Composition containing traditional Chinese medicine plant extracts, preparation and application in shampoo

Abstract

The invention relates to the technical field of daily cosmetics, in particular to a composition containing traditional Chinese medicine plant extracts, preparation of the composition and application of the composition in shampoo, and the composition containing the traditional Chinese medicine plant extracts is prepared from, by mass, 50-500 parts of water; 0.5-5 parts of a ginseng root extract; 0.5-4 parts of a Chinese arborvitae twig and leaf extract; 0.2-4 parts of a pseudo-ginseng root extract; 0.1-3 parts of a ginger extract; 0.2-4 parts of a radix sophorae flavescentis extract; 0.1-3 parts of a mulberry leaf extract; 0.5-4 parts of a rumex madaio makino extract; 0.4-4 parts of a cortex lycii radicis extract; 1-6 parts of a Chinese angelica extract; 1-6 parts of a polygonum multiflorum extract; 0.5-3 parts of a ligusticum wallichii extract; the composition containing the traditional Chinese medicine plant extracts has the following remarkable advantages and beneficial effects that through scientific compatibility of monarch, minister, assistant and guide, hair follicle regeneration and hair growth are strongly promoted; the alopecia is obviously prevented and improved; the scalp grease secretion is permanently and efficiently controlled; multiple targets cooperate, and the effect is comprehensive; the irritation is low, and the safety is high; and the preparation process is simple and easy to industrialize.

Description

Technical Field

[0001] This invention relates to the field of daily cosmetics technology, specifically to compositions containing extracts of traditional Chinese medicinal plants, their preparation, and their application in shampoos. Background Technology

[0002] Shampoo is one of the most commonly used daily cosmetic products, primarily used to cleanse the scalp and hair, removing oil, sweat, dead skin cells, dust, microorganisms, and residue from hair products. However, existing shampoos mainly focus on cleansing and basic conditioning, and their effectiveness is limited for the increasingly common problem of hair loss (such as androgenetic alopecia and seborrheic alopecia). Common hair loss problems are often accompanied by excessive scalp oil secretion (sebum secretion), and existing shampoos often struggle to simultaneously achieve both long-lasting oil control and effective promotion of hair follicle health and stimulation of new hair growth.

[0003] Existing hair loss prevention and hair regrowth products often contain chemical drugs, which pose potential irritation and side effects. Some products containing traditional Chinese medicine ingredients have formulas based on traditional experience, lacking sufficient research on the targeting of hair follicle regeneration, the synergistic mechanism of active ingredients, and their integration with modern scalp physiology, resulting in unstable or insignificant effects. In particular, there is a lack of compound compositions that can simultaneously and efficiently activate hair follicle stem cells, improve hair follicle microcirculation, inhibit key factors of hair follicle atrophy (such as DHT), and effectively regulate sebum secretion over a long period.

[0004] Therefore, developing a specialized composition based on active ingredients of traditional Chinese medicine that is low in irritation, can effectively promote hair follicle regeneration, prevent and improve hair loss, and effectively control scalp sebum secretion, and successfully applying it to shampoo products, is a technical problem that urgently needs to be solved. Summary of the Invention

[0005] This invention aims to address the shortcomings of existing shampoos in promoting hair follicle regeneration, preventing and improving hair loss, and providing long-lasting oil control. It provides a composition containing extracts from traditional Chinese medicinal plants. This composition achieves multi-target synergistic effects by carefully selecting medicinal ingredients with specific efficacy and optimizing their proportions. Specifically:

[0006] Activate hair follicle stem cells & promote hair papilla cell proliferation: The core ingredient contains highly effective hair growth activity, which directly acts on the key links of hair follicle regeneration.

[0007] Improves hair follicle microcirculation & anti-inflammatory: Promotes scalp blood circulation, provides sufficient nutrition to hair follicles, and reduces inflammation around hair follicles.

[0008] Inhibiting 5α-reductase activity and reducing DHT levels: targeting the key pathological mechanisms of androgenetic alopecia.

