Composition with skin aging delaying function as well as preparation method and application thereof

Abstract

The invention discloses a composition with a function of delaying skin aging as well as a preparation method and application of the composition. The composition comprises the following components in parts by weight: 40-45 parts of a white poria extract, 10-40 parts of a ginseng extract, 5-8 parts of a lotus seed extract, 5-8 parts of radix angelicae powder, 5-8 parts of aloe vera gel, 12-16 parts of 4D hyaluronic acid, 15-20 parts of glycerol, 3-5 parts of palmitoyl tetrapeptide-7 and the balance of deionized water. Through compatibility of the white poria extract, the ginseng extract, the lotus seed extract, the radix angelicae powder, the aloe vera gel, the 4D hyaluronic acid, the glycerol, the palmitoyl tetrapeptide-7 and the deionized water, the composition with the skin aging delaying function is prepared, and the composition has an obvious skin aging delaying effect and has an excellent improvement effect on various skin problems; the white poria extract and the ginseng extract are compatible in proportion to generate a definite synergistic effect instead of a simple additive effect; the moisturizing cream can moisturize and brighten the skin color, improve the dull yellow skin, and realize the effect of delaying skin aging.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of skin care compositions, in particular to a composition with the function of delaying skin aging and a preparation method and application thereof. BACKGROUND

[0002] The natural ability of the human body to resist free radicals is declining, human cells will age, and the skin will become rough. Under normal circumstances, the human body has an antioxidant defense system that can maintain a balance between oxidation and antioxidant to slow down the production of active oxygen and free radicals. However, environmental pollutants such as ultraviolet radiation, air pollution and chemicals in the environment can stimulate the human body to continuously produce free radicals, and a large number of free radicals can cause the antioxidant defense ability of the skin to decrease, causing damage to the skin and the appearance of skin aging phenomena such as dark lines, fine lines and wrinkles.

[0003] The existing Chinese invention patent with the publication number CN114009794B discloses a composition with the function of delaying skin aging and its application, which includes the following components in parts by weight: collagen peptide 45-65 parts, katsuwonus pelamis elastin peptide 2-6 parts, spearmint extract 2-8 parts, sodium hyaluronate 1-5 parts, and vitamin C 0.5-5 parts. The composition realizes the effects of anti-aging, delaying wrinkle production, and increasing skin elasticity through the synergistic effect of multiple functional ingredients, and can be applied to improve skin elasticity, reduce wrinkle production, and delay skin aging.

[0004] The existing Chinese invention patent with the publication number CN112137937B discloses an active composition with the function of delaying skin aging and its application, which includes dog rose fruit extract, tremella polysaccharide and sodium hyaluronate, with a weight ratio of (0.5-10):(0.5-10):(1-6). The present application compounding dog rose fruit extract, tremella polysaccharide and sodium hyaluronate in a certain proportion, the obtained composition has good stability, safety and no irritation, and the composition has a synergistic effect and good antioxidant effect, which is beneficial to alleviate skin aging.

[0005] At present, the compositions with the function of delaying skin aging as described above have limited effects on collagen regeneration and inflammation inhibition, which can greatly reduce the efficiency of cell repair and regeneration. Therefore, the present application proposes a composition with the function of delaying skin aging and a preparation method and application thereof. SUMMARY

[0006] The present application aims to provide a composition with the function of delaying skin aging and a preparation method and application thereof to solve the problems raised in the background art.

[0007] The first aspect of the present application provides the following technical solution: a composition with the function of delaying skin aging, the composition comprising the following components in parts by weight: white Poria cocos extract 40-45 parts, ginseng extract 10-40 parts, lotus seed extract 5-8 parts, white radix angelicae powder 5-8 parts, aloe vera gel 5-8 parts, 4D hyaluronic acid 12-16 parts, glycerol 15-20 parts, palmitoyl tetrapeptide-7 3-5 parts, and the balance being deionized water.

