Traditional Chinese medicine composition for treating qi stagnation and fluid deficiency and blood deficiency and dampness loss type pseudointestinal obstruction

Abstract

The invention relates to a traditional Chinese medicine composition for treating qi-stagnation and body fluid deficiency and blood-deficiency dampness loss type intestinal pseudoobstruction, which can effectively solve the medication problem of the qi-stagnation and body fluid deficiency and blood-deficiency dampness loss type intestinal pseudoobstruction. The traditional Chinese medicine preparation is prepared from the following traditional Chinese medicine raw materials by weight: radix asteris, semen raphani, fructus aurantii, radix rehmanniae, herba cistanche, angelica sinensis, peach kernels, fructus cannabis, rhizoma cimicifugae and liquorice, and is prepared by soaking the raw materials in water, boiling with strong fire, decocting with slow fire, filtering and concentrating. The traditional Chinese medicine composition disclosed by the invention is matched and mutually supported according to a main and secondary relationship of monarch, minister, assistant and guide, is scientifically prepared, has the effects of promoting qi circulation, nourishing yin, nourishing blood and moistening intestines, is convenient to take and good in effect, is a new breakthrough in medicines for treating qi stagnation, fluid deficiency and blood deficiency type intestinal pseudoobstruction, and has practical popularization and application values.

Description

TECHNICAL FIELD

[0001] The present application relates to traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating pseudo-intestinal obstruction caused by qi stagnation, fluid deficiency and blood deficiency. BACKGROUND

[0002] Intestinal pseudo-obstruction (IPO) has two characteristics: ① Intestinal motility abnormalities leading to intestinal contents emptying disorders: ② No evidence of mechanical intestinal obstruction. Pseudo-intestinal obstruction can be divided into acute intestinal pseudo-obstruction (AIPO) and chronic intestinal pseudo-obstruction (CIPO) according to the course of the disease. Among them, acute intestinal pseudo-obstruction refers to the symptoms of acute intestinal obstruction, namely Ogilivie syndrome. Chronic intestinal pseudo-obstruction is more common, which can be divided into primary and secondary. Chronic intestinal pseudo-obstruction was first proposed and officially named by Maldonado in 1970. Chronic intestinal pseudo-obstruction is not a certain disease, but a group of diseases characterized by "intestinal neuromuscular disorders leading to intestinal motility disorders".

[0003] CIPO is a refractory intestinal motility disorder. The treatment principles are gastrointestinal decompression, nutritional support, pain relief, recovery of gastrointestinal motility, prevention and treatment of infection, surgery, and organ transplantation. At present, there are still many challenges about this disease: due to low incidence, leading to insufficient understanding of clinicians, unclear pathogenesis, high misdiagnosis rate, and difficult treatment. There are still many places to be further studied in the future. Through genomics and molecular biology to help find the cause, dynamic MRI endoscopy and biopsy to help differential diagnosis, research on new types of prokinetic drugs to improve symptoms and restore intestinal motility, and through surgery and transplantation technology to improve the survival rate of patients with severe CIPO.

[0004] There is no disease name of pseudo-intestinal obstruction in ancient Chinese books. Its main clinical manifestations are emaciation, abdominal pain, abdominal distension, vomiting, anal stop of exhaust and defecation, loss of appetite, which belong to the category of "constipation" and "intestinal knot". The large intestine is responsible for transmission, and then it is transmitted to the stomach. So now let's look at the common problem of constipation, which is the failure of large intestine transmission, including lung descending, dry heat mechanism, fluid deficiency, and spleen deficiency. Weakness of the spleen and stomach, overthinking, long illness and various blood loss, resulting in blood deficiency and fluid deficiency, intestinal deficiency, resulting in constipation.

[0005] In summary, qi stagnation, fluid deficiency and blood deficiency are the pathogenesis of pseudo-intestinal obstruction. Based on the above theory, it is imperative to develop new traditional Chinese medicines for treating pseudo-intestinal obstruction based on the principles of promoting qi, nourishing yin, nourishing blood and moistening the intestines. SUMMARY

[0006] In view of the above, in order to overcome the deficiencies of the prior art, the purpose of the present application is to provide a traditional Chinese medicine composition for treating qi stagnation, fluid deficiency, blood deficiency and dampness type of pseudo intestinal obstruction, which can effectively solve the problem of treating qi stagnation, fluid deficiency, blood deficiency and dampness type of pseudo intestinal obstruction.

