Traditional Chinese medicine composition for treating vertigo disease and preparation method thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating vertigo and a preparation method thereof, and the traditional Chinese medicine composition is characterized by mainly comprising the following medicinal materials in parts by weight: 6-17 parts of fried spina date seed, 20-40 parts of calcined magnet, 4-8 parts of polygala tenuifolia, 4-8 parts of schisandra chinensis, 7-13 parts of alpinia oxyphylla, 7-13 parts of glossy privet fruit, 7-13 parts of poria cocos, 7-13 parts of rhizoma alismatis and 2-4 parts of liquorice. The medicine prepared from the traditional Chinese medicine composition provided by the invention takes nerve soothing as a core formula thought, and the medicines for regulating the kidney, clearing damp and calming the liver in the formula can exactly play a role in three common core pathogenesis of dizziness, such as dizziness caused by deficiency of liver and kidney, turbid dampness and floating liver yang, so that'simultaneous treatment 'is realized; and a new medicine is provided for clinically treating the vertigo disease.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, and more specifically, to a traditional Chinese medicine composition for treating vertigo and its preparation method. Background Technology

[0002] Persistent postural-perceptual vertigo (PPPD) is a chronic dizziness disorder characterized by persistent dizziness and unsteadiness, especially when standing or walking. These symptoms are usually not accompanied by a spinning sensation or nausea and vomiting. PPPD is a newly defined chronic vestibular dysfunction characterized by non-rotational vertigo and / or unsteadiness, defined as persistent non-rotational vertigo and unsteadiness lasting more than 3 months. It can occur spontaneously or during sudden movement, and symptoms worsen with upright posture, complex visual stimuli, and head movements. It is usually secondary to acute or episodic vestibular disorders and balance-related disorders. Clinical symptoms are as follows:

[0003] 1) One or more symptoms of dizziness, unsteadiness, or non-rotational vertigo (such as a feeling of being hazy, unclear, swollen, heavy-headed, lightheaded, swaying, jumping, bouncing, etc.).

[0004] 2) Symptoms occur frequently over a period of at least 3 months, but do not necessarily have to be present indefinitely (symptoms must be present for at least 15 out of 30 days). Most patients experience symptoms daily or almost daily, and the symptoms may worsen over time.

[0005] 3) The onset of the disease can be acute, paroxysmal, or chronic vestibular disorders, or other neurological or psychological diseases. It generally does not go through an asymptomatic period, and most of the diseases that occur before the onset of the disease are acute or paroxysmal diseases.

[0006] 4) Symptoms can occur regardless of specific triggers. Symptoms can be aggravated by standing posture, active or passive movement regardless of direction or position, moving visual stimuli, or complex visual environments.

[0007] 5) It can cause significant anxiety, aggravate existing mental illnesses, co-occur with multiple diseases, and affect daily life activities.

[0008] This demonstrates the close relationship between chronic vertigo and anxiety / insomnia, with the three often forming a symbiotic relationship. Chronic vertigo is a common trigger for anxiety and insomnia, while anxiety and insomnia can exacerbate chronic vertigo. Therefore, in the clinical treatment of chronic vertigo, in addition to addressing the vertigo itself (such as improving vestibular function and treating underlying diseases), it is also necessary to break the vicious cycle through physiological regulation to more effectively alleviate symptoms. Currently, most clinical treatments focus on symptomatic relief of vertigo and improvement of inner ear circulation using Western medicine. These primarily involve serotonin reuptake inhibitors (SRIs) and norepinephrine reuptake inhibitors (NRIs), including sertraline hydrochloride, escitalopram oxalate, paroxetine hydrochloride, fluoxetine hydrochloride, and fluvoxamine maleate. However, the efficacy of these drugs is not specific, so clinically, one or more treatment methods are often combined, such as drug therapy plus vestibular rehabilitation or cognitive behavioral therapy. In addition, some traditional Chinese medicines, such as Wuling capsules, are suitable for patients with mild symptoms or some patients with moderate psychogenic vertigo and PPPD. However, vestibular depressants such as antihistamines and benzodiazepines can delay vestibular recovery and should be avoided if possible.

[0009] Therefore, this invention proposes a traditional Chinese medicine composition for treating vertigo and its preparation method. Guided by traditional Chinese medicine theory, the composition takes "calming the mind" as the core concept. Through the kidney-regulating, dampness-removing, and liver-soothing drugs in the formula, it precisely targets the three common core pathogenesis of vertigo (liver and kidney deficiency, dampness obstructing the upper body, and liver yang rising), thereby achieving "comprehensive treatment" and providing a new drug for the clinical treatment of vertigo. Summary of the Invention

[0010] This invention aims to provide a traditional Chinese medicine composition for treating vertigo and its preparation method. The core concept of the composition is "calming the mind". By using drugs that regulate the kidney, remove dampness, and soothe the liver, the composition can effectively target the three common core pathogenesis of vertigo (liver and kidney deficiency, dampness obstructing the upper body, and liver yang rising), thereby achieving "comprehensive treatment" and solving the technical problems of non-specific efficacy and large side effects of existing drugs.

[0011] To achieve the above objectives, the present invention adopts the following technical solution:

[0012] On one hand, the present invention provides a traditional Chinese medicine composition for treating vertigo, the traditional Chinese medicine composition mainly composed of the following medicinal materials in parts by weight: 6-17 parts of stir-fried jujube seed, 20-40 parts of calcined magnetite, 4-8 parts of polygala tenuifolia, 4-8 parts of schisandra chinensis, 7-13 parts of alpinia oxyphylla, 7-13 parts of privet fruit, 7-13 parts of poria cocos, 7-13 parts of alisma plantago-aquatica, and 2-4 parts of licorice.

[0013] Preferably, the traditional Chinese medicine composition mainly consists of the following medicinal materials in parts by weight: 9-15 parts of stir-fried jujube seed, 22-33 parts of calcined magnetite, 4-6 parts of polygala tenuifolia, 6-8 parts of schisandra chinensis, 9-12 parts of alpinia oxyphylla, 9-11 parts of privet fruit, 9-12 parts of poria cocos, 8-10 parts of alisma plantago-aquatica, and 2-3 parts of licorice.

[0014] Preferably, the traditional Chinese medicine composition consists of the following medicinal materials in parts by weight: 10 parts of stir-fried jujube seed, 30 parts of calcined magnetite, 6 parts of polygala root, 6 parts of schisandra fruit, 10 parts of alpinia oxyphylla, 10 parts of privet fruit, 10 parts of poria cocos, 10 parts of alisma plantago-aquatica, and 3 parts of licorice root.

[0015] The weight of the aforementioned drugs can be measured in any unit of weight, such as grams, taels, jin, kilograms, or tons. The pharmaceutical composition of this invention can be formulated using general methods according to the proportions of each drug, and prepared into a clinically suitable dosage form as needed. All the medicinal materials used are Chinese medicinal materials that have passed qualified inspection and are sold in the market.

[0016] On the other hand, the present invention also provides a method for preparing a drug for treating vertigo using the above-mentioned traditional Chinese medicine composition, comprising the following steps:

[0017] S1. Weigh the medicinal materials in the Chinese medicine composition according to the weight parts, and pulverize the medicinal materials that include at least calcined magnetite;

[0018] S2. First, perform a first water extraction on the pulverized and calcined magnetite, then combine all the medicinal materials for a second water extraction, combine all the extracts, concentrate, and obtain a concentrated solution.

[0019] S3. The concentrate is prepared into a pharmaceutical preparation with or without the addition of excipients.

[0020] Preferably, the water extraction method is decoction, ultrasound-assisted extraction, or microwave-assisted extraction.

[0021] Preferably, the first water extraction time is 20-45 min; the second water extraction time is 40-90 min, and the number of extractions is 1-3; the material-to-liquid ratio in the first and second water extractions is 8-12 ml: 1 g.