[0008] The second aspect of the present application provides the following technical solution: a preparation method of a composition with the function of delaying skin aging, for preparing the composition with the function of delaying skin aging described above, comprising the following steps:

[0009] Step 1: adding deionized water and glycerol into a reaction kettle, and stirring at low speed until uniform and transparent;

[0010] Step 2: slowly adding 4D hyaluronic acid into the reaction kettle, adjusting the rotation speed of the reaction kettle to 2000 rpm, homogenizing for 10 minutes to ensure complete dissolution of the 4D hyaluronic acid, and then stopping heating and naturally cooling to room temperature;

[0011] Step 3: sequentially adding white Poria cocos extract, ginseng extract, and lotus seed extract, and stirring uniformly, and then adding aloe vera gel and palmitoyl tetrapeptide-7, and homogenizing for 10 minutes;

[0012] Step 4: adding deionized water and white radix angelicae powder into a dispersion tank, and stirring at high speed of 800 rpm for 15-20 minutes until forming a uniform and particle-free suspension slurry;

[0013] Step 5: adding the suspension slurry into the reaction kettle, and then high-speed homogenizing for 15 minutes, and then vacuum defoaming to obtain the composition with the function of delaying skin aging.

[0014] In Step 1, the mass ratio of deionized water to glycerol is 3:1.

[0015] In Step 1, the low-speed stirring conditions are: rotation speed of 100 rpm and temperature of 75±5℃.

[0016] In Step 3, the mass ratio of white Poria cocos extract to ginseng extract is 4:1.

[0017] In Step 3, the homogenization speed is 1500 rpm and the temperature is room temperature, specifically 35±5℃.

[0018] In Step 4, the mass ratio of deionized water to white radix angelicae powder is 3:1.

[0019] In Step 4, the particle size of the white radix angelicae powder is less than 600 mesh.

[0020] In step 5, the specific conditions of vacuum defoaming are as follows: the bubbles in the material body are removed under a vacuum degree of -0.05 to -0.06 MPa, and the process lasts for about 20 minutes until the material body is smooth and delicate.

[0021] In a third aspect, the present application provides the following technical solution: application of a composition with a skin aging delaying function, mixing the composition with a skin aging delaying function with one of the commonly used cosmetic water, essence, cream, eye cream and emulsion to obtain a skin care product with a skin aging delaying function, and the additive amount of the composition with a skin aging delaying function is 1-10% of the weight of the skin care product.

[0022] Compared with the prior art, the present application has the following beneficial effects:

[0023] The present application is prepared by compatibility of white Poria cocos extract, ginseng extract, lotus seed extract, white radix angelicae powder, aloe vera gel, 4D hyaluronic acid, glycerol, palmitoyl tetrapeptide-7 and deionized water, and a composition with a skin aging delaying function is obtained, which has obvious skin aging delaying effect and excellent improvement effect on various skin problems.

[0024] The compatibility of white Poria cocos extract and ginseng extract produces clear synergistic effect rather than simple additive effect, and can brighten skin color while moisturizing and improving yellowish skin, achieving the effect of delaying skin aging.

[0025] Through the synergistic effect of various functional ingredients, multiple effects are achieved, such as anti-aging and delaying wrinkle formation. DETAILED DESCRIPTION

[0026] The technical solutions of the present application are further described in detail below in combination with specific embodiments, but do not constitute any limitation on the present application, and any limited modifications made by anyone within the protection scope of the present application are still within the protection scope of the present application. It should be noted that the raw materials used in the technical solutions provided by the present application are purchased from the market through conventional means, except for special instructions.

[0027] Example 1

[0028] A preparation method of a composition with a skin aging delaying function, comprising the following steps:

[0029] Step 1: Add 54 parts of deionized water and 18 parts of glycerol into a reaction kettle, and stir at a low speed of 100 rpm and a temperature of 75±5℃ until uniform and transparent.

[0030] Step 2, slowly add 15 parts of 4D hyaluronic acid into the reaction kettle, adjust the rotation speed of the reaction kettle to 2000 rpm, homogenize for 10 minutes, ensure that the 4D hyaluronic acid is completely dissolved, then stop heating, and naturally cool to room temperature;

[0031] Step 3, add white beech mushroom extract 40 parts, ginseng extract 10 parts, lotus seed extract 6 parts in turn, and stir evenly, then add aloe vera gel 6 parts and palmitoyl tetrapeptide-7 4 parts, homogenize for 10 minutes, the homogenization speed is 1500 rpm, and the temperature is room temperature, specifically 35±5℃;

[0032] Step 4, in the dispersion tank, add 18 parts of deionized water and 6 parts of white xiaocai powder, stir at high speed of 800 rpm for 15-20 minutes, until a uniform and particle-free suspension slurry is formed;

[0033] Step 5, add the suspension slurry into the reaction kettle, then homogenize at high speed for 15 minutes, then remove the gas bubbles in the material under the vacuum degree of-0.05 to-0.06 MPa for about 20 minutes, until the material is smooth and smooth, to obtain the composition with the function of delaying skin aging.

