Preparation method of Yixiaohongpain capsule

Abstract

The invention discloses a preparation method of a Waixiao pain capsule. The preparation method comprises the following steps: (1) preparing raw medicinal powder as base powder; weighing Chinese angelica, pseudo-ginseng, dahurian angelica root and prepared kusnezoff monkshood root, crushing into coarse powder, sieving and mixing; (2) preparing mixed clear paste; step (3): mixing; adding the prepared clear paste into a spray trolley matched with a spray drying granulator, adding the raw medicinal powder prepared in the step (3) into the spray drying granulator, heating the raw medicinal powder to a set temperature, spraying the clear paste into the spray drying granulator through the spray trolley, and intermittently shaking bags to form a mixture; (4) crushing and sieving the mixture; (5) uniformly mixing the fine powder with paracetamol; and (6) filling the mixed medicine powder into capsules. The process steps of drying the clear paste and crushing the clear paste into dry powder are reduced, the operation process is remarkably simplified, the retention rate of effective components is higher, and the product quality and the production efficiency are improved.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical manufacturing technology, specifically to a method for preparing a lumbar pain relief capsule. Background Technology

[0002] In clinical practice, Yaoxitong capsules are mainly used as analgesics to treat patients with lumbar lesions. For example, patients with lumbar disc herniation, or those with damage to the lumbar muscles and deep fascia causing lumbar pain and difficulty bending over, can take Yaoxitong capsules orally for treatment.

[0003] The main ingredients of Yaoxitong Capsules include Angelica dahurica, Aconitum carmichaelii, Angelica pubescens, Dipsacus asper, Achyranthes bidentata, Panax notoginseng, Saposhnikovia divaricata, Clematis chinensis, Cibotium barbarum, Stephania tetrandra, Eucommia ulmoides, Dioscorea hypoglauca, Polygonum multiflorum, Taxillus chinensis, and Angelica sinensis. In the production of Yaoxitong Capsules, Panax notoginseng, Angelica sinensis, and Angelica dahurica are individually pulverized into fine powder. The remaining herbs are extracted and concentrated to form a thick paste, which is then dried to obtain a dry powder. This dry powder of traditional Chinese medicine and the fine powder of herbs are mixed with the raw material of the Western medicine ingredient "acetaminophen." The evenly mixed powder is then filled into hollow gelatin capsule shells to form capsules.

[0004] This preparation method requires drying the thick paste before pulverizing it into dry powder, which can easily lead to loss of the dry powder during the pulverization process. In addition, since the dry powder, raw medicinal powder, and Western medicine powder are all powders, the effective ingredients cannot be integrated together, and the content cannot be guaranteed to be uniform, resulting in reduced efficacy. Summary of the Invention

[0005] This invention aims to solve the technical problems existing in the prior art, and innovatively proposes a method for preparing Yaoxitong capsules. It uses raw medicinal powder as base powder and sprays it with the extracted extract for granulation. No other excipients need to be added, which reduces costs. The extract is sprayed into the raw medicinal powder, which reduces the steps of drying and pulverizing the extract into dry powder. This significantly simplifies the operation process, shortens the production cycle, and results in a higher retention rate of effective ingredients, thus improving product quality and production efficiency.

[0006] To achieve the above-mentioned objectives of this invention, this invention provides a method for preparing a lumbar pain relief capsule, comprising the following steps:

[0007] Step (1): Prepare raw medicinal powder as base powder;

[0008] Weigh out Angelica sinensis, Panax notoginseng, Angelica dahurica and processed Aconitum carmichaelii, grind them into coarse powder, sift them and mix them to obtain base powder;

[0009] Step (2): Prepare the mixed extract;

[0010] The following herbs were weighed: Angelica dahurica, processed Aconitum carmichaelii, Angelica pubescens, Dipsacus asper, Achyranthes bidentata, Panax notoginseng, Saposhnikovia divaricata, Clematis chinensis, Gentiana macrophylla, Cibotium barbarum, Stephania tetrandra, Piper kadsura, Eucommia ulmoides, Sophora flavescens, Polygonum multiflorum, Taxillus chinensis, Angelica sinensis, Drynaria fortunei, Carthamus tinctorius, Homalomena occulta, Paeonia lactiflora, and Cinnamomum cassia. Water was added to extract the extract, and the extract was concentrated to make a clear paste.

