Application of Reco18 in preparation of products for improving skin glossiness, smoothness, irregular menstruation, sleep or ovarian aging

Abstract

The invention discloses an application of Reco18 in preparation of a product for improving skin glossiness, smoothness, irregular menstruation, sleep or ovarian aging. Reco18 is a nutritional supplement preparation, the core component Reco18 is a component of follicular fluid, the research shows that the Reco18 can improve the skin condition of women and delay ovarian aging, specifically, the Reco18 can remarkably improve the skin glossiness, roughness and smoothness of women, effectively relieve sleep disorder, relieve dysmenorrhea and delay ovarian aging, and the Reco18 can be used for preparing the follicular fluid. The menstrual color is ruddy, and the safety is good.

Description

Technical Field

[0001] This invention relates to the field of Reco18 application technology, specifically to the application of Reco18 in the preparation of products that improve skin radiance, smoothness, menstrual irregularities, sleep, or ovarian aging. Background Technology

[0002] A woman's facial skin condition directly impacts her facial aesthetics. Genetics, environment, and age can all contribute to rough, dull skin. Long-term roughness weakens the skin's natural barrier function, making it more susceptible to external stimuli and accelerating aging, leading to premature fine lines and wrinkles, thus affecting a woman's appearance. Therefore, effective interventions are needed to improve a woman's skin condition.

[0003] In view of this, the present invention is hereby proposed. Summary of the Invention

[0004] The purpose of this invention is to provide an application of Reco18 in the preparation of products that improve skin radiance, smoothness, menstrual irregularities, sleep, or ovarian aging. In this invention, Reco18 is a nutritional supplement preparation, and its core component, Reco18, is a component of follicular fluid. Studies have shown that it can improve women's skin condition and delay ovarian aging. Moreover, this preparation has high safety and can be used by pregnant women and lactating mothers, with a wide range of applications.

[0005] In order to achieve the above-mentioned objectives of the present invention, the following technical solution is adopted:

[0006] The first aspect of this invention provides the application of Reco18 in the preparation of products that improve the luster of women's skin.

[0007] A second aspect of the present invention provides a product for improving the radiance of women's skin, the product containing Reco18.

[0008] A third aspect of the present invention provides the use of Reco18 in the preparation of products that improve the smoothness of women's skin.

[0009] A fourth aspect of the present invention provides a product for improving the smoothness of women's skin, the product containing Reco18.

[0010] The fifth aspect of this invention provides the use of Reco18 in the preparation of products that improve sleep quality.

[0011] A sixth aspect of the present invention provides a product for improving sleep quality, the product containing Reco18.

[0012] The seventh aspect of this invention provides the use of Reco18 in the preparation of products that improve menstrual irregularities.

[0013] The eighth aspect of the present invention provides a product for improving menstrual irregularities, the product containing Reco18.

[0014] The ninth aspect of this invention provides the use of Reco18 in the preparation of products that delay ovarian aging.

[0015] The tenth aspect of the present invention provides a product for delaying ovarian aging, the product containing Reco18.

[0016] Compared with the prior art, the beneficial effects of the present invention include at least the following:

[0017] In this invention, Reco18 is a nutritional supplement. Its core ingredient, Reco18, is a component of follicular fluid. Studies have shown that it can improve women's skin condition and delay ovarian aging. Specifically, Reco18 can significantly improve women's skin radiance (increase by 25.45%), roughness (SEr value ↑ 36.04%), and smoothness (SEsm value ↓ 9.13%), and effectively relieve sleep disorders (sleep onset time shortened by 56.12%), relieve dysmenorrhea (93.55% of subjects agreed), delay ovarian aging, and make menstrual blood more rosy and safe. Moreover, this preparation has high safety and can be used by pregnant women and breastfeeding mothers, with a wide range of applications. Attached Figure Description

[0018] To more clearly illustrate the specific embodiments of the present invention or the technical solutions in the prior art, the accompanying drawings used in the description of the specific embodiments or the prior art will be briefly introduced below. In all the drawings, similar elements or parts are generally identified by similar reference numerals. In the drawings, the elements or parts are not necessarily drawn to scale.