[0022] Preferably, the medicine is a decoction, granules, pills, powder, tablets, capsules, or syrup.

[0023] Preferably, before the second water extraction, all remaining medicinal materials, except for calcined magnetite, need to be soaked in water for 20-45 minutes.

[0024] Preferably, the soaking process further includes crushing all remaining medicinal materials, except for calcined magnetite, into powder.

[0025] Preferably, the preparation steps of the syrup further include: adding ethanol to the concentrate to make the volume fraction of ethanol in the solution 75%~85%, separating after alcohol precipitation, concentrating the clear liquid until there is no alcohol taste, and adding sucrose to make a syrup with a density of 1.8~1.32g / ml.

[0026] Preferably, the density of the concentrate is 1.25~1.45 g / ml, and the sucrose accounts for 30%~40% of the total solids of the syrup.

[0027] Preferably, the syrup further includes preservatives and flavoring agents; the preservatives are any one or more of sorbic acid and its salts, benzoic acid and its salts, or parabens; the flavoring agents include sweeteners and flavorings; the sweeteners are one or more of sucralose, sorbitol, stevia, aspartame, and xylitol.

[0028] On the other hand, the present invention also provides the application of the above-mentioned traditional Chinese medicine composition or the drug prepared by the above method in the preparation of a drug for treating vertigo, wherein the vertigo refers to a disease with symptoms related to sleep, mood or autonomic nervous system dysfunction, including vestibular migraine, Meniere's disease or persistent postural perceptual vertigo, wherein the persistent postural perceptual vertigo includes chronic vertigo in the elderly and benign vertigo in children.

[0029] The present invention selects the above-mentioned medicinal materials as medicinal materials because they have the following properties and effects:

[0030] Fried Jujube Seeds: Take clean, mature jujube seeds (dried seeds of *Ziziphus jujuba* Mill. var. *spinosa* (Bunge) Huex H.F. Chou, family Rhamnaceae), and fry according to the stir-frying method (General Rule 0213) until they puff up and darken slightly in color. Crush before use.

Properties and Channels Entered

Functions and Indications

[0031] Calcined Magnetite: Take clean magnetite (a spinel-type mineral, mainly containing iron(III) oxide (Fe3O4)) blocks, calcine until red-hot according to the calcination and quenching method (General Rule 0213), quench in vinegar, and grind into coarse powder. Use 30 kg of vinegar for every 100 kg of magnetite.

Properties and Channels Entered

Functions and Indications

[0032] Yuanzhi: The dried root of *Polygala nuifolia* Willd. or *Polygala ovoidensis* L., belonging to the Polygalaceae family. [Properties and Channels Entered] Bitter, pungent, warm. Enters the Heart, Kidney, and Lung channels. [Functions and Indications] Calms the mind and improves intelligence, harmonizes the Heart and Kidneys, resolves phlegm, and reduces swelling. Used for insomnia, excessive dreaming, forgetfulness, palpitations, mental confusion, cough with phlegm, carbuncles, boils, and breast swelling and pain caused by disharmony between the Heart and Kidneys.

[0033] Schisandra chinensis: The dried, ripe fruit of Schisandra chinensis (Turcz.) Baill., a plant in the Magnoliaceae family.

Properties and Channels Entered

Functions and Indications

[0034] Alpinia oxyphylla Miq. (Zingiberaceae family): The dried, mature fruit of Alpinia oxyphylla Miq.

Properties and Channels Entered

Functions and Indications

[0035] Privet fruit: The dried, ripe fruit of *Ligustrum lucidum* Ait., a plant in the Oleaceae family. [Properties and Channels Entered] Sweet, bitter, cool. Enters the Liver and Kidney channels. [Functions and Indications] Nourishes the Liver and Kidneys, improves eyesight and darkens hair. Used for Liver and Kidney Yin deficiency, dizziness and tinnitus, soreness and weakness of the lower back and knees, premature graying of hair, blurred vision, internal heat and thirst, and steaming fever; it is slightly cooling in nature, nourishes Kidney Yin and replenishes Liver Blood, and is not greasy or irritating to the stomach.

[0036] Poria: The dried sclerotium of the fungus Poriacocos (Schw.) Wolf (family Polyporaceae).

Properties and Channels Entered

Functions and Indications

[0037] Alisma plantago-aquatica: The dried tuber of Alisma orientale (Sam.) Juzep. or Alisma plantago-aquatica Linn., belonging to the Alismataceae family. [Properties and Channels Entered] Sweet, bland, cold. Enters the Kidney and Bladder channels. [Functions and Indications] Promotes diuresis and eliminates dampness, clears heat, resolves turbidity and lowers lipids. Used for dysuria, edema, diarrhea with scanty urine, phlegm retention and dizziness, painful urination due to heat, and hyperlipidemia.

[0038] Licorice: The dried root and rhizome of *Glycyrrhiza uralensis* Fisch., *Glycyrrhiza inflata* Bat., or *Glycyrrhiza glabra* L. (Fabaceae family). [Properties and Channels Entered] Sweet, neutral. Enters the Heart, Lung, Spleen, and Stomach channels. [Functions and Indications] Tonifies the spleen and replenishes qi, clears heat and detoxifies, resolves phlegm and relieves cough, alleviates spasms and pain, and harmonizes other herbs. Used for spleen and stomach weakness, fatigue, palpitations, shortness of breath, cough with excessive phlegm, abdominal and limb spasms and pain, carbuncles and boils, and to alleviate the toxicity and harshness of other drugs; it can also mitigate drug interactions.

[0039] The traditional Chinese medicine composition (prescription) provided by this invention comprises nine medicinal materials categorized into four types: calming the mind, regulating the kidneys, dispelling dampness and strengthening the spleen, and harmonizing the body. The calming herbs include stir-fried jujube seed, calcined magnetite, polygala tenuifolia, and schisandra chinensis. Stir-fried jujube seed is used in the prescription to nourish the mind, addressing the root cause of "mind malnourishment," and is a core nourishing and calming herb. Calcined magnetite is used to calm the mind, addressing "mind wandering" (such as insomnia accompanied by palpitations and irritability), and is a core sedative herb used in the largest dosage. Polygala tenuifolia assists in calming the mind and improving intelligence, while also clearing the heart orifices and preventing phlegm from disturbing the mind. Schisandra chinensis assists in calming the mind, while also replenishing qi and yin, preventing the calming herbs from depleting the body's vital energy. The kidney-regulating herbs include Alpinia oxyphylla and Ligustrum lucidum. Alpinia oxyphylla is used in this formula to warm the kidneys and invigorate Yang, addressing "kidney Yang deficiency" and facilitating "heart-kidney interaction," providing energy (kidney Yang warms heart Yang). Ligustrum lucidum nourishes kidney Yin and replenishes liver blood, forming a "dual tonification of Yin and Yang" with Alpinia oxyphylla's "kidney-warming" effect, preventing Alpinia oxyphylla's warming and drying properties from damaging Yin. The dampness-removing and spleen-strengthening herbs include Poria cocos and Alisma plantago-aquatica. Poria cocos is used to remove dampness (preventing dampness from impairing the spleen and phlegm from disturbing the mind), strengthen the spleen (preventing diuretics from damaging the spleen), and assist in calming the mind. Alisma plantago-aquatica enhances Poria cocos' dampness-removing power while clearing away dampness and heat (such as insomnia accompanied by dark yellow urine and mild bitter taste in the mouth). The harmonizing herb is Glycyrrhiza uralensis, used in this formula to harmonize the properties of the "heavy sedative herbs (magnetite), diuretics (Alpinia oxyphylla), and tonifying herbs."

