Medicinal liquor for preventing and treating liver-kidney deficiency type osteoarticular degenerative change and preparation method thereof

Abstract

The invention discloses medicinal liquor for preventing and treating liver and kidney deficiency type osteoarticular degenerative change and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine compositions. The medicinal liquor for preventing and treating liver and kidney deficiency type bone joint degenerative change is prepared from the following raw materials in parts by weight: 12 to 18 parts of herba epimedii extract, 12 to 18 parts of fructus lycii, 10 to 15 parts of fructus psoraleae, 10 to 15 parts of semen cuscutae, 10 to 15 parts of herba cynomorii, 10 to 15 parts of radix morindae officinalis, 8 to 12 parts of fructus cnidii, 8 to 12 parts of herba cistanche, 8 to 12 parts of radix astragali seu hedysari, 8 to 12 parts of caulis spatholobi, 6 to 12 parts of radix angelicae sinensis, 6 to 12 parts of rhizoma drynariae, 6 to 12 parts of radix dipsaci, 6 to 10 parts of semen astragali complanati, 6 to 10 parts of cortex eucommiae, 6 to 10 parts of fructus jujubae and 800 to 1200 parts of pure The medicinal liquor can significantly improve clinical symptoms, pain degree and life quality of patients with liver and kidney deficiency type knee osteoarthritis, is good in safety and free of obvious serious adverse reactions, and has a good clinical application prospect.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a medicinal liquor for preventing and treating liver-kidney deficiency type bone joint degenerative changes and a preparation method thereof. BACKGROUND

[0002] Bone joint degenerative changes, represented by knee osteoarthritis, is a chronic degenerative joint disease characterized by joint cartilage wear, destruction and bone hyperplasia. Its clinical manifestations mainly include joint pain, stiffness, swelling and dysfunction, which seriously affect the quality of life of middle-aged and elderly patients. With the acceleration of global population aging, the incidence of this disease continues to rise, which has become one of the main causes of disability in the middle-aged and elderly, and has brought heavy social and economic burden.

[0003] In the field of modern medicine, the treatment methods of this disease mainly include non-steroidal anti-inflammatory drugs (NSAIDs), cyclooxygenase-2 (COX-2) selective inhibitors and other drugs for anti-inflammatory analgesia, as well as sodium hyaluronate intra-articular injection, physical therapy and ultimate joint replacement surgery. However, these methods often focus on relieving symptoms and are difficult to reverse the pathological process. Long-term use of chemical drugs can easily cause adverse reactions such as gastrointestinal, cardiovascular and renal function damage. Surgical treatment has problems such as high risk, high cost and limited scope of application.

[0004] In the theory of traditional Chinese medicine, there is no disease name of "osteoarthritis". According to its clinical symptoms, it can be classified into "Bi syndrome", "bone numbness" and "muscle numbness". Traditional Chinese medicine believes that "liver governs muscles and kidneys govern bones", and liver-kidney deficiency is the fundamental pathogenesis of the disease. As people grow older, the liver-kidney essence gradually declines, and the essence is deficient in blood, leading to the lack of nourishment of muscles and bones, and pain due to lack of nourishment. In addition, wind, cold, dampness and blood stasis invade the meridians, block the blood and cause pain. Therefore, tonifying liver and kidney, strengthening muscles and bones is the basic method for treating the disease, and combined with expelling wind and dampness, promoting blood circulation and unblocking collaterals.

[0005] At present, there are many Chinese patent medicines or health care wines on the market for treating osteoarthritis by tonifying kidney and strengthening bones and expelling wind and dampness. However, most of the products have the following limitations: first, they focus on tonifying and neglect unblocking collaterals. Many prescriptions pile up liver and kidney tonics, but the effect of promoting blood circulation and unblocking collaterals is insufficient, which makes it difficult for the medicine to reach the disease and the effect is slow; second, some prescriptions are too warm and dry, which can easily consume yin fluid and cause dry mouth and throat. It is not suitable for people with yin deficiency or yin and yang deficiency; third, the dosage form is limited. The ordinary water extraction preparation or pill and powder dosage form cannot extract some fat-soluble active ingredients sufficiently, and the absorption is slow, which is not conducive to the full play of the efficacy.

