Tea composition capable of reducing blood uric acid as well as preparation method and application of tea composition

Abstract

The invention provides a tea composition for reducing blood uric acid as well as a preparation method and application thereof, and belongs to the technical field of tea compositions. The tea comprises the following raw materials in parts by weight: 1-10 parts of Baihao silver needle, 1-9 parts of large-leaf white tea, 1-9 parts of mulberry leaf tea, 1-9 parts of cyclocarya paliurus, 1-5 parts of dandelion, 1-8 parts of pericarpium citri reticulatae, 1-6 parts of corn stigma and 1-5 parts of rose. The tea has the effect of reducing blood uric acid, and is rich in tea soup aroma, pure in taste and long in aftertaste. According to the composition, the Baihao silver needle is used as a monarch material to directly act on the pathogenesis of damp-heat; corn stigma and dandelion are used as ministerial drugs to construct a double mechanism of inhibiting generation and promoting excretion; cyclocarya paliurus, mulberry leaves and large-leaf white tea are used as assistants to regulate and control metabolic disorder in a multi-target manner; the dried orange peel and the rose are used as guide materials to regulate medicine properties and improve symptoms. The whole formula focuses on the characteristic of'deficiency in root and excess in superficies' of hyperuricemia, and gives consideration to etiological treatment and symptom relief.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of tea compositions, and particularly relates to a tea composition for reducing blood uric acid, and a preparation method and application thereof. BACKGROUND

[0002] Hyperuricemia (gout) is a metabolic disease, and its pathological mechanism is related to purine metabolism disorder and uric acid excretion disorder. Long-term high blood uric acid can cause joint inflammation, kidney stones and other complications. Modern medical treatment mainly uses non-steroidal anti-inflammatory drugs, allopurinol and other drugs, but long-term use can easily lead to liver and kidney damage and electrolyte disorder, and some patients cannot benefit due to drug contraindications. This treatment dilemma prompts researchers to turn their attention to the field of traditional Chinese medicine.

[0003] In the theoretical system of traditional Chinese medicine, gout belongs to the category of "bi syndrome", and the pathogenesis is closely related to dampness-heat and blood stasis. Traditional Chinese medicine treatment has unique advantages through multi-target action mechanism: it can not only inhibit uric acid generation and promote excretion, but also relieve inflammatory reaction, and has the characteristics of high safety and wide applicability. However, the current research on traditional Chinese medicine compound is facing multiple challenges: first, the traditional formula often contains more than ten kinds of medicinal materials, such as the complex formula disclosed in CN113813342A, which not only increases the difficulty of preparation process, but also makes it difficult to identify the effective ingredients, affecting the quality control and pharmacological mechanism research; second, some prescriptions use unconventional medicinal materials such as cow bone marrow and tadpole, which raises ethical controversy and raw material acquisition problem; third, the existing therapies mainly focus on symptom improvement, and lack precise targeting for blood uric acid level regulation.

[0004] In view of the above problems, a tea composition is provided for chronic disease management of patients with gout or high uric acid, which has positive significance for the treatment of hyperuricemia. SUMMARY

[0005] Therefore, the purpose of the present application is to provide a tea composition which has the effect of reducing blood uric acid, and the tea soup has rich aroma, pure taste and long-lasting sweet aftertaste.

[0006] In order to achieve the above-mentioned purpose of the application, the present application provides the following technical solutions: A tea composition, comprising the following raw materials in parts by weight: 1-10 parts of white needle, 1-9 parts of large-leaf white tea, 1-9 parts of mulberry leaf tea, 1-9 parts of Chinese hackberry, 1-5 parts of dandelion, 1-8 parts of dried tangerine or orange peel, 1-6 parts of corn silk, and 1-5 parts of rose flower.

[0007] Preferably, the tea composition comprises the following raw materials in parts by weight: 3-8 parts of white needle, 3-8 parts of large-leaf white tea, 3-8 parts of mulberry leaf tea, 3-8 parts of Chinese hackberry, 2-4 parts of dandelion, 3-6 parts of dried tangerine or orange peel, 2-5 parts of corn silk, and 2-4 parts of rose flower.

