Foaming agent pharmaceutical composition for treating varicose vein of lower limb as well as preparation and use methods of foaming agent pharmaceutical composition

Abstract

The invention discloses a foaming agent pharmaceutical composition for treating varicose veins of lower limbs, which is composed of the following components: 6 ml of concentrated sodium chloride, 10 mg of sodium aescinate, one vitamin C (2 ml: 0.5 g) and 4 ml of air, according to the foaming agent pharmaceutical composition for treating varicose veins of lower limbs and a preparation and use method thereof, a foaming agent is formed through mixing and pushing of air and a solution, and the foaming agent is used for treating varicose veins of lower limbs. The contact area of the medicine and the blood vessel wall is obviously increased, the acting time is prolonged, the closing function of a vein valve can be repaired, a broken and reduced collagen fiber layer on the outer layer of the blood vessel can be repaired, the strength of the blood vessel wall is enhanced, and the effect of treating varicosity is improved.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of medicine, in particular to a foam medicament composition for treating varicose veins of lower limbs and a preparation and use method thereof. BACKGROUND

[0002] As a clinically high-occurring venous valve dysfunction disease, the core pathological mechanism of varicose veins of lower limbs lies in the incompetence of venous valve, the rupture or reduction of collagen fiber layer outside the blood vessel, the decrease of blood vessel wall strength, the expansion and deformation of lumen, and the blood backflow obstruction and accumulation in the lower limb veins. In the current clinical treatment, surgical treatment can directly treat the diseased blood vessels, but it causes great trauma and long postoperative recovery period, and causes great pain to the patient. Therefore, it is urgent to develop a new treatment composition which can specifically repair the closing function of venous valve, repair the ruptured and reduced collagen fiber layer outside the blood vessel, and enhance the strength of blood vessel wall, so as to improve the varicose vein symptoms from the pathological root and achieve more accurate and safer treatment effect. SUMMARY

[0003] The present application provides a foam medicament composition for treating varicose veins of lower limbs and a preparation and use method thereof, which improves the contact area and action time of the drug with the blood vessel wall by specific component ratio and foaming preparation, and enhances the treatment effect.

[0004] To achieve the above-mentioned purpose, the present application provides the following technical scheme: a foam medicament composition for treating varicose veins of lower limbs, characterized by comprising the following components: 6ml of concentrated sodium chloride, 10mg of sodium aescinate, one dose of vitamin C (2ml:0.5g), and 4ml of air.

[0005] Preferably, the concentrated sodium chloride has a specification of 10ml:1g.

[0006] Preferably, the method comprises the following steps: (1) mixing 6ml of concentrated sodium chloride, 10mg of sodium aescinate, and one dose of vitamin C to prepare an 8ml solution; (2) connecting a three-way joint after preparing the solution according to the ratio of (1) with a 20ml needle tube, connecting a 20ml needle tube to the other side of the three-way joint, and pushing the solution back and forth in the two needle tubes for 20 times until the solution becomes dense, to form a foam.

[0007] Preferably, the method comprises the following steps: The method comprises the following steps: positioning at the diseased lower limb vein, connecting a 5ml needle tube (which needs to suck 3-4ml of sodium chloride solution in advance) to the diseased blood vessel with an infusion needle, taking the corresponding volume of the prepared solution from bottom to top, replacing the 20ml needle tube with the 5ml needle tube, and injecting the solution into the blood vessel.

[0008] Compared with existing technologies, the beneficial effects of this invention are as follows: This foaming agent pharmaceutical composition for treating varicose veins of the lower extremities, along with its preparation and application method, forms a foaming agent through the mixing and propagation of air and solution. This significantly increases the contact area between the drug and the blood vessel wall, prolongs the duration of action, and is beneficial for repairing the closure function of venous valves, repairing broken and reduced collagen fiber layers on the outer layer of blood vessels, strengthening the blood vessel wall, and enhancing the therapeutic effect on varicose veins. Concentrated sodium chloride can increase the intracellular osmotic pressure, thereby causing intracellular water to move to the extracellular space, dehydrating the blood vessels and narrowing the lumen. 6 ml of concentrated sodium chloride is just enough to narrow the lumen without completely closing it, thus reducing... The purpose of the lumen is to enable the venous valves to close completely. Sodium aescinate mainly inhibits the action of proteases in the blood, preventing them from breaking down the outermost collagen fiber layer of blood vessels. In addition, sodium aescinate acts on the endothelial cells of blood vessels, enhancing the contractile ability of the blood vessel wall and improving the return of venous blood and lymph. Vitamin C participates in the synthesis of collagen, repairs damaged blood vessel walls, and enhances the strength of blood vessel walls. The three work synergistically to improve the therapeutic effect. Specific formulation and preparation methods ensure stable drug concentration, reducing dosage while lowering local irritation and systemic adverse reactions. The preparation process is standardized, and the injection method is highly operable, making it suitable for clinical application. Detailed Implementation

