Chinese patent medicine for preventing cold virus and preparation method thereof
By preparing traditional Chinese medicines using tea polyphenols, dried ginger, and licorice extracts, the problems of poor efficacy and significant side effects of existing drugs in preventing and treating cold viruses have been solved, achieving highly effective and safe prevention and treatment.
Patent Information
- Application Number
- CN202511001262.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-07-21
- Publication Date
- 2025-11-18
AI Technical Summary
Existing drugs have problems in preventing and treating cold viruses, such as poor preventive effect, low treatment effectiveness and obvious side effects. In particular, chemically synthesized drugs may produce toxic side effects on the human body, while traditional Chinese medicine has problems such as complex formulas and unstable efficacy.
Traditional Chinese medicine preparations using tea polyphenols, dried ginger extract, and licorice extract as main ingredients are prepared through bio-extraction technology and formulated according to the principles of traditional Chinese medicine (TCM) to produce dosage forms such as tablets, capsules, or granules.
It significantly improves the effectiveness of preventing and treating cold viruses, reduces adverse reactions, and has good product stability, with the active ingredients maintaining a high content during storage.
Smart Images
Figure CN120960376A_ABST
Abstract
Description
Technical Field
[0001] This invention belongs to the field of pharmaceutical technology, specifically, it relates to a traditional Chinese medicine for preventing cold viruses and its preparation method. Background Technology
[0002] The common cold is a frequent respiratory illness caused by various viruses. These viruses spread rapidly and can easily cause large-scale infections in populations, posing a serious threat to people's health and safety. Currently, there are many types of medications on the market for the prevention and treatment of cold viruses, but some of these medications have problems such as poor preventive effects, low treatment efficacy, and significant side effects.
[0003] While existing chemically synthesized drugs can inhibit viruses to some extent, they may produce significant toxic side effects on the human body, and long-term use can easily lead to drug resistance. Some traditional Chinese medicines, on the other hand, suffer from complex formulations and unstable efficacy. Therefore, developing a simple, effective, and safe traditional Chinese medicine for the prevention and treatment of cold viruses is of significant practical importance.
[0004] In view of this, the present invention is proposed. Summary of the Invention
[0005] To solve the above-mentioned technical problems, the basic concept of the technical solution adopted by the present invention is as follows:
[0006] A traditional Chinese medicine for preventing cold viruses is composed of the following ingredients in parts by weight:
[0007] Principal ingredient: 10-30 parts of tea polyphenols;
[0008] Assistant ingredient: 5-15 parts of dried ginger extract;
[0009] Adjuvant herb: 5-15 parts of licorice extract.
[0010] In a preferred embodiment of the present invention, the tea polyphenols are extracted from green tea, and the dried ginger extract and licorice extract are obtained by bio-extraction technology.
[0011] As a preferred embodiment of the present invention, the present invention also discloses a method for preparing a traditional Chinese medicine for preventing cold viruses, comprising the following steps:
[0012] Step S1: Extract tea polyphenols. Using green tea as raw material, the green tea is crushed, and an appropriate amount of water is added. The mixture is soaked at 80-90℃ for 1-2 hours and then filtered to obtain an extract. The extract is concentrated to obtain a concentrate. Ethanol is added to the concentrate, and the mixture is allowed to stand for 12-24 hours. The precipitate is then filtered to obtain a precipitate. The precipitate is dried to obtain tea polyphenols.
[0013] Step S2: Extract ginger extract. Take dried ginger, wash it clean and crush it. Use bio-extraction technology to extract the ginger extract. Specifically, add the dried ginger powder to the extraction tank, add 5-10 times the amount of water, and perform ultrasonic extraction at 50-60℃ 2-3 times, 30-60 minutes each time. Combine the extracts. Filter and concentrate the extract, and dry it to obtain ginger extract.
[0014] Step S3: Extract licorice extract. Take the dried roots and rhizomes of licorice, wash them clean, crush them, and extract them using bio-extraction technology.
[0015] Step S4: Mix the preparation. Mix the tea polyphenols obtained in Step 1, the dried ginger extract obtained in Step 2, and the licorice extract obtained in Step 3 evenly according to the above weight ratio, and prepare different dosage forms such as tablets, capsules, and granules as needed.