[0009] Long-lasting regulation of sebum secretion: balances scalp oil and creates a microenvironment conducive to hair growth.

[0010] Low irritation & high safety: Derived from natural plants, gentle and effective.

[0011] On one hand, the present invention provides a composition containing Chinese herbal plant extracts, wherein, by weight, the composition containing Chinese herbal plant extracts comprises the following components: 50-500 parts water; 0.5-5 parts ginseng root extract; 0.5-4 parts arborvitae leaf extract; 0.2-4 parts Panax notoginseng root extract; 0.1-3 parts ginger extract; 0.2-4 parts Sophora flavescens root extract; 0.1-3 parts mulberry leaf extract; 0.5-4 parts Rheum palmatum extract; 0.4-4 parts Lycium chinense root bark extract; 1-6 parts Angelica sinensis extract; 1-6 parts Polygonum multiflorum extract; 0.5-3 parts Ligusticum chuanxiong extract; wherein the mass ratio of Rheum palmatum extract to Lycium chinense root bark extract is 1:(0.6-1.1); the mass ratio of arborvitae leaf extract to Sophora flavescens root extract is (1-1.7):1; and the mass ratio of Angelica sinensis extract, Polygonum multiflorum extract and Ligusticum chuanxiong extract is (1-3):(1-3):(0.5-1.5).

[0012] As a preferred embodiment of the present invention, the composition containing the herbal plant extracts comprises, by weight, the following components: 60-300 parts water; 0.8-3 parts ginseng root extract; 0.8-3.5 parts arborvitae leaf extract; 0.3-3 parts Panax notoginseng root extract; 0.2-2.5 parts ginger extract; 0.2-2.5 parts Sophora flavescens root extract; 0.2-2 parts mulberry leaf extract; 0.8-3.5 parts Rheum palmatum extract; and 0.6-3 parts Lycium chinense. The extract consists of: 2-5 parts Angelica sinensis extract; 1-2.5 parts Polygonum multiflorum extract; 1-2.5 parts Ligusticum chuanxiong extract; wherein the mass ratio of Rheum palmatum extract and Lycium chinense root bark extract is 1:(0.8-1.0); the mass ratio of Platycladus orientalis leaf extract and Sophora flavescens root extract is (1.2-1.5):1; and the mass ratio of Angelica sinensis extract, Polygonum multiflorum extract and Ligusticum chuanxiong extract is (1.5-2.5):(1.5-2.5):(0.8-1.2).

[0013] The composition containing Chinese herbal plant extracts provided by this invention has the following analysis of the principal, assistant, adjuvant, and guiding herbs in its formulation:

[0014] The principal ingredients are Angelica sinensis extract and Polygonum multiflorum extract. Angelica sinensis nourishes and invigorates blood, regulates menstruation and relieves pain, and moistens dryness and lubricates the intestines. Its active ingredients (such as ferulic acid and ligustilide) can significantly promote hair follicle cell proliferation, improve microcirculation around hair follicles, and inhibit inflammatory factors, thus being the foundation of hair growth. Polygonum multiflorum nourishes the liver and kidneys, replenishes essence and blood, blackens hair, and strengthens muscles and bones. Its active ingredients (such as stilbene glycosides) can activate hair follicle stem cells, promote the secretion of growth factors by dermal papilla cells, and provide antioxidant protection for hair follicles, making it an essential medicine for blackening and promoting hair growth. Together, these two ingredients serve as the principal ingredients, leading the core effects of nourishing and invigorating blood, nourishing hair follicles, and activating regeneration.