[0009] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0010] The present invention provides a technical solution: a foam pharmaceutical composition for treating varicose veins of the lower extremities, characterized in that it is composed of the following components: 6 ml of concentrated sodium chloride, 10 mg of sodium aescinate, one vial of vitamin C (2 ml: 0.5 g) and 4 ml of air.

[0011] The specification for concentrated sodium chloride is 10ml:1g.

[0012] The following steps: (1) Mix 6 ml of concentrated sodium chloride, 10 mg of sodium aescinate, and one vial of vitamin C to make an 8 ml solution; (2) After preparing the solution according to the ratio in (1) using a 20ml syringe, connect the three-way valve. Connect an empty 20ml syringe to the other side of the three-way valve. Push the solution back and forth between the two syringes 20 times until it sinks, then stop the operation to form a foaming agent.

[0013] Concentrated sodium chloride can increase the osmotic pressure inside cells, causing water to move from inside the cells to outside the cells, dehydrating blood vessels and narrowing their lumen. 6 ml of concentrated sodium chloride is just enough to narrow the lumen without completely closing it. The purpose of narrowing the lumen is to enable the venous valves to close completely.

[0014] Sodium aescinate mainly inhibits the action of proteases in the blood, preventing them from breaking down the outermost collagen fiber layer of blood vessels. In addition, sodium aescinate acts on the endothelial cells of blood vessels, enhancing the contractile ability of the blood vessel wall and enhancing the return of venous blood and lymph.

[0015] Vitamin C participates in the synthesis of collagen, repairs damaged blood vessel walls, and enhances the strength of blood vessel walls.

[0016] Includes the following steps: At the site of the lesion in the lower limb vein, connect a 5ml syringe (with 3-4ml of sodium chloride solution pre-absorbed in the syringe) to the lesion vein and insert it into the vein. Use the prepared solution to draw the appropriate volume of solution from bottom to top, then remove the 5ml syringe and replace it with the 20ml syringe containing the solution to inject into the vein.

[0017] The patient is placed in a supine position. The varicose veins in the lower extremities are marked, and routine disinfection and draping are performed. 3 ml of sodium chloride solution is drawn into a 5 ml syringe, connected to an infusion needle, and punctured at a fixed point distal to the lesion. Blood is aspirated to confirm that the needle tip is inside the blood vessel. The 5 ml syringe is removed, and a 20 ml syringe containing 8 ml of foaming agent (containing 4 ml of air) is quickly connected. The foaming agent is slowly injected from distal to proximal, with 1-3 ml injected depending on the diameter and length of the blood vessel. Local pressure is applied for 5 minutes after injection to complete the treatment.

[0018] Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A foaming pharmaceutical composition for treating varicose veins of the lower extremities, characterized in that, It consists of the following ingredients: 6ml concentrated sodium chloride, 10mg sodium aescinate, one vial of vitamin C (2ml:0.5g) and 4ml air.

2. The foaming agent pharmaceutical composition according to claim 1, characterized in that, The concentrated sodium chloride is specified as 10ml:1g.

3. The method for preparing the foaming agent pharmaceutical composition according to claim 1, characterized in that, Includes the following steps: (1) Mix 6 ml of concentrated sodium chloride, 10 mg of sodium aescinate, and one vial of vitamin C to make an 8 ml solution; (2) After preparing the solution according to the ratio in (1) using a 20ml syringe, connect the three-way valve. Connect an empty 20ml syringe to the other side of the three-way valve. Push the solution back and forth between the two syringes 20 times until it sinks, then stop the operation to form a foaming agent.

4. The method of using the foaming agent pharmaceutical composition according to claim 1, characterized in that, Includes the following steps: At the site of the lesion in the lower limb vein, connect a 5ml syringe (with 3-4ml of sodium chloride solution pre-absorbed in the syringe) to the lesion vein and insert it into the vein. Use the prepared solution to draw the appropriate volume of solution from bottom to top, then remove the 5ml syringe and replace it with the 20ml syringe containing the solution to inject into the vein.