[0016] In a preferred embodiment of the present invention, the ethanol concentration is made to reach 60-70% in step S1.
[0017] In a preferred embodiment of the present invention, the extract in step S2 is concentrated to a relative density of 1.1-1.2.
[0018] In a preferred embodiment of the present invention, the bio-extraction in step S3 specifically involves: adding licorice powder into an extraction tank, extracting 2-3 times under reflux conditions for 1-2 hours each time, and combining the extracts; filtering the extract, recovering ethanol and concentrating it, and drying it to obtain licorice extract.
[0019] In a preferred embodiment of the present invention, after the licorice powder is added to the extraction tank, 6-12 times the amount of 70-80% ethanol solution is added.
[0020] In a preferred embodiment of the present invention, the recovered ethanol is concentrated to an extract with a relative density of 1.1-1.2.
[0021] Compared with the prior art, the present invention has the following advantages:
[0022] This invention relates to a traditional Chinese medicine formula based on the principles of monarch, minister, assistant, and guide in traditional Chinese medicine. The monarch ingredient, tea polyphenols, has broad-spectrum antibacterial effects, effectively inhibiting various pathogenic bacteria and viruses. The minister ingredient, dried ginger, has the effects of warming the middle jiao and dispelling cold, restoring yang and unblocking the meridians, and drying dampness and resolving phlegm, thus assisting tea polyphenols in their effects. The assistant ingredient, licorice, has the effects of tonifying the spleen and replenishing qi, clearing heat and detoxifying, and harmonizing the effects of other herbs, thus enhancing efficacy and reducing adverse reactions. The synergistic effect of these three ingredients makes this traditional Chinese medicine significantly effective in preventing and treating cold viruses.
[0023] The specific embodiments of the present invention will now be described in further detail with reference to the accompanying drawings. Attached Figure Description
[0024] In the attached diagram:
[0025] Figure 1 The inhibition rate of different ratios of samples against influenza A virus H1N1, and the linear plots comparing them with the single-component group;
[0026] Figure 2 This is a linear graph showing the change in tea polyphenol content of the tablets in Example 1 during a 6-month storage period;
[0027] Figure 3 This is a linear graph showing the change in gingerol content of the tablets in Example 1 during 6 months of storage.
[0028] Figure 4 This is a linear graph showing the change in glycyrrhizic acid content in the tablets of Example 1 during a 6-month storage period. Detailed Implementation
[0029] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments will be clearly and completely described below with reference to the accompanying drawings. The following embodiments are used to illustrate the present invention.
[0030] Example 1: Tablet Preparation
[0031] Raw material composition (parts by weight): 20 parts tea polyphenols, 10 parts dried ginger extract, and 10 parts licorice extract.
[0032] Tea polyphenol extraction: Dried Longjing green tea leaves were pulverized to 100 mesh using an ultra-micro pulverizer. Purified water was added at a solid-liquid ratio of 1:18, and the mixture was soaked in an 85℃ water bath for 1.5 hours, stirring every 20 minutes. The extract was filtered through a 0.2μm ceramic membrane and concentrated under reduced pressure at 60℃ to 1 / 5 of its original volume. 95% ethanol was added to the concentrate to achieve a final concentration of 65%. The extract was allowed to stand at 25℃ for 18 hours, centrifuged at 3000 r / min for 15 minutes, and the precipitate was collected. The precipitate was then freeze-dried under vacuum at -40℃ (vacuum degree 10 Pa) and pulverized to obtain tea polyphenol powder with a purity of 93%.
[0033] Extraction of dried ginger extract: Slices of dried ginger (2mm thick) were dried at 60℃ and then pulverized to 80 mesh. Purified water was added at a solid-liquid ratio of 1:8, and the mixture was ultrasonically extracted twice at 55℃ and 300W for 45 minutes each time. The extracts were combined. After plate and frame filtration, the extract was concentrated under reduced pressure at 70℃ to a relative density of 1.15 (measured at 60℃). The extract was then spray-dried (inlet air 180℃, outlet air 80℃) to obtain dried ginger extract powder, containing 9.2% gingerol.