[0040] The formulation concept and explanation of the traditional Chinese medicine composition provided by this invention are as follows:

[0041] 1. For dizziness caused by "liver and kidney deficiency and depletion of essence and blood" (core function: tonify liver and kidney, replenish essence and blood, nourish marrow)

[0042] Traditional Chinese medicine believes that "the brain is the sea of ​​marrow" and "the kidneys store essence and the liver stores blood. Essence and blood have the same origin and essence can generate marrow." If the liver and kidneys are deficient and the essence and blood are insufficient, the sea of ​​marrow will not be nourished (the brain will lack nourishment), which will easily lead to chronic and persistent dizziness (characteristics: mild dizziness, accompanied by soreness and weakness in the lower back and knees, fatigue, forgetfulness, insomnia, and worsening after exertion).

[0043] The drugs and their effects that directly target this pathogenesis in the formula:

[0044] 1) Privet fruit: Nourishes the liver and kidneys, and benefits essence and blood. It can directly replenish the yin and blood of the liver and kidneys, providing medicinal materials for the generation of "marrow sea", and fundamentally improve dizziness caused by "deficiency of essence and blood → insufficiency of marrow sea".

[0045] 2) Improves intelligence: It warms the kidneys and assists yang, forming a "yin-yang dual supplement" with the "kidney yin nourishment" of privet fruit. Kidney yin needs the warmth of kidney yang to better generate essence and blood, avoiding the "yin-cold stagnation" caused by simply nourishing yin, and indirectly helping to generate essence and blood;

[0046] 3) Stir-fried jujube seeds + Schisandra chinensis: Stir-fried jujube seeds nourish liver blood, while Schisandra chinensis invigorates qi and generates body fluids ("qi can generate blood, and body fluids can transform into blood"). Together with Ligustrum lucidum, they further replenish liver blood, invigorate qi and yin, and improve mild dizziness caused by "blood deficiency that cannot nourish the brain" (often accompanied by pale complexion and blurred vision when dizzy).

[0047] 2. For dizziness caused by "internal retention of dampness and turbidity and upward obstruction of phlegm" (core function: dispel dampness, clear turbidity and evil, and open the orifices).

[0048] Traditional Chinese medicine believes that "the spleen is responsible for transporting and transforming water and dampness." If the spleen and stomach are weak and the transport and transformation of water and dampness are abnormal, dampness and turbidity are easily accumulated into phlegm. When phlegm and turbidity obstruct the "clear orifices" (brain), dizziness with a heavy head and obvious drowsiness will occur (characteristics: dizziness feels like "a wet cloth is wrapped around the head", accompanied by abdominal distension, loss of appetite, white and greasy tongue coating, and less urination).

[0049] The drugs and their effects in this prescription targeting this pathogenesis are as follows:

[0050] 1) Poria cocos + Alisma plantago-aquatica: Poria cocos strengthens the spleen and removes dampness ("strengthening the spleen" can reduce the generation of dampness from the root), while Alisma plantago-aquatica promotes diuresis and eliminates dampness ("promoting diuresis" can directly expel the dampness that has already been generated). The two are used together to "take care of both the root cause and the symptoms" and quickly remove dampness and turbidity. When dampness is removed, there is no source for the generation of phlegm and turbidity, the clear orifices (brain) are not obscured, and dizziness is naturally relieved.

[0051] 2) Licorice: It tonifies the spleen and replenishes qi, assists Poria in strengthening the spleen, further enhances the ability to transport and transform water and dampness, and prevents the recurrence of dampness.

[0052] 3. For dizziness caused by "liver yang rising and mind being restless" (core function: calming liver yang, suppressing rising and restlessness, and stabilizing the mind)

[0053] If there is a deficiency of liver and kidney yin (as is the pathogenesis targeted by privet fruit), then "yin cannot control yang," and liver yang is prone to rise upward (similar to "too little water to extinguish a fire, so the fire rushes upward"). This upward disturbance of the clear orifices causes dizziness. At the same time, the upward movement of liver yang can disturb the mind, resulting in symptoms such as dizziness accompanied by irritability, headache, and insomnia (characteristics: headache is obvious during dizziness, worsens after emotional fluctuations, accompanied by insomnia and palpitations).

[0054] The drugs and their effects in this prescription targeting this pathogenesis are as follows:

[0055] 1) Calcined magnetite: It is heavy and has the core function of "calming the liver and suppressing yang, and calming the mind" - it can inhibit the upward rise of liver yang like a "ballast stone" and directly relieve dizziness and headache caused by liver yang disturbance; it can also calm the mind disturbed by liver yang and improve the superimposed symptoms of "dizziness + insomnia".

[0056] 2) Stir-fried jujube seeds: nourish liver blood and liver yin. "When liver blood is sufficient, liver yang is easily restrained" (similar to "when water is sufficient, fire is easily extinguished"). It also helps to "calm liver yang" with calcined magnetite, reducing the root cause of liver yang rising from the perspective of "nourishing yin".

[0057] 3) Yuanzhi: It mainly enters the heart and kidney meridians, tonifies the kidneys and improves intelligence, guides fire downward, promotes the balance between the descent of heart fire and the upward flow of kidney water (i.e., "communication between heart and kidney"), and allows the floating deficient yang to return to the kidney essence. By enhancing the communication function between the heart and kidney, it improves memory and concentration, and relieves symptoms of restlessness such as anxiety and confusion.

[0058] Therefore, it can be seen that this formula does not "single-target a certain type of symptom" in the treatment of dizziness, but rather forms a synergistic effect through three layers of logic:

[0059] Treating the root cause (tonifying the liver and kidneys, replenishing essence and blood): Privet fruit, Alpinia oxyphylla, stir-fried jujube seed, and Schisandra chinensis start from the "qi and blood of the liver and kidneys" to replenish the nourishment of the marrow sea (brain) and solve the root cause of "deficiency-type dizziness";

[0060] Treating the symptoms (removing dampness and turbidity, calming liver yang): Poria and Alisma remove dampness (preventing phlegm and turbidity from obstructing the orifices), calcined magnetite calms the liver and subdues yang (preventing liver yang from disturbing upwards), quickly relieving the "acute discomfort" of dizziness;

[0061] Regulate the mind (stabilize emotions and aid sleep): Polygala tenuifolia, stir-fried jujube seed, and calcined magnetite calm the mind and improve the vicious cycle of "dizziness → insomnia → anxiety → worsening of dizziness" (in clinical practice, dizziness is closely related to sleep and emotions, and a calm mind makes dizziness easier to relieve).

[0062] Compared with the prior art, the present invention has the following advantages:

[0063] The traditional Chinese medicine composition provided by this invention, through comprehensive conditioning of "tonifying the liver and kidneys, dispelling dampness and turbidity, and calming the mind," can effectively improve postural dizziness, anxiety, and insomnia symptoms in PPPD patients of different ages, with good safety profile, providing a clinical reference for the TCM treatment of PPPD. Furthermore, this TCM composition addresses both "improving dizziness symptoms" and "regulating mood and sleep," avoiding the problems of simply using vestibular inhibitors (such as betahistine) failing to alleviate psychological factors and simply using sedatives (such as alprazolam) with high dependence risks, demonstrating the advantage of "treating both the symptoms and the root cause." Detailed Implementation

[0064] Unless otherwise specified, the experimental methods used in the following examples are conventional methods.

[0065] Unless otherwise specified, all materials and reagents used in the following examples are commercially available.

[0066] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to specific embodiments. It should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the invention.

[0067] Example 1:

[0068] A method for preparing a drug for treating vertigo includes: weighing 7g of stir-fried jujube seed, 39g of calcined magnetite, 8g of polygala tenuifolia, 8g of schisandra chinensis, 7g of alpinia oxyphylla, 7g of privet fruit, 7g of poria cocos, 7g of alisma plantago-aquatica, and 4g of licorice, totaling 94g, and crushing them into powder.

