A medicine for reducing belly fat, its preparation method and application

Abstract

The present application belongs to the technical field of weight loss medicine, and particularly relates to a medicine for eliminating belly fat, a preparation method and application thereof, which is prepared from the following raw materials in parts by weight: 2-7 parts of rhubarb, 5-9 parts of hawthorn, 2-5 parts of dried tangerine or orange peel, 2-6 parts of fried wheat germ, 5-9 parts of fried pharbitidis, 5-9 parts of fried medicated leaven, 1-3 parts of vinegar five spirit fat, 1-3 parts of vinegar green peel, 1-3 parts of vinegar three milt, 1-3 parts of vinegar Chinese galangal, and 1-3 parts of vinegar cyperus rotundus. The present application also limits the preparation method of the medicine. The medicine for eliminating belly fat prepared from the above formula can regulate the stomach, spleen, liver and gallbladder, fundamentally eliminate belly fat, and avoid rebound.

Description

Technical Field

[0001] This invention belongs to the field of weight loss drug technology, specifically relating to a drug for reducing belly fat, its preparation method, and its application. Background Technology

[0002] Obesity can trigger a variety of diseases, such as hypertension, hyperlipidemia, coronary heart disease, heart failure, diabetes, fatty liver, hyperuricemia, and gout. It can also cause chronic wear and tear on bones and joints. Belly fat, also known as abdominal obesity or central obesity, is characterized by fat accumulation primarily in the abdomen. Compared to evenly distributed obesity throughout the body, belly fat poses a more direct threat to health due to its specific location. The formation of belly fat is related to multiple factors, such as diet, lifestyle habits, hormones, and genetics. Therefore, eliminating belly fat has significant clinical importance for health.

[0003] According to Traditional Chinese Medicine (TCM) theory, current mainstream TCM formulas for belly fat reduction primarily utilize diuretics and laxatives to reduce water retention, such as herbal teas containing 10g of mulberry leaves, lily bulbs, mulberries, asparagus root, cassia seeds, and senna leaves, or 2g of ginger peel, 3g of dried tangerine peel, 3g of mulberry bark, and 4g of poria. There are also formulas that strengthen the spleen, eliminate turbidity, regulate lipids, and aid digestion, such as those composed of cassia seeds, hawthorn, plantain seeds, dried tangerine peel, fleeceflower root, licorice root, and immature bitter orange peel, which simultaneously moisten the intestines, promote digestion, and regulate the liver and spleen. Some formulas also include hawthorn, lotus leaves, and cassia seeds to promote intestinal peristalsis and lipid metabolism, accelerating fat breakdown and excretion. However, due to significant individual differences, formula selection must be based on individual diagnosis. While formulas primarily focused on diuresis or laxatives may result in rapid short-term weight loss, they primarily reduce water weight, leading to rebound weight gain upon discontinuation and lacking sustained weight loss effects. Therefore, the development of other belly fat reduction medications is still necessary. Summary of the Invention

[0004] To solve the above-mentioned technical problems, the present invention provides a drug for reducing belly fat, its preparation method and application. The drug for reducing belly fat of the present invention has a sustained weight loss effect and does not cause rebound for a long time after stopping the drug.

[0005] The purpose of this invention is to provide a medicine for reducing belly fat, which is made from the following raw materials in parts by weight: 2-7 parts rhubarb, 5-9 parts hawthorn, 2-5 parts dried tangerine peel, 2-6 parts roasted malt, 5-9 parts roasted morning glory seeds, 5-9 parts roasted Shenqu (medicated leaven), 1-3 parts vinegar-processed Wulingzhi (a type of medicinal herb), 1-3 parts vinegar-processed green tangerine peel, 1-3 parts vinegar-processed Sparganium rhizome, 1-3 parts vinegar-processed Curcuma rhizome, and 1-3 parts vinegar-processed Cyperus rhizome.

[0006] The following steps are performed: Stir-fried Shenqu (a type of medicinal fermentation), hawthorn, and stir-fried morning glory seeds are mixed, pulverized, and extracted with 60%–70% ethanol solution. After drying, the principal drug extract is obtained. Vinegar-processed Citrus reticulata peel and vinegar-processed Cyperus rotundus are mixed and extracted with water to obtain the adjuvant drug extract. Stir-fried malt, rhubarb, tangerine peel, vinegar-processed Trogopterus xanthipes, vinegar-processed Sparganium stoloniferum, and vinegar-processed Curcuma zedoaria are mixed, pulverized, and then mixed evenly with the principal drug extract and the adjuvant drug extract to obtain a drug for reducing belly fat.

[0007] The formula above is explained as follows:

[0008] Traditional Chinese medicine theory holds that the stomach is responsible for receiving food and the spleen is responsible for digestion and transformation. When the spleen and stomach are in good condition, one eats in moderation, digestion and transformation are normal, the flow of qi is smooth, the source of transformation is sufficient, one has plenty of energy, and the body is naturally healthy.

[0009] Based on the characteristics of abdominal obesity, this invention designs a new self-formulated prescription and corresponding preparation method. First, stir-fried Shenqu (a type of medicinal fermentation) strengthens the spleen and stomach, hawthorn promotes digestion and strengthens the stomach, and stir-fried morning glory seeds clear heat and relieve constipation. Stir-fried Shenqu, hawthorn, and stir-fried morning glory seeds are the principal ingredients. After the principal ingredients are extracted with 60%~70% ethanol solution to obtain the principal ingredient extract, the effect of strengthening the spleen and stomach is better, and it has a high-efficiency effect on eliminating belly fat in people with abdominal obesity.

[0010] Then, roasted malt can invigorate the spleen and dispel stagnation and heat; rhubarb clears away accumulated heat, removes pathogens, and drains heat; it enters the liver meridian to eliminate stagnation; tangerine peel enters the spleen and lung meridians, regulates qi and strengthens the spleen, and is used for chest and abdominal distension, poor appetite, vomiting and diarrhea. Roasted malt, rhubarb, and tangerine peel are the assistant ingredients.

[0011] Next, adjuvant herbs are provided. Vinegar-processed Citrus reticulata peel enters the liver, gallbladder, and stomach meridians, and is mainly used to soothe the liver, regulate qi, and eliminate stagnation. Vinegar-processed Cyperus rotundus enters the liver meridian, enhancing its liver-soothing and pain-relieving effects, and also eliminating stagnation. Vinegar-processed Citrus reticulata peel and vinegar-processed Cyperus rotundus are used as adjuvant herbs. After water extraction, the water extracts are collected and combined with other herbs to maximize the weight-loss effect and have a good effect on preventing rebound after stopping the medication.