[0011] Step (3): Mix;

[0012] Add the prepared ointment to the spray trolley of the spray dryer granulator, add the raw medicinal powder prepared in step (3) to the spray dryer granulator, heat the raw medicinal powder to the set temperature, spray the ointment into the spray dryer granulator through the spray trolley, and intermittently shake the bag to form a mixture;

[0013] After the ointment has been sprayed out, the mixture is dried.

[0014] Step (4): Crush the mixture to form a fine powder and sieve it;

[0015] Step (5): Add the fine powder and paracetamol to a three-dimensional mixer and mix well to form a mixed powder;

[0016] Step (6): The mixed powder is filled into capsules using a fully automatic capsule filling machine to make lumbar pain relief capsules.

[0017] In the above scheme: in step (1), the sample is sieved through a 20-100 mesh sieve.

[0018] In the above scheme: In step (2), each raw material is added in the following weight proportions: Angelica dahurica 34-44 parts, processed Aconitum carmichaelii 21-31 parts, Angelica pubescens 47-57 parts, Dipsacus asper 48-56 parts, Achyranthes bidentata 48-56 parts, Panax notoginseng 43-50 parts, Saposhnikovia divaricata 50-60 parts, Clematis chinensis 45-57 parts, Gentiana macrophylla 47-57 parts, Acanthopanax senticosus 45-57 parts, Stephania tetrandra 75-86 parts, Piper kadsura 45-57 parts, Eucommia ulmoides 40-50 parts, Sophora flavescens 21-31 parts, Polygonum multiflorum 40-50 parts, Taxillus chinensis 21-31 parts, Angelica sinensis 21-31 parts, Drynaria fortunei 21-31 parts, Carthamus tinctorius 45-57 parts, Homalomena occulta 45-57 parts, Paeonia lactiflora 73-83 parts, and Cinnamomum cassia 45-57 parts.

[0019] In the above scheme: Step (2)

[0020] Extract from the text using the following method:

[0021] Step (2-1): Extraction in one step;

[0022] Weigh the medicine to be extracted and add it to the extraction vessel. Add water to soak it, then heat it to a boil and simmer it at a gentle boil. Filter the decoction.

[0023] Step (2-2): Secondary extraction;

[0024] Add water to the filter residue after filtration in step (1), boil, filter, and combine the decoctions;

[0025] Step (2-3): Concentrate the decoction;

[0026] The combined decoction is added to a concentration tank and concentrated to a clear extract with a relative density of 1.1 to 1.3.

[0027] In the above scheme, the soaking time in step (2-1) is 20 to 40 minutes.

[0028] In the above scheme: the mass of water added for the first time is 11 to 14 times the total mass of the drug to be extracted in step (2), and the mass of water added for the second time is 8 to 12 times the total mass of the drug to be extracted in step (2).

[0029] In the above scheme: in step (3), the spray gun frequency range of the spray cart is 25-35Hz, the spray gun pressure range is 0.35-0.45mpa; the drying temperature of the mixture is 70-80℃, the duration of each bag shaking is 10-20 seconds, and the interval between bag shaking is 150-190 seconds.

[0030] In the above scheme: In step (1), each raw material is added in the following weight proportions: Angelica sinensis 21-31 parts, Panax notoginseng 42-52 parts, Angelica dahurica 33-45 parts and processed Aconitum carmichaelii 21-30 parts. In summary, due to the adoption of the above technical scheme, the beneficial effects of the present invention are: Using a spray drying granulator, the extract is directly sprayed into the raw medicinal powder, without the need to dry and pulverize the extract into dry powder, reducing the number of process steps, significantly simplifying the operation process, shortening the production cycle, and avoiding the loss problem in the process of pulverizing into dry powder in the prior art as much as possible; Using the raw medicinal powder as the base powder and spray granulating it with the extracted extract, there is no need to add other excipients, reducing costs, and the raw medicinal powder directly absorbs the extract, resulting in a higher retention rate of effective ingredients. Spraying the extract in the form of spray makes the particles smaller and more uniform, and the absorption of the raw medicinal powder is also more uniform. At the same time, it avoids the situation of uneven mixing of all fine powders in the prior art, improving product quality and production efficiency. Attached Figure Description

[0031] The above and / or additional aspects and advantages of the present invention will become apparent and readily understood from the description of the embodiments taken in conjunction with the following drawings, in which:

[0032] Figure 1 This is a process flow diagram of the present invention. Detailed Implementation

[0033] The present invention will be further described below with reference to the accompanying drawings and embodiments.