[0069] Add 400ml of water to the calcined magnetite powder and extract with ultrasound for 20 minutes; filter and collect the extract; add the remaining medicinal powder to the calcined magnetite powder residue, add 1100ml of water and extract with ultrasound twice, each time for 1 hour; filter, combine all extracts, concentrate and add conventional excipients, and make tablets according to conventional methods.

[0070] Example 2:

[0071] A method for preparing a drug for treating vertigo includes: weighing 13g of stir-fried jujube seed, 21g of calcined magnetite, 4g of polygala tenuifolia, 4g of schisandra chinensis, 13g of alpinia oxyphylla, 13g of privet fruit, 13g of poria cocos, 13g of alisma plantago-aquatica, and 2g of licorice, totaling 62g, and crushing the calcined magnetite into powder.

[0072] Add 170ml of water to calcined magnetite powder and microwave-assisted extraction for 45 minutes. Filter and collect the extract. Simultaneously, soak the remaining medicinal materials in 500ml of water for 45 minutes, add the water to the residue from the calcined magnetite powder extraction, and microwave-assisted extraction three times, each time for 40 minutes. Filter, combine all extracts, concentrate, add conventional excipients, and prepare capsules according to conventional methods.

[0073] Example 3:

[0074] A method for preparing a drug for treating vertigo includes: weighing 11g of stir-fried jujube seed, 33g of calcined magnetite, 7g of polygala tenuifolia, 7g of schisandra chinensis, 11g of alpinia oxyphylla, 11g of privet fruit, 11g of poria cocos, 11g of alisma plantago-aquatica, and 2g of licorice, totaling 104g, and crushing them into powder.

[0075] Add 1000ml of water to calcined magnetite powder and microwave-assisted extraction for 30min; filter and collect the extract; add the remaining medicinal powder to the calcined magnetite powder residue, add 1000ml of water and microwave-assisted extraction 3 times, 1h each time, filter, combine all extracts, and concentrate to a density of 1.25g / ml; add ethanol to make the ethanol concentration of the concentrate 75%, precipitate for 24h, remove the precipitate, concentrate under reduced pressure (70~80℃, 0.8~0.9Mpa) until there is no alcohol taste, add sucrose accounting for 30% of the syrup solids, and add preservatives and flavoring agents according to conventional methods to prepare the syrup.

[0076] Example 4

[0077] A method for preparing a drug for treating vertigo includes: weighing 9g of stir-fried jujube seed, 27g of calcined magnetite, 8g of polygala tenuifolia, 8g of schisandra chinensis, 9g of alpinia oxyphylla, 9g of privet fruit, 9g of poria cocos, 9g of alisma plantago-aquatica, and 3g of licorice, totaling 91g; and crushing the calcined magnetite into powder.

[0078] Add 300ml of water to calcined magnetite powder and extract ultrasonically for 45min. Filter and collect the extract. Add the remaining medicinal materials to the calcined magnetite powder residue, add 1000ml of water and extract ultrasonically twice, 1.5h each time. Filter, combine all extracts, and concentrate to a density of 1.45g / ml. Add ethanol to make the ethanol concentration of the concentrate 85%, precipitate for 24h, remove the precipitate, concentrate under reduced pressure (70~80℃, 0.8~0.9Mpa) until there is no alcohol taste, add sucrose accounting for 40% of the syrup solids, and add preservatives and flavoring agents according to conventional methods to prepare the syrup.

[0079] Example 5:

[0080] A method for preparing a drug for treating vertigo includes: weighing 10g of stir-fried jujube seed, 30g of calcined magnetite, 6g of Polygala tenuifolia, 6g of Schisandra chinensis, 10g of Alpinia oxyphylla, 10g of Ligustrum lucidum, 10g of Poria cocos, 10g of Alisma plantago-aquatica, and 3g of Glycyrrhiza uralensis, totaling 95g. First, crush the calcined magnetite into powder, decoct it in 1200ml of water for 30 minutes; add the remaining medicinal materials, continue to decoct for 1 hour, filter, concentrate the extract to a volume of 400ml, and prepare a decoction.

[0081] Example 6:

[0082] A method for preparing a drug for treating vertigo includes: weighing 10g of stir-fried jujube seed, 25g of calcined magnetite, 6g of Polygala tenuifolia, 6g of Schisandra chinensis, 12g of Alpinia oxyphylla, 10g of Ligustrum lucidum, 12g of Poria cocos, 8g of Alisma plantago-aquatica, and 3g of Glycyrrhiza uralensis, totaling 92g. First, crush the calcined magnetite into powder, decoct it in 250ml of water for 30 minutes, and simultaneously soak the remaining medicinal materials in 750ml of water for 30 minutes. Add the remaining medicinal materials to the decoction of the calcined magnetite and continue decoction for 1 hour. Filter the mixture, concentrate the extract to a volume of 300ml, and prepare a decoction.

[0083] Example 7:

[0084] A method for preparing a drug for treating vertigo includes: weighing 15g of stir-fried jujube seed, 22g of calcined magnetite, 5g of Polygala tenuifolia, 6g of Schisandra chinensis, 9g of Alpinia oxyphylla, 10g of Ligustrum lucidum, 12g of Poria cocos, 9g of Alisma plantago-aquatica, and 3g of Glycyrrhiza uralensis, totaling 91g. First, crush the calcined magnetite, decoct it in 200ml of water for 25 minutes, while simultaneously soaking the remaining herbs in 600ml of water for 20 minutes. Add the remaining herbs to the decoction of the calcined magnetite, continue decoction for 45 minutes, filter, and concentrate the extract to approximately 250ml to prepare a decoction.

[0085] Clinical trial case:

[0086] To demonstrate that the medicine prepared by the traditional Chinese medicine composition of this invention (named "An Shen Tiao Shen Qu Shi Fang") has a positive effect on the treatment of vertigo, the inventors conducted clinical trials on the decoctions prepared in Examples 5-7. Selected clinical trial reports are as follows.

[0087] Case 1: Zhang, female, 45 years old.

[0088] I. Basic Information

[0089] Chief complaint: Persistent dizziness and unsteady vision for 6 months, related to changes in body position (standing up, walking, watching moving objects), accompanied by anxiety and insomnia for 3 months.

[0090] Past medical history: Six months ago, the patient underwent repositioning therapy for "benign paroxysmal positional vertigo" (BPPV). After the BPPV symptoms subsided, the patient experienced persistent dizziness. The patient denied any history of hypertension, diabetes, or mental illness. The patient had no history of long-term medication use.

[0091] Previous treatment: The patient had taken "betahistine mesylate tablets" (12mg / time, 3 times a day) for 1 month, but the dizziness symptoms did not improve significantly; later, "alprazolam tablets" (0.4mg / night) were added to help with sleep, and the time to fall asleep was shortened to 30 minutes, but the dizziness and anxiety were not relieved, and the patient stopped taking the medication on his own due to concerns about drug dependence.

[0092] II. Present Illness and Treatment Process

[0093] (1) Symptom characteristics:

[0094] Vertigo symptoms: Non-rotational dizziness, mainly characterized by "dizziness, heaviness in the head, and unsteady vision when standing / walking", which is persistent and aggravated by changes in body position (such as standing up from a sitting position or turning the head quickly) or in complex visual environments (such as crowded places in supermarkets). It can be slightly relieved after rest; the daily duration of attacks is >4 hours, affecting work (unable to stand for long periods of time to lecture) and daily life (afraid to go out alone).

[0095] Accompanying symptoms:

[0096] Mood: Persistent anxiety, worry that dizziness will suddenly worsen and cause a fall, noticeable tension when alone, occasionally accompanied by palpitations and chest tightness;

[0097] Sleep: Difficulty falling asleep (requires 1-2 hours to fall asleep), frequent awakenings after falling asleep (2-3 times per night), difficulty falling back asleep after waking up, and feeling tired upon waking up in the morning;

[0098] Other symptoms: mild lower back and knee pain, poor appetite, dark yellow urine, normal bowel movements.