[0008] Preferably, the raw materials include the following: white needle tea 5-6 parts, large leaf variety white tea 5-6 parts, mulberry leaf tea 5-6 parts, cyclobalanopsis gilva 5-6 parts, dandelion 2.5-3.5 parts, dried tangerine or orange peel 4-5 parts, corn silk 3-4 parts, and rose flower 2.5-3.5 parts.

[0009] Another object of the present application is to provide a preparation method of the tea composition, comprising the following steps: mixing the raw materials after being respectively pulverized to obtain a mixture, and then pouring hot water to the mixture to obtain tea soup.

[0010] Preferably, the raw materials are pulverized and then passed through a 50-100 mesh sieve.

[0011] Preferably, the temperature of the hot water is 80-100 DEG C.

[0012] Preferably, the ratio of the mixture to the hot water is 1g:30-200mL.

[0013] Preferably, the brewing time is 3-5 minutes.

[0014] Another object of the present application is to provide the application of the tea composition or the preparation method in the preparation of a medicine for reducing blood uric acid.

[0015] Another object of the present application is to provide a medicine for reducing blood uric acid, which contains the tea composition.

[0016] Compared with the prior art, the present application has the following beneficial effects: The present application provides a tea composition, which has the effect of reducing blood uric acid, and the tea soup has rich aroma, pure taste and long-lasting sweet aftertaste. The composition of the present application takes white needle tea as the monarch, directly attacking the pathogenesis of damp heat; corn silk and dandelion as the ministers, constructing the double mechanism of "inhibiting generation + promoting excretion"; cyclobalanopsis gilva, mulberry leaf and large leaf variety white tea as the assistants, regulating metabolic disorders through multiple targets; dried tangerine or orange peel and rose flower as the ministers, adjusting the medicinal properties and improving symptoms. The whole prescription closely follows the characteristics of "asthenia in origin and excess in superficiality" of hyperuricemia, and takes into account the etiological treatment and symptom relief.

[0017] The present application not only can avoid the liver and kidney damage caused by western medicine, but also has a simple prescription and easy-to-obtain raw materials, which brings significant benefits to health management. The present application provides a new idea for the development of new products of compound tea series. DETAILED DESCRIPTION

[0018] The present application provides a tea composition, comprising the following raw materials in parts by weight: 1-10 parts of white pekoe, 1-9 parts of large-leaf white tea, 1-9 parts of mulberry leaf tea, 1-9 parts of Cyclocarya paliurus, 1-5 parts of dandelion, 1-8 parts of dried tangerine or orange peel, 1-6 parts of corn silk, and 1-5 parts of rose flower. Preferably, the tea composition comprises the following raw materials in parts by weight: 3-8 parts of white pekoe, 3-8 parts of large-leaf white tea, 3-8 parts of mulberry leaf tea, 3-8 parts of Cyclocarya paliurus, 2-4 parts of dandelion, 3-6 parts of dried tangerine or orange peel, 2-5 parts of corn silk, and 2-4 parts of rose flower. More preferably, the tea composition comprises the following raw materials in parts by weight: 5-6 parts of white pekoe, 5-6 parts of large-leaf white tea, 5-6 parts of mulberry leaf tea, 5-6 parts of Cyclocarya paliurus, 2.5-3.5 parts of dandelion, 4-5 parts of dried tangerine or orange peel, 3-4 parts of corn silk, and 2.5-3.5 parts of rose flower.

[0019] In the present application, the white pekoe is a kind of white tea, which is prepared by only two processes of withering and baking without roasting and kneading, and only the bud or the bud and the first leaf are taken. The large-leaf white tea is mainly produced in Fuding City, Fujian Province, and is prepared by picking the first bud and the second or third leaf, and then by processes of fixation, kneading, and drying. The large-leaf white tea has a long and strong strip shape, and the silver hairs are shining. The inner quality of the large-leaf white tea has a strong and fresh aroma, a mellow and sweet taste, and a clear soup. The mulberry leaf tea is prepared by processes of picking, washing and airing, cutting, fixation, kneading, unblocking, drying, and flavoring, and the tender mulberry leaves are used as the raw material. The Cyclocarya paliurus is the skin, root, or leaf of the Cyclocarya paliurus in the Juglandaceae family. The dandelion is the dried whole plant of the Taraxacum mongolicum, the Taraxacum sinicum, or several species of the same genus, which is obtained by removing impurities, washing, cutting into segments, and drying. The dried tangerine or orange peel is the dried mature fruit peel of the Citrus reticulata and its cultivated varieties, which is obtained by picking the mature fruits, peeling the fruit peel, and drying. The corn silk is the style and stigma of the Zea mays in the Poaceae family, which is obtained by collecting in summer and autumn when the fruits are mature, removing impurities, and drying. The rose flower tea is prepared by using the petals or flower buds of the rose flower as the raw material.