[0034] Example 1

[0035] like Figure 1 As shown, a method for preparing a lumbar pain relief capsule includes the following steps:

[0036] Step (1): Prepare raw medicinal powder as base powder;

[0037] Weigh out 26g of Angelica sinensis, 47g of Panax notoginseng, 39g of Angelica dahurica and 26g of processed Aconitum carmichaelii, grind them into coarse powder, pass them through a 20-mesh sieve, and mix them together;

[0038] Step (2): Prepare the mixed extract;

[0039] Step (2-1): Extraction in one step;

[0040] Weigh out 39g of Angelica dahurica, 26g of processed Aconitum carmichaelii, 52g of Angelica pubescens, 52g of Dipsacus asper, 52g of Achyranthes bidentata, 47g of Panax notoginseng, 52g of Saposhnikovia divaricata, 52g of Clematis chinensis, 52g of Gentiana macrophylla, 52g of Acanthopanax senticosus, 78g of Stephania tetrandra, 52g of Piper kadsura, 46g of Eucommia ulmoides, 26g of Sophora flavescens, 46g of Polygonum multiflorum, 26g of Taxillus chinensis, 26g of Angelica sinensis, 26g of Drynaria fortunei, 52g of Carthamus tinctorius, 52g of Homalomena occulta, 78g of Paeonia lactiflora, and 52g of Cinnamomum cassia. Add the weighed herbs to an extraction vessel, add 12 times the amount of water for the first time, soak for 30 minutes, then heat to a boil, maintain a gentle boil and simmer for 2 hours, and filter the decoction.

[0041] Step (2-2): Secondary extraction;

[0042] Add 10 times the amount of water to the filter residue, boil for 1.5 hours, filter, and combine the decoctions;

[0043] Step (2-3): Concentrate the decoction;

[0044] The combined decoction was added to a concentration tank and concentrated to a clear extract with a relative density of 1.22–1.25 (measured at 60°C).

[0045] Step (3): Mix;

[0046] Add the prepared ointment to the spray trolley of the spray dryer granulator, add the raw medicinal powder prepared in step (3) to the spray dryer granulator, heat the raw medicinal powder to the set temperature, spray the ointment into the spray dryer granulator through the spray trolley, and intermittently shake the bag to make a mixture;

[0047] After the ointment has been sprayed out, the mixture is dried.

[0048] The spray gun frequency range of the spray cart is 25-35Hz, and the spray gun pressure range is 0.35-0.45MPa; the drying temperature of the mixture is 70-80℃, the duration of each bag shaking is 10-20 seconds, and the interval between bag shaking is 150-190 seconds.

[0049] Step (4): Crush the mixture to form a fine powder and pass it through an 80-mesh sieve;

[0050] Step (5): Add the fine powder and paracetamol to a three-dimensional mixer and mix well to form a mixed powder;

[0051] Step (6): The mixed powder is filled into capsules using a fully automatic capsule filling machine to make lumbar pain relief capsules.

[0052] Example 2

[0053] A method for preparing a lumbar pain relief capsule includes the following steps:

[0054] Step (1): Prepare raw medicinal powder as base powder;

[0055] Weigh out 21g of Angelica sinensis, 42g of Panax notoginseng, 33g of Angelica dahurica and 21g of processed Aconitum carmichaelii, grind them into coarse powder, pass them through a 20-mesh sieve, and mix them together;

[0056] Step (2): Prepare the mixed extract;

[0057] Step (2-1): Extraction in one step;

[0058] Weigh out 34 parts of Angelica dahurica, 21g of processed Aconitum carmichaelii, 47g of Angelica pubescens, 48g of Dipsacus asper, 48g of Achyranthes bidentata, 43g of Panax notoginseng, 50g of Saposhnikovia divaricata, 45g of Clematis chinensis, 47g of Gentiana macrophylla, 45g of Cibotium barbarum, 79g of Stephania tetrandra, 45g of Piper kadsura, 42g of Eucommia ulmoides, 23g of Sophora flavescens, 42g of Polygonum multiflorum, 23g of Taxillus chinensis, 21g of Angelica sinensis, 21g of Drynaria fortunei, 45g of Carthamus tinctorius, 45g of Homalomena occulta, 73g of Paeonia lactiflora, and 45g of Cinnamomum cassia. Add the weighed herbs to an extraction tank, add 12 times the amount of water for the first time, soak for 30 minutes, then heat to a boil, maintain a gentle boil and simmer for 2 hours, and filter the decoction.

