As shown, the detection line 21 is part of the aspiration line 13, and the optical detection device 22 is disposed on both sides of the aspiration line 13. The sample dispensing device is connected to the aspiration line 13. After the sampling needle 11 completes sampling, the sample dispensing device aspirates at least a portion of the blood sample near the isolation air column 60 into the detection line 21. That is to say, the erythrocyte sedimentation rate (ESR) detection module 20 is disposed on the aspiration line 13 near the sampling needle 11, using a portion of the aspiration line 13 as the detection line 21, eliminating the need for a separate detection line 21 and simplifying the structure. Based on this structural design, since the blood sample allocated to the ESR detection module 20 needs to flow through a section of the aspiration line 13 to reach the detection line 21, and the aspiration line 13 is filled with diluent, it is even more necessary to set up an isolation air column 60 between the blood sample and the diluent to reduce the degree of dilution of the blood sample as it flows through the aspiration line 13. Specifically, during the process of sampling needle 11 aspirating and dispensing the blood sample into blood routine testing pool 31 and then drawing it into testing tubing 21, the diluent and isolation air column 60 move accordingly, allowing for comparison. Figures 3 to 5 The positional change of the isolation gas column 60 within the sample aspiration line 13 can be observed. The volume of the detection line 21 is greater than or equal to 10 μL and less than or equal to 50 μL. Preferably, the volume of the detection line 21 is 40 μL, so that the sample aspiration line 13 has a suitable length.

[0040] The volume distance between the detection pipeline 21 and the needle tip of the sampling needle 11 is greater than a preset volume distance and less than or equal to 200 μL, and the volume distance between the blood sedimentation detection module 20 and the needle tip of the sampling needle 11 is greater than the preset volume distance and less than or equal to 200 μL. The preset volume distance is the sum of the preset maximum sample volume and the volume of the isolation air column 60. The maximum sample volume is the maximum volume of the blood sample that can be taken by the sampling needle 11 at one time by default of the blood analyzer 100. The volume of the blood sample actually collected each time is less than or equal to the maximum sample volume. Such a design can ensure that the distance between the detection pipeline 21 and the sampling needle 11 is close enough to reduce the dilution of the blood sample by the residual diluent in the pipeline and the residual blood in the pipeline wall, and can also ensure that the detection module and the isolation air column 60 do not overlap to avoid the influence of the heating process of the blood sedimentation detection module 20 on the isolation air column 60 during the sampling and sample distribution processes. It should be noted that the volume distance between the detection pipeline 21 and the needle tip of the sampling needle 11 is the volume distance between the end of the detection pipeline 21 close to the sampling needle 11 and the needle tip of the sampling needle 11, and the volume distance between the blood sedimentation detection module 20 and the needle tip of the sampling needle 11 is the volume distance between the end of the blood sedimentation detection module 20 close to the sampling needle 11 and the needle tip of the sampling needle 11.

[0041] Specifically, the blood sedimentation detection module 20 further comprises a heater 23, and the heater 23 is used to heat the blood sample in the detection pipeline 21. The distance between the heater 23 and the needle tip of the sampling needle 11 is greater than a preset volume distance and less than or equal to 200 μL. Such a design can ensure that the distance between the heater 23 and the sampling needle 11 is close enough to reduce the dilution of the sample by the residual diluent in the pipeline and the residual blood in the pipeline wall, and can also avoid the heating of the heater 23 from causing the isolation air column 60 to expand, thereby affecting the sampling accuracy or the subsequent sample distribution accuracy.

[0042] For the distribution sequence of the blood sample, for the sample that only needs to perform one of the blood routine detection or the blood sedimentation detection, the controller 50 controls the sample distribution device to distribute at least part of the blood sample to the corresponding detection cell or the detection pipeline 21; for the sample that needs to perform both the blood routine detection and the blood sedimentation detection, the controller 50 controls the sample distribution device to first distribute a first part of the blood sample close to the needle tip of the sampling needle 11 to the blood routine detection cell 31, and then distribute a second part of the blood sample close to the isolation air column 60 to the blood sedimentation detection module, so that only the part of the blood sample that needs to perform the blood sedimentation detection flows through the sampling pipeline 13, and the part of the blood sample that needs to perform the blood routine detection does not flow through the sampling pipeline 13, thereby improving the measurement efficiency. The controller 50 also controls the blood routine detection module 30 to start measuring after the first part of the blood sample is distributed, and controls the blood sedimentation detection module 20 to start measuring after the second part of the blood sample is distributed, thereby improving the measurement efficiency.