[0099] (2) Auxiliary examinations

[0100] Western medical examination:

[0101] Vestibular function examination: Electronystagmography (ENG) showed "normal vestibulo-ocular reflex function" and no positional nystagmus;

[0102] Balance function test: Romberg test (standing upright with eyes closed) positive (slight swaying of the body), straight walking test deviation <5°;

[0103] Psychological assessment: Self-Rating Anxiety Scale (SAS) score of 65 (moderate anxiety, normal <50), Pittsburgh Sleep Quality Index (PSQI) score of 14 (severe insomnia, normal <7).

[0104] Other: Blood pressure 125 / 80 mmHg, blood routine, liver and kidney function, electrolytes, and thyroid function were all normal, and cranial MRI showed no abnormalities.

[0105] The Four Diagnostic Methods in Traditional Chinese Medicine:

[0106] Visual examination: pale complexion, pale red tongue, thin white and slightly greasy coating;

[0107] Auscultation: No unusual odor;

[0108] Medical history: Fatigue, weakness, soreness and weakness in the lower back and knees, poor appetite, dark yellow urine, dry mouth but no desire to drink;

[0109] Palpation: The pulse is thready and wiry.

[0110] III. Diagnosis and Differentiation

[0111] (1) Western medicine diagnosis:

[0112] Persistent postural-perceptual dizziness (PPPD) (based on the 2017 Bárány Association diagnostic criteria: ① persistent dizziness / unsteadiness ≥3 months; ② related to postural changes and visual stimuli; ③ no clear vestibular organic lesion; ④ accompanied by anxiety / sleep disturbances).

[0113] (2) Traditional Chinese Medicine diagnosis:

[0114] Syndrome: Liver and kidney deficiency, dampness and turbidity obscuring the upper body, restlessness of mind

[0115] Diagnostic basis:

[0116] Liver and kidney deficiency: soreness and weakness in the lower back and knees (the kidneys govern the bones), pale complexion (insufficient liver blood), and weak pulse (deficiency of essence and blood);

[0117] Dampness and turbidity obstructing the upper body: dizziness and heaviness in the head, poor appetite (dampness trapping the spleen), thin white and slightly greasy tongue coating (dampness lingering internally), and yellowish urine (dampness and turbidity transforming into heat).

[0118] Restlessness: anxiety, insomnia, palpitations (due to malnourishment of the mind and spirit, and liver yang rising and disturbing the mind).

[0119] III. Treatment Plan

[0120] Take 200ml of the decoction prepared in Example 5 one hour after breakfast and one hour before bedtime. Take it continuously for 4 weeks as one course of treatment. During this period, discontinue other Western medicines that improve dizziness and sleep.

[0121] V. Follow-up visit results:

[0122] 1) See the table below for symptom improvement:

[0123]

[0124] 2) Specific manifestations:

[0125] Dizziness: The feeling of "floating" when standing or walking is significantly reduced. The patient can tolerate complex visual environments (such as supermarkets) for more than 30 minutes (before treatment, the patient could only tolerate 10 minutes). The patient can independently complete daily shopping, go up and down stairs, and resume some teaching work (can stand and lecture for 2 hours a day).

[0126] Anxiety: The tension disappeared when alone, and there was no longer any worry about "dizziness and falling". Symptoms such as palpitations and chest tightness did not reappear.

[0127] Sleep: Falling asleep takes 20-30 minutes, and I only wake up once during the night (occasional). I can fall back asleep within 10 minutes of waking up, and I feel more energetic in the morning than before.

[0128] Other: Lower back and knee pain relieved, appetite restored, urine color became clearer, and tongue coating became thinner and white (dampness and turbidity subsided).

[0129] Case 2: Li Moumou, male, 72 years old.

[0130] I. Basic Information

[0131] Chief complaint: Recurrent dizziness and heaviness for 4 years, which has worsened and been accompanied by unsteady walking and fear of falling for 6 months, as well as insomnia and anxiety for 3 months.

[0132] Past medical history: 10-year history of hypertension (regularly taking nifedipine sustained-release tablets, blood pressure controlled at 130-140 / 80-85 mmHg); hospitalized for lacunar infarction 2 years ago, with no obvious sequelae; denies history of diabetes or coronary heart disease; no history of long-term use of sedative-hypnotics.

[0133] Previous treatment: The patient had taken "betahistine mesylate tablets" (12mg / time, 3 times a day) for 2 months, but the dizziness and heaviness did not improve significantly. The community doctor suggested taking "eszolam tablets" to help with sleep, but the patient refused because he was worried that "taking it will cause dementia". He only relieved the symptoms by "drinking warm milk before bed", but the effect was not good.

[0134] II. Present Illness and Treatment Process

[0135] (1) Symptom characteristics (chronic vertigo in the elderly):

[0136] Symptoms of dizziness: mainly "persistent dizziness and heaviness in the head", without obvious vertigo. It is worse when getting up in the morning or after sitting for a long time. When walking, one needs to hold onto the wall or be helped by family members (for fear of falling). One feels "body swaying" after standing alone for more than 5 minutes. In the past 6 months, due to the worsening of dizziness, one basically stays at home and needs the assistance of family members for daily activities (such as dressing and washing).

[0137] Accompanying symptoms:

[0138] Emotions: Persistent anxiety, repeatedly saying "I'm afraid of breaking my leg", trembling with tension when seeing steps or thresholds, and unwilling to communicate with others;

[0139] Sleep: Difficulty falling asleep (requiring 2-3 hours of tossing and turning), frequent awakenings at night (every 1-2 hours), feeling "heavy head and palpitations" after waking up, unable to fall back asleep, feeling weak and lethargic upon waking up in the morning;

[0140] Other symptoms include: lower back and knee pain (needs to support the lower back when standing up after sitting for a long time), poor appetite (only eats a small half bowl of rice per day), loose stools (1-2 times per day), and clear and copious urine.

[0141] (2) Auxiliary examinations

[0142] Western medical examination:

[0143] Vestibular function examination: Electronystagmography (ENG) showed "mild bilateral vestibular function impairment", without positional nystagmus;

[0144] Balance function test: Romberg test (eyes closed, standing upright) positive (body sway amplitude >10°), Tinetti balance scale score 22 (moderate balance disorder, normal >28).

[0145] Psychological assessment: Self-Rating Anxiety Scale (SAS) score of 70 (severe anxiety, normal <50); Pittsburgh Sleep Quality Index (PSQI) score of 16 (severe insomnia, normal <7).

[0146] Other: Blood pressure 135 / 82 mmHg, fasting blood glucose 5.6 mmol / L, normal liver and kidney function, head CT showed "scattered lacunar lesions in the brain and brain atrophy" (consistent with physiological changes in the elderly).

[0147] The Four Diagnostic Methods in Traditional Chinese Medicine:

[0148] Visual examination: The complexion is pale (pale and dull), the hair is gray and sparse, the tongue is pale and swollen, and the coating is white and greasy;

[0149] Auscultation: The voice was low and there was no unusual odor;

[0150] Medical history: Fatigue, weakness, soreness and weakness in the lower back and knees, poor appetite, loose stools, clear and copious urine, and aversion to cold (cold hands and feet).

[0151] Palpation: The pulse is deep, thready, and weak.

[0152] III. Diagnosis and Differentiation

[0153] (1) Western medicine diagnosis:

[0154] Chronic vertigo (related to vestibular dysfunction), anxiety, insomnia, grade 1 hypertension (intermediate risk), scattered lacunar foci in the brain, and brain atrophy.