[0015] Assistant herbs: Rhubarb extract, Lycium bark extract, and Ligusticum chuanxiong extract. Rhubarb clears heat, cools the blood, and detoxifies; Lycium bark cools the blood, eliminates steaming heat, clears the lungs, and reduces fire. Together (in a specific ratio), they can significantly promote hair growth and inhibit key factors in hair follicle degeneration. Ligusticum chuanxiong invigorates blood circulation, dispels wind, and relieves pain. Its active ingredients (such as tetramethylpyrazine) powerfully dilate capillaries, improve scalp blood circulation, and enhance the delivery and absorption of the principal herbs and other ingredients, helping them reach the hair follicle target. These three herbs assist the principal herbs, enhancing hair growth efficacy and focusing on improving the hair follicle environment.

[0016] Adjuvant ingredients: Arborvitae leaf extract, Sophora flavescens root extract, Panax notoginseng root extract, and mulberry leaf extract. Arborvitae leaf cools the blood and stops bleeding, promotes hair growth and darkens hair; Sophora flavescens clears heat, dries dampness, and kills parasites. The combination of these two (in a specific ratio) can effectively inhibit sebum secretion, reducing hair follicle blockage and inflammation caused by excessive oil. Panax notoginseng invigorates blood circulation, removes blood stasis, and relieves pain; mulberry leaf disperses wind-heat, clears the lungs, and moistens dryness, possessing anti-inflammatory and antioxidant effects, helping to improve the scalp's healthy environment and reduce hair loss triggers. This group of adjuvant ingredients primarily addresses excessive sebum secretion and scalp inflammation, creating favorable conditions for hair follicle regeneration.

[0017] Ingredients: Ginseng root extract and ginger extract. Ginseng greatly replenishes vital energy, restores pulse and consolidates the body; its saponins can enhance hair follicle cell vitality and improve stress resistance. Ginger warms the middle and dispels cold; its gingerol (such as 6-gingerol) can stimulate scalp blood circulation and has a mild permeation-promoting effect, guiding the other ingredients directly to the affected area. The two ingredients harmonize the other ingredients, stimulate overall activity, and enhance the mildness and transdermal absorption efficiency of the composition.

[0018] On the other hand, the present invention provides a method for preparing the composition containing the extract of traditional Chinese medicine plants, comprising the following steps:

[0019] (a) Heat the water in the formula to 30-75°C;

[0020] (b) While stirring, add ginseng root extract, arborvitae leaf extract, Panax notoginseng root extract, ginger extract, Sophora flavescens root extract, mulberry leaf extract, rhubarb extract, Lycium chinense root bark extract, Angelica sinensis extract, Polygonum multiflorum extract, and Ligusticum chuanxiong extract in sequence.

[0021] (c) Maintain the temperature and continue stirring until the mixture is homogeneous;

[0022] (d) Perform post-processing to obtain the composition.

[0023] As a preferred embodiment of the present invention, the heating temperature in step (a) is 45-65°C.

[0024] As a preferred embodiment of the present invention, the stirring speed in step (c) is 100-500 rpm and the stirring time is 0.5-2 hours.

[0025] As a preferred embodiment of the present invention, the post-processing in step (d) includes a sterilization step, wherein the sterilization is ultraviolet sterilization or membrane filtration sterilization.

[0026] In another aspect, the present invention provides the application of the composition containing Chinese herbal plant extracts in the preparation of shampoos.

[0027] Compared with the prior art, the beneficial effects of the present invention are as follows: The composition containing extracts of traditional Chinese medicinal plants provided by the present invention, through scientific formulation of the principal, assistant, adjuvant, and guide herbs, has the following significant advantages and beneficial effects:

[0028] 1. Powerful Promotion of Hair Follicle Regeneration and Hair Growth: The principal ingredients, Angelica sinensis and Polygonum multiflorum, directly activate hair follicle stem cells and dermal papilla cells, while the secondary ingredients, Rheum palmatum, Lycium chinense root bark, and Ligusticum chuanxiong, synergistically enhance their effects, significantly improving hair follicle microcirculation and nutrient supply. Experiments show that after 20 days of using shampoo containing the composition of this invention, hair growth length can reach over 6.2 cm, and after 30 days, it can reach over 9.0 cm; hair follicle density is significantly increased (by 15-25%), and the proportion of resting follicles is significantly reduced (by 10-20%), superior to the control group and similar commercially available products.