[0019] Figure 1 This is a comparison image of skin gloss before and after using the sample in an embodiment of the present invention;

[0020] Figure 2 This is a comparison chart of skin roughness parameter SEr values ​​before and after using the sample in an embodiment of the present invention;

[0021] Figure 3 This is a comparison chart of the skin smoothness parameter SEsm values ​​before and after using the sample in an embodiment of the present invention;

[0022] Figure 4 The improvement rate of sleep quality as a subjective evaluation in this embodiment of the invention. Detailed Implementation

[0023] The embodiments of the technical solution of the present invention will be described in detail below with reference to the examples. The following embodiments are only used to illustrate the technical solution of the present invention more clearly, and are therefore only examples, and should not be used to limit the scope of protection of the present invention.

[0024] It should be noted that, unless otherwise stated, the technical or scientific terms used in this application should have the ordinary meaning as understood by one of ordinary skill in the art to which this invention pertains.

[0025] This invention provides an application of Reco18 in the preparation of products that improve the luster of women's skin.

[0026] Another embodiment of the present invention provides a product for improving the radiance of women's skin, the product containing Reco18.

[0027] Another embodiment of the present invention provides the use of Reco18 in the preparation of products that improve the smoothness of women's skin.

[0028] Another embodiment of the present invention provides a product for improving the smoothness of women's skin, the product containing Reco18.

[0029] Another embodiment of the present invention provides the application of Reco18 in the preparation of products that improve sleep quality.

[0030] Another embodiment of the present invention provides a product for improving sleep quality, the product containing Reco18.

[0031] Another embodiment of the present invention provides the application of Reco18 in the preparation of products for improving menstrual disorders.

[0032] Another embodiment of the present invention provides a product for improving menstrual irregularities, the product containing Reco18.

[0033] Another embodiment of the present invention provides the application of Reco18 in the preparation of products that delay ovarian aging.

[0034] Another embodiment of the present invention provides a product for delaying ovarian aging, the product containing Reco18.

[0035] In this invention, Reco18 is a nutritional supplement. Its core ingredient, Reco18, is a component of follicular fluid. Studies have shown that it can improve women's skin condition and delay ovarian aging. Specifically, Reco18 can significantly improve women's skin radiance (increase by 25.45%), roughness (SEr value ↑ 36.04%), and smoothness (SEsm value ↓ 9.13%), and effectively relieve sleep disorders (sleep onset time shortened by 56.12%), relieve dysmenorrhea (93.55% of subjects agreed), delay ovarian aging, and make menstrual blood more rosy and safe. Moreover, this preparation has high safety and can be used by pregnant women and breastfeeding mothers, with a wide range of applications.

[0036] The technical solution of the present invention will be further described in detail below through specific embodiments.

[0037] Example

[0038] This example is a study on the effects of Reco18 on improving skin radiance and smoothness, menstrual irregularities, sleep quality, or delaying ovarian aging in women:

[0039] 1. Materials and Methods

[0040] 1.1 Clinical Data

[0041] Thirty-two women were selected from those enrolled between October 19, 2023 and December 14, 2023, with 31 ultimately completing the study. Their ages ranged from 31 to 40 years, with a mean age of (36.77 ± 3.04) years. Inclusion criteria: ① Healthy women aged 30–40 years; ② Patients with rough skin, reported poor sleep quality, and dysmenorrhea; ③ Informed consent was given for this study. Exclusion criteria: ① Women who had used antihistamines within the past week or immunosuppressants within the past month; ② Women with inflammatory skin diseases; ③ Patients with insulin-dependent diabetes mellitus; ④ Patients with asthma or chronic respiratory diseases; ⑤ Patients who had received chemotherapy for cancer within the past six months.

[0042] 1.2 Methods

[0043] The participants were given samples containing Reco18 for intervention. The specific method was: take 4 tablets (0.5g / tablet) of DaChao Reco18 (commercially available product) after breakfast and dinner, twice a day, for 56 consecutive days.

