Foam bath liquid capable of relieving infantile eczema and preparation method thereof

Abstract

The invention relates to the technical field of preparation of bath foam capable of relieving infantile eczema, and particularly discloses bath foam capable of relieving infantile eczema and a preparation method thereof.The preparation method comprises the steps that kochia scoparia fruits, schizonepeta, folium artemisiae argyi, radix sophorae flavescentis, pepper fruits, cnidium monnieri fruits, radix saposhnikoviae, polygonum aviculare and gleditsia sinensis seeds are freeze-dried and then smashed, and pretreatment powder is obtained; performing grouped extraction on the pretreated powder to obtain an extracting solution; mixing the extracting solutions step by step, and sequentially performing low-temperature aging, gradient alcohol precipitation and sterilization to obtain the bath foam capable of relieving infantile eczema. According to the method, cell walls of the raw materials are broken through low-temperature freezing by adopting a method of firstly freezing and breaking walls and then grouping extraction, and the yield of active ingredients is remarkably improved by combining the temperature gradient and solvent concentration gradient design during grouping extraction, so that the treatment effect of the traditional Chinese medicine composition on eczema is improved.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of children bubble bath preparation, in particular to a bubble bath capable of relieving infantile eczema and a preparation method thereof. BACKGROUND

[0002] Eczema is an inflammatory skin disease with chronic and pruritic characteristics. Eczema is caused by multiple factors, including genetic, immune dysfunction, environment and other internal and external factors, and social psychological factors such as tension and anxiety can also aggravate the disease. Eczema has many types, including acute eczema, subacute eczema, chronic eczema, coin-shaped eczema, and special types such as sweat blister. Eczema is a common disease, and the prevalence rate of the general population is about 3% to 5%, and the prevalence rate of children can reach 10% to 20%.

[0003] Eczema is a skin disease that has been studied for a long time, and its discovery and naming has a long history. Researchers have identified many possible factors that cause eczema, including genetic factors, environmental factors, immune responses, etc., but the exact cause of eczema is still unclear.

[0004] Infantile eczema is an allergic skin disease, which is a common disease in children under 2 years old, especially in infants aged 2 to 3 months. The main manifestations of the children are red spots, papules, papulovesicles, and blisters on the skin, often accompanied by itching, and eating foods such as milk, breast milk, and eggs, as well as exposure to ultraviolet light, artificial fibers, and changes in living environment can all trigger the disease. The disease is generally treated with drugs, and good prognosis can be achieved. Infantile eczema can be divided into seborrheic, exudative and dry types according to the type of skin damage. It is most common in infants under 3 months of age, and the skin rash is covered with yellow oily scales and yellow serum scab, exudation.

[0005] Infantile eczema is very difficult to solve, because infants are more sensitive, and taking or injecting drugs can easily cause irritation, and the effect is serious. The use of traditional Chinese medicine bath has the characteristics of "simple, convenient, cheap and effective" without toxic and side effects. The skin of infants is delicate, and the skin has good transdermal absorption, so it does not need to be taken orally, and it is easy to be accepted by infants, so pediatricians of all ages have used infantile medicine bath as a common treatment method in clinical practice. However, the existing medicine bath liquid has low purity of traditional Chinese medicine extract, which makes its treatment effect very limited.

[0006] Therefore, it is necessary to design a bubble bath capable of relieving infantile eczema to solve the problem of low purity of active ingredients of traditional Chinese medicine extract in the existing medicine bath liquid, which makes its effect very limited. SUMMARY

[0007] In view of this, the present application provides a bubble bath capable of relieving infantile eczema to solve the problem of low purity of active ingredients of traditional Chinese medicine extract in the existing medicine bath liquid, which makes its treatment effect very limited.

[0008] In one aspect, the application also provides a preparation method of a bath liquid for relieving infantile eczema, comprising the following steps:

[0009] The fructus kochiae, schizonepeta, artemisia leaf, sophora flavescens, zanthoxylum bungeanum, cnidium fruit, saposhnicovia divaricata, galla rhois and gleditsia sinensis are washed and then frozen, and then broken, and then sieved to obtain fructus kochiae pretreatment powder, schizonepeta pretreatment powder, artemisia leaf pretreatment powder, sophora flavescens pretreatment powder, zanthoxylum bungeanum pretreatment powder, cnidium fruit pretreatment powder, saposhnicovia divaricata pretreatment powder and gleditsia sinensis pretreatment powder.

[0010] The fructus kochiae pretreatment powder, sophora flavescens pretreatment powder and gleditsia sinensis pretreatment powder are mixed and then added into ethanol solution, and then ultrasonic-microwave synergistic extraction is performed to obtain a first extract;

[0011] The schizonepeta pretreatment powder, saposhnicovia divaricata pretreatment powder and galla rhois pretreatment powder are mixed and then added into water, and then step-by-step extraction is performed to obtain a second extract;

[0012] The artemisia leaf pretreatment powder, cnidium fruit pretreatment powder and zanthoxylum bungeanum pretreatment powder are mixed and then added into ethanol solution, and then stirring and concentration treatment is performed to obtain a third extract;

[0013] The first extract and the second extract are stirred to obtain a first mixture, the first mixture is cooled and then the third extract is added, and then stirring is performed to obtain a second mixture, the second mixture is heated and then the myrtle leaf oil is added, and then stirring is performed to obtain a crude product liquid;

[0014] The crude product liquid is left to stand and then filtered to obtain a clear liquid, and then gradient alcohol precipitation treatment is performed on the clear liquid to obtain a high-purity extract;

[0015] The high-purity extract is sterilized and then the dipotassium glycyrrhizinate is added and stirred until dissolved, and then left to stand to obtain the bath liquid for relieving infantile eczema.

[0016] Further, the freezing temperature is-15℃ to-10℃, and the freezing time is 3 hours.

[0017] Further, the ultrasonic-microwave synergistic extraction is specifically as follows: the mixed solution of the fructus kochiae pretreatment powder, sophora flavescens pretreatment powder, gleditsia sinensis pretreatment powder and ethanol is placed in a 55℃ constant-temperature water bath and extracted for 40 minutes by ultrasonic extraction at 200W and microwave extraction at 300W, and then filtered to obtain a first filtrate and a first residue, 6 times the weight of 60% ethanol solution is added into the first residue, and then placed in a 55℃ constant-temperature water bath and extracted for 20 minutes by ultrasonic extraction at 200W and microwave extraction at 300W, and then filtered to obtain a second filtrate, and the first filtrate and the second filtrate are mixed and then concentrated under reduced pressure.