[0043] As Figure 6As shown in another embodiment of the present application, the detection pipeline 21 is connected to the sample suction pipeline 13. That is to say, the detection pipeline 21 is no longer a part of the sample suction pipeline 13, but is connected to the sample suction pipeline 13, and the blood sample flows through the sample suction pipeline 13 to the detection pipeline 21. After the sampling needle 11 completes sampling, the second power device 25 in the sample separation device sucks at least part of the blood sample close to the isolation air column 60 to the detection pipeline 21. At this time, preferably, the volume distance between the blood sedimentation detection module 20 and the needle tip of the sampling needle 11 is greater than a preset volume distance and less than or equal to 200 μL, and the preset volume distance is the sum of the preset maximum sample suction amount and the volume of the isolation air column 60.

[0044] As shown in another embodiment of the present application, the detection pipeline 21 is connected to the sample suction pipeline 13. That is to say, the detection pipeline 21 is no longer a part of the sample suction pipeline 13, but is connected to the sample suction pipeline 13, and the blood sample flows through the sample suction pipeline 13 to the detection pipeline 21. After the sampling needle 11 completes sampling, the second power device 25 in the sample separation device sucks at least part of the blood sample close to the isolation air column 60 to the detection pipeline 21. At this time, preferably, the volume distance between the blood sedimentation detection module 20 and the needle tip of the sampling needle 11 is greater than a preset volume distance and less than or equal to 200 μL, and the preset volume distance is the sum of the preset maximum sample suction amount and the volume of the isolation air column 60. Figure 7 As shown in another embodiment of the present application, the blood sedimentation detection module 20 is connected to the sampling needle 11, and specifically, the detection pipeline 21 is connected to the sampling needle 11, that is to say, one outlet of the sampling needle 11 is connected to the sample suction pipeline 13, and the other outlet is connected to the blood sedimentation detection module 20. At this time, the volume distance between the blood sedimentation detection module 20 and the needle tip of the sampling needle 11 is greater than the volume distance H between the outlet connected to the blood sedimentation detection module 20 and the needle tip of the sampling needle 11 and less than or equal to 200 μL. Since the detection pipeline 21 is relatively close to the sampling needle 11, the detection pipeline 21 can not be filled with diluent or can be filled with diluent but without isolation air column. Of course, the detection pipeline 21 can also be filled with diluent and provided with an isolation air column 70. At this time, the volume distance between the blood sedimentation detection module 20 and the needle tip of the sampling needle 11 is greater than a preset volume distance and less than or equal to 200 μL, and the preset volume distance is the sum of the volume distance H between the outlet connected to the blood sedimentation detection module 20 and the needle tip of the sampling needle 11 and the volume of the isolation air column 70. Specifically, before the sampling needle 11 sucks the blood sample, the second power device 25 in the sample separation device first sucks a certain amount of gas so that an isolation air column 70 is formed before the blood sample and the diluent after the sampling needle 11 sucks the blood sample.

[0045] In another embodiment of the present application, the blood routine detection pool is connected to the sample suction pipeline, and the sample separation device is connected to the blood routine detection pool. After the sampling needle completes sampling, the sample separation device sucks at least part of the blood sample close to the isolation air column to the blood routine detection pool. Preferably, the volume distance between the blood routine detection pool and the needle tip of the sampling needle is greater than a preset volume distance and less than or equal to 200 μL; further, the volume distance between the blood routine detection module and the needle tip of the sampling needle is greater than a preset volume distance and less than or equal to 200 μL, and the preset volume distance is the sum of the preset maximum sample suction amount and the volume of the isolation air column.

[0046] As shown in another embodiment of the present application, the blood routine detection pool is connected to the sample suction pipeline, and the sample separation device is connected to the blood routine detection pool. After the sampling needle completes sampling, the sample separation device sucks at least part of the blood sample close to the isolation air column to the blood routine detection pool. Preferably, the volume distance between the blood routine detection pool and the needle tip of the sampling needle is greater than a preset volume distance and less than or equal to 200 μL; further, the volume distance between the blood routine detection module and the needle tip of the sampling needle is greater than a preset volume distance and less than or equal to 200 μL, and the preset volume distance is the sum of the preset maximum sample suction amount and the volume of the isolation air column. Figure 3As shown, in another embodiment of the present application, the detection tube 21 is connected to the sampling needle 11, and the detection tube 21 is fixed relative to the sampling needle 11 in at least one direction of movement. Here, the detection tube 21 is connected to the sampling needle 11, including that the detection tube 21 is directly connected to the sampling needle 11, and also including that the detection tube 21 is indirectly connected to the sampling needle 11 through the sample suction tube 13 or other structures. In general, the detection tube 21 is fixed relative to the sampling needle 11 in at least one direction of movement, where the direction of movement refers to the direction of movement of the sampling needle 11. In this case, when the sampling needle 11 moves, the distance between the sampling needle 11 and the detection tube 21 in at least one direction does not change, so that a shorter connecting tube can be provided between the sampling needle 11 and the detection tube 21, without having to consider the problem that the connecting tube also needs to be lengthened accordingly when the sampling needle 11 moves relative to the detection tube 21 during sample suction, sample distribution, etc., thereby reducing the loss of blood in the connecting tube, the difficulty of cleaning, etc. When the connecting tube is filled with dilution liquid, the dilution degree of the blood sample flowing from the sampling needle 11 to the detection tube 21 can also be reduced due to the shorter length of the connecting tube.