[0007] The technical solution solved by the present application is a traditional Chinese medicine composition for treating qi stagnation, fluid deficiency, blood deficiency and dampness type of pseudo intestinal obstruction, which is prepared from the following traditional Chinese medicine raw materials by weight: Ziyu 10-20g, Raisin 25-35g, Jujube 10-20g, Rehmannia 15-25g, Cistanche 15-25g, Angelica 10-20g, Peach Kernel 4-8g, Hemp Seed 10-20g, Rhizoma Cimicifugae 4-8g and Licorice 4-6g. The above traditional Chinese medicine raw materials are added with water 400-600ml, soaked at 18-25℃ for 15-25 minutes, then boiled with strong fire and simmered with weak fire for 20-30 minutes, filtered to obtain the first filtrate. The residue is added with water 300-400ml, boiled with strong fire and simmered with weak fire for 10-15 minutes, filtered, the residue is discarded, and the second filtrate is obtained. The two filtrates are combined and mixed, concentrated to 1 / 3-1 / 2 of the amount of water added twice, which is the finished product of decoction.

[0008] The traditional Chinese medicine composition of the present application is matched according to the primary and secondary relationship of monarch, minister, assistant and guide, and supports each other. After scientific preparation, it has the functions of promoting qi and nourishing yin, nourishing blood and moistening intestines. It is convenient to use and has good effect. It is a new breakthrough in the treatment of qi stagnation, fluid deficiency, blood deficiency and dampness type of pseudo intestinal obstruction, and has practical popularization and application value. DETAILED DESCRIPTION

[0009] The specific embodiments of the present application will be described in detail below in combination with examples and specific cases.

[0010] The present application can be given by the following examples in specific implementation:

[0011] Example 1

[0012] A traditional Chinese medicine composition for treating qi stagnation, fluid deficiency, blood deficiency and dampness type of pseudo intestinal obstruction is prepared from the following traditional Chinese medicine raw materials by weight: Ziyu 15g, Raisin 30g, Jujube 15g, Rehmannia 20g, Cistanche 20g, Angelica 15g, Peach Kernel 6g, Hemp Seed 15g, Rhizoma Cimicifugae 6g and Licorice 5g. The above traditional Chinese medicine raw materials are added with water 500ml, soaked at 21℃ for 20 minutes, then boiled with strong fire and simmered with weak fire for 25 minutes, filtered to obtain the first filtrate. The residue is added with water 350ml, boiled with strong fire and simmered with weak fire for 12 minutes, filtered, the residue is discarded, and the second filtrate is obtained. The two filtrates are combined and mixed, concentrated to 360ml, which is the finished product of decoction.

[0013] Example 2

[0014] A traditional Chinese medicine composition for treating pseudo-intestinal obstruction of qi stagnation, fluid deficiency and blood deficiency, which is made of the following traditional Chinese medicine materials by weight: 10g of radix platycladi, 25g of semen raphani, 10g of fructus aurantii, 15g of radix rehmanniae, 15g of herba cistanche, 10g of radix angelicae sinensis, 4g of semen persicae, 10g of semen cannabis, 4g of radix cimicifugae and 4g of radix glycyrrhizae. The above traditional Chinese medicine materials are added with 400ml of water, soaked for 25 minutes at 18℃, then boiled with strong fire and decocted with gentle fire for 20 minutes, filtered to obtain the first filtrate. The residue is added with 300ml of water, boiled with strong fire and decocted with gentle fire for 15 minutes, filtered, the residue is discarded to obtain the second filtrate. The two filtrates are combined, mixed, concentrated to 300ml to obtain the final product of decoction.

[0015] Example 3

[0016] A traditional Chinese medicine composition for treating pseudo-intestinal obstruction of qi stagnation, fluid deficiency and blood deficiency, which is made of the following traditional Chinese medicine materials by weight: 20g of radix platycladi, 35g of semen raphani, 20g of fructus aurantii, 25g of radix rehmanniae, 25g of herba cistanche, 20g of radix angelicae sinensis, 8g of semen persicae, 20g of semen cannabis, 8g of radix cimicifugae and 6g of radix glycyrrhizae. The above traditional Chinese medicine materials are added with 600ml of water, soaked for 15 minutes at 25℃, then boiled with strong fire and decocted with gentle fire for 30 minutes, filtered to obtain the first filtrate. The residue is added with 400ml of water, boiled with strong fire and decocted with gentle fire for 15 minutes, filtered, the residue is discarded to obtain the second filtrate. The two filtrates are combined, mixed, concentrated to 500ml to obtain the final product of decoction.