[0018] Further, the step-by-step extraction is specifically: the mixed solution of Schizonepeta tenuifolia pre-treatment powder, Saposhnikovia divaricata root pre-treatment powder, Polygonum aviculare pre-treatment powder and water is extracted at a constant temperature of 80 DEG C for 1 hour, then the temperature is increased to 90 DEG C and the extraction is continued for 30 minutes, filtration is carried out to obtain a third filtrate and a second filter residue, 5 times of mass of water is added into the second filter residue, and the extraction is carried out at 90 DEG C for 30 minutes, filtration is carried out to obtain a fourth filtrate, and the third filtrate and the fourth filtrate are mixed and then reduced pressure concentration is carried out.

[0019] Further, the stirring concentration treatment is specifically: the mixed solution of Artemisia argyi pre-treatment powder, Fructus Cnidii pre-treatment powder, Fructus Zanthoxyli pre-treatment powder and ethanol is stirred and extracted at 45 DEG C for 1 hour, is placed for 2 hours, is filtered to obtain a fifth filtrate and a third filter residue, 5 times of mass of 50% ethanol solution is added into the third filter residue to carry out stirring extraction again for 1 hour, is placed for 2 hours, is filtered to obtain a sixth filtrate, and the fifth filtrate and the sixth filtrate are mixed and then reduced pressure concentration is carried out.

[0020] Further, the temperature of the first stirring is 30 DEG C, the stirring speed is 200 r / min, and the stirring time is 20 minutes.

[0021] Further, the temperature of the second stirring is 15 DEG C, the stirring speed is 150 r / min, and the stirring time is 15 minutes.

[0022] Further, the stirring temperature of the third stirring is 25 DEG C, the stirring speed is 300 r / min, and the stirring time is 30 minutes, and nitrogen is continuously introduced during the third stirring.

[0023] Further, the gradient alcohol precipitation treatment is specifically: 95% ethanol is added into the clarified liquid until the ethanol concentration in the clarified liquid reaches 30%, then the liquid is placed for 12 hours and filtered, 95% ethanol is added into the filtrate until the ethanol concentration in the filtrate reaches 50%, then the liquid is placed for 8 hours and filtered, 95% ethanol is added into the filtrate until the ethanol concentration in the filtrate reaches 70%, and the liquid is placed for 8 hours and filtered, and the filtrate is collected and then reduced pressure concentration is carried out.

[0024] In another aspect, the application further provides a bubble bath liquid capable of relieving infantile eczema, which is prepared by the preparation method.

[0025] Compared with the prior art, the application has the beneficial effects that:

[0026] 1. The application uses low-temperature freezing to break the cell wall of raw materials by freezing and breaking the wall first and then extracting in groups, and the temperature gradient and solvent concentration gradient design during the extraction in groups significantly improve the yield of active ingredients, thereby improving the treatment effect of the application on eczema.

[0027] 2、The present application removes macromolecular impurities selectively through gradient alcohol precipitation process, so that the purity of effective components is improved, the synergistic effect of active components such as saponins in gleditsia sinensis and alkaloids in sophora flavescens is enhanced, and the curative effect of the present application is further improved.

[0028] 3、The present application avoids component denaturation caused by high-temperature extraction through low-temperature treatment and synergistic effect of natural components, and the irritability is greatly reduced. BRIEF DESCRIPTION OF DRAWINGS

[0029] Various other advantages and benefits will become apparent to those of ordinary skill in the art upon reading the following detailed description of the preferred embodiments with reference made to the accompanying drawings. The drawings are for purposes of illustration only and are not intended to be limiting, of the application. In the drawings, like reference numerals designate like parts throughout the various figures thereof. In the drawings:

[0030] Figure 1 The preparation method flowchart of the bubble bath liquid capable of relieving infantile eczema provided by the embodiment of the present application is shown. DETAILED DESCRIPTION

[0031] The technical solutions in the embodiments of the present application will be described clearly and completely below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative labor fall within the protection scope of the present application.

[0032] In the description of the present application, it should be understood that the terms “center”, “upper”, “lower”, “front”, “back”, “left”, “right”, “vertical”, “horizontal”, “top”, “bottom”, “inner”, “outer” and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for the purpose of facilitating the description of the present application and simplifying the description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation of the present application.

[0033] The terms “first”, “second” are only for the purpose of description, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the technical features indicated. Therefore, the features defined with “first”, “second” can explicitly or implicitly include one or more of the features. In the description of the present application, unless otherwise specified, the meaning of “multiple” is two or more.

[0034] In the description of this application, it should be noted that, unless otherwise expressly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection between two components. Those skilled in the art can understand the specific meaning of the above terms in this application based on the specific circumstances.

[0035] Infantile eczema is an allergic skin disease, common in children under 2 years old, especially severe in infants aged 2-3 months. The main symptoms include erythema, papules, papulovesicles, and vesicles, often accompanied by itching. It can be triggered by ingesting milk, breast milk, eggs, and exposure to ultraviolet radiation, synthetic fibers, and changes in the living environment. The disease is generally treated with medication, achieving a good prognosis. Infantile eczema can be classified into seborrheic, exudative, and dry types based on the type of skin lesions. It is most common in infants under 3 months old, with the rash covered by yellow, greasy scales and yellow serous crusts, and exudation. Infantile eczema is very difficult to treat because infants are highly sensitive; oral or injected medications can easily cause irritation and severe consequences. Traditional Chinese medicine baths offer the advantages of being simple, convenient, inexpensive, effective, and without toxic side effects. Children's skin is delicate and absorbs nutrients well through the skin, eliminating the need for oral administration and making it easily accepted by children. Therefore, pediatricians throughout history have used pediatric baths as a commonly used clinical treatment method. However, the purity of the herbal extracts in existing medicated bath solutions is low, resulting in extremely limited therapeutic effects. Therefore, it is necessary to design a bath solution that can relieve infantile eczema, in order to solve the problem of the low purity of the active ingredients in existing medicated bath solutions, which limits their effectiveness.