[0029] 2. Significantly prevents and improves hair loss: The composition effectively inhibits 5α-reductase activity and reduces local DHT levels in the scalp (inhibition rate up to 40-60%), thereby halting the key pathological process of androgenetic alopecia. Simultaneously, by improving the healthy environment of hair follicles and inhibiting inflammation, it effectively reduces hair loss caused by seborrheic dermatitis and other conditions. Clinical observations show a significant reduction in hair loss after use.

[0030] 3. Long-lasting and highly effective control of scalp sebum secretion: The adjuvant herbs, Platycladus orientalis leaf and Sophora flavescens, produce excellent synergistic oil-controlling effects under specific ratios. Experiments have shown that after one month of using shampoo containing the composition of this invention, the sebum secretion inhibition rate can reach more than 50%, and after two months it can reach more than 65%. The oil-controlling effect is long-lasting and stable, significantly better than the control composition with single ingredients or imbalanced ratios and commercially available oil-controlling shampoos.

[0031] 4. Synergistic effect of multiple targets: The composition acts on multiple targets such as hair follicle activation, microcirculation improvement, DHT inhibition, anti-inflammation, and oil control, which solves the problems of hair loss and oily scalp from the root and achieves the dual goals of "hair growth and strengthening" and "refreshing oil control".

[0032] 5. Low irritation and high safety: All ingredients are derived from natural plant extracts, making them gentle and non-irritating. Testing has shown that the composition and the shampoo made from it are chemically stable (pH 5.5-6.5), meet microbiological standards, and show no or mild irritation in skin irritation tests, making it suitable for long-term use.

[0033] 6. Simple preparation process, easy to industrialize: The preparation method is simple to operate, the conditions are mild, no complicated equipment is required, and it is suitable for large-scale production. Detailed Implementation

[0034] To make the objectives, technical solutions, and advantages of this invention clearer, the technical solutions in the embodiments of this invention will be described more clearly and completely below. Obviously, the described embodiments are only some embodiments of this invention, and not all embodiments. Based on the embodiments of this invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this invention.

[0035] The sources of the raw materials used in the following embodiments of the present invention are as follows (only examples, not limited thereto):

[0036] Ginseng root extract, Panax notoginseng root extract: Xi'an Lvtian Biotechnology Co., Ltd.; Platycladus orientalis leaf extract: Baoji Kosmai Biotechnology Co., Ltd.; Ginger extract, mulberry leaf extract: Shaanxi Huinengda Biotechnology Co., Ltd.; Sophora flavescens root extract: Henan Kangzhiwang Biotechnology Co., Ltd.; Rheum palmatum extract: Shaanxi Xintianyu Biotechnology Co., Ltd.; Lycium chinense root bark extract: Fufeng Sinote Biotechnology Co., Ltd.; Angelica sinensis extract (containing ferulic acid ≥1%): Lanzhou Foci Pharmaceutical Co., Ltd.; Polygonum multiflorum extract (containing stilbene glycoside ≥20%): Guangdong Yifang Pharmaceutical Co., Ltd.; Ligusticum chuanxiong extract (containing ligustrazine ≥1%): Sichuan Xinhehua Traditional Chinese Medicine Pieces Co., Ltd.

[0037] Experimental methods not specified in the examples are generally performed under standard conditions or conditions recommended by the manufacturer.

[0038] Example 1: Composition and its preparation (focusing on balanced hair growth and oil control)

[0039] Raw materials (parts by weight):

[0040] 150 parts water; 1.5 parts ginseng root extract; 2.0 parts arborvitae leaf extract; 1.2 parts notoginseng root extract; 1.0 part ginger extract; 1.5 parts sophora flavescens root extract (arborvitae leaf and sophora flavescens = 1.33:1); 0.8 parts mulberry leaf extract; 1.8 parts rhubarb extract; 1.5 parts lycium chinense root bark extract (rhubarb and lycium chinense root bark = 1:0.83); 3.0 parts angelica sinensis extract; 3.0 parts polygonum multiflorum extract (angelica sinensis and polygonum multiflorum = 1:1); 1.2 parts chuanxiong extract (angelica sinensis, polygonum multiflorum, and chuanxiong = 2.5:2.5:1).