[0059] Step (2-2): Secondary extraction;

[0060] Add 10 times the amount of water to the filter residue, boil for 1.5 hours, filter, and combine the decoctions;

[0061] Step (2-3): Concentrate the decoction;

[0062] The combined decoction was added to a concentration tank and concentrated to a clear extract with a relative density of 1.22–1.25 (measured at 60°C).

[0063] Step (3): Mix;

[0064] Add the prepared ointment to the spray trolley of the spray dryer granulator, add the raw medicinal powder prepared in step (3) to the spray dryer granulator, heat the raw medicinal powder to the set temperature, spray the ointment into the spray dryer granulator through the spray trolley, and intermittently shake the bag to make a mixture;

[0065] After the ointment has been sprayed out, the mixture is dried.

[0066] The spray gun frequency range of the spray cart is 25-35Hz, and the spray gun pressure range is 0.35-0.45MPa; the drying temperature of the mixture is 70-80℃, the duration of each bag shaking is 10-20 seconds, and the interval between bag shaking is 150-190 seconds.

[0067] Step (4): Crush the mixture to form a fine powder and pass it through an 80-mesh sieve;

[0068] Step (5): Add the fine powder and paracetamol to a three-dimensional mixer and mix well to form a mixed powder;

[0069] Step (6): The mixed powder is filled into capsules using a fully automatic capsule filling machine to make lumbar pain relief capsules.

[0070] Example 3

[0071] A method for preparing a lumbar pain relief capsule includes the following steps:

[0072] Step (1): Prepare raw medicinal powder as base powder;

[0073] Weigh out 31g of Angelica sinensis, 52g of Panax notoginseng, 45g of Angelica dahurica and 30g of processed Aconitum carmichaelii, grind them into coarse powder, pass them through a 20-mesh sieve, and mix them together;

[0074] Step (2): Prepare the mixed extract;

[0075] Step (2-1): Extraction in one step;

[0076] Weigh out 44g of Angelica dahurica, 31g of processed Aconitum carmichaelii, 57g of Angelica pubescens, 56g of Dipsacus asper, 56g of Achyranthes bidentata, 50g of Panax notoginseng, 56g of Saposhnikovia divaricata, 57g of Clematis chinensis, 57g of Gentiana macrophylla, 47g of Cibotium barbarum, 86g of Stephania tetrandra, 57g of Piper kadsura, 40-50g of Eucommia ulmoides, 31g of Sophora flavescens, 50g of Polygonum multiflorum, 31g of Taxillus chinensis, 31g of Angelica sinensis, 31g of Drynaria fortunei, 57g of Carthamus tinctorius, 57g of Homalomena occulta, 83g of Paeonia lactiflora, and 57g of Cinnamomum cassia. Add the weighed herbs to an extraction tank, add 12 times the amount of water for the first time, soak for 30 minutes, then heat to a boil, maintain a gentle boil and simmer for 2 hours, and filter the decoction.

[0077] Step (2-2): Secondary extraction;

[0078] Add 10 times the amount of water to the filter residue, boil for 1.5 hours, filter, and combine the decoctions;

[0079] Step (2-3): Concentrate the decoction;

[0080] The combined decoction was added to a concentration tank and concentrated to a clear extract with a relative density of 1.22–1.25 (measured at 60°C).

[0081] Step (3): Mix;

[0082] Add the prepared ointment to the spray trolley of the spray dryer granulator, add the raw medicinal powder prepared in step (3) to the spray dryer granulator, heat the raw medicinal powder to the set temperature, spray the ointment into the spray dryer granulator through the spray trolley, and intermittently shake the bag to make a mixture;

[0083] After the ointment has been sprayed out, the mixture is dried.

[0084] The spray gun frequency range of the spray cart is 25-35Hz, and the spray gun pressure range is 0.35-0.45MPa; the drying temperature of the mixture is 70-80℃, the duration of each bag shaking is 10-20 seconds, and the interval between bag shaking is 150-190 seconds.

[0085] Step (4): Crush the mixture to form a fine powder and pass it through an 80-mesh sieve;

[0086] Step (5): Add the fine powder and paracetamol to a three-dimensional mixer and mix well to form a mixed powder;

[0087] Step (6): The mixed powder is filled into capsules using a fully automatic capsule filling machine to make lumbar pain relief capsules.