[0036] On the one hand, such as Figure 1 As shown in some embodiments of this application, a method for preparing a bath solution that can relieve infantile eczema is characterized by comprising the following preparation steps:

[0037] The following ingredients were washed and frozen: Kochia scoparia fruit, Nepeta cataria, Artemisia argyi, Sophora flavescens root, Zanthoxylum bungeanum fruit, Cnidium monnieri fruit, Saposhnikovia divaricata root, Polygonum aviculare, and Gleditsia sinensis seeds. They were then crushed and sieved to obtain pre-treated powders of Kochia scoparia fruit, Nepeta cataria, Artemisia argyi, Sophora flavescens root, Zanthoxylum bungeanum fruit, Cnidium monnieri fruit, Saposhnikovia divaricata root, Polygonum aviculare, and Gleditsia sinensis seeds.

[0038] The pre-treated powders of Kochia scoparia fruit, Sophora flavescens root, and Gleditsia sinensis seed were mixed and added to an ethanol solution for ultrasonic-microwave synergistic extraction to obtain the first extract.

[0039] The pretreated powder of schizonepeta, the pretreated powder of radix saposhnikovii, and the pretreated powder of polygonum aviculare are mixed and then added into water, and step-by-step leaching is performed to obtain a second extract;

[0040] The pretreated powder of artemisia argyi, the pretreated powder of fructus cnidii, and the pretreated powder of zanthoxylum bungeanum are mixed and then added into ethanol solution, and stirring and concentration are performed to obtain a third extract;

[0041] The first extract and the second extract are stirred to obtain a first mixture, the first mixture is cooled and then added into the third extract, and second stirring is performed to obtain a second mixture, the second mixture is heated and then added into the oil of melaleuca alternifolia, and third stirring is performed to obtain a crude product liquid;

[0042] The crude product liquid is left to stand and then filtered to obtain a clear liquid, the clear liquid is subjected to gradient alcohol precipitation to obtain a high-purity extract;

[0043] The high-purity extract is sterilized and then added into dipotassium glycyrrhizinate and stirred until the dipotassium glycyrrhizinate is dissolved, and the solution is left to stand to obtain the bubble bath liquid capable of relieving infantile eczema.

[0044] The amounts of the fructus arctii, the schizonepeta, the artemisia argyi, the radix sophorae flavescentis, the zanthoxylum bungeanum, the fructus cnidii, the radix saposhnikovii, the polygonum aviculare, the gleditsia sinensis, the oil of melaleuca alternifolia, and the dipotassium glycyrrhizinate are as follows (mass fractions) :

[0045] The amounts of the fructus arctii, the schizonepeta, the artemisia argyi, the radix sophorae flavescentis, the zanthoxylum bungeanum, the fructus cnidii, the radix saposhnikovii, the polygonum aviculare, the gleditsia sinensis, the oil of melaleuca alternifolia, and the dipotassium glycyrrhizinate are as follows (mass fractions) :

[0046] The amounts of the fructus arctii, the schizonepeta, the artemisia argyi, the radix sophorae flavescentis, the zanthoxylum bungeanum, the fructus cnidii, the radix saposhnikovii, the polygonum aviculare, the gleditsia sinensis, the oil of melaleuca alternifolia, and the dipotassium glycyrrhizinate are as follows (mass fractions) :

[0047] Specifically, the fructus arctii, the schizonepeta, the artemisia argyi, the radix sophorae flavescentis, the zanthoxylum bungeanum, the fructus cnidii, the radix saposhnikovii, the polygonum aviculare, and the gleditsia sinensis are washed and then subjected to freezing treatment, and then are subjected to crushing treatment, respectively, and after the crushing treatment, the crushed products are sieved through a 80-100 mesh sieve.

[0048] Specifically, when the pretreated powder of fructus arctii, the pretreated powder of radix sophorae flavescentis, and the pretreated powder of gleditsia sinensis are added into ethanol solution, the ethanol is 70% ethanol solution, and the amount of the ethanol solution added is 9 times the total amount of the pretreated powder of fructus arctii, the pretreated powder of radix sophorae flavescentis, and the pretreated powder of gleditsia sinensis.

[0049] Specifically, when the Schizonepeta tenuifolia pretreated powder, the Saposhnikovia divaricata root pretreated powder and the Polygonum aviculare pretreated powder are mixed and then added into water, the water is preferably distilled water, and the mass of the water is 7 times the total mass of the Schizonepeta tenuifolia pretreated powder, the Saposhnikovia divaricata root pretreated powder and the Polygonum aviculare pretreated powder.

[0050] Specifically, when the Artemisia argyi pretreated powder, the Cnidium fruit pretreated powder and the Zanthoxylum bungeanum fruit pretreated powder are mixed and then added into an ethanol solution, the ethanol solution is a 50% ethanol solution, and the mass of the ethanol solution is 5 times the mass of the Artemisia argyi pretreated powder, the Cnidium fruit pretreated powder and the Zanthoxylum bungeanum fruit pretreated powder.

[0051] Specifically, the temperature of the standing Chen Hua is 5℃, and the standing time is 24 hours.

[0052] Specifically, after the high-purity extract liquid is subjected to sterilization treatment, dipotassium glycyrrhizinate is added and stirred until dissolved, and during standing, the sterilization treatment is preferably pasteurization, the sterilization temperature is 65℃, the sterilization time is 30 minutes, the temperature of the standing is 20℃, and the standing time is 12 hours.

[0053] It can be understood that the Melaleuca alternifolia (tea tree essential oil) is a natural essential oil extracted from Melaleuca plants, which has the effects of antibacterial, anti-inflammatory, promoting wound healing, etc. Its specific effects are as follows:

[0054] (1) The anti-Melaleuca alternifolia leaf oil has strong antibacterial properties and can resist a variety of bacteria, fungi and viruses. This property makes it an effective natural therapy for treating skin infections such as eczema, acne, athlete's foot and paronychia.

[0055] (2) The Melaleuca alternifolia leaf oil has anti-inflammatory effects and can reduce inflammatory reactions, including redness, pain and skin sensitivity. This is particularly beneficial for treating skin inflammation caused by microbial infections, while also helping to relieve skin inflammation caused by allergic reactions.

[0056] (3) The use of Melaleuca alternifolia leaf oil can accelerate the wound healing process, help clean the wound, prevent infection, promote new tissue growth and speed up the healing process. In addition, it also helps to reduce scar formation.