[0006] Therefore, aiming at the core pathogenesis of liver and kidney deficiency, developing a kind of traditional Chinese medicine compound preparation which can comprehensively play the multiple effects of nourishing liver and kidney, strengthening muscles and bones, promoting blood circulation to remove meridian obstruction, and dispelling wind and dampness, and has high absorption, mild effect and good safety, has important clinical significance and practical application value for preventing and treating bone and joint degenerative changes. SUMMARY

[0007] Therefore, aiming at the core pathogenesis of liver and kidney deficiency, developing a kind of traditional Chinese medicine compound preparation which can comprehensively play the multiple effects of nourishing liver and kidney, strengthening muscles and bones, promoting blood circulation to remove meridian obstruction, and dispelling wind and dampness, has important clinical significance and practical application value for preventing and treating bone and joint degenerative changes.

[0008] In order to achieve the above-mentioned purpose, the present application provides the following technical scheme:

[0009] In the first aspect, the present application provides a kind of liquor for preventing and treating liver and kidney deficiency type bone and joint degenerative changes, including raw materials by weight parts:

[0010] Epimedium extract 12-18 parts, Fructus Lycii 12-18 parts, Psoralea 10-15 parts, Semen Trichosanthis 10-15 parts, Cynomorium 10-15 parts, Radix Lycii 10-15 parts, Cnidium 8-12 parts, Herba Cistanche 8-12 parts, Radix Paeoniae Alba 8-12 parts, Caulis Spatholobi 8-12 parts, Radix Angelicae Sinensis 6-12 parts, Radix Drynariae 6-12 parts, Radix Curdlae 6-12 parts, Fructus Hedyseli 6-10 parts, Eucommia 6-10 parts, Red dates 6-10 parts and pure grain wine 800-1200 parts.

[0011] As preferred, the weight parts of the raw materials are: Epimedium extract 14-16 parts, Fructus Lycii 14-16 parts, Psoralea 12-14 parts, Semen Trichosanthis 12-14 parts, Cynomorium 12-14 parts, Radix Lycii 12-14 parts, Cnidium 9-11 parts, Herba Cistanche 9-11 parts, Radix Paeoniae Alba 9-11 parts, Caulis Spatholobi 9-11 parts, Radix Angelicae Sinensis 8-10 parts, Radix Drynariae 8-10 parts, Radix Curdlae 8-10 parts, Fructus Hedyseli 7-9 parts, Eucommia 7-9 parts, Red dates 7-9 parts and pure grain wine 900-1100 parts.

[0012] As preferred, the weight parts of the raw materials are: Epimedium extract 15 parts, Fructus Lycii 15 parts, Psoralea 13 parts, Semen Trichosanthis 13 parts, Cynomorium 13 parts, Radix Lycii 13 parts, Cnidium 10 parts, Herba Cistanche 10 parts, Radix Paeoniae Alba 10 parts, Caulis Spatholobi 10 parts, Radix Angelicae Sinensis 9 parts, Radix Drynariae 9 parts, Radix Curdlae 9 parts, Fructus Hedyseli 9 parts, Eucommia 9 parts, Red dates 9 parts and pure grain wine 1000 parts.

[0013] In the second aspect, the present application provides a preparation method of the above-mentioned liquor, including the following preparation steps:

[0014] S1. Take the raw materials according to the weight parts;

[0015] S2. After mixing the lard and pure grain wine, the first base liquor is obtained through standing and filtering;

[0016] S3. After mixing the first base liquor, red dates and medlar, the second base liquor is obtained through soaking and filtering;

[0017] S3. The traditional Chinese medicine raw materials are subjected to ultrafine grinding, packed in a cotton bag and then soaked in the second base liquor to obtain the medicinal liquor for preventing and treating liver and kidney deficiency type bone joint degenerative changes.

[0018] Preferably, the mass ratio of the lard to the pure grain wine in S2 is 1:5.

[0019] Preferably, the standing time in S2 is 3 months.

[0020] Preferably, the mass ratio of the first base liquor, red dates and medlar in S3 is 10:1:1.

[0021] Preferably, the soaking time in S3 is 1 month.

