A herbal exosome composition for eye care and treatment and a method of preparing the same

CN121243252BActive Publication Date: 2026-07-03ORUIJUN (GUANGZHOU) BIOTECHNOLOGY CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ORUIJUN (GUANGZHOU) BIOTECHNOLOGY CO LTD
Filing Date
2025-10-22
Publication Date
2026-07-03

AI Technical Summary

Technical Problem

Current treatments for dry eye syndrome suffer from short drug retention time, low bioavailability, and lack of targeting, leading to poor patient compliance. Traditional herbal medicines also have poor solubility and limited bioavailability.

Method used

By combining herbal exosomes with mesenchymal stem cell exosomes and utilizing the synergistic effect of phospholipid complex carriers and thermosensitive hydrogels, a herbal exosome composition was prepared. Herbal active ingredients were loaded by gradient centrifugation and electroporation, and a biphasic sustained-release carrier system was used to prolong the drug's residence time on the ocular surface, thereby improving bioavailability and targeting.

Benefits of technology

It achieves synergistic anti-inflammatory and repair effects of herbal exosomes and MSC exosomes, and the long-term retention and sustained release of the drug on the ocular surface improves bioavailability, reduces the frequency of administration and improves efficacy.

✦ Generated by Eureka AI based on patent content.

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Abstract

This invention relates to the fields of biomedicine and ophthalmic drug technology, specifically to an herbal exosome composition for eye care and treatment and its preparation method. The composition comprises a synergistic combination of herbal exosomes and mesenchymal stem cell exosomes, and also includes a nano-sustained-release carrier system. The herbal exosomes are extracted from the traditional herb licorice using gradient centrifugation combined with size exclusion chromatography, and the active herbal components astragaloside and quercetin are loaded onto the exosomes using electroporation to enhance their pharmacological activity. The nano-sustained-release carrier system has a biphasic sustained-release structure: the inner phase is a phospholipid complex carrying herbal exosomes and mesenchymal stem cell exosomes, and the outer phase is a thermosensitive hydrogel; it is liquid at room temperature, but rapidly transforms into a gel state after being instilled onto the ocular surface, significantly prolonging the drug's residence time on the ocular surface, improving bioavailability, and endowing it with targeted sustained-release capability against ocular surface tissues.
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