A Naphthalene-type Chalcone Compound, Its Preparation Method and Application

By synthesizing a naphthyl-type chalcone compound to replace the benzene ring structure in traditional chalcone compounds, the inhibitory activity against HDAC6 protein was improved, overcoming the limitations of existing chalcone compounds in HDAC6 inhibition and achieving effective inhibition of tumor cells.

CN121248445BActive Publication Date: 2026-05-26BOZHOU UNIV
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Patent Information

Application Number
CN202511412810.2
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-09-29
Publication Date
2026-05-26
Estimated Expiration
2045-09-29

AI Technical Summary

Technical Problem

Existing chalcone compounds have certain limitations in inhibiting HDAC6 protein activity, making it difficult to further improve the therapeutic effect on diseases related to abnormal HDAC6 expression.

Method used

A novel naphthalene-type chalcone compound was designed and synthesized. The compound with a naphthalene ring structure was prepared by Claisen-Schmidt reaction and condensation reaction, replacing the traditional benzene ring structure, in order to improve the inhibitory activity against HDAC6 protein.

Benefits of technology

Some naphthyl chalcone compounds have shown good inhibitory effects on HDAC6 protein, and can significantly inhibit the proliferation of tumor cells, showing potential application prospects in the treatment of diseases related to abnormal expression of HDAC6 activity.

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Abstract

This invention discloses a naphthyl chalcone compound, its preparation method, and its application, relating to the field of medicinal chemistry. The structural formula of the naphthyl chalcone compound is shown below. This invention utilizes computer-aided drug design to obtain a series of naphthyl chalcone compounds, some of which exhibit good inhibitory effects on HDAC6 protein and can significantly inhibit the proliferation of tumor cells. These compounds can be used to develop tumor therapeutic drugs related to abnormal expression of HDAC6 activity.
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Citation Information

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