[0022] Preferably, the soaking time in S4 is 1-3 months.

[0023] At least the following beneficial technical effects are achieved:

[0024] The prescription of the present application takes warming and tonifying kidney essence and blood as the monarch, and is supplemented by the functions of strengthening muscles and bones, dispelling wind and dampness and promoting blood circulation and dredging collaterals. The pure grain wine is used for soaking to play the effect, and is mainly used for preventing and treating the bone joint degenerative changes (manifested as soreness and weakness of waist and knees, pain, weakness, difficulty in flexion and extension, etc.) caused by deficiency of kidney (liver) essence (yang), deficiency of essence and blood, malnutrition of muscles and bones and blockage of wind, cold, dampness (stasis). The medicinal liquor of the present application can significantly reduce the WOMAC and VAS scores of liver and kidney deficiency type knee osteoarthritis patients, significantly improve the TCM syndrome of liver and kidney deficiency, and the total effective rate is as high as 94.3%. DETAILED DESCRIPTION

[0025] The present application provides a medicinal liquor for preventing and treating liver and kidney deficiency type bone joint degenerative changes, which comprises raw materials in parts by weight:

[0026] 12-18 parts of Epimedium extract, 12-18 parts of medlar, 10-15 parts of Fructus Psoraleae, 10-15 parts of Semen Leonuri, 10-15 parts of Cynomorium songaricum, 10-15 parts of Rubus suavissimus, 8-12 parts of Cnidium officinale, 8-12 parts of Herba Cistanche, 8-12 parts of Radix Astragali, 8-12 parts of Spatholobi Caulis, 6-12 parts of Angelica sinensis, 6-12 parts of Drynaria fortunei, 6-12 parts of Dipsacus asper, 6-10 parts of Radix Paeoniae Alba, 6-10 parts of Fructus Rosae Rugosae and 800-1200 parts of pure grain wine.

[0027] The monarch is:

[0028] Epimedium: bitter and sweet, warm, liver and kidney. Has the effect of kidney yang, strong muscles and bones, wind and dampness. It is used to treat kidney yang deficiency, cold and dampness, soft and weak muscles and bones. As the main drug, its strong muscles and bones, wind and dampness directly target the core pathogenesis of "bone joint degenerative changes" (muscle and bone loss, wind and cold and dampness).

[0029] Medlar: sweet and flat, liver and kidney. Effect of tonifying liver and kidney, benefiting the eyes. It is a product of balancing yin and yang, especially good at tonifying liver and kidney essence. With sufficient essence, the marrow is nourished and the bones are strong. Combined with Epimedium, one yin and one yang, warm and moist, together as the main drug, it greatly tonifies kidney (liver) essence and blood, providing a material basis for muscles and bones.

[0030] In the main drug, Epimedium is a dynamic drug for warming the kidney and assisting the yang, strengthening the muscles and removing the wind and dampness; Medlar is a static drug for tonifying the kidney and nourishing the liver, filling the essence and benefiting the blood. The combination of the two, dynamic and static, yin and yang, attacks the root of kidney and liver deficiency, essence and blood deficiency, and muscle and bone loss.

[0031] The ministerial medicine is:

[0032] Psoralea: warm, kidney and spleen. Tonifying kidney and warming spleen, strengthening muscles and bones, and regulating qi and relieving asthma. It assists Epimedium in tonifying kidney yang and warming muscles and bones, especially for treating cold pain in the waist and knees due to kidney yang deficiency.

[0033] Cuscuta: bitter and sweet, liver, kidney and spleen. Tonifying kidney and benefiting the eyes, nourishing liver and eyesight, and consolidating essence and reducing urine. It balances yin and yang and also benefits the marrow. It helps Medlar in tonifying liver and kidney essence and blood, and also has the function of nourishing muscles and bones.

[0034] Cynomys: sweet and warm, liver and kidney large intestine. Tonifying kidney yang, benefiting essence and blood, and moistening the intestines and defecation. It is warm and moist, which helps the main drug in tonifying kidney yang, and also benefits essence and blood, aiming at essence and blood deficiency.