[0155] (2) Traditional Chinese Medicine diagnosis:

[0156] Syndrome: Liver and kidney deficiency, spleen dampness retention, and restlessness

[0157] Diagnostic basis:

[0158] Liver and kidney deficiency: Elderly patients may experience soreness and weakness in the lower back and knees, aversion to cold (kidney yang deficiency), pale complexion, weak and thready pulse (essence and blood deficiency), and brain atrophy (marrow deficiency).

[0159] Spleen dampness retention: loss of appetite, loose stools (spleen deficiency and impaired transport), white and greasy tongue coating (dampness retention), dizziness and heaviness in the head (dampness obstructing the sensory orifices).

[0160] Restlessness: anxiety (fear of falling), insomnia, palpitations (the mind is not nourished, and the kidney yang is insufficient to warm the heart yang).

[0161] IV. Treatment Plan

[0162] Take 150ml of the decoction prepared in Example 6 one hour after breakfast and one hour before bedtime. Take it continuously for 6 weeks as one course of treatment (elderly patients take effect more slowly, so the course of treatment should be extended). During the course of treatment, continue to take antihypertensive drugs regularly and discontinue other drugs to improve dizziness.

[0163] V. Follow-up visit results:

[0164] 1) See the table below for symptom improvement:

[0165]

[0166] 2) Specific manifestations:

[0167] Dizziness and balance: The feeling of heaviness in the head has been significantly reduced, the "shaking" sensation when getting up in the morning has been reduced, and the person can stand alone for more than 15 minutes. When walking, the person does not need to hold onto the wall (only needs a family member to help them when turning around). The person can take a slow walk indoors alone (20 minutes each time), and can occasionally go downstairs in the community with a family member (previously, the person was completely afraid to go out).

[0168] Anxiety: The worry about "falling" has been significantly reduced. When seeing steps or thresholds, the person no longer gets nervous and trembles. The person is willing to have simple conversations with neighbors and occasionally mentions "wanting to go downstairs to get some sun".

[0169] Sleep quality: Falling asleep takes 30-40 minutes, and the person only wakes up once during the night (usually around 4 a.m.). After waking up, the person can fall back asleep after drinking a small amount of warm water (without having to toss and turn). The person is more energetic in the morning and can dress and wash up on their own (previously, they needed help from family members).

[0170] Other symptoms: lower back and knee pain relieved, no need to support the lower back when getting up after sitting for a long time; appetite improved, able to eat a small bowl of rice at each meal, stool formed (once a day), cold hands and feet symptoms lessened, tongue turned pale red with a thin white coating (dampness and turbidity subsided).

[0171] Case 3: Liu Moumou, female, 15 years old.

[0172] I. Basic Information

[0173] Chief complaint: Persistent dizziness and unsteady gait for 4 months, related to standing, walking, and looking at the blackboard (dynamic visual stimulation), accompanied by test anxiety and insomnia for 2 months. He had previously taken a week off from school because he was "afraid to go to school alone due to dizziness".

[0174] Past medical history: Three months ago, the patient was diagnosed with vestibular neuritis at another hospital due to dizziness after a cold. After two weeks of treatment with betahistine mesylate, the vertigo was relieved, but persistent dizziness remained. The patient denied any history of anemia, hypertension, or mental illness. The patient had no history of long-term medication or drug allergies.

[0175] Previous treatment: Cervical spine X-ray (normal physiological curvature), blood routine (hemoglobin 130g / L), vestibular function (electron nystagmus showed "symmetrical vestibular function on both sides, no positional nystagmus"), ruling out organic lesions; the community doctor suggested "psychological counseling + vestibular rehabilitation training", but the patient refused because "dizziness worsened during training" and took "vitamin B12" for 1 month on his own, but the symptoms did not improve.

[0176] II. Present Illness and Diagnostic Process:

[0177] (1) Symptom characteristics (consistent with the core clinical characteristics of adolescent PPPD):

[0178] Vertigo symptoms: Non-rotational dizziness, mainly characterized by "dizziness when standing, unsteady vision when walking, and worsening dizziness when looking at a moving blackboard / classmates", consistent with the "posture / visual dependence" characteristic of PPPD; dizziness can be relieved when sitting still and closing the eyes; symptoms last for more than 6 hours per day; in severe cases, the patient needs to hold onto a table to stand and is unable to complete physical education classes (such as running and jumping rope); for the past month, the patient has requested parental accompaniment to school due to "fear of dizziness and falling in the classroom" and is afraid to leave the seat during breaks.

[0179] Accompanying symptoms (typical comorbidities of PPPD in adolescents):

[0180] Emotions and Social Aspects: Significant pre-exam anxiety (worried that dizziness will affect answering questions, and always suffers from insomnia the night before the exam), refuses to participate in class group activities (such as spring outings and sports meets), fearing "dizziness and embarrassment in front of others"; has difficulty concentrating when communicating with classmates, often misses topics due to "dizziness", and gradually develops social avoidance;

[0181] Sleep: Difficulty falling asleep (after lying down, I keep thinking "Will I feel dizzy at school tomorrow?", and it takes 1.5-2 hours to fall asleep), light sleep (I wake up when I hear the alarm clock or the sound of family members walking around), still feeling dizzy and weak when I wake up in the morning, and frequently feeling sleepy in class (I have been reminded by the teacher to "distract myself" 5 times in the past 2 weeks).

[0182] Other symptoms include: loss of appetite (daily food intake reduced by 1 / 4 compared to before) and constipation (once every 2-3 days) due to prolonged emotional stress; decreased menstrual flow (lasting 3 days each time, with darker color); and occasional heart palpitations and sweaty palms (during anxiety episodes).

[0183] (2) Auxiliary examinations

[0184] Western medical examination:

[0185] Vestibular function and balance assessment: Video head impulse test (vHIT) was normal, Romberg test (eyes closed, upright) was positive (body sway amplitude 8°), and dynamic posture recorder (CDP) showed "increased visual dependence score (65 points, normal <40 points) and decreased somatosensory score (30 points, normal >50 points)" (typical balance dysfunction of PPPD).

[0186] Psychological assessment: Childhood Anxiety Disorders Screening Scale (RCADS) score 72 (moderate anxiety, normal <50), Pittsburgh Sleep Quality Index (PSQI) score 13 (severe insomnia, normal <7), Dizziness Disability Scale (DHI) score 68 (moderate disability).

[0187] Other: Blood pressure 112 / 70 mmHg, fasting blood glucose 5.1 mmol / L, liver and kidney function and thyroid function were all normal, and no abnormalities were found on cranial MRI.

[0188] The Four Diagnostic Methods in Traditional Chinese Medicine:

[0189] Visual examination: pale complexion (blood deficiency), pale red tongue with a thin white and slightly greasy coating (dampness retention), and slight bluish-black discoloration around the eyes (restlessness).

[0190] Auscultation: The voice is weak and the speech is slow when answering questions (indicating nervousness);

[0191] Medical history: Dizziness worsens when standing or looking at moving objects, and is relieved when closing eyes or sitting. Accompanied by anxiety, insomnia, poor appetite, constipation, scanty menstruation, and dry mouth but no desire to drink.

[0192] Palpation: The pulse is wiry and thready (indicating liver stagnation and blood deficiency).

[0193] III. Diagnosis and Differentiation

[0194] (1) Western medicine diagnosis (meeting the 2017 Bárány Association PPPD diagnostic criteria):

[0195] Persistent postural-perceptual dizziness (PPPD), anxiety state (associated with PPPD), and insomnia disorder (associated with both PPPD and anxiety).

[0196] (2) Traditional Chinese Medicine diagnosis:

[0197] Syndrome: Liver Qi stagnation and blood deficiency, internal obstruction of dampness and turbidity, and restlessness of mind

[0198] Diagnostic basis:

[0199] Liver stagnation and blood deficiency: Adolescent girls with high academic pressure (liver stagnation) may experience pale complexion, scanty menstruation, and weak pulse (blood deficiency). Dizziness may be related to emotional stress (liver stagnation depletes blood).