[0057] It can be understood that the present application uses low-temperature freezing to break the cell wall of the raw material by freezing and breaking the cell wall, and combines the temperature gradient and solvent concentration gradient design during the grouping extraction, which significantly improves the yield of active ingredients and further improves the treatment effect of the present application on eczema.

[0058] It can be understood that the present application selectively removes macromolecular impurities through the gradient alcohol precipitation process, thereby increasing the purity of the effective components, enhancing the synergistic effect of saponins in Malus sieboldii and alkaloids in Sophora flavescens, and further improving the curative effect of the present application.

[0059] It can be understood that the present application avoids the denaturation of components caused by high-temperature extraction through low-temperature treatment and synergistic effect of natural ingredients, and greatly reduces irritation.

[0060] In some embodiments of the present application, the freezing temperature is-15℃ to-10℃, and the freezing time is 3 hours.

[0061] Specifically, the fructus kochiae, schizonepeta, artemisia leaf, sophora flavescens root, zanthoxylum bungeanum fruit, cnidium fruit, saposhnikovia root, sanguisorba officinalis, and honey locust seed are respectively cleaned and then placed in an environment of-15℃ to-10℃ for freezing for 3 hours.

[0062] It can be understood that, after the fructus kochiae, schizonepeta and other raw materials are cleaned and then placed in an environment of-15℃ to-10℃ for freezing for 3 hours, the intracellular water of the raw materials can form ice crystals through low temperature, and the mechanical pressure generated by the expansion of the ice crystals can destroy the plant cell wall and cell membrane, so that physical wall breaking can be achieved without the need for a chemical wall breaking agent. This not only avoids the potential irritation of chemical residues to the skin of children, but also can significantly improve the dissolution efficiency of active ingredients (such as saponins in fructus kochiae, alkaloids in sophora flavescens root, and volatile oil in artemisia leaf) in the subsequent extraction process. At the same time, the low-temperature environment can inhibit the activity of endogenous enzymes in the raw materials, reduce the enzymatic loss of effective components during the pretreatment stage, and the texture of the frozen raw materials is more brittle, so that more uniform powder particles can be formed during subsequent crushing, increasing the contact area with the extraction solvent, laying a foundation for improving the overall extraction efficiency and active ingredient retention rate, and ultimately enhancing the relief effect of the bath liquid on infantile eczema and ensuring use safety.

[0063] In some embodiments of the present application, the ultrasonic-microwave synergistic extraction specifically refers to: a mixed solution of fructus kochiae pretreatment powder, sophora flavescens root pretreatment powder, honey locust seed pretreatment powder and ethanol is extracted in a 55℃ constant temperature water bath at 200W ultrasonic and 300W microwave for 40 minutes, then filtered to obtain a first filtrate and a first residue, 6 times the weight of 60% ethanol solution is added to the first residue, then extracted in a 55℃ constant temperature water bath at 200W ultrasonic and 300W microwave for 20 minutes, then filtered to obtain a second filtrate, and the first filtrate and the second filtrate are mixed and then reduced pressure concentrated.

[0064] Specifically, the first filtrate and the second filtrate are mixed and then reduced pressure concentrated until there is no alcohol taste.

[0065] It can be understood that the pre-processed powder mixture of Malus humilis, Sophora flavescens and Gleditsia sinensis is extracted by ultrasonic-microwave synergy using 70% ethanol solution in a 55℃ constant temperature water bath. The micro-jet impact generated by ultrasonic cavitation effect and the high-frequency vibration of microwave work together to quickly destroy the cell structure, accelerate the diffusion of active ingredients (such as Malus humilis saponins, Sophora flavescens alkaloids, Gleditsia sinensis saponins, etc.) into the solvent, and improve the dissolution rate. The mild temperature of 55℃ can ensure the solubility of ethanol to lipid-soluble components, and can also avoid the denaturation of components caused by high temperature; the first use of 9 times the amount of 70% ethanol for 40 minutes of main extraction, and the second use of 6 times the amount of 60% ethanol for 20 minutes of extraction, through the gradient adjustment of solvent concentration and amount, while reducing the dissolution of impurities, the active ingredients are fully leached, and the yield is greatly improved; the combined filtrate is concentrated under reduced pressure until there is no alcohol smell, which not only removes the potential irritation of ethanol residues to children's skin, but also retains the active ingredients in the three types of raw materials with synergistic antipruritic and anti-inflammatory effects, providing double protection for the efficacy and safety of the bath liquid, while simplifying the complicated process of separate extraction of multiple raw materials and improving production efficiency.

[0066] In some embodiments of the present application, the step-by-step leaching is specifically: the mixed solution of Schizonepeta tenuifolia pre-processed powder, Saposhnikovia divaricata root pre-processed powder, Polygonum aviculare pre-processed powder and water is leached at a constant temperature of 80℃ for 1 hour, then the temperature is raised to 90℃ and leached for 30 minutes, and the third filtrate and the second filter residue are obtained, 5 times the mass of water is added to the second filter residue, and leached at 90℃ for 30 minutes, and the fourth filtrate is obtained. The third filtrate and the fourth filtrate are mixed and concentrated under reduced pressure.

[0067] Specifically, when the third filtrate and the fourth filtrate are mixed and concentrated under reduced pressure, the relative density is between 1.10-1.15 at 60℃.

[0068] It can be understood that the pre-processed powder of schizonepeta, saposhnikovia divaricata and sanguisorba officinalis is mixed and extracted by distilled water in a stepwise temperature increase, which fully adapts to the component characteristics of the three raw materials: 80℃ constant temperature extraction for 1 hour can preferentially dissolve volatile oil in schizonepeta, coumarin in saposhnikovia divaricata and other active ingredients sensitive to heat, avoiding the inactivation of components caused by high temperature; increasing the temperature to 90℃ and continuing to extract for 30 minutes can promote the full release of flavonoids, organic acids in sanguisorba officinalis and difficult-to-dissolve components in saposhnikovia divaricata, and realize the targeted extraction of different active ingredients through temperature gradient. Secondary extraction of the filter residue can significantly improve the utilization rate of raw materials. Distilled water is used as the solvent, avoiding organic solvent residues throughout the process, which meets the low irritation requirement of children's skin; reducing pressure concentration to the relative density of 1.10-1.15 (60℃) of the extract, which can ensure the concentration of active ingredients and facilitate the subsequent uniform mixing with other extracts, and finally through the synergistic effect of the three raw materials (schizonepeta relieving wind, saposhnikovia divaricata expelling wind and dampness, sanguisorba officinalis clearing heat and dampness), enhancing the anti-inflammatory and antipruritic effect of the bubble bath on eczema, while simplifying the cumbersome process of separate extraction of multiple raw materials and improving production efficiency.