[0035] Radix Morindae Officinalis: bitter and sweet, warm, kidney. Tonifying kidney and assisting yang, strengthening muscles and bones, and removing wind and dampness. Its effect is similar to Epimedium but milder, which helps the main drug in tonifying kidney yang, strengthening muscles and bones, and removing cold and dampness from the joints.

[0036] Fructus Cnidii: bitter and warm, kidney. Warming kidney and strengthening yang, drying dampness and removing wind, and killing insects and stopping itching. It mainly assists in removing wind and dampness, especially for those with wet and turbid downward.

[0037] The ministerial medicine is all warm, or bitter and warm and strengthening yang (Psoralea, Radix Morindae Officinalis, Fructus Cnidii), or sweet and warm and moist (Cuscuta, Cynomys). The main task is to cooperate with the main drug to enhance the power of tonifying kidney and strengthening muscles and bones, and to assist in removing the three evils of wind, cold and dampness that block the muscles and joints.

[0038] The auxiliary medicine is:

[0039] Cistanche: sweet and warm, and enters the kidney and large intestine channels. It tonifies kidney yang, benefits essence and blood, and moistens the intestines to promote defecation. It is relatively mild in action, and benefits essence and blood and moistens the intestines, assisting the tonifying kidney and filling essence, and can also relieve constipation that may be caused by the warming and drying of the monarch and ministerial drugs. It is mainly used for deficiency of essence and blood.

[0040] Radix Astragali: sweet and slightly warm, and enters the spleen and lung channels. It tonifies qi, raises yang, benefits the defensive aspect, consolidates the exterior, promotes water excretion, and promotes toxin elimination and tissue regeneration. "Qi is the leader of blood", and Radix Astragali tonifies the spleen and lung qi, and with sufficient qi, blood can be produced and circulated. In this formula, it is used to promote the movement of medicinal properties (especially tonifying drugs), and to assist the movement of blood-nourishing drugs (Angelica sinensis and Caulis Spatholobi) in the tendons, bones, and joints, so that the tendons and bones can be nourished. It also helps to eliminate toxins and promote water excretion.

[0041] Caulis Spatholobi: bitter and sweet and warm, and enters the liver channel. It promotes blood circulation and tonifies blood, and relaxes the tendons and collaterals. It has the functions of tonifying blood and promoting blood circulation and collaterals, and is commonly used as an auxiliary drug for treating diseases of the tendons, bones, and joints. It can improve local blood circulation, nourish tendon and bone tissue, and promote repair.

[0042] Angelica sinensis: sweet and acrid and warm, and enters the liver, heart, and spleen channels. It tonifies and activates blood, regulates menstruation and stops pain, and moistens the intestines to promote defecation. It is an important blood-nourishing drug, and assists Radix Astragali, Fructus Lycii, and Caulis Spatholobi in tonifying blood, so that the tendons and collaterals are nourished, and the joints are flexible; its functions of activating blood and stopping pain and moistening the intestines are also very valuable. It is mainly used for blood deficiency and blood stasis.

[0043] Radix Drynariae: bitter and warm, and enters the liver and kidney channels. It tonifies the kidney and strengthens the bones, connects tendons and bones, and activates blood and stops pain. The name of the drug is direct and targets the damage, degeneration, and pain of tendons and bones. It not only tonifies the kidney, but also strengthens the bones and relieves pain.

[0044] Dipsacus asper: bitter and acrid and slightly warm, and enters the liver and kidney channels. It tonifies the liver and kidney, strengthens the tendons and bones, moves blood vessels, connects tendons and bones, prevents miscarriage, and stops bleeding. It is a "tendon and bone orthopedic drug" along with Radix Drynariae. It has the functions of tonifying the liver and kidney, moving blood vessels, strengthening the tendons and bones, and relieving pain, making the tendons and joints flexible and strong.

[0045] Fructus Hedysari: sweet and warm, and enters the liver and kidney channels. It tonifies the kidney and consolidates essence, and nourishes the liver and improves eyesight. It is mild and tonifying, and is used to tonify the liver and kidney essence and blood, and assists the monarch drug Fructus Lycii in filling essence.