[0017] Example 4

[0018] A traditional Chinese medicine composition for treating pseudo-intestinal obstruction of qi stagnation, fluid deficiency and blood deficiency, which is made of the following traditional Chinese medicine materials by weight: 10g of radix platycladi, 35g of semen raphani, 10g of fructus aurantii, 25g of radix rehmanniae, 15g of herba cistanche, 20g of radix angelicae sinensis, 4g of semen persicae, 20g of semen cannabis, 4g of radix cimicifugae and 6g of radix glycyrrhizae. The above traditional Chinese medicine materials are added with 400ml of water, soaked for 15 minutes at 25℃, then boiled with strong fire and decocted with gentle fire for 30 minutes, filtered to obtain the first filtrate. The residue is added with 300ml of water, boiled with strong fire and decocted with gentle fire for 15 minutes, filtered, the residue is discarded to obtain the second filtrate. The two filtrates are combined, mixed, concentrated to 350ml to obtain the final product of decoction.

[0019] Example 5

[0020] A traditional Chinese medicine composition for treating qi stagnation, fluid deficiency, blood deficiency and dampness, which is prepared from the following traditional Chinese medicine raw materials by weight: 20g of radix platycladi, 25g of semen raphani, 20g of fructus aurantii, 15g of radix rehmanniae, 25g of herba cistanche, 10g of angelica sinensis, 8g of semen persicae, 10g of semen cannabis, 8g of radix cimicifugae and 4g of radix glycyrrhizae. The above traditional Chinese medicine raw materials are added with 600ml of water, soaked for 25 minutes at 18℃, then boiled with strong fire and decocted with weak fire for 20 minutes, filtered to obtain the first filtrate. The filter residue is added with 300ml of water, boiled with strong fire and decocted with weak fire for 15 minutes, filtered, the filter residue is discarded, the second filtrate is obtained, and the two filtrates are combined, mixed, concentrated to 420ml to obtain the finished decoction.

[0021] The traditional Chinese medicine composition can be prepared into a decoction, powder, pill, capsule or oral liquid which is acceptable in medicine according to the needs of taking.

[0022] According to the composition given in the above embodiment, any amount of traditional Chinese medicine can be prepared according to the needs. The given embodiment is only used to illustrate the specific implementation of the present application, but is not used to limit the protection scope of the present application. The technical core and key of the present application are the compatibility of the traditional Chinese medicine composition.

[0023] In the above given raw medicine, among them:

[0024] Radix platycladi: pungent, bitter, warm, lung meridian, moistening lung and promoting qi, eliminating phlegm and reducing qi.

[0025] Semen raphani: pungent, sweet, flat, lung, spleen and stomach meridian, eliminating food and reducing distension, expelling phlegm and reducing qi.

[0026] Fructus aurantii: bitter, sour, slightly cold, lung, spleen, liver, stomach and large intestine meridian, regulating qi, broadening the middle, removing stagnation and reducing distension.

[0027] Radix rehmanniae: sweet, bitter, cold, heart, liver and kidney meridian, clearing heat and cooling blood, nourishing yin and generating fluid.

[0028] Herba cistanche: warm, bitter and salty, kidney and large intestine meridian, tonifying kidney yang, benefiting essence and blood, moistening intestine and defecation.

[0029] Angelica sinensis: sweet and pungent, warm, liver, heart and spleen meridian, tonifying blood, regulating menstruation and relieving pain, moistening intestine and defecation.

[0030] Semen persicae: bitter and sweet, flat, heart, liver and large intestine meridian, activating blood and removing blood stasis, moistening intestine and defecation.

[0031] Semen cannabis: sweet, flat, spleen, stomach and large intestine meridian, moistening dryness and lubricating intestine.

[0032] Radix cimicifugae: pungent and slightly sweet, slightly cold, lung, spleen, stomach and large intestine meridian, releasing the exterior, removing heat and resolving toxin, raising yang qi.