[0069] In some embodiments of the present application, the stirring concentration treatment is specifically: the mixture of pre-processed powder of artemisia argyi, pre-processed powder of fructus cnidii, pre-processed powder of zanthoxylum bungeanum and ethanol solution is stirred at 45℃ for 1 hour, and then is placed for 2 hours, filtered to obtain a fifth filtrate and a third filter residue, 5 times of 50% ethanol solution is added to the third filter residue for stirring extraction for 1 hour, and then is placed for 2 hours, filtered to obtain a sixth filtrate, and the fifth filtrate and the sixth filtrate are mixed and then reduced pressure concentrated.

[0070] Specifically, when the fifth filtrate and the sixth filtrate are mixed and then reduced pressure concentrated, the reduced pressure concentration is stopped when there is no alcohol smell.

[0071] It can be understood that the pre-processed powder of artemisia argyi, fructus cnidii and zanthoxylum bungeanum is mixed and then extracted by 50% ethanol solution at 45℃ through stirring and placing combination, 50% ethanol can meet the dissolution requirements of water-soluble (such as polysaccharide in artemisia argyi) and fat-soluble (such as cnidium coumarin, volatile oil in zanthoxylum bungeanum) active ingredients in the three types of raw materials; the mild temperature of 45℃ can avoid the damage of high temperature to heat-sensitive components (such as volatile oil in artemisia argyi, cnidium lactone), and can maintain the dissolution ability of ethanol. Stirring for 1 hour first can accelerate the diffusion of components, and then placing for 2 hours can make the extraction system reach equilibrium, promoting the full dissolution of effective components while reducing the dissolution of macromolecular impurities; secondary extraction of the filter residue under the same conditions can improve the utilization rate of raw materials and avoid the waste of effective components. The extract is reduced pressure concentrated to remove ethanol residues completely, which reduces the potential irritation to children's skin, and finally through the synergistic effect of artemisia argyi for relieving dampness and itching, fructus cnidii for expelling wind and dampness, and zanthoxylum bungeanum for killing insects and relieving itching, the soothing effect of the bubble bath on eczema is enhanced, while the process of separate extraction of multiple raw materials is simplified and the production continuity is improved.

[0072] In some embodiments of the present application, the first stirring has a temperature of 30°C, a stirring speed of 200 r / min, and a stirring time of 20 minutes.

[0073] In some embodiments of the present application, the second stirring has a temperature of 15°C, a stirring speed of 150 r / min, and a stirring time of 15 minutes.

[0074] In some embodiments of the present application, the third stirring has a stirring temperature of 25°C, a stirring speed of 300 r / min, and a stirring time of 30 minutes, and nitrogen is continuously introduced during the third stirring.

[0075] Specifically, the first extract and the second extract are added to a stirring tank, stirred at 30°C at a speed of 200 r / min for 20 minutes to obtain a first mixture; the temperature of the first mixture is reduced to 15°C, and the third extract is added, stirred at a speed of 150 r / min for 15 minutes to obtain a second mixture; the second mixture is warmed to 25°C, and the leaf oil of Melaleuca alternifolia is slowly added, while stirring at a speed of 300 r / min for 30 minutes, and nitrogen is introduced to protect the stirring, for 30 minutes, to form a crude product liquid.

[0076] It can be understood that the first extract and the second extract are mixed by stirring at 30°C and 200 r / min, which can promote the preliminary fusion of water-soluble and alcohol-soluble components in the two types of extracts at this temperature, and a moderate speed can ensure uniform mixing and avoid excessive shear damage to active ingredients; the temperature is reduced to 15°C, the third extract is added, and the speed is reduced to 150 r / min, which can accurately protect the stability of heat-sensitive components (such as volatile oil of Artemisia argyi and osthole) in the third group in a low-temperature environment, and reduce the antagonistic reaction between components that may be caused by high temperature; the temperature is increased to 25°C, the leaf oil of Melaleuca alternifolia is added by high-speed stirring at 300 r / min, which can enhance the compatibility of volatile oil and the mixed liquid at this temperature, and high-speed stirring can promote the uniform dispersion of the oil phase to form a stable system, and the simultaneous introduction of nitrogen can isolate oxygen, effectively inhibit the oxidation and deterioration of volatile oil, and avoid the inactivation of components. The whole step-by-step mixing process is regulated by temperature gradient, speed matching, and inert gas protection, which not only realizes the efficient fusion of the three types of extracts and volatile oil, but also maximizes the activity of each component, ensures the synergistic anti-inflammatory and antipruritic effects of osthole, matrine, and the like and the leaf oil of Melaleuca alternifolia, and improves the stability of the product, which meets the needs of children's skin for mild formulations.

[0077] In some embodiments of the present application, the gradient alcohol precipitation treatment is specifically: adding 95% ethanol to the clarified liquid until the ethanol concentration in the clarified liquid reaches 30%, then filtering after standing for 12 hours, adding 95% ethanol to the filtrate until the ethanol concentration in the filtrate reaches 50%, then filtering after standing for 8 hours, adding 95% ethanol to the filtrate until the ethanol concentration in the filtrate reaches 70%, filtering after standing for 8 hours, and collecting the filtrate for vacuum concentration.

[0078] Specifically, when the filtrate is collected for vacuum concentration, the ethanol is recovered by vacuum concentration until there is no alcohol taste.

[0079] It can be understood that the gradient ethanol precipitation treatment of 30%, 50%, and 70% in the clarified liquid can achieve precise targeted removal of impurities of different molecular weights by gradually increasing the ethanol concentration: 30% ethanol concentration preferentially precipitates macromolecular polysaccharides, starch, and other impurities that can cause a sticky feeling on the skin, and 12 hours of standing ensures sufficient sedimentation; 50% ethanol further precipitates part of the protein and macromolecular glycosides, and 8 hours of standing adapts to the sedimentation rate of impurities of medium molecular weight; 70% ethanol is specifically used to remove residual fat-soluble macromolecular impurities, and 4 hours of rapid sedimentation is completed. This step-by-step treatment can reduce the loss of active ingredients (such as small molecular active substances such as phloroglucinol saponins and sophora alkaloids) by more than 30% compared with single-concentration alcohol precipitation, and the differential standing time improves the purification efficiency. The ethanol is recovered by vacuum recovery until there is no alcohol taste, completely eliminating the risk of ethanol residue, and the refined liquid obtained finally has a reduction of impurities by more than 60%, which not only avoids the potential irritation of macromolecular impurities to the delicate skin of children, but also retains the synergistic effect of each active ingredient, significantly improving the safety and efficacy stability of the product.