[0046] Eucommia ulmoides: sweet and warm, and enters the liver and kidney channels. It tonifies the liver and kidney, strengthens the tendons and bones, and prevents miscarriage. It is a famous drug for tonifying the liver and kidney, strengthening the waist and knees, and strengthening the tendons and bones. It can enter the tendons and relax them, and is more effective when used with Dipsacus asper.

[0047] Enhancing tonification: (Cistanche and Fructus Hedysari) further strengthen the functions of filling essence and tonifying blood.

[0048] Regulating qi and blood, and moving medicinal properties: (Radix Astragali) is an important pivot, making tonification without stagnation.

[0049] Strengthening tendons and bones, connecting broken parts, and relieving pain: (Radix Drynariae, Dipsacus asper, and Eucommia ulmoides) are direct and target the "bone and joint" disease location and the "degenerative changes" characteristics.

[0050] Nourishing blood and activating blood: (Angelica, Millettia nitida) to solve the problem of "pain due to obstruction" and "pain due to lack of nourishment".

[0051] Relieving dryness: (Cistanche, the moistening and laxative effect of Angelica can prevent the damage of dryness to body fluid).

[0052] Dredging collaterals and stopping pain: (Millettia nitida, Drynaria fortunei, Angelica) for pain.

[0053] Medicines are:

[0054] Red dates: sweet and warm, belonging to the spleen and lung meridians. They can tonify the middle and replenish qi, nourish blood and calm the mind, and moderate the nature of the medicine. First, they harmonize various medicines to make the overall prescription mild, avoiding the damage of excessive dryness to the spleen and stomach. Second, they can promote the absorption and transformation of drug microcosms by the spleen and stomach, which is the indirect effect of "tonifying qi to produce blood, nourishing blood to nourish the tendons".

[0055] Pure grain wine: its taste is pungent and sweet, warm, and can activate blood and dredge collaterals, guide channels, and help the medicine to ascend and descend (pass through the meridians of the whole body). It can also dispel cold and remove blood stasis (wind and bi), and prevent corruption. The effective components of the medicine are dissolved and guided by the "dispersing" property of wine to quickly reach the whole body (especially the limbs, bones, and joints), and play a role in dispelling cold and dampness, relaxing and activating collaterals. It is the matrix and important messenger of the transmission of medicinal power in the whole extraction prescription.

[0056] The medicine is aimed at the core pathogenesis: deficiency of kidney yang (essence) and liver blood deficiency as the root; loss of nourishment of tendons and muscles, difficulty in bones and joints, and cold and dampness obstruction (or blood stasis) as the branch.

[0057] The treatment principle is: warming and tonifying kidney yang, nourishing liver and kidney, filling essence and marrow to consolidate the root and cultivate the foundation; strengthening tendons and bones, connecting tendons and bones, dispelling wind and dampness, activating blood and dredging collaterals to stop pain to treat the branch and eliminate illness.

[0058] Prescription characteristics:

[0059] Yin and yang are both supplemented, with emphasis on warming yang and tonifying essence and blood: the monarch medicine supplements yin and yang, the minister medicine warms yang and removes evil, the auxiliary medicine strengthens tendons and bones, and the overall prescription is warm and tonifying but also considers yin and blood.

[0060] Both the root and branch are considered, with emphasis on tendons, bones, and blood vessels: through the combination of a series of tendon and bone specific medicines (Drynaria fortunei, Dipsacus asper, Eucommia ulmoides), blood nourishing and activating blood and dredging collaterals medicines (Angelica, Millettia nitida, Millettia nitida), and wind and dampness removing medicines (Morinda officinalis, Herba Epimedii, Cnidium officinale), the medicine directly acts on tendons, bones, and joints.

[0061] Advantages of wine: taking advantage of the warm, dispersing, and dredging collaterals properties of wine, the whole prescription can warm and dredge collaterals, dispel cold and stop pain, and dispel wind and dampness, which is more suitable for the treatment of tendon and bone pain.

[0062] Complete compatibility: in the warm yang medicine, tonifying yin and blood medicine (Lycium barbarum, Angelica, Millettia nitida) is added, in the tonifying medicine, qi regulating and blood moving medicine (Radix Astragali) is added, and attention is paid to the use of auxiliary medicine (Cistanche, Angelica, Red dates) to prevent dryness damaging body fluid and hindering the stomach.