[0041] Preparation method:

[0042] 1. Add 150 parts of water to a reaction vessel equipped with stirring and heating, and heat to 55°C.

[0043] 2. Turn on the stirrer (300 rpm) and add the following extracts in sequence: ginseng root extract, arborvitae leaf extract, notoginseng root extract, ginger extract, sophora flavescens root extract, mulberry leaf extract, rhubarb extract, lycium bark extract, angelica extract, polygonum multiflorum extract, and chuanxiong extract.

[0044] 3. Maintain a stirring temperature of 55°C and a stirring speed of 300 rpm for 1.5 hours to ensure that all extracts are fully dissolved and evenly dispersed.

[0045] 4. Cool the mixture to below 40°C and filter it through a 0.22μm microporous membrane for sterilization.

[0046] 5. A clear to slightly turbid brownish-yellow composition solution is obtained, which is the composition of the present invention.

[0047] Example 2: Composition and its preparation (focusing on potent hair growth)

[0048] Raw materials (parts by weight):

[0049] Water 100 parts; Ginseng root extract 2.0 parts; Platycladus orientalis leaf extract 1.5 parts; Panax notoginseng root extract 1.5 parts; Ginger extract 1.2 parts; Sophora flavescens root extract 1.2 parts (Platycladus orientalis leaf Sophora flavescens = 1.25:1); Mulberry leaf extract 0.5 parts; Rheum palmatum extract 2.2 parts; Lycium chinense root bark extract 2.0 parts (Rheum palmatum and Lycium chinense root bark = 1:0.91); Angelica sinensis extract 4.0 parts; Polygonum multiflorum extract 4.0 parts (Angelica sinensis and Polygonum multiflorum = 1:1); Ligusticum chuanxiong extract 1.5 parts (Angelica sinensis, Polygonum multiflorum and Ligusticum chuanxiong ≈ 2.67:2.67:1).

[0050] Preparation method: Same as in Example 1, heating temperature 60℃, stirring speed 350 rpm, stirring time 1.2 hours.

[0051] Example 3: Composition and its preparation (focusing on oil control and gentle hair growth)

[0052] Raw materials (parts by weight):

[0053] Water 200 parts; Ginseng root extract 1.0 part; Platycladus orientalis leaf extract 2.5 parts; Panax notoginseng root extract 1.0 part; Ginger extract 0.8 parts; Sophora flavescens root extract 1.6 parts (Platycladus orientalis leaf Sophora flavescens ≈ 1.56:1); Mulberry leaf extract 1.0 part; Rheum palmatum extract 1.5 parts; Lycium chinense root bark extract 1.4 parts (Rheum palmatum and Lycium chinense root bark ≈ 1:0.93); Angelica sinensis extract 2.5 parts; Polygonum multiflorum extract 2.0 parts (Angelica sinensis and Polygonum multiflorum = 1.25:1); Ligusticum chuanxiong extract 1.0 part (Angelica sinensis, Polygonum multiflorum and Ligusticum chuanxiong = 2.5:2:1).

[0054] Preparation method: Same as in Example 1, heating temperature 50℃, stirring speed 250 rpm, stirring time 2 hours.

[0055] Example 4: Preparation of Shampoo

[0056] A shampoo was prepared based on the composition prepared in Example 1.