[0034] Example 2

[0035] A preparation method of a composition with the function of delaying skin aging, comprising the following steps:

[0036] Step 1, add 54 parts of deionized water and 18 parts of glycerol into the reaction kettle, stir at a rotation speed of 100 rpm and a temperature of 75±5℃, until uniform and transparent;

[0037] Step 2, slowly add 15 parts of 4D hyaluronic acid into the reaction kettle, adjust the rotation speed of the reaction kettle to 2000 rpm, homogenize for 10 minutes, ensure that the 4D hyaluronic acid is completely dissolved, then stop heating, and naturally cool to room temperature;

[0038] Step 3, add white beech mushroom extract 40 parts, ginseng extract 20 parts, lotus seed extract 6 parts in turn, and stir evenly, then add aloe vera gel 6 parts and palmitoyl tetrapeptide-7 4 parts, homogenize for 10 minutes, the homogenization speed is 1500 rpm, and the temperature is room temperature, specifically 35±5℃;

[0039] Step 4, in the dispersion tank, add 18 parts of deionized water and 6 parts of white xiaocai powder, stir at high speed of 800 rpm for 15-20 minutes, until a uniform and particle-free suspension slurry is formed;

[0040] Step 5, the suspension slurry is added to the reaction kettle, then high-speed homogenization for 15 minutes, and then the gas bubbles in the material body are removed under a vacuum degree of -0.05 to -0.06 MPa for about 20 minutes until the material body is smooth and fine, to obtain the composition with the function of delaying skin aging.

[0041] Example 3

[0042] A preparation method of a composition with the function of delaying skin aging, comprising the following steps:

[0043] Step 1, 54 parts of deionized water and 18 parts of glycerol are added to the reaction kettle, and low-speed stirring is carried out at a rotation speed of 100 rpm and a temperature of 75±5℃ until it is uniformly transparent;

[0044] Step 2, 15 parts of 4D hyaluronic acid are slowly added to the reaction kettle, the rotation speed of the reaction kettle is adjusted to 2000 rpm, and homogenization is carried out for 10 minutes to ensure that the 4D hyaluronic acid is completely dissolved, then the heating is stopped, and the natural cooling is carried out to room temperature;

[0045] Step 3, 40 parts of white hoelen extract, 30 parts of ginseng extract and 6 parts of lotus seed extract are sequentially added and uniformly stirred, then 6 parts of aloe vera gel and 4 parts of palmitoyl tetrapeptide-7 are added, homogenization is carried out for 10 minutes at a homogenization speed of 1500 rpm and a temperature of room temperature, specifically 35±5℃;

[0046] Step 4, 18 parts of deionized water and 6 parts of angelica powder are added to the dispersion tank, and high-speed stirring is carried out at 800 rpm for 15-20 minutes until a uniformly particulate-free suspension slurry is formed;

[0047] Step 5, the suspension slurry is added to the reaction kettle, then high-speed homogenization for 15 minutes, and then the gas bubbles in the material body are removed under a vacuum degree of -0.05 to -0.06 MPa for about 20 minutes until the material body is smooth and fine, to obtain the composition with the function of delaying skin aging.

[0048] Example 4

[0049] A preparation method of a composition with the function of delaying skin aging, comprising the following steps:

[0050] Step 1, 54 parts of deionized water and 18 parts of glycerol are added to the reaction kettle, and low-speed stirring is carried out at a rotation speed of 100 rpm and a temperature of 75±5℃ until it is uniformly transparent;

[0051] Step 2, 15 parts of 4D hyaluronic acid are slowly added to the reaction kettle, the rotation speed of the reaction kettle is adjusted to 2000 rpm, and homogenization is carried out for 10 minutes to ensure that the 4D hyaluronic acid is completely dissolved, then the heating is stopped, and the natural cooling is carried out to room temperature;

[0052] Step 3, add white beech mushroom extract 40 parts, ginseng extract 40 parts, lotus seed extract 6 parts in sequence, and stir uniformly, then add aloe vera gel 6 parts and palmitoyl tetrapeptide-7 4 parts, homogenize for 10 minutes, the homogenization speed is 1500 rpm, and the temperature is room temperature, specifically 35±5℃;