[0020] In the present application, the raw materials can be obtained by conventional commercial channels.

[0021] The tea composition of the present application takes baihao yinzhen as the monarch, which is pungent and belongs to the lung and stomach channels, has the effects of clearing heat and resolving toxicity, generating fluid and relieving thirst, and resisting oxidation, is the core of the whole prescription dosage regulation, and embodies its dominant position. Hyperuricemia is often related to internal accumulation of dampness and heat, and baihao yinzhen has strong heat-clearing effect and can directly attack the root of internal accumulation of heat and toxicity. Corn silk and dandelion are the ministers, corn silk belongs to the bladder and liver channels, has the effects of diuresis and swelling reduction, and can promote uric acid excretion by increasing glomerular filtration rate; dandelion belongs to the liver and stomach channels, has the effects of clearing heat and resolving toxicity, diuresis and relieving stranguria, and has the effects of protecting liver and gallbladder and inhibiting uric acid reabsorption, and the two are used together to form a “generation-excretion” double-pathway regulation, assist the monarch, and strengthen the effect of the prescription in reducing blood uric acid. Qingqianliu, mulberry leaf tea and large-leaf white tea are the adjuvants, qingqianliu belongs to the spleen and kidney channels, regulates sugar and lipid metabolism, improves internal environment disorder and insulin resistance, and reduces the inducement of uric acid synthesis; mulberry leaf tea belongs to the lung and liver channels, has the effects of clearing liver and improving eyesight, inhibiting intestinal absorption of purines, and improving abnormal purine metabolism; large-leaf white tea belongs to the heart and liver channels, assists in clearing heat and resolving toxicity, and enhances the antioxidant capacity, and forms a “double white tea” compatibility with the monarch baihao yinzhen to enhance the ability of the whole prescription in clearing dampness and heat; the three are used together to regulate metabolic disorder in multiple targets. Pericarpium citri reticulatae and rose flower are the guides, pericarpium citri reticulatae belongs to the spleen and lung channels, regulates qi and invigorates the spleen, dries dampness and resolves phlegm, prevents cold and cold injury to the stomach, guides the medicinal effects into the spleen and stomach, and promotes absorption; rose flower belongs to the liver and spleen channels, soothes the liver and relieves depression, regulates medicinal properties, and improves qi stagnation and blood stasis, and rose flower promotes blood circulation to relieve pain, and relieves joint pain symptoms; the whole prescription contains many cold and cool medicines, pericarpium citri reticulatae has warm nature and can neutralize, avoids damage to the spleen and stomach yang qi, and ensures the safety of long-term medication, and pericarpium citri reticulatae and rose flower are used together to regulate medicinal properties and improve symptoms.

[0022] The present application takes baihao yinzhen as the monarch, directly attacks the pathogenesis of dampness and heat; corn silk and dandelion are the ministers, and form a “inhibit generation + promote excretion” double mechanism; qingqianliu, mulberry leaf and large-leaf white tea are the adjuvants, and regulate metabolic disorder in multiple targets; pericarpium citri reticulatae and rose flower are the guides, and regulate medicinal properties and improve symptoms. The whole prescription is closely related to the characteristics of “deficiency in origin and excess in superficiality” of hyperuricemia, and takes into account etiological treatment and symptom relief.

[0023] The present application also provides a preparation method of the tea composition, which comprises the following steps: mixing the raw materials after being crushed to obtain a mixture, and then pouring hot water to the mixture in a bag to obtain tea soup.