[0057] Shampoo formula (percentage by weight):

[0058] The composition of the present invention (Example 1): 20.0%;

[0059] Sodium lauryl ether sulfate (AES): 10.0%;

[0060] Cocamidopropyl betaine (CAB-35): 6.0%;

[0061] Decyl glucoside (APG0810): 4.0%;

[0062] Disodium cocoamphodiacetate: 3.0%;

[0063] Glycerin: 3.0%;

[0064] Polyquaternium-10: 0.8%;

[0065] Guar gum hydroxypropyltrimethylammonium chloride: 0.5%;

[0066] Citric acid (to adjust pH to 6.0): as needed;

[0067] Sodium benzoate: 0.3%;

[0068] Fragrance: 0.5%;

[0069] Deionized water: Add to 100%.

[0070] Preparation method:

[0071] 1. Add deionized water to the main pot and heat to 70-75℃.

[0072] 2. Add AES, CAB-35, APG0810 and disodium cocoamphodiacetate in sequence, and stir until dissolved.

[0073] 3. Cool to 45-50℃, add glycerol, polyquaternium-10, and guar hydroxypropyltrimethylammonium chloride, and stir to disperse evenly.

[0074] 4. Add the composition of the present invention (Example 1) and stir until homogeneous.

[0075] 5. Adjust the pH of the system to 6.0±0.2 using citric acid.

[0076] 6. Cool down to below 40℃, add sodium benzoate and flavoring, and stir well.

[0077] 7. Cool to room temperature, discharge the material, and obtain the finished shampoo.

[0078] Example 5: Composition Performance Testing

[0079] 1. Test on the effect of hair follicle regeneration and hair growth (mouse model):

[0080] Methods: C57BL / 6 mice (6-8 weeks old, with dorsal hair loss in the resting phase) were used. The hair-removed area (2x2cm²) was randomly divided into groups (n=10 / group). The following treatments were applied daily: Group 1: physiological saline (negative control); Group 2: the composition of Example 1 (diluted 3-fold); Group 3: the composition of Example 2 (diluted 3-fold); Group 4: the core extract of commercially available traditional Chinese medicine anti-hair loss shampoo A (diluted to the same concentration); Group 5: commercially available chemical anti-hair loss and hair growth liquid B (main ingredients: ketoconazole + caffeine).

[0081] Observation indicators:

[0082] Skin darkening area %: A direct indicator reflecting the hair follicle entering the growth phase (hair follicles in the growth phase contain melanin). Photos were taken on days 7 and 14, and the percentage of darkened area was analyzed using ImageJ software.

[0083] Hair length: On days 14 and 21, the length of newly grown hair was measured at 8 random locations and the average value was taken.

[0084] Follicle density & cycle: On day 21, skin tissue was taken from the back, stained with H&E, and the total number of hair follicles per unit area and the proportion of hair follicles in the anagen, catagen, and telogen phases were counted under a microscope.

[0085] Hair follicle stem cell marker (K15) expression: Immunohistochemical staining analysis of the number of K15 positive cells in the hair follicle bulge.

[0086] Results: (See Table 1 below)

[0087] Table 1: Test Results of Hair Follicle Regeneration and Hair Growth Effects

[0088]

[0089] Conclusion: The compositions of Examples 1 and 2 were significantly superior to the saline group and two commercially available anti-hair loss products (A and B) in promoting skin darkening (hair follicle activation), accelerating hair growth, increasing hair follicle density, increasing the proportion of hair follicles in the growth phase, and activating hair follicle stem cells (K15 expression). In particular, the compositions of this invention showed outstanding effects in the hair follicle stem cell activation index (K15+ cell count).

[0090] Example 2 (focusing on strong hair growth) is slightly better than Example 1 (balanced type) in terms of hair growth rate and hair follicle density.

[0091] 2. DHT inhibition rate test (in vitro 5α-reductase inhibition experiment):

[0092] Methods: The human recombinant 5α-reductase type II (SRD5A2) kit was used to test the inhibition rate of different concentrations of the compositions of Examples 1 and 3 and the positive control drug finasteride on the conversion of testosterone to DHT.