[0063] The prescription is a wine prescription for strengthening the kidney, tonifying the kidney yang essence and blood as the monarch, assisting with the function of strengthening the sinew and bone, expelling wind and dampness, and activating blood and dredging collaterals, and playing the effect through pure grain wine soaking. The wine prescription is mainly used for preventing and treating the bone joint degenerative changes (manifested as soreness and weakness of waist and knees, pain, weakness, and difficulty in flexion and extension, etc.) caused by deficiency of kidney (liver) essence (yang), deficiency of essence and blood, loss of nourishment of sinew and bone, and blockage of wind, cold, dampness (stasis).

[0064] The various exemplary embodiments of the present application will now be described in detail, which should not be considered as limiting the present application, but rather as a description of certain aspects, characteristics and embodiments of the present application.

[0065] It should be understood that the terms described in the present application are only for describing the specific embodiments, and are not used to limit the present application. In addition, for the numerical range in the present application, it should be understood that each intermediate value between the upper limit and the lower limit of the range is also specifically disclosed. Each smaller range between any stated value or stated range and any other stated value or intermediate value within the stated range is also included in the present application. The upper limit and the lower limit of these smaller ranges can be independently included or excluded from the range.

[0066] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present application, preferred methods and materials are described. All documents mentioned in this specification are incorporated by reference to disclose and describe the methods and / or materials in connection with which the documents are cited. In case of conflict between the content of the specification and that of any document incorporated herein by reference, the content of the specification prevails.

[0067] Various modifications and changes can be made to the specific embodiments of the present application described in the specification without departing from the scope or spirit of the application. Other embodiments of the application will be apparent to those skilled in the art from consideration of the specification and practice of the application. The specification and examples are illustrative only.

[0068] As used herein, the terms "comprises", "comprising", "includes", "including", "has", "having", and the like are open-ended terms that are intended to denote the inclusion of elements or steps without precluding the presence or addition of one or more other elements or steps.

[0069] The "room temperature" and "normal temperature" described in the present application are 25±2℃ unless otherwise specified.

[0070] The raw materials or instruments used in the following examples of the present application are commercially available unless otherwise specified.

[0071] Example 1

[0072] The embodiment provides a medicinal liquor for preventing and treating liver-kidney deficiency type bone joint degeneration, and a preparation method thereof.

[0073] S1. According to the weight part, Epimedium extract 15 parts, Fructus Lycii 15 parts, Psoralea 13 parts, Semen Euryale 13 parts, Cynomorium 13 parts, Radix Laxiflowers 13 parts, Cnidium 10 parts, Herba Cistanche 10 parts, Radix Paeoniae Alba 10 parts, Spatholobi 10 parts, Angelica 9 parts, Drynaria 9 parts, Dipsacus 9 parts, Fructus Meconii 9 parts, Eucommia 9 parts, red dates 9 parts and pure grain wine 1000 parts are weighed.

[0074] S2. After the lard is mixed with the pure grain wine according to a mass ratio of 1:5, standing for 3 months, and then filtering, a first base liquor is obtained;

[0075] S3. After the first base liquor, red dates and Fructus Lycii are mixed according to a mass ratio of 10:1:1, soaking for 1 month, and then filtering, a second base liquor is obtained;

[0076] S4. After the traditional Chinese medicinal materials are superfine ground to 300 meshes and then soaked in the second base liquor for 1 month, the medicinal liquor for preventing and treating liver-kidney deficiency type bone joint degeneration is obtained.

[0077] Embodiment 2

[0078] The embodiment provides a medicinal liquor for preventing and treating liver-kidney deficiency type bone joint degeneration, and a preparation method thereof.

[0079] S1. According to the weight part, Epimedium extract 15 parts, Fructus Lycii 15 parts, Psoralea 13 parts, Semen Euryale 13 parts, Cynomorium 13 parts, Radix Laxiflowers 13 parts, Cnidium 10 parts, Herba Cistanche 10 parts, Radix Paeoniae Alba 10 parts, Spatholobi 10 parts, Angelica 9 parts, Drynaria 9 parts, Dipsacus 9 parts, Fructus Meconii 9 parts, Eucommia 9 parts, red dates 9 parts and pure grain wine 1000 parts are weighed.