[0024] In the preparation method of the present application, the raw materials are preferably crushed and then sieved through a 50-100 mesh sieve, and more preferably sieved through a 60-80 mesh sieve. The present application can ensure the uniformity and fineness of the powder by crushing the raw materials, can effectively improve the taste of tea, and is also helpful for the rapid dissolution and release of each component. The crushed raw material powder is mixed, and then preferably sterilized by ultraviolet lamp irradiation, and the power of the ultraviolet lamp is 90uw / cm 2The sterilization time is 20 min, and the wavelength of the ultraviolet lamp is 253.7 nm. The tea composition can be guaranteed to be hygienic and safe through sterilization. The mixture can be loaded into a packaging bag before brewing the tea composition, the packaging bag is a filter paper + PET non-woven fabric composite bag, through loading into the packaging bag, the freshness of the tea composition can be maintained, and pollution can be prevented. Preferably, the temperature of the hot water is 80-100 DEG C, the tea composition is brewed with the hot water at the temperature for 3-5 min, and the effective substances of the raw materials can be fully extracted. Preferably, the ratio of the mixture to the hot water is 1g:30-200ml, and more preferably 1g:100-150ml. The brewing is preferably repeated 4-6 times.

[0025] The application further provides application of the tea composition or the preparation method in preparation of a medicine for reducing blood uric acid.

[0026] The application further provides a medicine for reducing blood uric acid, which contains the tea composition.

[0027] The technical solutions provided by the application are described in detail below in combination with examples, but they should not be understood as limitations to the protection scope of the application.

[0028] Example 1 A tea composition, raw materials are as follows in proportion by weight: White needle 6 parts, large leaf white tea 5 parts, mulberry leaf tea 5 parts, 5 parts of Qing Qianliu, 3 parts of dandelion, 4 parts of dried tangerine or orange peel, 3 parts of corn silk, and 3 parts of rose.

[0029] The preparation method is as follows: The raw materials are crushed and passed through an 80-mesh sieve, the powders of the raw materials are mixed in proportion, the mixed powder is sterilized by using an ultraviolet lamp, the power of the ultraviolet lamp is 90uw / cm 2 , the sterilization time is 20 min, the wavelength of the ultraviolet lamp is 253.7 nm, after sterilization, the mixture is loaded into a filter paper + PET non-woven fabric composite bag, 85 DEG C hot water is used to brew the mixture for 3 min according to the ratio of 1g:100ml, and the tea soup is collected, the brewing is repeated 5 times, and the tea soups are combined.

[0030] Example 2 A tea composition, raw materials are as follows in proportion by weight: White needle 6 parts, large leaf white tea 5 parts, mulberry leaf tea 5 parts, 5 parts of Qing Qianliu, 3 parts of dandelion, 4 parts of dried tangerine or orange peel, 3 parts of corn silk, and 3 parts of rose.

[0031] The preparation method is the same as that in example 1.

[0032] Example 3 A tea composition, raw materials are as follows in proportion by weight: White tea 4 parts, large leaf species white tea 6 parts, mulberry leaf tea 2 parts, green money willow 4 parts, dandelion 5 parts, dried tangerine or orange peel 7 parts, corn silk 5 parts, rose 1 part.

[0033] The preparation method is the same as that of Example 1.

[0034] Comparative Example 1 Compared with Example 1, the difference is that white tea is not added.

[0035] Comparative Example 2 Compared with Example 1, the difference is that large leaf species white tea is not added.

[0036] Comparative Example 3 Compared with Example 1, the difference is that green money willow and dandelion are not added.

[0037] Comparative Example 4 Compared with Example 1, the difference is that the raw materials are as follows in terms of weight parts: White tea 2 parts, large leaf species white tea 3 parts, mulberry leaf tea 5 parts, green money willow 5 parts, dandelion 8 parts, dried tangerine or orange peel 4 parts, corn silk 8 parts, rose 3 parts.