[0093] Results: (See Table 2 below)

[0094] Table 2: Results of 5α-reductase type II inhibition rate test

[0095]

[0096] Conclusion: The compositions of the present invention (Examples 1 and 3) all exhibited good inhibitory activity against 5α-reductase type II in vitro, thereby reducing DHT production; the higher the concentration, the stronger the inhibition rate. Although their IC50 values ​​were higher than those of the drug finasteride, as a natural compound composition applied to shampoo (topical application), they effectively act on the scalp target and have higher safety. The inhibitory effect of Example 1 was slightly stronger than that of Example 3, which is related to the higher concentration of the hair growth active ingredient therein.

[0097] 3. Oil control effect test (human volunteers):

[0098] Subjects: 30 volunteers diagnosed with seborrheic alopecia or simple oily scalp (half male and half female, aged 25-45) were randomly divided into 3 groups (n=10 / group).

[0099] Methods: Group 1: Shampoo containing 20% ​​of the composition of Example 1 (prepared according to the method of Example 4); Group 2: Shampoo containing 20% ​​of the composition of Example 3 (prepared according to the method of Example 4); Group 3: Commercially available strong oil-control shampoo C (main ingredients: salicylic acid + zinc pyrithione).

[0100] Directions for use: Take 5g of shampoo each time and wash your hair and scalp using the standard method once a day for 8 consecutive weeks.

[0101] Observation indicators:

[0102] Sebum secretion rate (Sebumeter®): Tests sebum at the hairline on the forehead. Measurements are taken before use (T0), 4 weeks after use (T4), and 8 weeks after use (T8). The sebum secretion inhibition rate is calculated (inhibition rate % = [(T0 value - Tn value) / T0 value] × 100%).

[0103] Subjective greasiness rating: Volunteers recorded the greasiness of their scalp daily (0 points: not oily at all, 10 points: extremely oily).

[0104] Results: (See Table 3 below)

[0105] Table 3: Results of Human Tests on Oil Control Effect

[0106]

[0107] (Note: Data is Mean ± SD)

[0108] Conclusion: After 4 and 8 weeks of use of shampoos containing the compositions of the present invention (Examples 1 and 3), the sebum secretion inhibition rate was significantly higher than that of the commercially available strong oil-control shampoo group C (p<0.05).

[0109] Example 3 shampoo (focused on oil control) was slightly better than Example 1 shampoo (balanced type) in terms of inhibition rate at T4 and T8 and subjective oiliness score at T8, reflecting the difference in formulation focus.

[0110] Volunteers reported that the shampoo of this invention has a long-lasting oil-control effect, and the refreshing feeling after washing can be maintained for a longer period of time, with no significant dryness or irritation reported.

[0111] Example 6: Physicochemical and Safety Testing of Shampoo

[0112] The shampoo prepared in Example 4 was tested as follows: pH value: 6.15 (consistent with the slightly acidic environment of the scalp); viscosity: 4200 cP (moderate, easy to apply); heat and cold resistance stability: (40℃, 24h; -10℃, 24h) after returning to room temperature, there were no significant changes in appearance, viscosity and pH.

[0113] Microbiological indicators: Total bacterial count, molds and yeasts, thermotolerant coliforms, Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans were all not detected (compliant with cosmetic safety regulations).

[0114] Skin irritation test (rabbit): The score of repeated skin irritation tests was 0.3 (indicating non-irritation).

[0115] Human patch test: 30 volunteers were covered with patches for 48 hours, and no adverse reactions such as erythema or edema occurred (irritation response rate 0%).

[0116] Conclusion: The composition containing traditional Chinese medicine plant extracts provided by this invention and its application in shampoo, by introducing core hair growth components such as Angelica sinensis, Polygonum multiflorum, and Ligusticum chuanxiong, and scientifically formulating them based on the theory of principal, assistant, and adjuvant herbs, significantly enhances the hair follicle regeneration and hair growth efficacy of the original patented composition, while retaining excellent oil control effects. In vitro and in vivo experiments and human trial data fully demonstrate that this composition can effectively activate hair follicle stem cells, promote hair growth, inhibit DHT production, and effectively control scalp sebum secretion, while being safe and gentle. The shampoo made from it has clear multiple effects of preventing hair loss, promoting hair growth, and controlling oil, with significantly better effects than the positive control in the prior art and similar commercially available products, showing good market application prospects.