[0033] Gancao: nature flat taste Gan, return to heart, lung, spleen, stomach. Supplement spleen and tonifying qi, clear heat and detoxification, expelling phlegm and relieving cough, relieve pain.

[0034] In the recipe, the purple, raphanus sativus, the promotion of lung qi, the row of gas and the middle, the raw land of Yin and dry, the four are the monarch; the flesh of the orchid benefits the blood, lubricates the intestines, the angelica blood and blood, lubricates the intestines, the peach kernel and the hemp seed oil lubricates the fat, nourishes the blood and lubricates the intestines, the four are the minister; the promotion of the middle gas is the auxiliary medicine; the licorice root adjusts the medicine, and the medicine is the servant. The above-mentioned medicines are effectively combined according to the primary and secondary relationship of monarch, minister and auxiliary, support each other, and are scientifically prepared, and the medicines are played together, with the function of promoting qi and nourishing Yin, nourishing blood and lubricating intestines, effectively treating qi stagnation, blood deficiency and dryness, and the effect is good, and the experiment has obtained very good beneficial technical effect, and the experimental data is as follows (taking example 1):

[0035] 1 Case source

[0036] The case comes from 40 patients with qi stagnation, blood deficiency and dryness type of pseudo intestinal obstruction selected from September 2024 to May 2025 in outpatient and ward.

[0037] 2 Diagnosis standard

[0038] 2.1.1 Diagnosis standard of pseudo intestinal obstruction (IPO)

[0039] (1) Clinical manifestations:

[0040] ① The typical clinical symptoms of IPO are abdominal pain, abdominal distension, vomiting, anal stop of exhaust and defecation, emaciation, anemia, etc.

[0041] ② Signs: abdominal bulge, no obvious tenderness, fixed tenderness point, no muscle tension, no mobile dullness, decreased or increased intestinal sound, and water sound can be heard.

[0042] (2) X-ray manifestations:

[0043] ① Typical performance of abdominal plain film or abdominal perspective shows that the abdominal cavity gas liquid plane is small and scattered, without large span gas liquid plane and overlapping arrangement ladder change.

[0044] ② Atypical performance is more abdominal gas and more content.

[0045] 2.2 TCM diagnosis standard

[0046] Referring to "Guiding principles for clinical research of new drugs of traditional Chinese medicine (trial)", combined with clinical practice:

[0047] Qi stagnation, blood deficiency and dryness

[0048] Main symptoms: abdominal pain, abdominal distension, vomiting, dry stool and difficult to discharge

[0049] Sub-symptoms: emaciation, yellowish complexion, pale nails

[0050] Tongue and pulse: red tongue, little moss, fine pulse.

[0051] 3. Inclusion criteria:

[0052] 1) Meet the diagnosis of IPO and have not been treated;

[0053] 2) Age: 18-75.

[0054] 4. Exclusion criteria:

[0055] 1) Pregnant, lactating women, and those who are intolerant to the drugs used in this test;

[0056] 2) Combined with severe cardiovascular and cerebrovascular diseases, liver and kidney diseases, severe mental diseases or intellectual disabilities, and those who cannot cooperate;

[0057] 5. Experimental grouping

[0058] Forty patients with pseudo-intestinal obstruction (qi stagnation and fluid deficiency, blood deficiency and loss of wetness) treated in the outpatient and inpatient departments from September 2024 to May 2025 were selected as experimental subjects, and the patients were divided into a treatment group and a control group according to a random number table, with 20 patients in each group.

[0059] 6. Experimental scheme

[0060] Course of treatment: 4 weeks

[0061] Control group: Mosapride (16 pills x 18 bags, GMP code Z20090013, Handan Pharmaceutical Co., Ltd.), taken orally before meals, 1 tablet each time.

[0062] Treatment group: Mosapride (same usage as the control group) combined with traditional Chinese medicine, 150-250 ml each time, morning and evening (with the formula amount as one dose, one dose per day).

[0063] 7. Efficacy evaluation criteria

[0064] The scoring criteria in Table 1 are adopted, and the following formula is used to evaluate the efficacy:

[0065] Efficacy determination value = (pre-treatment score - post-treatment score) / pre-treatment score x 100%

[0066] The efficacy criteria are as follows: marked effect: determination value > 2 / 3, effective: 1 / 3 < determination value < 2 / 3, ineffective: determination value < 1 / 3.