[0038] Example 4 SPF Kunming mice (purchased from Huisheng Biotechnology Co., Ltd.) were used as experimental animals, and the body weight was 18-22 g. First, the Kunming male mice were randomly divided into six groups under the condition of normal diet and water. Each group was treated as follows: Blank control group: only normal diet and water were provided, and 0.4 mL of normal saline was administered by gavage at the same time as other groups; Model group: 250 mg / Kg of uric acid oxidase inhibitor oxypurinol was injected intraperitoneally every day for 8 consecutive days to construct a hyperuricemia model. 2 hours after injection of oxypurinol on the 8th day, 0.4 mL of normal saline was administered by gavage for 7 consecutive days; Positive control group: 250 mg / Kg of uric acid oxidase inhibitor oxypurinol was injected intraperitoneally every day for 8 consecutive days. 2 hours after injection of oxypurinol on the 8th day, Goutshu tablets (400 mg / kg of Goutshu was dissolved in 15 mL of normal saline to prepare a 20 mg / mL solution, which was then administered by gavage) were administered by gavage for 7 consecutive days; Low-dose uric acid-lowering compound tea group: 250 mg / Kg of uric acid oxidase inhibitor oxypurinol was injected intraperitoneally every day for 8 consecutive days. 2 hours after injection of oxypurinol on the 8th day, 30 g of the tea leaf composition in Example 1 was used to prepare tea soup by using 500 mL of hot water (85°C) to brew for 3 minutes. The tea soup was collected, repeated 3 times, and combined. 0.25 mL per mouse was administered by gavage for 7 consecutive days; The uric acid-lowering compound tea high-dose group: 30g of the tea leaf composition in Example 1 was taken, 500mL of hot water (85℃) was used to brew for 3min to collect the tea soup, and the process was repeated for 3 times, the tea soup was combined, and 0.8mL per mouse was administered by gavage for 7 consecutive days after 2h of injection of the uric acid oxidase inhibitor oxypurinol at a dose of 250mg / Kg per day for 8 consecutive days. The uric acid-lowering compound tea high-dose group: 30g of the tea leaf composition in Example 1 was taken, 500mL of hot water (85℃) was used to brew for 3min to collect the tea soup, and the process was repeated for 3 times, the tea soup was combined, and 0.8mL per mouse was administered by gavage for 7 consecutive days after 2h of injection of the uric acid oxidase inhibitor oxypurinol at a dose of 250mg / Kg per day for 8 consecutive days.

[0039] After 7 days of continuous gavage, the blood uric acid levels of the mice in each group were detected, and the results are shown in Table 1.

[0040] Table 1 Serum uric acid content

[0041] It can be seen that the tea leaf composition can promote uric acid excretion and reduce the serum uric acid level, and the low, medium and high doses of the uric acid-lowering compound tea can significantly reduce the uric acid content in the serum, and have a significant uric acid-lowering effect and reduce the blood uric acid level.

[0042] Example 5 Effect of different tea leaf compositions on reducing blood uric acid.

[0043] 70 high blood uric acid patients were selected, and the selection criteria are as follows: Male: under normal purine diet, the average of two consecutive fasting blood uric acid levels on different days is >420 μmol / L (>7 mg / dL); Female: under normal purine diet, the average of two consecutive fasting blood uric acid levels on different days is >360 μmol / L (>6 mg / dL).

[0044] The high blood uric acid patients were randomly divided into 7 groups, and the tea soup of Examples 1 to 3 and Comparative Examples 1 to 4 was drunk, 6g was brewed each time, twice a day, and continuously drunk for 30 days. Follow-up visits were made to the patients to count the curative effect, and the standard for judging the curative effect was: Cure: blood uric acid continues to meet the standard for ≥6 months, asymptomatic period ≥2 months, related examination (liver and kidney function, urine routine) is normal, lifestyle is stable, and doctor's assessment is permitted; Effective: 1. Serum uric acid: asymptomatic hyperuricemia: < 420 μmol / L when no complications; < 360 μmol / L when complications; < 360 μmol / L when no tophi or chronic arthritis; < 300 μmol / L when tophi or frequent attacks; 2. Clinical improvement: joint swelling and pain disappeared for > 2 months, no acute attacks, improved kidney function, and good control of cardiovascular risk indicators; Ineffective: serum uric acid value did not decrease, and clinical symptoms did not improve.

[0045] Efficiency % = (number of cured + number of effective) / total number of volunteers x 100%, as shown in Table 2.