[0117] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A composition containing extracts of traditional Chinese medicinal plants, characterized in that: The composition containing Chinese herbal plant extracts, by weight, comprises the following components: 50-500 parts water; 0.5-5 parts ginseng root extract; 0.5-4 parts arborvitae leaf extract; 0.2-4 parts Panax notoginseng root extract; 0.1-3 parts ginger extract; 0.2-4 parts Sophora flavescens root extract; 0.1-3 parts mulberry leaf extract; 0.5-4 parts Rheum palmatum extract; 0.4-4 parts Lycium chinense root bark extract; 1-6 parts Angelica sinensis extract; 1-6 parts Polygonum multiflorum extract; 0.5-3 parts Ligusticum chuanxiong extract; The mass ratio of Rheum palmatum extract to Lycium chinense root bark extract was 1:(0.6-1.1); the mass ratio of Platycladus orientalis leaf extract to Sophora flavescens root extract was (1-1.7):1; and the mass ratio of Angelica sinensis extract, Polygonum multiflorum extract and Ligusticum chuanxiong extract was (1-3):(1-3):(0.5-1.5).

2. The composition containing traditional Chinese medicine plant extracts according to claim 1, characterized in that: The composition containing the herbal plant extracts comprises, by weight, the following components: 60-300 parts water; 0.8-3 parts ginseng root extract; 0.8-3.5 parts arborvitae leaf extract; 0.3-3 parts Panax notoginseng root extract; 0.2-2.5 parts ginger extract; 0.2-2.5 parts Sophora flavescens root extract; 0.2-2 parts mulberry leaf extract; 0.8-3.5 parts Rheum palmatum extract; 0.6-3 parts Lycium chinense root bark extract; 2-5 parts Angelica sinensis extract; 1-2.5 parts Polygonum multiflorum extract; 1-2.5 parts Ligusticum chuanxiong extract; The mass ratio of Rheum palmatum extract to Lycium chinense root bark extract was 1:(0.8-1.0); the mass ratio of Platycladus orientalis leaf extract to Sophora flavescens root extract was (1.2-1.5):1; and the mass ratio of Angelica sinensis extract, Polygonum multiflorum extract and Ligusticum chuanxiong extract was (1.5-2.5):(1.5-2.5):(0.8-1.2).

3. The method for preparing the composition containing traditional Chinese medicine plant extracts according to any one of claims 1-2, characterized in that: Includes the following steps: (a) Heat the water in the formula to 30-75°C; (b) While stirring, add ginseng root extract, arborvitae leaf extract, Panax notoginseng root extract, ginger extract, Sophora flavescens root extract, mulberry leaf extract, rhubarb extract, Lycium chinense root bark extract, Angelica sinensis extract, Polygonum multiflorum extract, and Ligusticum chuanxiong extract in sequence. (c) Maintain the temperature and continue stirring until the mixture is homogeneous; (d) Perform post-processing to obtain the composition.

4. A method for preparing a composition containing traditional Chinese medicine plant extracts as described in claim 3, characterized in that: The heating temperature in step (a) is 45-65℃.

5. The method for preparing the composition containing traditional Chinese medicine plant extracts according to claim 3, characterized in that: The stirring speed in step (c) is 100-500 rpm, and the stirring time is 0.5-2 hours.

6. The method for preparing the composition containing traditional Chinese medicine plant extracts according to claim 3, characterized in that: The post-processing in step (d) includes a sterilization step, wherein the sterilization is ultraviolet sterilization or membrane filtration sterilization.

7. The use of a composition containing Chinese herbal plant extracts as described in any one of claims 1-2 in the preparation of shampoo.

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