[0047] As an optional embodiment, the detection tube 21 is provided on the sampling and distribution module 10. As shown, Figures 3-5 As shown, the blood sedimentation detection module 20 is provided on the sampling and distribution module 10. The sampling and distribution module 10 includes a moving assembly and a driving device, the sampling needle 11 is mounted to the moving assembly, and the driving device is used to drive the moving assembly and the sampling needle 11 to move in a predetermined direction; specifically, the blood sedimentation detection module 20 is provided on the moving assembly. In this embodiment, the driving device can be a motor, and the moving assembly includes a horizontal moving assembly 141 and a vertical moving assembly 142 that move horizontally and vertically, respectively, under the drive of the driving device. The sampling and distribution module 10 further includes a horizontal guide rail 143 and a vertical guide rail 144. The horizontal moving assembly 141 is mounted to the horizontal guide rail 143, and the driving device drives the horizontal moving assembly 141 to move along the horizontal guide rail 143. The vertical guide rail 144 is mounted to the horizontal moving assembly 141, and the vertical moving assembly 142 is mounted to the vertical guide rail 144. The driving device drives the vertical moving assembly 142 to move along the vertical guide rail 144. The sampling needle 11 is mounted to the vertical moving assembly 142. The detection tube 21 can be provided on the horizontal moving assembly 141 or the vertical moving assembly 142. Figures 3-5 In this embodiment, the detection tube 21 is provided on the horizontal moving assembly 141. When the detection tube 21 is provided on the horizontal moving assembly 141, the distance between the detection tube 21 and the sampling needle 11 in the horizontal direction remains unchanged; when the detection tube 21 is provided on the vertical moving assembly 142, the distance between the detection tube 21 and the sampling needle 11 always remains unchanged.

[0048] It can be understood that the structure of the motion assembly and the guide rail can also be that the horizontal guide rail 143 is mounted to the vertical motion assembly 142, and the sampling needle 11 is mounted to the horizontal motion assembly 141. The detection tube 21 can be arranged on the horizontal motion assembly 141 or the vertical motion assembly 142. When the detection tube 21 is arranged on the horizontal motion assembly 141, the distance between the detection tube 21 and the sampling needle 11 is always kept unchanged, and when the detection tube 21 is arranged on the vertical motion assembly 142, the distance between the detection tube 21 and the sampling needle 11 in the vertical direction is kept unchanged.

[0049] It can be understood that the structure and motion form of the motion assembly carrying the sampling needle 11 are not limited to the forms included in the above-mentioned embodiments. For example, the driving device can drive the motion assembly to rotate, and at the same time, since the detection tube 21 is arranged on the motion assembly, the detection tube 21 is kept stationary relative to the sampling needle 11.

[0050] Further, the blood sedimentation detection module 20 is arranged stationary relative to the sampling needle 11 in at least one motion direction. Specifically, the blood sedimentation detection module 20 is arranged on the sampling and dispensing module 10, or arranged on the motion assembly, or arranged on the horizontal motion assembly 141 or the vertical motion assembly 142. The blood sedimentation detection module 20 at least includes the detection tube 21 and the optical detection device 22. The weight of the blood sedimentation detection module 20 is greater than or equal to 20 g and less than or equal to 50 g; the volume of the detection tube 21 is greater than or equal to 10 μL and less than or equal to 50 μL. Preferably, the volume of the detection tube 21 is 40 μL.