[0067] Table 1 Scoring criteria

[0068]

[0069] 8. Evaluation of clinical efficacy

[0070] Among the treatment group, 1 case was ineffective, 6 cases were effective, 13 cases were markedly effective, and the total effective rate was 95%; among the control group, 6 cases were ineffective, 11 cases were effective, 3 cases were markedly effective, and the total effective rate was 70%. The difference between the two groups was statistically significant (P<0.05), and the treatment group was obviously superior to the control group in terms of curative effect.

[0071] Table 2: Clinical curative effect evaluation [n (%)]

[0072] Group Example Invalid (human) Valid (human) Effective (human) Total effective rate Treatment group 20 1(5％) 6(30％) 13(65％) 95％ Control group 20 6(30％) 11(55％) 3(15％) 70％

[0073] During the whole clinical medication, no adverse reactions were found, indicating that the medication is safe.

[0074] At the same time of the experiment of Example 1, the same experiment was also conducted on other examples, and the same and similar results were obtained, which are not listed here.

[0075] 9. Conclusion

[0076] As can be seen from the above, the raw material of the present application is rich, the preparation method is simple, easy to take, low in cost, good in effect, the components support each other according to the primary and secondary compatibility relationship of monarch, minister, assistant and messenger, and have the functions of promoting qi, nourishing yin, nourishing blood and moistening intestines through scientific preparation. The whole prescription not only has stable curative effect, safe medication, and good long-term curative effect, but also is not easy to repeat, is easy to be accepted by patients, is effectively used for treating qi stagnation, fluid deficiency, blood deficiency and dampness type of pseudo intestinal obstruction, has a high effective rate of 95%, is a drug innovation for treating pseudo intestinal obstruction, and has actual clinical use value.

Claims

1. A traditional Chinese medicine composition for treating pseudo-intestinal obstruction of qi stagnation and fluid deficiency and blood deficiency and dampness, characterized in that, This decoction is prepared from the following Chinese medicinal materials by weight: 10-20g of Aster tataricus, 25-35g of Radish seed, 10-20g of Citrus aurantium, 15-25g of Rehmannia glutinosa, 15-25g of Cistanche deserticola, 10-20g of Angelica sinensis, 4-8g of Prunus persica, 10-20g of Cannabis sativa seed, 4-8g of Cimicifuga foetida, and 4-6g of Glycyrrhiza uralensis. Add 400-600ml of water to the above-mentioned medicinal materials and soak at 18-25℃ for 15-25 minutes. Then bring to a boil over high heat, simmer over low heat for 20-30 minutes, and filter to obtain the first filtrate. Add another 300-400ml of water to the dregs, bring to a boil over high heat, simmer over low heat for 10-15 minutes, filter, discard the dregs, and obtain the second filtrate. Combine the two filtrates, mix well, and concentrate to 1 / 3 to 1 / 2 of the total amount of water added in the two batches to obtain the finished decoction.

2. The traditional Chinese medicine composition for treating qi stagnation and fluid deficiency, blood deficiency and dampness, and blood deficiency and dampness type of pseudo intestinal obstruction according to claim 1, characterized in that, This decoction is made from the following Chinese medicinal materials by weight: 15g Aster tataricus, 30g Raphanus sativus seeds, 15g Citrus aurantium, 20g Rehmannia glutinosa, 20g Cistanche deserticola, 15g Angelica sinensis, 6g Prunus persica seeds, 15g Cannabis sativa seeds, 6g Cimicifuga foetida, and 5g Glycyrrhiza uralensis. Add 500ml of water to the above-mentioned Chinese medicinal materials and soak at 21℃ for 20 minutes. Then bring to a boil over high heat and simmer over low heat for 25 minutes. Filter to obtain the first filtrate. Add 350ml of water to the residue, bring to a boil over high heat, simmer over low heat for 12 minutes, filter, discard the residue, and obtain the second filtrate. Combine the two filtrates, mix well, and concentrate to 360ml to obtain the finished decoction.