[0046] Table 2 Effect of different tea compositions on reducing serum uric acid

[0047] According to the results in Table 2, the tea composition provided in the present application has good effect on reducing serum uric acid.

[0048] Typical cases 1. Li, 490 μmol / L in August 2022, clinical: right thumb joint has slight swelling and pain, X-ray is normal, 4 months of taking the tea prepared according to Example 1, twice a day, each time brewing 6 g, after 30 days of drinking, the clinical symptoms disappeared, the serum uric acid was 297 μmol / L, and the serum uric acid was 299 μmol / L in April 2023, and no clinical symptoms were found.

[0049] 2. Wang, diagnosed with gout in both feet in May 2019, and acute gout relapse in April 2022, redness, swelling, stiffness, serum uric acid 450 μmol / L, first taking the acute phase drug regimen, 25 days stable, then taking the tea prepared according to Example 2, twice a day, each time brewing 6 g, after 30 days of drinking, serum uric acid 328 μmol / L, no recurrence after 6 months of follow-up, serum uric acid 290 μmol / L.

[0050] 3. Duan, diagnosed with gout for 13 years, came to the clinic in July 2022, serum uric acid 790 μmol / L, took the tea prepared according to Example 3, twice a day, each time brewing 6 g, after 30 days of drinking, serum uric acid 305 μmol / L, clinical symptoms disappeared, no recurrence after 6 months of follow-up.

[0051] The above only describes the preferred embodiments of the present application, and it should be noted that for ordinary skilled persons in the art, without departing from the principles of the present application, a number of improvements and refinements can be made, which should also be considered within the scope of protection of the present application.

Claims

1. A tea composition, characterized in that, By weight, it includes the following ingredients: 1-10 parts Baihao Yinzhen (Silver Needle White Tea), 1-9 parts Da Ye Zhong Bai Cha (Large Leaf White Tea), 1-9 parts Sang Ye Cha (Mulberry Leaf Tea), 1-9 parts Qing Qian Liu (Eucommia ulmoides), 1-5 parts Dandelion, 1-8 parts Chenpi (Dried Tangerine Peel), 1-6 parts Corn Silk, and 1-5 parts Rose.

2. The tea composition according to claim 1, characterized in that, By weight, it includes the following ingredients: 3-8 parts Baihao Yinzhen (Silver Needle White Tea), 3-8 parts Da Ye Zhong Bai Cha (Large Leaf White Tea), 3-8 parts Sang Ye Cha (Mulberry Leaf Tea), 3-8 parts Qing Qian Liu (Eucommia ulmoides), 2-4 parts Dandelion, 3-6 parts Dried Tangerine Peel, 2-5 parts Corn Silk, and 2-4 parts Rose.

3. The tea composition according to claim 1, characterized in that, By weight, it includes the following ingredients: 5-6 parts Baihao Yinzhen (Silver Needle White Tea), 5-6 parts Da Ye Zhong Bai Cha (Large Leaf White Tea), 5-6 parts Sang Ye Cha (Mulberry Leaf Tea), 5-6 parts Qing Qian Liu (Eucommia ulmoides), 2.5-3.5 parts Dandelion, 4-5 parts Dried Tangerine Peel, 3-4 parts Corn Silk, and 2.5-3.5 parts Rose.

4. The method for preparing the tea composition according to claim 1, characterized in that, The process includes the following steps: each raw material is crushed separately and then mixed to obtain a mixture. The mixture is then bagged and brewed with hot water to obtain tea.

5. The preparation method according to claim 4, characterized in that, The raw materials are crushed and then passed through a 50-100 mesh sieve.

6. The preparation method according to claim 4, characterized in that, The hot water temperature is 80~100℃.

7. The preparation method according to claim 4, characterized in that, The ratio of the mixture to hot water is 1g:30~200mL.

8. The preparation method according to claim 4, characterized in that, The steeping time is 3 to 5 minutes.

9. The use of the tea composition according to any one of claims 1-3 or the preparation method according to any one of claims 4-8 in the preparation of a drug for lowering blood uric acid.

10. A drug for lowering blood uric acid, characterized in that, The tea composition comprising any one of claims 1-3.

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