[0051] It can be understood by those skilled in the art that all or part of the functions of the above-mentioned embodiments can be realized by hardware or by a computer program. When all or part of the functions of the above-mentioned embodiments are realized by a computer program, the program can be stored in a computer readable storage medium, which can include a read-only memory, a random access memory, a magnetic disk, an optical disk, a hard disk, etc. The above-mentioned functions are realized by executing the program by a computer. For example, the program is stored in the memory of the device, and when the program in the memory is executed by the processor, the above-mentioned all or part of the functions are realized. In addition, when all or part of the functions of the above-mentioned embodiments are realized by a computer program, the program can also be stored in a server, another computer, a disk, an optical disk, a flash disk or a mobile hard disk, etc. The program is saved in the memory of the local device by downloading or copying, or the system of the local device is updated, and when the program in the memory is executed by the processor, the above-mentioned all or part of the functions of the embodiments are realized.

[0052] The above application of specific examples to illustrate the present application, is only used to help understand the present application, and not to limit the present application. For the general technical personnel in the art, according to the idea of the present application, the above specific embodiments can be changed.

Claims

1. A blood analyzer, characterized in that, include: The sampling and distribution module includes a sampling device and a sample dispensing device for collecting blood samples. The sampling device includes a sampling needle and a first power device. The first power device is used to drive the sampling needle to collect blood samples, and the sample dispensing device is used to distribute the collected blood samples to different detection modules. The erythrocyte sedimentation rate (ESR) detection module includes a detection pipeline and an optical detection device. The detection pipeline provides a detection site for the blood sample, and the optical detection device is used to irradiate the blood sample in the detection pipeline with light and detect the degree of absorption or scattering of light by the blood sample in the detection pipeline to obtain the erythrocyte sedimentation rate of the blood sample. A routine blood test module includes a routine blood test pool and a routine blood test device. The routine blood test pool provides a testing site for blood samples, and the routine blood test device is used to perform routine blood tests on the blood samples in the routine blood test pool. A fluid path support module is used to provide fluid path support for the sampling distribution module, the erythrocyte sedimentation rate detection module, and the complete blood count detection module; The sampling device further includes a suction tube connecting the sampling needle and the first power device; the liquid support module is connected to the suction tube, at least part of the suction tube is filled with diluent, and an isolation air column is provided between the blood sample and the diluent after the sampling needle collects the blood sample.

2. The blood analyzer according to claim 1, characterized in that, The volume of the isolation air column is greater than or equal to 5 μL and less than or equal to 20 μL.

3. The blood analyzer according to claim 2, characterized in that, The volume of the isolation air column is greater than or equal to 10 μL and less than or equal to 15 μL.

4. The blood analyzer according to claim 1, characterized in that, The detection tubing is part of the aspiration tubing, and the optical detection device is located on both sides of the aspiration tubing; the sample dispensing device is connected to the aspiration tubing, and after the sampling needle completes sampling, the sample dispensing device draws at least a portion of the blood sample near the isolation column into the detection tubing.

5. The blood analyzer according to claim 4, characterized in that, The volumetric distance between the detection tubing and the tip of the sampling needle is greater than a preset volumetric distance but less than or equal to 200 μL. The preset volumetric distance is the sum of the preset maximum aspiration volume and the volume of the isolation gas column.

6. The blood analyzer according to claim 5, characterized in that, The erythrocyte sedimentation rate (ESR) detection module also includes a heater for heating the blood sample in the detection tubing. The distance from the heater to the tip of the sampling needle is greater than a preset volume distance and less than or equal to 200 μL. The preset volume distance is the sum of the preset maximum aspiration volume and the volume of the isolation air column.

7. The blood analyzer according to claim 1, characterized in that, The blood analyzer also includes a controller, which controls the sample dispensing device to first allocate a first portion of the blood sample near the tip of the sampling needle to the routine blood test pool, and then allocate a second portion of the blood sample near the isolation air column to the erythrocyte sedimentation rate (ESR) measurement module.

8. The blood analyzer according to claim 1, characterized in that, The detection tubing is connected to the sampling tubing; the sampling device is connected to the detection tubing, and after the sampling needle completes sampling, the sampling device draws at least a portion of the blood sample near the isolation column into the detection tubing.

9. The blood analyzer according to claim 8, characterized in that, The volumetric distance between the detection tubing and the tip of the sampling needle is greater than a preset volumetric distance but less than or equal to 200 μL. The preset volumetric distance is the sum of the preset maximum aspiration volume and the volume of the isolation gas column.

10. The blood analyzer according to claim 1, characterized in that, The blood routine test pool is connected to the sampling tubing, and the sampling device is connected to the blood routine test pool. After the sampling needle completes sampling, the sampling device draws at least a portion of the blood sample near the isolation air column into the blood routine test pool. The volumetric distance between the blood routine test pool and the tip of the sampling needle is greater than a preset volumetric distance and less than or equal to 200 μL. The preset volumetric distance is the sum of the preset maximum aspiration volume and the volume of the isolation air column.

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