[0053] Step 4, in the dispersion tank, add deionized water 18 parts and white peony powder 6 parts, stir at high speed 800 rpm for 15-20 minutes, until a uniform and particle-free suspension slurry is formed;

[0054] Step 5, add the suspension slurry into the reaction kettle, then homogenize at high speed for 15 minutes, then remove the gas bubbles in the material under the vacuum degree of-0.05 to-0.06 MPa for about 20 minutes, until the material is smooth and smooth, to obtain the composition with the function of delaying skin aging.

[0055] Comparative Example 1

[0056] Compared with Example 1, the white beech mushroom extract is replaced by deionized water, and the content and process of other components remain unchanged.

[0057] Comparative Example 2

[0058] Compared with Example 1, the ginseng extract is replaced by deionized water, and the content and process of other components remain unchanged.

[0059] Comparative Example 3

[0060] Compared with Example 1, the white beech mushroom extract is replaced by ginseng extract, and the content and process of other components remain unchanged.

[0061] Comparative Example 4

[0062] Compared with Example 1, the ginseng extract is replaced by white beech mushroom extract, and the content and process of other components remain unchanged.

[0063] Comparative Example 5

[0064] Compared with Example 1, the white beech mushroom extract and the ginseng extract are both replaced by deionized water, and the content and process of other components remain unchanged.

[0065] Experimental Example

[0066] In order to prove the technical points of the technical solutions provided in the present application, the experimental data of Examples 1-4 and Comparative Examples 1-5 provided in the present application are given below;

[0067] In vitro test-free radical scavenging test

[0068] According to the principle and experiment of DPPH free radical scavenging, Examples 1-4 and Comparative Examples 1-5 are verified.

[0069] Test principle:

[0070] DPPH is dark purple in appearance, and also in solution. When a system has free radicals, the free radicals can be captured by the unpaired electrons of DPPH after the addition of DPPH. The color changes from dark purple to light yellow or colorless after the reaction. DPPH has the advantages of simple identification, easy detection, low price, etc. It can be detected by a simple spectrophotometer. The maximum absorption peak is at 517 nm wavelength, and the absorbance is linearly related to its concentration. If it is necessary to quantify the reacted DPPH, a certain concentration gradient of DPPH solution can be prepared in advance to draw an absorbance curve to determine the remaining content in the solution.

[0071] Experimental process

[0072] Preparation of reagents

[0073] DPPH ethanol solution: 40 mg of DPPH was weighed and dissolved in anhydrous ethanol and diluted to 1000 mL in a volumetric flask. The concentration of DPPH was prepared to be 40 mg / L. It was stored in a low-temperature refrigerator and protected from light, with a shelf life of 5 days.

[0074] Test solution: The compositions of Examples 1-4 and Comparative Examples 1-5 were diluted to a concentration of 1.0% with phosphate buffer.

[0075] The calculation formula of the DPPH free radical scavenging rate of the sample is:

[0076] Relative DPPH free radical scavenging rate (%) = [1-(A1-A2) / A3] x 100. Free radical scavenging experiment: taking 2 mL of 0.2 mM DPPH as the working solution, A1 is the absorbance of 2 mL of 95% ethanol plus 2 mL of DPPH working solution; A2 is the absorbance measured at 517 nm after 2 mL of different concentrations of the sample to be tested are added to 2 mL of DPPH, mixed and reacted at room temperature for 30 min in the dark; A3 is the control, and the value is the absorbance measured by adding 2 mL of anhydrous ethanol to 2 mL of the sample solution corresponding to the concentration. The absorbance of each sample was measured in the experiment, and the DPPH free radical scavenging rate of the sample was calculated;

[0077] The test data results are shown in Table 1.