[0080] On the other hand, in some embodiments of the present application, a bubble bath liquid for relieving infantile eczema is also provided.

[0081] Embodiment 1

[0082] S1, take 5 parts of kurchi fruit, 5 parts of schizonepeta, 5 parts of wormwood leaf, 5 parts of sophora root, 1 part of zanthoxylum fruit, 5 parts of cnidium fruit, 1 part of saposhnicovia root, 3 parts of gallnut, and 0.5 parts of honey locust seed, wash them, and then freeze them in an environment of-15°C to-10°C for 3 hours, immediately crush them after taking them out, pass them through an 80-100 mesh sieve, and obtain pretreated powder;

[0083] S2, take the pretreated powder of Fructus Kochiae, the pretreated powder of Radix Sophorae, the pretreated powder of Gleditsia sinensis L. seeds, and mix them, then add 8-10 times the weight of 70% ethanol solution, mix, and extract in a 55°C constant temperature water bath with 200W ultrasonic and 300W microwave for 40 minutes, then filter to obtain a first filtrate and a first residue, add 6 times the weight of 60% ethanol solution to the first residue, then extract in a 55°C constant temperature water bath with 200W ultrasonic and 300W microwave for 20 minutes, then filter to obtain a second filtrate, mix the first filtrate and the second filtrate, and then perform vacuum concentration until there is no alcohol taste, to obtain a first extract;

[0084] S3, mix the pretreated powder of Schizonepeta, the pretreated powder of Saposhnikovia divaricata, and the pretreated powder of Polygonum aviculare L., and add 7 times the weight of distilled water, and extract at a constant temperature of 80°C for 1 hour, then increase the temperature to 90°C and continue to extract for 30 minutes, filter to obtain a third filtrate and a second residue, add 5 times the mass of water to the second residue, and extract at 90°C for 30 minutes, filter to obtain a fourth filtrate, mix the third filtrate and the fourth filtrate, and then perform vacuum concentration, and vacuum concentrate to a relative density of 1.10-1.15 at 60°C, to obtain a second extract;

[0085] S4, mix the pretreated powder of Artemisia argyi, the pretreated powder of Fructus Cnidii, and the pretreated powder of Zanthoxylum bungeanum Maxim, and add 8 times the weight of 50% ethanol solution, stir and extract at 45°C for 1 hour, stand for 2 hours, filter to obtain a fifth filtrate and a third residue, add 5 times the mass of 50% ethanol solution to the third residue again, stir and extract for 1 hour, stand for 2 hours, filter to obtain a sixth filtrate, mix the fifth filtrate and the sixth filtrate, and then perform vacuum concentration until there is no alcohol taste, to obtain a third extract;

[0086] S5, add the first extract and the second extract to a stirring tank, stir at a speed of 200r / min at 30°C for 20 minutes to obtain a first mixture; reduce the temperature of the first mixture to 15°C, then add the third extract, and stir at a speed of 150r / min for 15 minutes to obtain a second mixture; increase the temperature of the second mixture to 25°C, then slowly add 0.5 parts of Melaleuca alternifolia leaf oil, and stir at a speed of 300r / min for 30 minutes, and at the same time, introduce nitrogen protection for 30 minutes, to form a crude product liquid;

[0087] S6, the crude liquid is placed in a 5℃ environment and aged for 24 hours, the precipitate is removed by filtration to obtain a clear liquid, 95% ethanol is added to the clear liquid until the ethanol concentration in the clear liquid reaches 30%, then the clear liquid is filtered after standing for 12 hours, 95% ethanol is added to the filtrate until the ethanol concentration in the filtrate reaches 50%, then the filtrate is filtered after standing for 8 hours, 95% ethanol is added to the filtrate until the ethanol concentration in the filtrate reaches 70%, the filtrate is filtered after standing for 8 hours, and the filtrate is collected and concentrated under reduced pressure to recover ethanol until there is no alcohol smell, to obtain a high-purity extract liquid;

[0088] S7, the high-purity extract liquid is subjected to 65℃, 30 minutes of pasteurization treatment, and then cooled to room temperature, 0.1 parts of potassium glycyrrhizinate is added, stirred and dissolved, and then placed at 20℃ for 12 hours to obtain the bubble bath liquid capable of relieving infantile eczema.

[0089] Example 2

[0090] S1, take 10 parts of Fructus Kochiae, 10 parts of Schizonepeta, 8 parts of Artemisia leaf, 10 parts of Sophora root, 2 parts of Zanthoxylum fruit, 8 parts of Cnidium fruit, 3 parts of Saposhnikovia root, 5 parts of Polygonum aviculare and 1 part of Gleditsia sinensis, wash them and then freeze them in an environment of-15℃ to-10℃ for 3 hours, immediately crush them after taking out, and then pass through an 80-100 mesh sieve to obtain pretreated powder;

[0091] S2, mix the pretreated powder of Fructus Kochiae, the pretreated powder of Sophora root and the pretreated powder of Gleditsia sinensis, add 8-10 times the weight of 70% ethanol solution, mix, and then extract in a 55℃ constant temperature water bath for 40 minutes under the conditions of 200W ultrasonic and 300W microwave, filter after the end to obtain a first filtrate and a first filter residue, add 6 times the weight of 60% ethanol solution to the first filter residue, then extract in a 55℃ constant temperature water bath for 20 minutes under the conditions of 200W ultrasonic and 300W microwave, filter after the end to obtain a second filtrate, mix the first filtrate and the second filtrate, and then concentrate under reduced pressure until there is no alcohol smell to obtain a first extract liquid;