[0012] Finally, the main ingredients were determined. Vinegar-processed Sparganium and Vinegar-processed Curcuma zedoaria work together to eliminate food stagnation and hardness, treating abdominal pain and chest tightness caused by food stagnation; Vinegar-processed Trogopterus dung enters the liver, enhancing its effects of dispersing blood stasis and relieving pain; Vinegar-processed Sparganium, Vinegar-processed Curcuma zedoaria, and Vinegar-processed Trogopterus dung are used as the guiding ingredients, mixed with the assistant ingredients, pulverized, and then combined with other drugs to exert a sustained and stable weight-loss effect, with no rebound after discontinuation of the medication.

[0013] In summary, the above-mentioned formula of the present invention for eliminating belly fat regulates the stomach, spleen, liver, gallbladder, and other aspects, fundamentally eliminating belly fat and preventing rebound after stopping the medication.

[0014] Preferably, the above-mentioned medicine for reducing belly fat is made from the following raw materials in parts by weight: 2 parts rhubarb, 5 parts hawthorn, 2 parts dried tangerine peel, 2 parts roasted malt, 5 parts roasted morning glory seeds, 5 parts roasted Shenqu (medicated leaven), 1 part vinegar-processed five-spice powder, 1 part vinegar-processed green tangerine peel, 1 part vinegar-processed sparganium rhizome, 1 part vinegar-processed turmeric, and 2 parts vinegar-processed cyperus rhizome.

[0015] Preferably, the above-mentioned medicine for reducing belly fat is made from the following raw materials in parts by weight: 7 parts rhubarb, 9 parts hawthorn, 5 parts dried tangerine peel, 6 parts roasted malt, 9 parts roasted morning glory seeds, 9 parts roasted Shenqu (medicated leaven), 3 parts vinegar-processed five-spice powder, 3 parts vinegar-processed green tangerine peel, 3 parts vinegar-processed sparganium rhizome, 3 parts vinegar-processed turmeric, and 3 parts vinegar-processed cyperus rhizome.

[0016] Preferably, the above-mentioned medicine for reducing belly fat is made from the following raw materials in parts by weight: 5 parts rhubarb, 6 parts hawthorn, 4 parts dried tangerine peel, 5 parts roasted malt, 8 parts roasted morning glory seeds, 8 parts roasted Shenqu (medicated leaven), 2 parts vinegar-processed five-spice powder, 2 parts vinegar-processed green tangerine peel, 2 parts vinegar-processed sparganium rhizome, 2 parts vinegar-processed turmeric, and 1 part vinegar-processed cyperus rhizome.

[0017] This invention also provides a method for preparing a medicine for reducing belly fat, comprising the following steps:

[0018] Prepare each ingredient according to its weight proportions;

[0019] Processing of principal ingredient: After pulverizing the stir-fried Shenqu, hawthorn and stir-fried morning glory seeds, add 60% to 70% ethanol solution with a volume fraction of 8 to 10 times the mass of the pulverized material, let stand for 2 to 5 hours to extract, filter, dry, and obtain the principal ingredient extract.

[0020] Adjuvant processing: After mixing vinegar-processed green tangerine peel and vinegar-processed Cyperus rotundus, add water equivalent to 8 to 10 times the mass of the mixture, soak for 1 to 2 hours, filter, and dry to obtain adjuvant extract;

[0021] After mixing roasted malt, rhubarb, dried tangerine peel, vinegar-processed five-spice powder, vinegar-processed three-edged sparganium, and vinegar-processed turmeric, grind them into a fine powder of 100-120 mesh.

[0022] The fine powder is mixed evenly with the extracts of the principal drug and the adjuvant drug to obtain a drug for reducing belly fat.

[0023] Preferably, in the preparation method of the above-mentioned medicine for reducing belly fat, the temperature for static extraction and soaking is 15℃~35℃.

[0024] This invention provides an application of the aforementioned medicine for reducing belly fat, wherein the medicine is prepared into a pill for reducing belly fat, and the preparation method is as follows:

[0025] Prepare a 70% (v / v) ethanol solution;

[0026] The medicine for reducing belly fat is molded using an ethanol solution. The amount of ethanol solution added is 1% to 2% of the total mass of the medicine. The pills are then soaked in water, sieved, and the sieve holes are 3.5 mm in diameter to make wet pills. After drying, the pills for reducing belly fat are obtained.

[0027] Preferably, each 20 wet pills weigh 0.9g to 1.0g.

[0028] Preferably, the wet pellets are dried at 75°C.

[0029] The present invention also provides an application of the above-mentioned drug for reducing belly fat, wherein the drug is compounded with calcium gluconate, and the calcium gluconate and the drug are mixed at a mass ratio of 1:300~500 to prepare a compound weight loss drug.

[0030] It should be noted that the preparation method provided by the present invention is applicable to environmental conditions of >0℃ and less than45℃. If the actual ambient temperature of the equipment is taken as the standard, there is no need to deliberately increase or decrease the temperature, thereby reducing equipment energy consumption and benefiting the environment.

[0031] Compared with the prior art, the present invention has the following beneficial effects:

[0032] The self-formulated formula of this invention is as follows: 2-7 parts rhubarb, 5-9 parts hawthorn, 2-5 parts dried tangerine peel, 2-6 parts roasted malt, 5-9 parts roasted morning glory seeds, 5-9 parts roasted Shenqu (medicated leaven), 1-3 parts vinegar-processed Wulingzhi (a type of medicinal powder), 1-3 parts vinegar-processed Citrus reticulata peel, 1-3 parts vinegar-processed Sparganium stoloniferum, 1-3 parts vinegar-processed Curcuma zedoaria, and 1-3 parts vinegar-processed Cyperus rotundus. Furthermore, this invention also incorporates a specific preparation process: roasted Shenqu, hawthorn, and roasted morning glory seeds are mixed, pulverized, and extracted with a 60%-70% ethanol solution, then dried to obtain the principal drug extract; vinegar-processed Citrus reticulata peel and vinegar-processed Cyperus rotundus are mixed and extracted with water to obtain the adjuvant drug extract; roasted malt, rhubarb, dried tangerine peel, vinegar-processed Wulingzhi, vinegar-processed Sparganium stoloniferum, and vinegar-processed Curcuma zedoaria are mixed, pulverized, and then mixed evenly with the principal drug extract and the adjuvant drug extract to obtain a drug for reducing belly fat.