[0200] Internal obstruction of dampness and turbidity: poor appetite, slightly greasy tongue coating (spleen deficiency generates dampness, and dampness and turbidity obstruct the clear orifices), dry mouth without thirst (dampness and turbidity trap the spleen, and body fluids are not distributed).

[0201] Restlessness: Postural / visual dizziness caused by PPPD leads to anxiety, insomnia (malnourishment of the mind), and social avoidance (uneasy mind leads to reluctance to contact people), which conforms to the pathological cycle of PPPD: "dizziness → anxiety → insomnia → worsening dizziness".

[0202] IV. Treatment Plan

[0203] One hour after lunch and one hour before bedtime, take 250ml of the decoction prepared in Example 7. Take it continuously for 4 weeks as one course of treatment (the symptoms of PPPD in adolescents improve quickly, while taking into account the academic cycle). During the period, other medications to improve dizziness are discontinued, and no Western medicine intervention is given for anxiety and insomnia symptoms (to avoid the risk of drug dependence in adolescents).

[0204] V. Follow-up visit results

[0205] 1) See the table below for symptom improvement:

[0206]

[0207] 2) Specific manifestations:

[0208] Dizziness and balance: The feeling of heaviness in the head has been significantly reduced, the "shaking" sensation when getting up in the morning has been reduced, and the person can stand alone for more than 15 minutes. When walking, the person does not need to hold onto the wall (only needs a family member to help them when turning around). The person can take a slow walk indoors alone (20 minutes each time), and can occasionally go downstairs in the community with a family member (previously, the person was completely afraid to go out).

[0209] Anxiety: The worry about "falling" has been significantly reduced. When seeing steps or thresholds, the person no longer gets nervous and trembles. The person is willing to have simple conversations with neighbors and occasionally mentions "wanting to go downstairs to get some sun".

[0210] Sleep quality: Falling asleep takes 30-40 minutes, and the person only wakes up once during the night (usually around 4 a.m.). After waking up, the person can fall back asleep after drinking a small amount of warm water (without having to toss and turn). The person is more energetic in the morning and can dress and wash up on their own (previously, they needed help from family members).

[0211] Other symptoms: lower back and knee pain relieved, no need to support the lower back when getting up after sitting for a long time; appetite improved, able to eat a small bowl of rice at each meal, stool formed (once a day), cold hands and feet symptoms lessened, tongue turned pale red with a thin white coating (dampness and turbidity subsided).

[0212] The core pathological mechanism of PPPD in Case 1 was "vestibular-visual-somatosensory integration dysfunction," often accompanied by a "psychological-physiological vicious cycle" (dizziness → anxiety / insomnia → worsening dizziness). The patient's use of the decoction prepared in Example 5 improved the key pathogenesis of PPPD as follows:

[0213] Tonify the liver and kidneys and improve somatic sensory integration: Ligustrum lucidum nourishes kidney yin and replenishes liver blood, and benefits intelligence, warms the kidneys and assists yang. The two "tonify yin and yang" to solve the problem of "liver and kidney deficiency" that causes soreness in the lower back and knees and decreased sense of balance (the kidneys govern bones and produce marrow, and when the marrow sea is full, somatic sensation is stable); stir-fried jujube seeds replenish liver blood and help improve dizziness and pale complexion caused by "liver blood deficiency".

[0214] Eliminating dampness and turbidity, and relieving obstruction of the sensory orifices: Poria cocos strengthens the spleen and eliminates dampness (reducing the generation of dampness and turbidity from the root), while Alisma plantago-aquatica promotes diuresis and eliminates dampness (directly expelling dampness). The combination of the two clears away the "dizziness and heaviness in the head" caused by "dampness and turbidity obstructing the head", and restores the normal integration of vestibular signals in the sensory orifices (brain).

[0215] Calming the mind and soothing the liver, breaking the psychological-physiological cycle: Calcined magnetite calms the mind and soothes the liver, targeting anxiety and palpitations caused by "liver yang rising upwards," inhibiting the overactivation of the vestibular-limbic system (alleviating the amplifying effect of anxiety on dizziness); Polygala tenuifolia invigorates the heart and kidneys, and Schisandra chinensis astringes the heart yin, working synergistically with stir-fried Ziziphus jujuba var. spinosa to "calm the mind and soothe the nerves," improving insomnia (improved sleep can enhance the compensatory ability of the vestibular system and reduce dizziness attacks).

[0216] The PPPD patient in Case 2 was an elderly patient with chronic vertigo. Due to "more severe liver and kidney deficiency, weakened spleen and stomach function, and low drug tolerance", the dosage of Alisma plantago-aquatica and calcined magnetite was reduced compared to the decoction taken in Case 1. This was to avoid diarrhea caused by excessive diuresis in elderly patients with spleen deficiency, reduce the stimulation of the heavy and sluggish nature on the weak spleen and stomach of the elderly, and at the same time retain the effects of "calming the liver and suppressing yang, and calming the mind". The dosage of Poria cocos and Alpinia oxyphylla was increased to strengthen the spleen and remove dampness, improve the elderly patient's "poor appetite and loose stools", strengthen the warming of the kidney and assisting yang, and relieve "fear of cold and soreness of the waist and knees". At the same time, "when the kidney yang is sufficient, the heart yang will be warmed", which helps to improve the restlessness of the mind.

[0217] The core pathological mechanism of the patient's dizziness is the superposition of "physiological functional decline (liver and kidney deficiency, spleen deficiency)" and "psychological fear (fear of falling → anxiety → aggravation of dizziness)". Taking the decoction prepared in Example 6 improved the key pathogenesis of PPPD as follows:

[0218] Nourishing the liver and kidneys and replenishing the marrow: Ligustrum lucidum nourishes kidney yin and replenishes liver blood, while Alpinia oxyphylla warms the kidneys and assists yang. The two "replenish yin and yang" to improve the insufficient marrow in the elderly caused by "liver and kidney deficiency" (dizziness related to brain atrophy) and soreness in the waist and knees; stir-fried jujube seeds replenish liver blood and help relieve the dizziness and heaviness caused by "blood deficiency that cannot nourish the sensory orifices".

[0219] Strengthening the spleen and stomach, and removing dampness and turbidity: Poria strengthens the spleen and Alisma removes dampness. It targets the dampness and turbidity caused by "spleen deficiency and impaired transport" in the elderly, clears the dizziness and heaviness caused by "dampness and turbidity obscuring the clear orifices", and improves poor appetite and loose stools, and enhances the nutritional absorption capacity of elderly patients (providing a foundation for the body's recovery).

[0220] Calming the mind and relieving anxiety: Calcined magnetite calms the mind and soothes the liver, alleviating anxiety in elderly patients caused by dizziness and fear of falling; Polygala tenuifolia invigorates the heart and kidneys, and Schisandra chinensis astringes the heart yin, working synergistically with stir-fried Ziziphus jujuba var. spinosa to calm the mind and soothe the nerves, improving insomnia. After sleep is improved, elderly patients regain energy, increase their tolerance to dizziness, further reduce anxiety, and break the cycle of dizziness → anxiety → insomnia → worsening dizziness.

[0221] The PPPD patient in Case 3 was an adolescent PPPD patient. Based on the principle of "treatment according to syndrome differentiation" and combined with the patient's specific symptoms, the dosage of Polygala tenuifolia, calcined magnetite, and Alpinia oxyphylla was reduced compared to the decoction taken in Case 1. This was to avoid adolescents resisting taking the medicine due to its bitter taste and heavy feeling, and to prevent the warm and drying medicine (Alpinia oxyphylla) from damaging Yin (adolescents' Yin and blood are not sufficient and they are easily affected by warm and drying medicines). The dosage of stir-fried Ziziphus jujuba var. spinosa and Poria cocos was increased to strengthen "nourishing blood and calming the mind, strengthening the spleen and removing dampness", which is in line with the common concurrent symptoms of "blood deficiency and spleen deficiency" in adolescent PPPD.