[0034] Licorice extract extraction: Dried licorice roots and rhizomes were sliced (3 mm thick) and pulverized to 60 mesh. A 75% ethanol solution was added at a solid-liquid ratio of 1:10, and the mixture was refluxed twice in an 80°C water bath (2 hours the first time, 1.5 hours the second time). The extracts were combined. After filtration through filter paper, the ethanol was recovered until no alcohol odor remained. The extract was concentrated to a relative density of 1.15 (measured at 60°C), and then vacuum-dried at 60°C (0.08 MPa) to obtain licorice extract powder with a glycyrrhizic acid content of 11.5%.
[0035] Mixed formulation: The above three extracts are added into a three-dimensional mixer in proportion and mixed at 20 r / min for 30 minutes. Then, 5% povidone K30 ethanol solution (concentration 50%) is added to make a soft mass. The mass is granulated by passing it through an 18-mesh sieve, dried at 60℃, and then compressed into tablets. Each tablet weighs 0.5g and contains 0.3g of active ingredients (including 15% tea polyphenols, 1.2% gingerol, and 1.5% glycyrrhizic acid).
[0036] Example 2: Capsule Preparation
[0037] Raw material composition (parts by weight): 10 parts tea polyphenols, 5 parts dried ginger extract, and 5 parts licorice extract.
[0038] Extraction process: Biluochun green tea was used for tea polyphenol extraction. The tea was pulverized to 80 mesh, with a solid-liquid ratio of 1:15, soaked at 80℃ for 1 hour, and the final ethanol concentration was 60%. The tea was then allowed to stand for 12 hours. The remaining parameters were the same as in Example 1, yielding tea polyphenols with a purity of 92%. The ginger extract was extracted with a solid-liquid ratio of 1:5, using ultrasonic extraction at 50℃ for 3 times (30 minutes each time), and concentrated to a relative density of 1.1 (measured at 60℃), with a gingerol content of 8.5%. The licorice extract was extracted with 70% ethanol, with a solid-liquid ratio of 1:6, and refluxed twice (1 hour each time), concentrated to a relative density of 1.1 (measured at 60℃), with a glycyrrhizic acid content of 10.2%.
[0039] Mixed formulation: Mix the extracts in proportion, mix for 25 minutes at 20 rpm using a three-dimensional mixer, granulate, and fill into No. 0 capsules. Each capsule weighs 0.3g and contains 0.18g of active ingredient.
[0040] Example 3: Granule Preparation
[0041] Raw material composition (parts by weight): 30 parts tea polyphenols, 15 parts dried ginger extract, and 15 parts licorice extract.
[0042] Extraction process: Tea polyphenols were extracted with a solid-liquid ratio of 1:20, soaked at 90℃ for 2 hours, with a final ethanol concentration of 70%, and allowed to stand for 24 hours to achieve a purity of 91%; dried ginger extract was extracted with a solid-liquid ratio of 1:10, ultrasonically extracted twice at 60℃ (60 minutes each time), and concentrated to a relative density of 1.2 (measured at 60℃), with a gingerol content of 8.8%; licorice extract was extracted with 80% ethanol at a solid-liquid ratio of 1:12, refluxed three times (1.5 hours each time), and concentrated to a relative density of 1.2 (measured at 60℃), with a glycyrrhizic acid content of 10.8%.
[0043] Mixed formulation: After mixing, granulation, drying, and granulation, it is packaged into 10g sachets, with an active ingredient content of 2.1g / sachet.
[0044] Example 4: Comparison of effects of different formulation ratios
[0045] The samples from Examples 1-3 were selected for in vitro antiviral experiments (using influenza A virus H1N1 as the test strain). The results showed that the virus inhibition rate of Example 1 was 82.3%, Example 2 was 65.7%, and Example 3 was 88.5%, all of which were significantly higher than the single-component groups (tea polyphenol group 61.2%, dried ginger extract group 42.5%, and licorice extract group 38.7%), proving that the three had a significant synergistic effect.