[0033] Based on the above-mentioned formulation and preparation method, the medicine for eliminating belly fat prepared by this invention can fundamentally eliminate belly fat and prevent rebound. Experimental results show that the total effective rate, cure rate and efficacy rate of the medicine are all high. Detailed Implementation

[0034] To enable those skilled in the art to better understand and implement the technical solutions of the present invention, the present invention will be further described below in conjunction with specific embodiments.

[0035] Unless otherwise specified, all reagents used in this invention are commercially available, and all methods used are conventional techniques in the art.

[0036] In the following examples and control group, the water soaking and static extraction were performed at room temperature, i.e., 25°C.

[0037] It should be noted that the medicinal materials described in this invention are also commonly referred to by the following corresponding names in the field. The following are merely different names, and the medicinal materials represented in each group of names are the same:

[0038] Vinegar-processed Sparganium corresponds to Sparganium (vinegar-processed) or vinegar-processed Sparganium; vinegar-processed Curcuma corresponds to Curcuma (vinegar-processed) or vinegar-processed Curcuma; vinegar-processed Trogopterus Dung corresponds to Trogopterus Dung (vinegar-fried) or vinegar-fried Trogopterus Dung; vinegar-processed Cyperus corresponds to Cyperus (vinegar-processed) or vinegar-processed Cyperus; vinegar-processed Citrus Reticulatae corresponds to Citrus Reticulatae (vinegar-processed) or vinegar-processed Citrus Reticulatae; stir-fried Dioscorea Massa (Shenqu) corresponds to Dioscorea Massa (Shenqu); stir-fried Malt corresponds to Malt (Shenqu); stir-fried Morning Glory Seed corresponds to Morning Glory Seed (Shenqu).

[0039] I. Different formula settings.

[0040] Example 1

[0041] A medicine for reducing belly fat is made from the following ingredients in parts by weight: 5 parts rhubarb, 6 parts hawthorn, 4 parts dried tangerine peel, 5 parts roasted malt, 8 parts roasted morning glory seeds, 8 parts roasted Shenqu (medicated leaven), 2 parts vinegar-processed five-spice powder, 2 parts vinegar-processed green tangerine peel, 2 parts vinegar-processed sparganium rhizome, 2 parts vinegar-processed turmeric, and 1 part vinegar-processed cyperus rhizome.

[0042] The preparation method of the medicine for reducing belly fat includes the following steps:

[0043] Processing of the principal ingredient: After mixing stir-fried Shenqu, hawthorn and stir-fried morning glory seeds, the mixture was pulverized into 80-mesh powder to obtain the pulverized material. Then, 70% ethanol solution with a volume fraction equivalent to 8 times the mass of the pulverized material was added, and the mixture was allowed to stand for 2 hours for extraction. The mixture was then filtered through a 100-mesh filter and dried at 45°C to obtain the principal ingredient extract.

[0044] Adjuvant processing: After mixing vinegar-processed green tangerine peel and vinegar-processed Cyperus rotundus, add water equivalent to 8 times the mass of the mixture, soak for 1 hour, filter through a 100-mesh filter, and dry at 45°C to obtain the adjuvant extract;

[0045] Mix roasted malt, rhubarb, dried tangerine peel, vinegar-processed five-spice powder, vinegar-processed three-edged sparganium, and vinegar-processed turmeric, and grind them into a fine powder of 100 mesh.

[0046] The above fine powder is mixed with the principal drug extract and the adjuvant drug extract in a two-dimensional mixer for 30 minutes until the mixture is uniform, thus obtaining a drug for reducing belly fat.

[0047] Example 2

[0048] A medicine for reducing belly fat is made from the following ingredients in parts by weight: 7 parts rhubarb, 9 parts hawthorn, 5 parts dried tangerine peel, 6 parts roasted malt, 9 parts roasted morning glory seeds, 9 parts roasted Shenqu (medicated leaven), 3 parts vinegar-processed five-spice powder, 3 parts vinegar-processed green tangerine peel, 3 parts vinegar-processed sparganium rhizome, 3 parts vinegar-processed turmeric, and 3 parts vinegar-processed cyperus rhizome.

[0049] The preparation method of the medicine for reducing belly fat includes the following steps:

[0050] Processing of the principal ingredient: After mixing stir-fried Shenqu, hawthorn and stir-fried morning glory seeds, the mixture was pulverized into 80-mesh powder to obtain the pulverized material. Then, 70% ethanol solution with a volume fraction equivalent to 8 times the mass of the pulverized material was added, and the mixture was allowed to stand for 2 hours for extraction. The mixture was then filtered through a 100-mesh filter and dried at 45°C to obtain the principal ingredient extract.

[0051] Adjuvant processing: After mixing vinegar-processed green tangerine peel and vinegar-processed Cyperus rotundus, add water equivalent to 8 times the mass of the mixture, soak for 1 hour, filter through a 100-mesh filter, and dry at 45°C to obtain the adjuvant extract;

[0052] Mix roasted malt, rhubarb, dried tangerine peel, vinegar-processed five-spice powder, vinegar-processed three-edged sparganium, and vinegar-processed turmeric, and grind them into a fine powder of 100 mesh.

[0053] The above fine powder is mixed with the principal drug extract and the adjuvant drug extract in a two-dimensional mixer for 30 minutes until the mixture is uniform, thus obtaining a drug for reducing belly fat.

[0054] Example 3

[0055] A medicine for reducing belly fat is made from the following ingredients in parts by weight: 2 parts rhubarb, 5 parts hawthorn, 2 parts dried tangerine peel, 2 parts roasted malt, 5 parts roasted morning glory seeds, 5 parts roasted Shenqu (medicated leaven), 1 part vinegar-processed five-spice powder, 1 part vinegar-processed green tangerine peel, 1 part vinegar-processed sparganium rhizome, 1 part vinegar-processed turmeric, and 2 parts vinegar-processed cyperus rhizome.

[0056] The preparation method of the medicine for reducing belly fat includes the following steps:

[0057] Processing of the principal ingredient: After mixing stir-fried Shenqu, hawthorn and stir-fried morning glory seeds, the mixture was pulverized into 80-mesh powder to obtain the pulverized material. Then, 70% ethanol solution with a volume fraction equivalent to 8 times the mass of the pulverized material was added, and the mixture was allowed to stand for 2 hours for extraction. The mixture was then filtered through a 100-mesh filter and dried at 45°C to obtain the principal ingredient extract.