[0222] The core pathological mechanism of this patient's vertigo is "vestibular-visual-somatosensory integration disorder" and "psycho-physiological vicious cycle". Taking the decoction prepared in Example 7 improved the key pathogenesis of PPPD as follows:

[0223] Nourishing the liver and blood, improving somatic sensory integration: Fried jujube seeds nourish liver blood, privet fruit nourishes kidney yin (essence and blood share the same origin), and schisandra fruit astringes yin and generates fluids. The three work together to supplement the abnormal somatic sensory signals caused by "blood deficiency" (teenager PPPD is often caused by high academic pressure and staying up late, which depletes blood and aggravates insufficient somatic sensory dependence); when liver blood is sufficient, the "liver governs the free flow of qi" function is normal, relieving liver stagnation caused by academic pressure and reducing the amplifying effect of anxiety on dizziness.

[0224] Eliminate dampness and strengthen the spleen, and relieve obstruction of the sensory orifices: Poria cocos strengthens the spleen and eliminates dampness, while Alisma plantago-aquatica promotes diuresis and clears heat. This formula is specifically for adolescents whose "irregular diet (such as snacks and cold drinks) leads to spleen deficiency and dampness" - dampness obstructs the sensory orifices and interferes with vestibular signal transmission, aggravating "posture / visual related dizziness". Eliminating dampness can restore vestibular-visual integration function and reduce the sensitivity of PPPD symptoms.

[0225] Calming the mind and soothing the liver breaks the vicious cycle: Calcined magnetite calms the mind and soothes the liver, suppressing yang and calming the nerves. It can both suppress the "mental turbulence" caused by "vestibular signal disorder" (improving anxiety caused by dizziness) and inhibit the excessive stimulation of the vestibular system by "liver yang turbulence". Polygala tenuifolia invigorates the heart and kidneys and calms the mind. Together with roasted jujube seed, it improves insomnia. After sleep is improved, the balance of neurotransmitters (such as serotonin) in the adolescent brain is restored, enhancing the compensatory ability of the vestibular system, further reducing dizziness, and breaking the PPPD closed loop of "dizziness → anxiety → insomnia → worsening dizziness".

[0226] In summary, the traditional Chinese medicine composition provided by this invention effectively treats vertigo in patients of different ages. Vertigo refers to diseases with symptoms related to sleep, mood, or autonomic nervous system dysfunction, including vestibular migraine, Meniere's disease, or persistent postural-perceptual vertigo (PPPD). PPPD includes chronic vertigo in the elderly and benign vertigo in children. However, in clinical application, due to individual differences among PPPD patients (e.g., some patients have less pronounced dampness and turbidity, with yin deficiency being the primary symptom), the dosage of the medicine can be adjusted or modified according to the principle of "treatment based on syndrome differentiation," combined with the patient's specific symptoms (e.g., differences in the predominance of dampness and turbidity, yin deficiency, liver yang, etc.), to improve efficacy. The prescription can also be adjusted (e.g., adding Atractylodes lancea for severe dampness and turbidity, and adding Ophiopogon japonicus for severe yin deficiency).

[0227] This specific embodiment is merely an explanation of the present invention and is not intended to limit the invention. After reading this specification, those skilled in the art can make modifications to this embodiment without contributing any inventive step, but such modifications are protected by patent law as long as they are within the scope of the claims of the present invention.

Claims

1. A traditional Chinese medicine composition for treating vertigo, characterized in that, The traditional Chinese medicine composition mainly consists of the following medicinal materials in parts by weight: 6-17 parts of stir-fried jujube seed, 20-40 parts of calcined magnetite, 4-8 parts of polygala root, 4-8 parts of schisandra fruit, 7-13 parts of alpinia oxyphylla, 7-13 parts of privet fruit, 7-13 parts of poria cocos, 7-13 parts of alisma plantago-aquatica, and 2-4 parts of licorice root.

2. The traditional Chinese medicine composition for treating vertigo according to claim 1, characterized in that, The traditional Chinese medicine composition mainly consists of the following medicinal materials in parts by weight: 9-15 parts of stir-fried jujube seed, 22-33 parts of calcined magnetite, 4-6 parts of polygala tenuifolia, 6-8 parts of schisandra chinensis, 9-12 parts of alpinia oxyphylla, 9-11 parts of privet fruit, 9-12 parts of poria cocos, 8-10 parts of alisma plantago-aquatica, and 2-3 parts of licorice.

3. The traditional Chinese medicine composition for treating vertigo according to claim 1, characterized in that, The traditional Chinese medicine composition mainly consists of the following medicinal materials in parts by weight: 10 parts of stir-fried jujube seed, 30 parts of calcined magnetite, 6 parts of polygala root, 6 parts of schisandra fruit, 10 parts of alpinia oxyphylla, 10 parts of privet fruit, 10 parts of poria cocos, 10 parts of alisma plantago-aquatica, and 3 parts of licorice root.

4. A method for preparing a drug for treating vertigo using the traditional Chinese medicine composition according to any one of claims 1-3, characterized in that, Includes the following steps: S1. Weigh the medicinal materials in the Chinese medicine composition according to the weight parts, and pulverize the medicinal materials that include at least calcined magnetite; S2. First, perform a first water extraction on the pulverized and calcined magnetite, then combine all the medicinal materials for a second water extraction, combine all the extracts, concentrate, and obtain a concentrated solution. S3. The concentrate is prepared into a pharmaceutical preparation with or without the addition of excipients.

5. The method according to claim 4, characterized in that, The water extraction method is decoction, ultrasound-assisted extraction, or microwave-assisted extraction.

6. The method according to claim 4, characterized in that, The first water extraction time is 20-45 min; the second water extraction time is 40-90 min, and the extraction is performed 1-3 times; the material-to-liquid ratio in the first and second water extractions is 8-12 ml: 1 g.

7. The method according to claim 4, characterized in that, Before the second water extraction, all remaining medicinal materials, except for calcined magnetite, need to be soaked in water for 20-45 minutes.

8. The method according to claim 4, characterized in that, The second step also includes crushing all remaining medicinal materials, except for calcined magnetite, into powder.

9. The method according to claim 4, characterized in that, The medicine is a decoction, granules, pills, powder, tablets, capsules, or syrup.

10. The method according to claim 8, characterized in that, The preparation steps of the syrup further include: adding ethanol to the concentrate to make the volume fraction of ethanol in the solution 75%~85%, separating after alcohol precipitation, concentrating the clear liquid until there is no alcohol taste, and adding sucrose to make a syrup with a density of 1.8~1.32g / ml.

11. The method according to claim 10, characterized in that, The concentration has a density of 1.25~1.45 g / ml, and the sucrose accounts for 30%~40% of the total solids in the syrup.

12. The method according to claim 10, characterized in that, The syrup also includes preservatives and flavoring agents; the preservatives are any one or more of sorbic acid and its salts, benzoic acid and its salts, or parabens; the flavoring agents include sweeteners and flavorings; the sweeteners are one or more of sucralose, sorbitol, stevia, aspartame, and xylitol.

13. The use of the traditional Chinese medicine composition according to any one of claims 1-3 or the drug prepared by the method according to any one of claims 5-12 in the preparation of a drug for treating vertigo, characterized in that, The vertigo disorders refer to diseases with symptoms related to sleep, mood, or autonomic nervous system dysfunction, including vestibular migraine, Meniere's disease, or persistent postural perceptual vertigo, which includes chronic vertigo in the elderly and benign vertigo in children.

Images