[0044] 1.3 Observation Indicators

[0045] (1) Compare the changes in skin glossiness of the participants before and after the intervention. In this study, the Glossymeter GL200 was used to detect the glossiness of the patients' faces. The specific method was as follows: After the participants cleaned their faces with facial cleanser, they sat quietly in the laboratory at a temperature of 21±1℃ and a humidity of 50±10%RH for 30 minutes. Then, the glossiness of the cheek skin was detected by the device. The higher the glossiness, the better the skin condition.

[0046] (2) Compare the changes in roughness and smoothness of the participants before and after the intervention. In this study, VisioScanVC20plus was used to detect the roughness and smoothness of the patients' faces. The specific method was as follows: After the participants cleaned their faces with facial cleanser, they sat quietly in the laboratory at a temperature of 21±1℃ and a humidity of 50±10%RH for 30 minutes. Then, the device was used to detect the roughness and smoothness of the cheek skin. The higher the roughness, the lower the degree of skin roughness, and the higher the smoothness, the better the degree of skin smoothness.

[0047] (3) Compare the changes in sleep quality of the participants before and after the intervention. Sleep quality was investigated using a self-made assessment scale with a total of 10 items. A 4-point scoring method was used: ① None, 0 points; ② < 1 time / week, 1 point; ③ 1 to 2 times / week, 2 points; ④ ≥ 3 times / week, 3 points.

[0048] (4) Statistical analysis and results of menstrual status before and after medication

[0049] The following indicators were collected through a self-report questionnaire from the participants:

[0050] Relief of menstrual cramps: The degree of acceptance of the statement that "the sample can relieve menstrual cramps" after 56 days of use (5-point scale: 1 = disagreement to 5 = agreement);

[0051] Improved menstrual color: Level of acceptance of the finding that "menstrual blood became more rosy after taking the sample";

[0052] Statistical methods:

[0053] Agreement Calculation: Combine "somewhat agree" (4 points) and "agree" (5 points) into a positive feedback and calculate the percentage;

[0054] Significance test for improvement in dysmenorrhea: The McNemar test was used to compare the change in the incidence of dysmenorrhea before and after the medication (the original report's D0 inclusion criteria required "dysmenorrhea in the past six months", i.e., 100% baseline dysmenorrhea rate);

[0055] Data visualization: Using Python 3.8 to draw stacked bar charts.

[0056] (5) Statistics on the occurrence of adverse reactions.

[0057] 1.4 Statistical Analysis

[0058] Statistical analysis was performed using SPSS 22.0 software. A p-value < 0.05 was considered statistically significant.

[0059] 2. Results

[0060] 2.1 Changes in various indicators of the participants in this group before intervention

[0061] After the intervention, the skin luster, roughness, smoothness and sleep quality scores of the participants in this group were higher than before the intervention, and the differences were significant (P<0.05), as shown in Table 1.

[0062] Table 1. Changes in various indicators before and after intervention in the participants of this group.

[0063]

[0064] 2.2 Improved skin condition

[0065] 2.2.1 Gloss

[0066] After intervention, the mean Gloss increased by 25.45% (7.25±1.30 vs 9.10±1.30, t=10.24, P<0.001, Cohen'sd=1.43), and all subjects showed a positive change. Figure 1 ).

[0067] 2.2.2 Roughness (SEr)

[0068] SEr value increased by 36.04% (3.88±0.85 vs 5.28±1.58, Z=-4.87, P<0.001), and 90.32% of subjects showed improvement. Figure 2 ).

[0069] 2.2.3 Smoothness (SEsm)

[0070] SEsm value decreased by 9.13% (285.82±78.71 vs 259.74±76.45, Z=-4.92, P<0.001), and 96.77% of subjects responded ( Figure 3 ).

[0071] 2.3 Improved sleep quality

[0072] 2.3.1 Objective Indicators

[0073] The changes in sleep parameters are shown in Table 2;

[0074] Table 2

[0075]

[0076]

[0077] As shown in Table 2:

[0078] Time to fall asleep: 50.00±27.23 minutes → 21.94±11.60 minutes (a decrease of 56.12%)

[0079] Actual sleep time: 5.58±0.75 hours → 7.98±4.16 hours (42.65% increase).