[0058] Adjuvant processing: After mixing vinegar-processed green tangerine peel and vinegar-processed Cyperus rotundus, add water equivalent to 8 times the mass of the mixture, soak for 1 hour, filter through a 100-mesh filter, and dry at 45°C to obtain the adjuvant extract;

[0059] Mix roasted malt, rhubarb, dried tangerine peel, vinegar-processed five-spice powder, vinegar-processed three-edged sparganium, and vinegar-processed turmeric, and grind them into a fine powder of 100 mesh.

[0060] The above fine powder is mixed with the principal drug extract and the adjuvant drug extract in a two-dimensional mixer for 30 minutes until the mixture is uniform, thus obtaining a drug for reducing belly fat.

[0061] Example 4

[0062] A compound weight loss drug is prepared by combining a drug for reducing belly fat with calcium gluconate. The calcium gluconate and the drug are mixed at a mass ratio of 1:300.

[0063] One of the medicines for reducing belly fat is made from the following ingredients in parts by weight: 5 parts rhubarb, 6 parts hawthorn, 4 parts dried tangerine peel, 5 parts roasted malt, 8 parts roasted morning glory seeds, 8 parts roasted Shenqu (medicated leaven), 2 parts vinegar-processed five-spice powder, 2 parts vinegar-processed green tangerine peel, 2 parts vinegar-processed sparganium rhizome, 2 parts vinegar-processed turmeric, and 1 part vinegar-processed cyperus rhizome.

[0064] The preparation method of the medicine for reducing belly fat includes the following steps:

[0065] Processing of the principal ingredient: After mixing stir-fried Shenqu, hawthorn and stir-fried morning glory seeds, the mixture was pulverized into 80-mesh powder to obtain the pulverized material. Then, 70% ethanol solution with a volume fraction equivalent to 8 times the mass of the pulverized material was added, and the mixture was allowed to stand for 2 hours for extraction. The mixture was then filtered through a 100-mesh filter and dried at 45°C to obtain the principal ingredient extract.

[0066] Adjuvant processing: After mixing vinegar-processed green tangerine peel and vinegar-processed Cyperus rotundus, add water equivalent to 8 times the mass of the mixture, soak for 1 hour, filter through a 100-mesh filter, and dry at 45°C to obtain the adjuvant extract;

[0067] Mix roasted malt, rhubarb, dried tangerine peel, vinegar-processed five-spice powder, vinegar-processed three-edged sparganium, and vinegar-processed turmeric, and grind them into a fine powder of 100 mesh.

[0068] The above fine powder is mixed with the principal drug extract and the adjuvant drug extract in a two-dimensional mixer for 30 minutes until the mixture is uniform, thus obtaining a drug for reducing belly fat.

[0069] Example 5

[0070] A compound weight loss drug is prepared by combining a drug for reducing belly fat with calcium gluconate. The calcium gluconate and the drug are mixed at a mass ratio of 1:500.

[0071] One of the medicines for reducing belly fat is made from the following ingredients in parts by weight: 5 parts rhubarb, 6 parts hawthorn, 4 parts dried tangerine peel, 5 parts roasted malt, 8 parts roasted morning glory seeds, 8 parts roasted Shenqu (medicated leaven), 2 parts vinegar-processed five-spice powder, 2 parts vinegar-processed green tangerine peel, 2 parts vinegar-processed sparganium rhizome, 2 parts vinegar-processed turmeric, and 1 part vinegar-processed cyperus rhizome.

[0072] The preparation method of the medicine for reducing belly fat includes the following steps:

[0073] Processing of the principal ingredient: After mixing stir-fried Shenqu, hawthorn and stir-fried morning glory seeds, the mixture was pulverized into 80-mesh powder to obtain the pulverized material. Then, 70% ethanol solution with a volume fraction equivalent to 8 times the mass of the pulverized material was added, and the mixture was allowed to stand for 2 hours for extraction. The mixture was then filtered through a 100-mesh filter and dried at 45°C to obtain the principal ingredient extract.

[0074] Adjuvant processing: After mixing vinegar-processed green tangerine peel and vinegar-processed Cyperus rotundus, add water equivalent to 8 times the mass of the mixture, soak for 1 hour, filter through a 100-mesh filter, and dry at 45°C to obtain the adjuvant extract;

[0075] Mix roasted malt, rhubarb, dried tangerine peel, vinegar-processed five-spice powder, vinegar-processed three-edged sparganium, and vinegar-processed turmeric, and grind them into a fine powder of 100 mesh.

[0076] The above fine powder is mixed with the principal drug extract and the adjuvant drug extract in a two-dimensional mixer for 30 minutes until the mixture is uniform, thus obtaining a drug for reducing belly fat.

[0077] Example 6

[0078] A pill for reducing belly fat, prepared as follows:

[0079] Prepare a 70% (v / v) ethanol solution;

[0080] The medicine for reducing belly fat is molded using a 70% ethanol solution (volume fraction). The amount of ethanol solution added is 1% of the total mass of the medicine. The pills are then soaked in water, sieved, and the sieve has a hole diameter of 3.5 mm to make wet pills. Each 20 wet pills weigh 0.9 g. After drying in a hot air circulating oven at 75°C, the pills for reducing belly fat are obtained.

[0081] The medicine for reducing belly fat is made from the following ingredients in parts by weight: 5 parts rhubarb, 6 parts hawthorn, 4 parts dried tangerine peel, 5 parts roasted malt, 8 parts roasted morning glory seeds, 8 parts roasted Shenqu (medicated leaven), 2 parts vinegar-processed five-spice powder, 2 parts vinegar-processed green tangerine peel, 2 parts vinegar-processed sparganium rhizome, 2 parts vinegar-processed turmeric, and 1 part vinegar-processed cyperus rhizome.

[0082] The preparation method for a drug to reduce belly fat includes the following steps:

[0083] Processing of the principal ingredient: After mixing stir-fried Shenqu, hawthorn and stir-fried morning glory seeds, the mixture was pulverized into 80-mesh powder to obtain the pulverized material. Then, 70% ethanol solution with a volume fraction equivalent to 8 times the mass of the pulverized material was added, and the mixture was allowed to stand for 2 hours for extraction. The mixture was then filtered through a 100-mesh filter and dried at 45°C to obtain the principal ingredient extract.