[0078] Table 1 Relative DPPH free radical scavenging rate Sample name Concentration (%) Removal rate (%) Example 1 1.0 86±4.32 Example 2 1.0 82±3.47 Example 3 1.0 84±2.85 Example 4 1.0 83±3.64 Comparative Example 1 1.0 41±2.18 Comparative Example 2 1.0 40±2.54 Comparative Example 3 1.0 38±1.96 Comparative Example 4 1.0 39±1.87 Comparative Example 5 1.0 35±1.43

[0079] Conclusion

[0080] From the test results, it can be seen that the compositions prepared in Examples 1-4 have outstanding DPPH free radical scavenging ability, with a scavenging rate of about 80% or more. The compositions prepared in Comparative Examples 1-5 have poor DPPH free radical scavenging ability, with a scavenging rate of about 40%; and comparing Example 1 with Examples 2-4 shows that when the mass ratio of white Poria cocos extract to ginseng extract is 4:1, the DPPH free radical scavenging ability is optimal, and Example 1 is the optimal example; comparing Example 1 with Comparative Examples 1-5 shows that the combination of white Poria cocos extract and ginseng extract in a ratio of 4:1 produces a clear synergistic effect rather than a simple additive effect; the combination of white Poria cocos extract and ginseng extract has a relatively optimal effect in scavenging DPPH free radicals; it is significantly better than Comparative Examples 1-5 of the same concentration, indicating that the composition of the present application can hydrate and moisturize the skin while brightening the skin color and improving dull and yellowish skin, achieving the effect of delaying skin aging.

[0081] All other examples obtained by a person of ordinary skill in the art without making creative efforts based on the examples in the present application belong to the scope of protection of the present application.

Claims

1. A composition having the function of delaying skin aging, characterized in that: The composition comprises the following components by weight: 40-45 parts of Poria cocos extract, 10-40 parts of ginseng extract, 5-8 parts of lotus seed extract, 5-8 parts of Angelica dahurica powder, 5-8 parts of aloe vera gel, 12-16 parts of 4D hyaluronic acid, 15-20 parts of glycerin, 3-5 parts of palmitoyl tetrapeptide-7, and the balance being deionized water.

2. A method for preparing a composition having the function of delaying skin aging, used to prepare the composition having the function of delaying skin aging as described in claim 1, characterized in that, Includes the following steps: Step 1: Add deionized water and glycerin to the reaction vessel and stir at low speed until it becomes uniform and transparent; Step 2: Slowly add 4D hyaluronic acid into the reaction vessel, adjust the rotation speed of the reaction vessel to 2000 rpm, homogenize for 10 minutes to ensure that the 4D hyaluronic acid is completely dissolved, then stop heating and allow it to cool naturally to room temperature; Step 3: Add Poria cocos extract, ginseng extract, and lotus seed extract in sequence and stir well. Then add aloe vera gel and palmitoyl tetrapeptide-7 and homogenize for 10 minutes. Step 4: In a dispersion tank, add deionized water and angelica powder, and stir at high speed of 800 rpm for 15-20 minutes until a uniform, particle-free suspension is formed. Step 5: Add the suspension slurry to the reactor, then homogenize at high speed for 15 minutes, followed by vacuum degassing to obtain the composition with the function of delaying skin aging.

3. The method for preparing a composition with anti-aging function according to claim 2, characterized in that, In step 1, the mass ratio of deionized water to glycerol is 3:

1.

4. The method for preparing a composition with anti-aging function according to claim 2, characterized in that, In step 1, the conditions for low-speed stirring are: 100 rpm and 75±5℃.

5. A method for preparing a composition with anti-aging function according to claim 2, characterized in that, In step 3, the mass ratio of Poria cocos extract to ginseng extract is 4:

1.

6. A method for preparing a composition with anti-aging function according to claim 2, characterized in that, In step 3, the homogenization speed is 1500 rpm and the temperature is room temperature, specifically 35±5℃.

7. The method for preparing a composition with anti-aging function according to claim 2, characterized in that, In step 4, the mass ratio of deionized water to angelica powder is 3:

1.

8. A method for preparing a composition with anti-aging function according to claim 2, characterized in that, In step 4, the particle size of Angelica dahurica powder is less than 600 mesh.

9. A method for preparing a composition with anti-aging function according to claim 2, characterized in that, In step 5, the specific conditions for vacuum degassing are as follows: remove air bubbles from the material under a vacuum of -0.05 to -0.06 MPa for about 20 minutes until the material is fine and smooth.

10. The application of the composition with anti-aging function according to claim 1, characterized in that, The composition having the function of delaying skin aging is mixed with one of commonly used toners, serums, face creams, eye creams and lotions to obtain a skin care product with the function of delaying skin aging. The amount of the composition having the function of delaying skin aging is 1 to 10% of the weight of the skin care product.