Claims

1. A method for preparing a lumbar pain relief capsule, characterized in that: Includes the following steps: Step (1): Prepare raw medicinal powder as base powder; Weigh out Angelica sinensis, Panax notoginseng, Angelica dahurica and processed Aconitum carmichaelii, grind them into coarse powder, sift them and mix them to obtain base powder; Step (2): Prepare the mixed extract; The following herbs were weighed: Angelica dahurica, processed Aconitum carmichaelii, Angelica pubescens, Dipsacus asper, Achyranthes bidentata, Panax notoginseng, Saposhnikovia divaricata, Clematis chinensis, Gentiana macrophylla, Cibotium barbarum, Stephania tetrandra, Piper kadsura, Eucommia ulmoides, Sophora flavescens, Polygonum multiflorum, Taxillus chinensis, Angelica sinensis, Drynaria fortunei, Carthamus tinctorius, Homalomena occulta, Paeonia lactiflora, and Cinnamomum cassia. Water was added to extract the extract, and the extract was concentrated to make a clear paste. Step (3): Mix; Add the prepared ointment to the spray trolley of the spray dryer granulator, add the raw medicinal powder prepared in step (3) to the spray dryer granulator, heat the raw medicinal powder to the set temperature, spray the ointment into the spray dryer granulator through the spray trolley, and intermittently shake the bag to form a mixture; After the ointment has been sprayed out, the mixture is dried. Step (4): Crush the mixture to form a fine powder and sieve it; Step (5): Add the fine powder and paracetamol to a three-dimensional mixer and mix well to form a mixed powder; Step (6): The mixed powder is filled into capsules using a fully automatic capsule filling machine to make lumbar pain relief capsules.

2. The method for preparing a lumbar pain relief capsule according to claim 1, characterized in that: In step (1), the sample is sieved through a 20-100 mesh sieve.

3. The method for preparing a lumbar pain relief capsule according to claim 1, characterized in that, In step (2), each raw material is added in the following weight proportions: Angelica dahurica 34-44 parts, processed Aconitum carmichaelii 21-31 parts, Angelica pubescens 47-57 parts, Dipsacus asper 48-56 parts, Achyranthes bidentata 48-56 parts, Panax notoginseng 43-50 parts, Saposhnikovia divaricata 50-60 parts, Clematis chinensis 45-57 parts, Gentiana macrophylla 47-57 parts, Acanthopanax senticosus 45-57 parts, Stephania tetrandra 75-86 parts, Piper kadsura 45-57 parts, Eucommia ulmoides 40-50 parts, Sophora flavescens 21-31 parts, Polygonum multiflorum 40-50 parts, Taxillus chinensis 21-31 parts, Angelica sinensis 21-31 parts, Drynaria fortunei 21-31 parts, Carthamus tinctorius 45-57 parts, Homalomena occulta 45-57 parts, Paeonia lactiflora 73-83 parts, and Cinnamomum cassia 45-57 parts.

4. The method for preparing a lumbar pain relief capsule according to claim 3, characterized in that, Step (2) Extract from the text using the following method: Step (2-1): Extraction in one step; Weigh the medicine to be extracted and add it to the extraction vessel. Add water to soak it, then heat it to a boil and simmer it at a gentle boil. Filter the decoction. Step (2-2): Secondary extraction; Add water to the filter residue after filtration in step (1), boil, filter, and combine the decoctions; Step (2-3): Concentrate the decoction; The combined decoction is added to a concentration tank and concentrated to a clear extract with a relative density of 1.1 to 1.

3.

5. The method for preparing a lumbar pain relief capsule according to claim 2, characterized in that: The soaking time in step (2-1) is 20 to 40 minutes.

6. The method for preparing a lumbar pain relief capsule according to claim 2, characterized in that: The first addition of water is 11 to 14 times the total mass of the drug to be extracted in step (2), and the second addition of water is 8 to 12 times the total mass of the drug to be extracted in step (2).

7. The method for preparing a lumbar pain relief capsule according to claim 1, characterized in that: In step (3), the spray gun frequency range of the spray cart is 25-35Hz, the spray gun pressure range is 0.35-0.45MPa, the mixture drying temperature is 70-80℃, the duration of each bag shaking is 10-20 seconds, and the interval between bag shaking is 150-190 seconds.

8. The method for preparing a lumbar pain relief capsule according to claim 1, characterized in that: In step (1), each raw material is added in the following weight proportions: Angelica sinensis 21-31 parts, Panax notoginseng 42-52 parts, Angelica dahurica 33-45 parts and processed Aconitum carmichaelii 21-30 parts.

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