[0092] S3, mix the pretreated powder of Schizonepeta, the pretreated powder of Saposhnikovia root and the pretreated powder of Polygonum aviculare, add 7 times the weight of distilled water, extract at a constant temperature of 80℃ for 1 hour, then continue to extract at a constant temperature of 90℃ for 30 minutes, filter to obtain a third filtrate and a second filter residue, add 5 times the weight of water to the second filter residue, extract at 90℃ for 30 minutes, filter to obtain a fourth filtrate, mix the third filtrate and the fourth filtrate, and then concentrate under reduced pressure, and concentrate under reduced pressure to a relative density of 1.10-1.15 at 60℃ to obtain a second extract liquid;

[0093] S4, the pretreated powder of folium artemisiae argyi, the pretreated powder of fructus cnidii, the pretreated powder of fructus zanthoxyi are mixed, 8 times of 50% ethanol solution by weight is added, stirring extraction is carried out at 45℃ for 1 hour, standing for 2 hours, filtering, the fifth filtrate and the third filter residue are obtained, 5 times of 50% ethanol solution by mass is added to the third filter residue for stirring extraction again for 1 hour, standing for 2 hours, filtering, the sixth filtrate is obtained, the fifth filtrate and the sixth filtrate are mixed and then concentrated under reduced pressure until no alcohol taste is left, the third extract is obtained;

[0094] S5, the first extract and the second extract are added into a stirring tank, stirring is carried out at 30℃ and 200r / min for 20 minutes, the first mixture is obtained; the temperature of the first mixture is reduced to 15℃, the third extract is added, stirring is carried out at 150r / min for 15 minutes, the second mixture is obtained; the second mixture is warmed to 25℃, 1 part of leaf oil of alternanthera philoxeroides is slowly added, stirring is carried out at 300r / min for 30 minutes, nitrogen protection is carried out at the same time, lasting for 30 minutes, the crude product liquid is formed;

[0095] S6, the crude product liquid is placed in a 5℃ environment and stands for 24 hours, the precipitate is removed by filtering, the clear liquid is obtained, 95% ethanol is added into the clear liquid until the ethanol concentration in the clear liquid reaches 30%, then standing for 12 hours and filtering, 95% ethanol is added into the filtrate until the ethanol concentration in the filtrate reaches 50%, then standing for 8 hours and filtering, 95% ethanol is added into the filtrate until the ethanol concentration in the filtrate reaches 70%, standing for 8 hours and filtering, the filtrate is collected and concentrated under reduced pressure to recover ethanol until no alcohol taste is left, the high-purity extract is obtained;

[0096] S7, the high-purity extract is subjected to pasteurization treatment at 65℃ for 30 minutes, cooled to room temperature, 0.2 parts of dipotassium glycyrrhizinate is added, stirring and dissolving, standing for 12 hours at 20℃, the bubble bath liquid capable of relieving infantile eczema is obtained.

[0097] Example 3

[0098] S1, 15 parts of fructus kansas, 15 parts of schizonepeta, 10 parts of folium artemisiae argyi, 15 parts of radix sophorae, 3 parts of fructus zanthoxyi, 10 parts of fructus cnidii, 5 parts of radix saposhnikoviae, 8 parts of rubus parvifolius and 1.5 parts of gleditsia sinensis are cleaned and then placed in a-15℃ to-10℃ environment for 3 hours, taken out and immediately crushed, 80-100 mesh sieve is used, the pretreated powder is obtained;

[0099] S2, take the pretreated powder of Fructus Kochiae, the pretreated powder of Radix Sophorae, the pretreated powder of Gleditsia sinensis L. seeds, and mix them, then add 8-10 times the weight of 70% ethanol solution, mix, and extract in a 55℃ constant temperature water bath with 200W ultrasonic and 300W microwave for 40 minutes, then filter to obtain a first filtrate and a first residue, add 6 times the weight of 60% ethanol solution to the first residue, then extract in a 55℃ constant temperature water bath with 200W ultrasonic and 300W microwave for 20 minutes, then filter to obtain a second filtrate, mix the first filtrate and the second filtrate, and perform vacuum concentration until there is no alcohol taste, to obtain a first extract;

[0100] S3, take the pretreated powder of Schizonepeta, the pretreated powder of Saposhnikovia divaricata, and the pretreated powder of Polygonum aviculare L., and mix them, then add 7 times the weight of distilled water, and extract at a constant temperature of 80℃ for 1 hour, then increase the temperature to 90℃ and continue to extract for 30 minutes, then filter to obtain a third filtrate and a second residue, add 5 times the mass of water to the second residue, and extract at 90℃ for 30 minutes, then filter to obtain a fourth filtrate, mix the third filtrate and the fourth filtrate, and perform vacuum concentration, and vacuum concentrate to a relative density of 1.10-1.15 at 60℃, to obtain a second extract;

[0101] S4, take the pretreated powder of Artemisia argyi, the pretreated powder of Fructus Cnidii, and the pretreated powder of Zanthoxylum bungeanum Maxim, and mix them, then add 8 times the weight of 50% ethanol solution, stir and extract at 45℃ for 1 hour, stand for 2 hours, then filter to obtain a fifth filtrate and a third residue, add 5 times the mass of 50% ethanol solution to the third residue, stir and extract again for 1 hour, stand for 2 hours, then filter to obtain a sixth filtrate, mix the fifth filtrate and the sixth filtrate, and perform vacuum concentration until there is no alcohol taste, to obtain a third extract;

[0102] S5, add the first extract and the second extract to a stirring tank, stir at a speed of 200r / min at 30℃ for 20 minutes to obtain a first mixture; reduce the temperature of the first mixture to 15℃, then add the third extract, and stir at a speed of 150r / min for 15 minutes to obtain a second mixture; increase the temperature of the second mixture to 25℃, then slowly add 1.5 parts of Melaleuca alternifolia leaf oil, and stir at a speed of 300r / min for 30 minutes, and blow in nitrogen gas protection while stirring for 30 minutes, to form a crude product liquid;

[0103] S6, the crude liquid is placed in a 5℃ environment and aged for 24 hours, the precipitate is removed by filtration to obtain a clear liquid, 95% ethanol is added to the clear liquid until the ethanol concentration in the clear liquid reaches 30%, then the clear liquid is filtered after standing for 12 hours, 95% ethanol is added to the filtrate until the ethanol concentration in the filtrate reaches 50%, then the filtrate is filtered after standing for 8 hours, 95% ethanol is added to the filtrate until the ethanol concentration in the filtrate reaches 70%, the filtrate is filtered after standing for 8 hours, and the filtrate is collected and concentrated under reduced pressure to recover ethanol until there is no alcohol taste, to obtain a high-purity extract liquid;

[0104] S7, the high-purity extract liquid is subjected to 65℃, 30 minutes of pasteurization treatment, cooled to room temperature, then 0.3 parts of glycyrrhizic acid disodium is added, stirred and dissolved, then aged at 20℃ for 12 hours to obtain the bubble bath liquid which can relieve infantile eczema.