[0080] 2.3.2 Subjective Scoring

[0081] The improvement rate of nine indicators, including difficulty falling asleep and nighttime awakenings, ranged from 64.71% to 90.63% (all P < 0.05), and 93.55% of the participants approved of the overall effect. Figure 4 ).

[0082] 2.4 Improvement in menstrual cycle

[0083] 2.4.1 Dysmenorrhea relief effect

[0084] Baseline data: All 31 subjects reported experiencing dysmenorrhea in the past six months at enrollment (100% incidence rate);

[0085] After intervention: 93.55% (29 / 31) of the subjects agreed that dysmenorrhea was relieved (4-5 points), of which 80.65% (25 / 31) gave a score of 5 (complete agreement);

[0086] Significance test: The incidence of dysmenorrhea before and after intervention was compared using the McNemar test. The complete relief rate of dysmenorrhea (no dysmenorrhea) reached 77.42% (24 / 31), P<0.001 (χ²). 2 =22.04, df=1).

[0087] 2.4.2 Improvement of menstrual color

[0088] 83.87% (26 / 31) of the participants reported that their menstrual blood color was more rosy (4-5 points), of which 61.29% (19 / 31) agreed with a score of 5 (Table 3).

[0089] Table 3

[0090] Evaluation indicators 4 points of agreement 5 points of agreement Overall approval rating (4+5 points) Menstrual cramp relief 12.90％ 80.65％ 93.55％ Menstrual blood color is more reddish 22.58％ 61.29％ 83.87％

[0091] 2.4.3 Typical Improvement Cases

[0092] Subject 009 (35 years old): Baseline dysmenorrhea score of 3 (severe abdominal pain), which dropped to 0 (no pain) after intervention; menstrual color changed from dark red to bright red.

[0093] Subject 015 (34 years old): Previously dependent on ibuprofen for dysmenorrhea, stopped taking the medication after 56 days and the pain score dropped from 4 to 1.

[0094] 2.5 Adverse reactions among participants in this group

[0095] No adverse skin reactions were observed in any of the participants in this study group during their use of DaChao Reco18. 100% of the subjects (31 / 31) denied experiencing adverse reactions such as menstrual cycle disorders or abnormal menstrual flow after taking the product; the subjects' self-reported experiences after use are shown in Table 4.

[0096] Table 4

[0097] My experience after using the sample - 1 D56 approval rating The sample tasted good. 90.32％ The sample can relieve menstrual cramps after taking it. 93.55％ The sample showed that menstrual blood became more rosy after consumption. 83.87％ The skin was smoother after taking the sample. 87.10％ After taking the sample, the skin became more hydrated and radiant. 80.65％ The sample showed improved sleep quality after taking it. 93.55％ After taking the sample, I felt refreshed every morning upon waking up. 90.32％ Overall acceptance of the sample 93.55％ Feelings after using the sample - 2 D56 approval rating Are there any adverse reactions after taking the sample? none

[0098] In summary, Reco18 can significantly improve women's skin radiance (increase by 25.45%), roughness (SEr value ↑ 36.04%), and smoothness (SEsm value ↓ 9.13%), and effectively alleviate sleep disorders (sleep onset time shortened by 56.12%), relieve menstrual cramps (93.55% of subjects agreed), delay ovarian aging, and make menstrual blood more rosy with good safety.

[0099] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features therein. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention, and they should all be covered within the scope of the claims and specification of the present invention.

Claims

1. Application of Reco18 in the preparation of products that improve the radiance of women's skin.

2. A product for improving the radiance of women's skin, characterized in that, The product contains Reco18.

3. Application of Reco18 in the preparation of products that improve the smoothness of women's skin.

4. A product for improving the smoothness of women's skin, characterized in that, The product contains Reco18.

5. Application of Reco18 in the preparation of products that improve sleep quality.

6. A product for improving sleep quality, characterized in that, The product contains Reco18.

7. Application of Reco18 in the preparation of products to improve menstrual disorders.

8. A product for improving menstrual irregularities, characterized in that, The product contains Reco18.

9. Application of Reco18 in the preparation of products that delay ovarian aging.

10. A product for delaying ovarian aging, characterized in that, The product contains Reco18.

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