[0046] Table 1: Comparison of in vitro antiviral experimental results with different ratios
[0047]
[0048]
[0049] Example 5: Stability Test
[0050] The tablets from Example 1 were stored at a temperature of 25℃±2℃ and a relative humidity of 60%±5% for 6 months, and the content changes were detected monthly: the content of tea polyphenols decreased from the initial 15% to 14.7%, gingerol decreased from 1.2% to 1.18%, and glycyrrhizic acid decreased from 1.5% to 1.49%. All indicators met the pharmacopoeia requirements, indicating that the product has good stability.
[0051] Table 2: Tablet stability test results of Example 1
[0052]
[0053]
[0054] Figure 1The order of the mid-wave peaks is as follows: Example 1 virus inhibition rate 82.3%, Example 2 virus inhibition rate 65.7%, Example 3 virus inhibition rate 88.5%, single component group - tea polyphenol virus inhibition rate 61.2%; single component group - dried ginger extract virus inhibition rate 42.5%; single component group - licorice extract virus inhibition rate 38.7%.
Claims
1. A traditional Chinese medicine for preventing cold viruses, characterized in that, It consists of the following raw materials in parts by weight: Principal ingredient: 10-30 parts of tea polyphenols; Assistant ingredient: 5-15 parts of dried ginger extract; Adjuvant herb: 5-15 parts of licorice extract.
2. The traditional Chinese medicine for preventing cold viruses according to claim 1, characterized in that, The tea polyphenols were extracted from green tea, and the dried ginger extract and licorice extract were obtained using bio-extraction technology.
3. A method for preparing a traditional Chinese medicine for preventing cold viruses according to any one of claims 1 or 2, characterized in that, Includes the following steps: Step S1: Extract tea polyphenols. Using green tea as raw material, the green tea is crushed, and an appropriate amount of water is added. The mixture is soaked at 80-90℃ for 1-2 hours and then filtered to obtain an extract. The extract is concentrated to obtain a concentrate. Ethanol is added to the concentrate, and the mixture is allowed to stand for 12-24 hours. The precipitate is then filtered to obtain a precipitate. The precipitate is dried to obtain tea polyphenols. Step S2: Extract ginger extract. Take dried ginger, wash it clean and crush it. Use bio-extraction technology to extract the ginger extract. Specifically, add the dried ginger powder to the extraction tank, add 5-10 times the amount of water, and perform ultrasonic extraction at 50-60℃ 2-3 times, 30-60 minutes each time. Combine the extracts. Filter and concentrate the extract, and dry it to obtain ginger extract. Step S3: Extract licorice extract. Take the dried roots and rhizomes of licorice, wash them clean, crush them, and extract them using bio-extraction technology. Step S4: Mix the preparation. Mix the tea polyphenols obtained in Step 1, the dried ginger extract obtained in Step 2, and the licorice extract obtained in Step 3 evenly according to the above weight ratio, and prepare different dosage forms such as tablets, capsules, and granules as needed.
4. The method for preparing a traditional Chinese medicine for preventing cold viruses according to claim 1, characterized in that, In step S1, the ethanol concentration is increased to 60-70%.
5. The method for preparing a traditional Chinese medicine for preventing cold viruses according to claim 1, characterized in that, In step S2, the extract is concentrated to a relative density of 1.1-1.
2.
6. The method for preparing a traditional Chinese medicine for preventing cold viruses according to claim 1, characterized in that, The bio-extraction in step S3 specifically involves: adding licorice powder to an extraction tank and extracting it 2-3 times under reflux conditions, each time for 1-2 hours, and combining the extracts; filtering the extract, recovering the ethanol and concentrating it, and drying it to obtain the licorice extract.
7. The method for preparing a traditional Chinese medicine for preventing cold viruses according to claim 6, characterized in that, After the licorice powder is added to the extraction tank, 6-12 times the amount of 70-80% ethanol solution is added.
8. The method for preparing a traditional Chinese medicine for preventing cold viruses according to claim 6, characterized in that, The recovered ethanol is concentrated to an extract with a relative density of 1.1-1.2.