[0084] Adjuvant processing: After mixing vinegar-processed green tangerine peel and vinegar-processed Cyperus rotundus, add water equivalent to 8 times the mass of the mixture, soak for 1 hour, filter through a 100-mesh filter, and dry at 45°C to obtain the adjuvant extract;

[0085] Mix roasted malt, rhubarb, dried tangerine peel, vinegar-processed five-spice powder, vinegar-processed three-edged sparganium, and vinegar-processed turmeric, and grind them into a fine powder of 100 mesh.

[0086] The above fine powder is mixed with the principal drug extract and the adjuvant drug extract in a two-dimensional mixer for 30 minutes until the mixture is uniform, thus obtaining a drug for reducing belly fat.

[0087] The relationships between the principal, assistant, adjuvant, and guiding herbs in Example 1 were adjusted to explore the effects of different formulations on the reduction of belly fat. The control group was set up as follows:

[0088] Control group 1

[0089] A medicine for reducing belly fat contains only the principal and assistant herbs of Example 1, with the following formula: 5 parts rhubarb, 6 parts hawthorn, 4 parts dried tangerine peel, 5 parts roasted malt, 8 parts roasted morning glory seeds, and 8 parts roasted Shenqu (medicated leaven).

[0090] The preparation method of the medicine for reducing belly fat includes the following steps:

[0091] Processing of the principal ingredient: After mixing stir-fried Shenqu, hawthorn and stir-fried morning glory seeds, the mixture was pulverized into 80-mesh powder to obtain the pulverized material. Then, 70% ethanol solution with a volume fraction equivalent to 8 times the mass of the pulverized material was added, and the mixture was allowed to stand for 2 hours for extraction. The mixture was then filtered through a 100-mesh filter and dried at 45°C to obtain the principal ingredient extract.

[0092] Grind roasted malt, rhubarb, and dried tangerine peel into a fine powder of 100 mesh;

[0093] The above fine powder and the extract of the principal drug are mixed in a two-dimensional mixer for 30 minutes until they are evenly mixed to obtain a drug for reducing belly fat.

[0094] Control group 2

[0095] A medicine for reducing belly fat contains only the principal, assistant, and adjuvant herbs of Example 1, with the following formula: 5 parts rhubarb, 6 parts hawthorn, 4 parts dried tangerine peel, 5 parts roasted malt, 8 parts roasted morning glory seeds, 8 parts roasted Shenqu (medicated leaven), 2 parts vinegar-processed green tangerine peel, and 1 part vinegar-processed Cyperus rotundus.

[0096] The preparation method of the medicine for reducing belly fat includes the following steps:

[0097] Processing of the principal ingredient: After mixing stir-fried Shenqu, hawthorn and stir-fried morning glory seeds, the mixture was pulverized into 80-mesh powder to obtain the pulverized material. Then, 70% ethanol solution with a volume fraction equivalent to 8 times the mass of the pulverized material was added, and the mixture was allowed to stand for 2 hours for extraction. The mixture was then filtered through a 100-mesh filter and dried at 45°C to obtain the principal ingredient extract.

[0098] Adjuvant processing: After mixing vinegar-processed green tangerine peel and vinegar-processed Cyperus rotundus, add water equivalent to 8 times the mass of the mixture, soak for 1 hour, filter through a 100-mesh filter, and dry at 45°C to obtain the adjuvant extract;

[0099] Grind roasted malt, rhubarb, and dried tangerine peel into a fine powder of 100 mesh;

[0100] The above fine powder is mixed with the principal drug extract and the adjuvant drug extract in a two-dimensional mixer for 30 minutes until the mixture is uniform, thus obtaining a drug for reducing belly fat.

[0101] Control group 3

[0102] A medicine for reducing belly fat contains only the principal, assistant, and guiding herbs of Example 1, with the following formula: 5 parts rhubarb, 6 parts hawthorn, 4 parts dried tangerine peel, 5 parts roasted malt, 8 parts roasted morning glory seeds, 8 parts roasted Shenqu (medicated leaven), 2 parts vinegar-processed Wulingzhi (a type of medicinal powder), 2 parts vinegar-processed Sanleng (another type of medicinal powder), and 2 parts vinegar-processed Ezhu (a type of medicinal herb).

[0103] The preparation method of the medicine for reducing belly fat includes the following steps:

[0104] Processing of the principal ingredient: After mixing stir-fried Shenqu, hawthorn and stir-fried morning glory seeds, the mixture was pulverized into 80-mesh powder to obtain the pulverized material. Then, 70% ethanol solution with a volume fraction equivalent to 8 times the mass of the pulverized material was added, and the mixture was allowed to stand for 2 hours for extraction. The mixture was then filtered through a 100-mesh filter and dried at 45°C to obtain the principal ingredient extract.

[0105] Mix roasted malt, rhubarb, dried tangerine peel, vinegar-processed five-spice powder, vinegar-processed three-edged sparganium, and vinegar-processed turmeric, and grind them into a fine powder of 100 mesh.

[0106] The above fine powder and the extract of the principal drug are mixed in a two-dimensional mixer for 30 minutes until they are evenly mixed to obtain a drug for reducing belly fat.

[0107] Control group 4

[0108] A medicine for reducing belly fat is proposed, with adjustments made to the formulation of Example 1. The formula is modified as follows: stir-fried morning glory seeds, hawthorn, and stir-fried Shenqu (medicated leaven) are the principal ingredients; rhubarb and stir-fried malt are the assistant ingredients; vinegar-processed green tangerine peel and vinegar-processed Cyperus rotundus are the adjuvant ingredients; and vinegar-processed Sparganium stoloniferum, vinegar-processed Curcuma zedoaria, and vinegar-processed Trogopterus xanthipes are added as follows: Rhubarb 6 parts, Hawthorn 18 parts, Tangerine peel 3 parts, Stir-fried malt 12 parts, Stir-fried morning glory seeds 18 parts, stir-fried Shenqu 18 parts, vinegar-processed Trogopterus xanthipes 3 parts, vinegar-processed green tangerine peel 3 parts, vinegar-processed Sparganium stoloniferum 2 parts, vinegar-processed Curcuma zedoaria 2 parts, and vinegar-processed Cyperus rotundus 2 parts. This formula is an improvement on a previously researched formulation, primarily used to treat indigestion, but its effect on reducing belly fat is unsatisfactory. Even after adjusting the preparation process of this formula, the effect on reducing belly fat remains unsatisfactory.