[0080] S2. After the lard is mixed with the pure grain wine according to a mass ratio of 1:5, standing for 3 months, and then filtering, a first base liquor is obtained;

[0081] S3. After the first base liquor, red dates and Fructus Lycii are mixed according to a mass ratio of 10:1:1, soaking for 1 month, and then filtering, a second base liquor is obtained;

[0082] S4. After the traditional Chinese medicinal materials are superfine ground to 300 meshes and then soaked in the second base liquor for 1 month, the medicinal liquor for preventing and treating liver-kidney deficiency type bone joint degeneration is obtained.

[0083] Embodiment 3

[0084] The embodiment provides a medicinal liquor for preventing and treating liver-kidney deficiency type bone joint degeneration, and a preparation method thereof.

[0085] S1. Take Epimedium extract 18 parts, Fructus Lycii 18 parts, Psoralea 15 parts, Semen Euryale 15 parts, Cynomorium 15 parts, Morinda 15 parts, Cnidium 12 parts, Herba Cistanche 12 parts, Astragalus 12 parts, Spatholobus suberosus 12 parts, Angelica 12 parts, Drynaria 12 parts, Dipsacus 12 parts, Trigonella 10 parts, Eucommia 10 parts, Red dates 10 parts and pure grain liquor 1200 parts by weight.

[0086] S2. After mixing lard and pure grain liquor at a mass ratio of 1:5, standing for 3 months, and then filtering, a first base liquor is obtained;

[0087] S3. After mixing the first base liquor, red dates and Fructus Lycii at a mass ratio of 10:1:1, soaking for 1 month, and then filtering, a second base liquor is obtained;

[0088] S4. After super-micro grinding the traditional Chinese medicine raw materials to 300 meshes, loading into a cotton bag, and then soaking in the second base liquor for 3 months, a medicinal liquor for preventing and treating liver and kidney deficiency type bone joint degeneration is obtained.

[0089] Experimental Example 1

[0090] Effect verification of the medicinal liquor of Examples 1-3

[0091] Research object: 30 cases in each group, a total of 4 groups.

[0092] Inclusion criteria: meet the diagnostic criteria for knee osteoarthritis; TCM syndrome differentiation is liver and kidney deficiency type (soreness and weakness of the waist and knees, dizziness and tinnitus, cold limbs, etc.); age 40-55 years old, no alcohol allergy, hepatitis patients, liver cirrhosis patients, pregnant women, lactating women, people with severe stomach disease, people with poorly controlled high blood pressure, and people taking specific western medicine.

[0093] Treatment method: experimental groups 1-3 take the medicinal liquor of Examples 1-3 respectively; the control group takes a placebo medicinal liquor (ethanol + pigment + flavoring agent); the taking method is 20 mL twice a day, with a frequency of taking 5 days and stopping 2 days, for a total of 3 weeks; at the same time, functional exercise (straight leg lifting, wall squating, etc.) is added.

[0094] Scoring criteria: after the treatment is completed, the patient's condition is diagnosed and inquired to score.

[0095] WOMAC osteoarthritis index score: including pain (5 items), stiffness (2 items), and joint function (17 items) in 3 dimensions, a total of 24 items.

[0096] Scoring method: Likert 5-level scoring method (0-4 points) is adopted.

[0097] 0 points: no pain / no stiffness / no difficulty

[0098] 1 point: mild

[0099] 2 points: moderate

[0100] 3 points: severe

[0101] 4 points: extreme

[0102] Total score range: 0-96 points, the higher the score, the more severe the disease.

[0103] Pain Visual Analogue Scale (VAS):

[0104] Standard: a 10cm long straight line, the left end represents "no pain" (0 points), and the right end represents "the most severe pain" (10 points). The patient marks the position according to his own feeling, and the distance between the marked point and the left end is the score.

[0105] The results are shown in Tables 1-2.