3. The traditional Chinese medicine composition for treating qi stagnation and fluid deficiency, blood deficiency and dampness, and blood deficiency and dampness type of pseudo intestinal obstruction according to claim 1, characterized in that, This decoction is made from the following Chinese medicinal materials by weight: 10g Aster tataricus, 25g Raphanus sativus seeds, 10g Citrus aurantium, 15g Rehmannia glutinosa, 15g Cistanche deserticola, 10g Angelica sinensis, 4g Prunus persica seeds, 10g Cannabis sativa seeds, 4g Cimicifuga foetida, and 4g Glycyrrhiza uralensis. Add 400ml of water to the above-mentioned Chinese medicinal materials and soak at 18℃ for 25 minutes. Then bring to a boil over high heat, simmer over low heat for 20 minutes, filter, and obtain the first filtrate. Add another 300ml of water to the residue, bring to a boil over high heat, simmer over low heat for 15 minutes, filter, discard the residue, and obtain the second filtrate. Combine the two filtrates, mix well, and concentrate to 300ml to obtain the finished decoction.

4. The traditional Chinese medicine composition for treating qi stagnation and fluid deficiency, blood deficiency and dampness, and blood deficiency and dampness type of pseudo intestinal obstruction according to claim 1, characterized in that, This decoction is made from the following Chinese medicinal materials by weight: 20g Aster tataricus, 35g Raphanus sativus seeds, 20g Citrus aurantium, 25g Rehmannia glutinosa, 25g Cistanche deserticola, 20g Angelica sinensis, 8g Prunus persica seeds, 20g Cannabis sativa seeds, 8g Cimicifuga foetida, and 6g Glycyrrhiza uralensis. Add 600ml of water to the above-mentioned Chinese medicinal materials and soak at 25℃ for 15 minutes. Then bring to a boil over high heat, simmer over low heat for 30 minutes, filter, and obtain the first filtrate. Add another 400ml of water to the residue, bring to a boil over high heat, simmer over low heat for 15 minutes, filter, discard the residue, and obtain the second filtrate. Combine the two filtrates, mix well, and concentrate to 500ml to obtain the finished decoction.

5. The traditional Chinese medicine composition for treating pseudo-intestinal obstruction of the type caused by qi stagnation and fluid deficiency, and blood deficiency and lack of moisture, according to claim 1, is characterized in that... This decoction is made from the following Chinese medicinal materials by weight: 10g Aster tataricus, 35g Raphanus sativus seeds, 10g Citrus aurantium, 25g Rehmannia glutinosa, 15g Cistanche deserticola, 20g Angelica sinensis, 4g Prunus persica seeds, 20g Cannabis sativa seeds, 4g Cimicifuga foetida, and 6g Glycyrrhiza uralensis. Add 400ml of water to the above-mentioned Chinese medicinal materials and soak at 25℃ for 15 minutes. Then bring to a boil over high heat and simmer over low heat for 30 minutes. Filter to obtain the first filtrate. Add another 300ml of water to the residue, bring to a boil over high heat, simmer over low heat for 15 minutes, filter, and discard the residue to obtain the second filtrate. Combine the two filtrates, mix well, and concentrate to 350ml to obtain the finished decoction.

6. The traditional Chinese medicine composition for treating pseudo-intestinal obstruction of the type caused by qi stagnation and fluid deficiency, and blood deficiency and lack of moisture, according to claim 1, is characterized in that... This decoction is made from the following Chinese medicinal materials by weight: 20g Aster tataricus, 25g Raphanus sativus seeds, 20g Citrus aurantium, 15g Rehmannia glutinosa, 25g Cistanche deserticola, 10g Angelica sinensis, 8g Prunus persica seeds, 10g Cannabis sativa seeds, 8g Cimicifuga foetida, and 4g Glycyrrhiza uralensis. Add 600ml of water to the above-mentioned Chinese medicinal materials and soak at 18℃ for 25 minutes. Then bring to a boil over high heat, simmer over low heat for 20 minutes, filter, and obtain the first filtrate. Add another 300ml of water to the residue, bring to a boil over high heat, simmer over low heat for 15 minutes, filter, discard the residue, and obtain the second filtrate. Combine the two filtrates, mix well, and concentrate to 420ml to obtain the finished decoction.

7. The traditional Chinese medicine composition according to any one of claims 1-6 can be formulated into any medically acceptable dosage form as needed for administration.

8. The traditional Chinese medicine composition according to claim 7, characterized in that, The dosage form is a decoction, powder, pill, capsule, or oral liquid.

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