[0109] The preparation method of the medicine for reducing belly fat includes the following steps:

[0110] Processing of principal ingredient: After pulverizing the stir-fried morning glory seeds, hawthorn, and stir-fried Shenqu into powder of 80 mesh, the powder was added to a 70% ethanol solution with a volume fraction equivalent to 8 times the mass of the powder. The mixture was allowed to stand for 2 hours for extraction, filtered through a 100-mesh filter, and dried at 45°C to obtain the principal ingredient extract.

[0111] Adjuvant processing: After mixing vinegar-processed green tangerine peel and vinegar-processed Cyperus rotundus, a mixture was obtained. Water equivalent to 8 times the mass of the mixture was added, and the mixture was soaked for 1 hour. The mixture was then filtered through a 100-mesh filter and dried at 45°C to obtain the adjuvant extract.

[0112] Mix roasted malt, rhubarb, dried tangerine peel, vinegar-processed five-spice powder, vinegar-processed three-edged sparganium, and vinegar-processed turmeric, and grind them into a fine powder of 100 mesh.

[0113] The above fine powder is mixed with the principal drug extract and the adjuvant drug extract in a two-dimensional mixer for 30 minutes until the mixture is uniform, thus obtaining a drug for reducing belly fat.

[0114] II. Different preparation methods.

[0115] Control group 5

[0116] A medicine for reducing belly fat is made from the following ingredients in parts by weight: 5 parts rhubarb, 6 parts hawthorn, 4 parts dried tangerine peel, 5 parts roasted malt, 8 parts roasted morning glory seeds, 8 parts roasted Shenqu (medicated leaven), 2 parts vinegar-processed five-spice powder, 2 parts vinegar-processed green tangerine peel, 2 parts vinegar-processed sparganium rhizome, 2 parts vinegar-processed turmeric, and 1 part vinegar-processed cyperus rhizome.

[0117] The preparation method of the medicine for reducing belly fat includes the following steps.

[0118] After mixing all the ingredients, add water equivalent to 8 times the total mass of the mixture and boil for 15 minutes. Filter through a 100-mesh filter, concentrate by rotary evaporation at 45°C, and dry at 45°C to obtain the water-based extract, which is the medicine for reducing belly fat.

[0119] Control group 6

[0120] A medicine for reducing belly fat is made from the following ingredients in parts by weight: 5 parts rhubarb, 6 parts hawthorn, 4 parts dried tangerine peel, 5 parts roasted malt, 8 parts roasted morning glory seeds, 8 parts roasted Shenqu (medicated leaven), 2 parts vinegar-processed five-spice powder, 2 parts vinegar-processed green tangerine peel, 2 parts vinegar-processed sparganium rhizome, 2 parts vinegar-processed turmeric, and 1 part vinegar-processed cyperus rhizome.

[0121] The preparation method of the medicine for reducing belly fat includes the following steps.

[0122] After mixing all the raw materials, add 70% ethanol solution with a volume fraction equivalent to 8 times the total mass of the mixture, let stand for 2 hours for extraction, filter through a 100-mesh filter, concentrate by rotary evaporation at 45°C, and dry at 45°C to obtain the ethanol extract, which is the medicine for reducing belly fat.

[0123] Control group 7

[0124] A medicine for reducing belly fat is made from the following ingredients in parts by weight: 5 parts rhubarb, 6 parts hawthorn, 4 parts dried tangerine peel, 5 parts roasted malt, 8 parts roasted morning glory seeds, 8 parts roasted Shenqu (medicated leaven), 2 parts vinegar-processed five-spice powder, 2 parts vinegar-processed green tangerine peel, 2 parts vinegar-processed sparganium rhizome, 2 parts vinegar-processed turmeric, and 1 part vinegar-processed cyperus rhizome.

[0125] The preparation method of the medicine for reducing belly fat includes the following steps.

[0126] Processing of the principal ingredient: After mixing stir-fried Shenqu, hawthorn and stir-fried morning glory seeds, the mixture was pulverized into 80-mesh powder to obtain the pulverized material. Then, 70% ethanol solution with a volume fraction equivalent to 8 times the mass of the pulverized material was added, and the mixture was allowed to stand for 2 hours for extraction. The mixture was then filtered through a 100-mesh filter and dried at 45°C to obtain the principal ingredient extract.

[0127] Adjuvant processing: After mixing vinegar-processed green tangerine peel and vinegar-processed Cyperus rotundus, add water equivalent to 8 times the mass of the mixture, soak for 1 hour, filter through a 100-mesh filter, and dry at 45°C to obtain the adjuvant extract;

[0128] Processing of the medicinal ingredients: Mix vinegar-processed Sparganium rhizome, vinegar-processed Curcuma rhizome, and vinegar-processed Trogopterus dung, add water equivalent to 8 times the mass of the ingredients to the mixture and decoct for 15 minutes. Filter the mixture through a 100-mesh sieve and dry it at 45°C to obtain the extract of the medicinal ingredients.

[0129] Grind roasted malt, rhubarb, and dried tangerine peel into a fine powder of 100 mesh;

[0130] The above fine powder is mixed with the principal drug extract and the adjuvant drug extract in a two-dimensional mixer for 30 minutes until the mixture is uniform, thus obtaining a drug for reducing belly fat.

[0131] control group 8

[0132] A medicine for reducing belly fat is made from the following ingredients in parts by weight: 5 parts rhubarb, 6 parts hawthorn, 4 parts dried tangerine peel, 5 parts roasted malt, 8 parts roasted morning glory seeds, 8 parts roasted Shenqu (medicated leaven), 2 parts vinegar-processed five-spice powder, 2 parts vinegar-processed green tangerine peel, 2 parts vinegar-processed sparganium rhizome, 2 parts vinegar-processed turmeric, and 1 part vinegar-processed cyperus rhizome.

[0133] The preparation method of the medicine for reducing belly fat includes the following steps.

[0134] Treatment of principal herbs: Add 70% ethanol solution (volume fraction) equivalent to 8 times the mass of roasted malt to roasted malt, rhubarb, and tangerine peel, let stand for 2 hours to extract, filter through a 100-mesh filter, and dry at 45℃ to obtain the principal herb extract.