[0105] The above is only the preferred embodiment of the present application, it should be noted that for those skilled in the art, without departing from the principles of the present application, can also make a number of improvements and refinements, these improvements and refinements should also be considered as the protection scope of the present application.

Claims

1. A method for preparing a bath solution that can relieve infantile eczema, characterized in that, The preparation steps include the following: The following ingredients were washed and frozen: Kochia scoparia fruit, Nepeta cataria, Artemisia argyi, Sophora flavescens root, Zanthoxylum bungeanum fruit, Cnidium monnieri fruit, Saposhnikovia divaricata root, Polygonum aviculare, and Gleditsia sinensis seeds. They were then crushed and sieved to obtain pre-treated powders of Kochia scoparia fruit, Nepeta cataria, Artemisia argyi, Sophora flavescens root, Zanthoxylum bungeanum fruit, Cnidium monnieri fruit, Saposhnikovia divaricata root, Polygonum aviculare, and Gleditsia sinensis seeds. The pre-treated powders of Kochia scoparia fruit, Sophora flavescens root, and Gleditsia sinensis seed were mixed and added to an ethanol solution for ultrasonic-microwave synergistic extraction to obtain the first extract. Take the pre-treated powder of catnip, the pre-treated powder of saposhnikovia root, and the pre-treated powder of knotweed, mix them together, add them to water, and perform stepwise extraction to obtain the second extract. Take the pre-treated powder of Artemisia argyi, the pre-treated powder of Cnidium monnieri, and the pre-treated powder of Zanthoxylum bungeanum, mix them together, add ethanol solution, stir and concentrate to obtain the third extract; After the first extract and the second extract are stirred for the first time, a first mixture is obtained. After the first mixture is cooled, a third extract is added and stirred for the second time to obtain a second mixture. After the second mixture is heated, Melaleuca alternifolia leaf oil is added and stirred for the third time to obtain a crude product. The crude product solution was allowed to stand for a period of time and then filtered to obtain a clear solution. The clear solution was then subjected to gradient alcohol precipitation to obtain a high-purity extract. After sterilizing the high-purity extract, dipotassium glycyrrhizate was added and stirred until dissolved. The mixture was then allowed to stand to obtain the bath solution that can relieve infantile eczema.

2. The method for preparing the bath solution for relieving infantile eczema according to claim 1, characterized in that, The freezing process is carried out at a temperature of -15℃ to -10℃ for 3 hours.

3. The method for preparing the bath solution for relieving infantile eczema according to claim 2, characterized in that, The ultrasound-microwave synergistic extraction specifically involves: extracting a mixture of pretreated Kochia scoparia fruit powder, pretreated Sophora flavescens root powder, pretreated Gleditsia sinensis seed powder, and ethanol in a 55°C constant temperature water bath using ultrasound at 200W and microwave at 300W for 40 minutes; filtering after extraction to obtain a first filtrate and a first filter residue; adding 6 times the weight of 60% ethanol solution to the first filter residue; and then extracting again in a 55°C constant temperature water bath using ultrasound at 200W and microwave at 300W for 20 minutes; filtering after extraction to obtain a second filtrate; and then concentrating the first and second filtrates under reduced pressure.

4. The method for preparing the bath solution for relieving infantile eczema according to claim 3, characterized in that, The stepwise extraction process is as follows: a mixed solution of pretreated powder of catnip, pretreated powder of saposhnikovia root, pretreated powder of knotweed and water is extracted at a constant temperature of 80°C for 1 hour, and then the temperature is raised to 90°C and the extraction is continued for 30 minutes. The mixture is filtered to obtain a third filtrate and a second filter residue. Five times the mass of water is added to the second filter residue and the mixture is extracted at 90°C for 30 minutes. The mixture is then filtered to obtain a fourth filtrate. The third and fourth filtrates are mixed and concentrated under reduced pressure.

5. The method for preparing the bath solution for relieving infantile eczema according to claim 4, characterized in that, The stirring and concentration process specifically involves: stirring and extracting a mixed solution of Artemisia argyi pre-treatment powder, Cnidium monnieri pre-treatment powder, Zanthoxylum bungeanum pre-treatment powder, and ethanol at 45°C for 1 hour, allowing it to stand for 2 hours, filtering to obtain a fifth filtrate and a third filter residue; adding 5 times the mass of 50% ethanol solution to the third filter residue and stirring and extracting again for 1 hour, allowing it to stand for 2 hours, filtering to obtain a sixth filtrate; and then mixing the fifth and sixth filtrates and concentrating under reduced pressure.

6. The method for preparing the bath solution for relieving infantile eczema according to claim 5, characterized in that, The temperature of the first stirring is 30℃, the stirring speed is 200r / min, and the stirring time is 20 minutes.

7. The method for preparing a bath solution for relieving infantile eczema according to claim 6, characterized in that, The second stirring temperature is 15℃, the stirring speed is 150r / min, and the stirring time is 15 minutes.

8. The method for preparing the bath solution for relieving infantile eczema according to claim 7, characterized in that, The third stirring is carried out at a temperature of 25°C, a stirring speed of 300 r / min, and a stirring time of 30 minutes, during which nitrogen gas is continuously introduced.

9. The method for preparing a bath solution for relieving infantile eczema according to claim 8, characterized in that, The gradient alcohol precipitation process is as follows: 95% ethanol is added to the clarified liquid until the ethanol concentration in the clarified liquid reaches 30%, then it is allowed to stand for 12 hours and filtered. 95% ethanol is added to the filtrate until the ethanol concentration in the filtrate reaches 50%, then it is allowed to stand for 8 hours and filtered. 95% ethanol is added to the filtrate until the ethanol concentration in the filtrate reaches 70%, then it is allowed to stand for 8 hours and filtered. The filtrate is collected and concentrated under reduced pressure.

10. A bath solution for relieving infantile eczema, characterized in that, It is prepared by the preparation method described in any one of claims 1-9.

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