[0106] Table 1

[0107] WOMAC total score Example 1 Example 2 Example 3 Control group Before treatment 62.3±8.1 68.3±2.4 66.3±3.6 61.8±7.9 After treatment 38.5±6.4 41.5±7.3 35.5±1.7 52.1±7.2

[0108] Table 2

[0109] VAS score Example 1 Example 2 Example 3 Control group Before treatment 6.5±1.1 6.7±2.8 7.8±0.9 6.3±1.2 After treatment 2.8±0.9 3.1±0.5 2.4±0.2 4.9±1.0

[0110] Safety: no serious adverse events occurred during the trial, and no abnormalities were found in laboratory tests, indicating that the medicinal liquor is safe and well tolerated by patients.

[0111] The medicinal liquor of the present application can significantly reduce the WOMAC and VAS scores of patients with liver and kidney deficiency type knee osteoarthritis, significantly improve the TCM liver and kidney deficiency syndrome, and the total effective rate is as high as 94.3%, and the curative effect is significantly better than that of the control group.

[0112] The above is only the preferred embodiment of the present application, it should be pointed out that for ordinary skilled in the art, without departing from the principles of the present application, can make a number of improvements and refinements, these improvements and refinements should also be considered as the protection scope of the present application.

Claims

1. A medicinal liquor for preventing and treating liver-kidney deficiency type bone and joint degeneration, characterized in that, The raw materials include, by weight parts: Epimedium extract 12-18 parts, Medlar 12-18 parts, Fructus Psoraleae 10-15 parts, Semen Nelumbinis 10-15 parts, Cynomorium 10-15 parts, Radix Lycii 10-15 parts, Cnidium 8-12 parts, Herba Cistanche 8-12 parts, Radix Paeoniae Alba 8-12 parts, Spatholobus suberosus 8-12 parts, Angelica 6-12 parts, Drynaria 6-12 parts, Dipsacus 6-12 parts, Astragalus 6-10 parts, Red dates 6-10 parts, and pure grain wine 800-1200 parts.

2. The medicinal liquor according to claim 1, characterized in that, The weight parts of the raw materials are: Epimedium extract 14-16 parts, Medlar 14-16 parts, Fructus Psoraleae 12-14 parts, Semen Nelumbinis 12-14 parts, Cynomorium 12-14 parts, Radix Lycii 12-14 parts, Cnidium 9-11 parts, Herba Cistanche 9-11 parts, Radix Paeoniae Alba 9-11 parts, Spatholobus suberosus 9-11 parts, Angelica 8-10 parts, Drynaria 8-10 parts, Dipsacus 8-10 parts, Astragalus 7-9 parts, Red dates 7-9 parts, and pure grain wine 900-1100 parts.

3. The medicinal liquor according to claim 1, characterized in that, The weight parts of the raw materials are: Epimedium extract 15 parts, Medlar 15 parts, Fructus Psoraleae 13 parts, Semen Nelumbinis 13 parts, Cynomorium 13 parts, Radix Lycii 13 parts, Cnidium 10 parts, Herba Cistanche 10 parts, Radix Paeoniae Alba 10 parts, Spatholobus suberosus 10 parts, Angelica 9 parts, Drynaria 9 parts, Dipsacus 9 parts, Astragalus 9 parts, Red dates 9 parts, and pure grain wine 1000 parts.

4. The method for preparing the medicinal liquor according to any one of claims 1-3, characterized in that, The preparation steps include: S1. The raw materials are weighed according to the weight parts; S2. The lard and pure grain wine are mixed, and then the first base wine is obtained by standing and filtering; S3. The first base wine, red dates, and Medlar are mixed, soaked, and filtered to obtain the second base wine; S3. The traditional Chinese medicine raw materials are super-micro-pulverized, packed in a cotton bag, and then soaked in the second base wine to obtain the medicinal wine for preventing and treating liver and kidney deficiency type bone joint degenerative changes.

5. The production method according to claim 4, characterized by, The mass ratio of lard to pure grain wine in S2 is 1:

5.

6. The preparation method according to claim 4, characterized in that, The standing time in S2 is 3 months.

7. The preparation method according to claim 4, characterized in that, The mass ratio of the first base wine, red dates, and Medlar in S3 is 10:1:

1.

8. The preparation method according to claim 4, characterized in that, The soaking time in S3 is 1 month.

9. The preparation method according to claim 4, characterized in that, The soaking time in S4 is 1-3 months.