[0135] Adjuvant processing: Rhubarb, vinegar-processed green tangerine peel, and vinegar-processed Cyperus rotundus are mixed to obtain a mixture. Add water equivalent to 8 times the mass of the mixture, soak for 1 hour, filter through a 100-mesh filter, and dry at 45°C to obtain the adjuvant extract.

[0136] Mix the stir-fried Shenqu (a type of medicinal fermentation), stir-fried morning glory seeds, hawthorn, vinegar-processed Wulingzhi (a type of medicinal fermentation), vinegar-processed Sanleng (a type of medicinal sparganium), and vinegar-processed Ezhu (a type of medicinal herb), and grind them into a fine powder of 100 mesh.

[0137] The above fine powder is mixed with the principal drug extract and the adjuvant drug extract in a two-dimensional mixer for 30 minutes until the mixture is uniform, thus obtaining a drug for reducing belly fat.

[0138] To facilitate comparison of the differences between different embodiments and the control group, Table 1 is used to illustrate the differences.

[0139] Table 1. Main differences between different embodiments and comparative examples

[0140]

[0141] The effectiveness of this invention was verified by the following experiment.

[0142] (1) Since this invention is a drug for reducing belly fat, the following inclusion criteria for abdominal obesity are used for patient inclusion:

[0143] (1.1) Waist circumference: Men ≥ 90cm, women ≥ 85cm. Or waist-to-hip ratio: Men ≥ 0.90, women ≥ 0.85.

[0144] (1.2) Simple obesity: BMI ≥ 28 kg / m² 2 .

[0145] (1.3) Weight change of less than 5 kg within 3 months prior to medication.

[0146] (1.4) Age: 20-50 years old. All patients voluntarily participate in and cooperate with the treatment and follow-up. There are no gender restrictions.

[0147] (1.5) Previous history of weight loss failure: The individual reported that at least once, through diet intervention + exercise intervention for ≥12 weeks, the weight loss did not reach the expected level, or the individual was unable to maintain the weight loss, and rebounded within 4 weeks.

[0148] (1.6) Exclusion factors: Use of any prescription / nonprescription weight loss drugs, GLP-1 drugs, traditional Chinese medicine, meal replacements, etc. within the past 3 months; weight loss surgery in the past or during the planned trial period; uncontrolled hypertension (≥160 / 100 mmHg), history of severe cardiovascular and cerebrovascular diseases, active hepatobiliary and pancreatic diseases, pregnancy or breastfeeding.

[0149] (2) Method of administration

[0150] Each group consisted of 60 patients. Patients in different groups received different medications, as detailed in Table 2. The medication was administered twice daily, morning and evening, 6g each time, for 7 days per course. Efficacy was observed after 6 courses of treatment. During medication, a healthy diet should be maintained, and overeating should be avoided.

[0151] (3) Criteria for judging therapeutic efficacy

[0152] (3.1) Cured: The indicators of (1.1) and (1.2) have all returned to healthy values, and there is no rebound after 2 months of stopping medication, or no rebound after more than 2 months.

[0153] (3.2) Effective: waist circumference decreased by ≥5cm, weight decreased by ≥5%, but waist circumference and weight still did not reach healthy values; and rebound occurred 1 month after stopping the medication.

[0154] Among them, a healthy weight value is 18.5 kg / m². 2 ≤BMI<24kg / m 2 A healthy waist circumference is defined as <85cm for men and <80cm for women.

[0155] (3.3) Ineffective: Patients who do not meet (3.1) and (3.2). That is, the reduction in waist circumference and the reduction in weight do not meet the target; or even if the target is met temporarily, the weight rebounds after 1 month of stopping the medication.

[0156] The efficacy results of different formulations are shown in Table 2, and the efficacy results of different preparation methods are shown in Table 3.

[0157] The formulas for calculating the cure rate are as follows in Tables 2 and 3:

[0158] Cure rate = (number of cured patients / total number of patients) * 100%, with the result rounded to two decimal places.

[0159] The formula for calculating the efficiency is as follows:

[0160] Effectiveness rate = (Number of effective participants / Total number of participants) * 100%, and the result is rounded to two decimal places.

[0161] The inefficiency calculation formula is as follows:

[0162] Inefficiency = 1 - Cure Rate - Effective Rate

[0163] The formula for calculating the overall effectiveness is as follows:

[0164] Overall effectiveness rate = cure rate + effectiveness rate.

[0165] Table 2. Statistical analysis of the efficacy of different formulations

[0166]

[0167] As shown in Table 2, the overall effective rate of Examples 1 to 5 of the present invention was higher than that of the control groups. Among them, Examples 4 and 5, after being compounded with calcium gluconate, showed an improvement in overall effective rate, cure rate, and effective rate compared with Examples 1 to 3, indicating that calcium gluconate is effective in enhancing the weight loss effect of abdominal obesity.

[0168] Table 3. Statistical analysis of the efficacy of different preparation methods

[0169]

[0170] The results in Table 3 indicate that the overall effective rate of the drug obtained using traditional decoction and alcohol extraction methods is lower than that of the example group. Furthermore, even when the adjuvant and guiding drugs are treated in the same way as the assistant drugs, or the treatment methods for the principal and assistant drugs are changed, the effect is still not as good as that of the example group. The reason for this is that the 70% ethanol extract of the principal drug, the complete components of the assistant and guiding drugs, and the water extract of the adjuvant drugs contribute more to the effect of reducing belly fat. Changing the preparation method will significantly reduce the overall effective rate of the drug. To ensure the efficacy of the drug, the preparation process provided in the examples of this invention should be used.

[0171] Furthermore, according to follow-up data after drug withdrawal, patients cured in Examples 1-3 and 6 of this application did not experience a relapse for a minimum of 2 months and a maximum of 5 months. Patients cured in Examples 4 and 5 did not experience a relapse for a minimum of 3 months and a maximum of 6 months. In contrast, patients cured in the control group only maintained a relapse-free period of 2 months.

[0172] It should be noted that irregular eating habits, excessive consumption of high-sugar and high-fat foods, lack of exercise, and irregular sleep patterns are contributing factors to obesity. These contributing factors should be avoided after discontinuing the medication of this invention. It should be noted that these contributing factors are due to the patient's own actions; any rebound effect after discontinuing the medication for reducing belly fat due to these contributing factors should not be interpreted as the medication being ineffective.

[0173] It should be noted that when numerical ranges are involved in this invention, it should be understood that the two endpoints of each numerical range and any value between the two endpoints can be selected. Since the steps and methods used are the same as those in the embodiments, preferred embodiments are described in this invention to avoid redundancy. "Primary herb processing: After crushing fried Shenqu (a type of medicinal fermentation), hawthorn, and fried morning glory seeds, a pulverized material is obtained. An ethanol solution with a volume fraction of 60% to 70% (8 to 10 times the mass of the pulverized material) is added, and the mixture is allowed to stand for 2 to 5 hours for extraction." "Adjuvant herb processing: After mixing vinegar-processed Citrus reticulata peel and vinegar-processed Cyperus rotundus, a mixture is obtained. An ethanol solution with a mass of 8 to 10 times the mass of the mixture is added, and the mixture is soaked for 1 to 2 hours." "After mixing fried malt, rhubarb, tangerine peel, vinegar-processed Trogopterus xanthipes, vinegar-processed Sparganium stoloniferum, and vinegar-processed Curcuma zedoaria, the mixture is pulverized into a fine powder of 100 to 120 mesh." "The soaking temperature is 15℃ to 35℃." "The ethanol solution is used to mold the 'belly fat reduction' medicine, and the amount of ethanol solution added is 1% to 2% of the total mass of the 'belly fat reduction' medicine." Any of the values ​​mentioned within this range, and the resulting embodiments, show comparable overall effectiveness, efficacy rate, and cure rate, with an error not exceeding 3%. Therefore, the above value ranges all fall within the inventive concept of this application and should be protected.

[0174] Although preferred embodiments of the present invention have been described, those skilled in the art, upon learning the inventive concept of the present invention, can make other changes and modifications to these embodiments, all of which fall within the scope of the present invention.

[0175] Obviously, those skilled in the art can make various modifications and variations to this invention without departing from its spirit and scope. If such modifications and variations fall within the scope of equivalents of this invention, then this invention also intends to include these modifications and variations.

Claims

1. A weight-loss drug, characterized in that, It is made from the following ingredients in parts by weight: rhubarb 2-7 parts, hawthorn 5-9 parts, dried tangerine peel 2-5 parts, roasted malt 2-6 parts, roasted morning glory seed 5-9 parts, roasted Shenqu 5-9 parts, vinegar-processed five-spice powder 1-3 parts, vinegar-processed green tangerine peel 1-3 parts, vinegar-processed sparganium rhizome 1-3 parts, vinegar-processed turmeric 1-3 parts, vinegar-processed cyperus rhizome 1-3 parts; The preparation method of weight-loss drugs includes the following steps: Prepare each ingredient according to its weight proportions; Processing of principal ingredient: After pulverizing the stir-fried Shenqu, hawthorn and stir-fried morning glory seeds, add 8 to 10 times the mass of the pulverized material in a 60% to 70% ethanol solution, let stand for 2 to 5 hours to extract, filter and dry to obtain the principal ingredient extract; Adjuvant processing: After mixing vinegar-processed green tangerine peel and vinegar-processed Cyperus rotundus, add 8 to 10 times the mass of water to the mixture, soak for 1 to 2 hours, filter, and dry to obtain adjuvant extract; After mixing roasted malt, rhubarb, dried tangerine peel, vinegar-processed five-spice powder, vinegar-processed three-edged sparganium, and vinegar-processed turmeric, grind them into a fine powder of 100-120 mesh. The fine powder is mixed evenly with the principal drug extract and the adjuvant drug extract to obtain a weight loss drug.

2. The weight-loss drug according to claim 1, characterized in that, It is made from the following ingredients in parts by weight: 2 parts rhubarb, 5 parts hawthorn, 2 parts dried tangerine peel, 2 parts roasted malt, 5 parts roasted morning glory seeds, 5 parts roasted Shenqu (medicated leaven), 1 part vinegar-processed five-spice powder, 1 part vinegar-processed green tangerine peel, 1 part vinegar-processed sparganium rhizome, 1 part vinegar-processed turmeric, and 2 parts vinegar-processed cyperus rhizome.

3. The weight-loss drug according to claim 1, characterized in that, It is made from the following ingredients in parts by weight: 7 parts rhubarb, 9 parts hawthorn, 5 parts dried tangerine peel, 6 parts roasted malt, 9 parts roasted morning glory seeds, 9 parts roasted Shenqu (medicated leaven), 3 parts vinegar-processed five-spice powder, 3 parts vinegar-processed green tangerine peel, 3 parts vinegar-processed sparganium rhizome, 3 parts vinegar-processed turmeric, and 3 parts vinegar-processed cyperus rhizome.

4. The weight-loss drug according to claim 1, characterized in that, It is made from the following ingredients in parts by weight: 5 parts rhubarb, 6 parts hawthorn, 4 parts dried tangerine peel, 5 parts roasted malt, 8 parts roasted morning glory seeds, 8 parts roasted Shenqu (medicated leaven), 2 parts vinegar-processed five-spice powder, 2 parts vinegar-processed green tangerine peel, 2 parts vinegar-processed sparganium rhizome, 2 parts vinegar-processed turmeric, and 1 part vinegar-processed cyperus rhizome.

5. The method for preparing the weight-loss drug according to any one of claims 1 to 4, characterized in that, Includes the following steps: Prepare each ingredient according to its weight proportions; Processing of principal ingredient: After pulverizing the stir-fried Shenqu, hawthorn and stir-fried morning glory seeds, add 8 to 10 times the mass of the pulverized material in a 60% to 70% ethanol solution, let stand for 2 to 5 hours to extract, filter and dry to obtain the principal ingredient extract; Adjuvant processing: After mixing vinegar-processed green tangerine peel and vinegar-processed Cyperus rotundus, add 8 to 10 times the mass of water to the mixture, soak for 1 to 2 hours, filter, and dry to obtain adjuvant extract; After mixing roasted malt, rhubarb, dried tangerine peel, vinegar-processed five-spice powder, vinegar-processed three-edged sparganium, and vinegar-processed turmeric, grind them into a fine powder of 100-120 mesh. The fine powder is mixed evenly with the principal drug extract and the adjuvant drug extract to obtain a weight loss drug.

6. The preparation method according to claim 5, characterized in that, The temperature for both static extraction and soaking is 15℃~35℃.

7. A compound weight-loss drug, characterized in that, The weight-loss drug of claim 1 is compounded with calcium gluconate, and the calcium gluconate and the drug are mixed at a mass ratio of 1:300~500 to prepare a compound weight-loss drug.

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