Trifluoro sucrose, preparation method thereof, atomizing matrix, electronic atomizing device and buccal product

Abstract

The invention discloses trifluorosucrose and a preparation method thereof, an atomization matrix, an electronic atomization device and a buccal product, and the preparation method comprises the following steps: in a first organic solvent, under the action of a first catalyst, sucralose and iodide are subjected to a first reaction to obtain triiodosucrose and chloride; in a second organic solvent, under the action of a second catalyst, triiodo sucrose and silver fluoride are subjected to a second reaction to obtain trifluorosucrose and silver iodide; wherein the reaction formula of the first reaction is as follows: nC12H19Cl3O8 + 3MIn-> nC12H19I3O8 + 3MCln; and the reaction formula of the second reaction is as follows: C12H19I3O8 + 3AgF to C12H19F3O8 + 3AgI. According to the preparation method of the trifluorosucrose, the trifluorosucrose can be prepared, compared with sucralose, the trifluorosucrose has better high temperature resistance, the sweetness of the trifluorosucrose is equivalent to that of the sucralose, and the trifluorosucrose can be used as a sweetening agent and is particularly suitable for application scenes in a high-temperature environment.

Description

Technical Field

[0001] This application relates to the fields of food or pharmaceutical technology, and in particular to a trifluorosucrose and its preparation method, an atomizing matrix, an electronic atomizing device, and oral products. Background Technology

[0002] Electronic atomizing devices are inhalation devices that mimic traditional tobacco products. They use electric heating, ultrasound, or other methods to atomize a matrix, producing an aerosol for the user to inhale. Compared to traditional tobacco products, electronic atomizing devices reduce the harm to users from harmful combustion byproducts such as tar, carbon monoxide, and acrolein. Therefore, electronic atomizing devices are increasingly favored by users. In addition to active ingredients (such as nicotine and / or nicotine derivatives), the atomizing matrix usually contains flavorings to improve taste. Sucralose, which is about 600 times sweeter than sucrose and participates almost entirely in metabolism, is mostly excreted unchanged (low in calories), and is therefore widely used in the food and pharmaceutical industries. Sucralose is also commonly used as a sweetener in atomizing matrices; however, sucralose is relatively unstable at high temperatures. When electronic atomizing devices are operating at high temperatures, sucralose may decompose to produce harmful substances, resulting in a poor taste and affecting the user experience. Summary of the Invention

[0003] This application provides a trifluorosucrose and its preparation method, a sweetener, an atomizing matrix, and a mouth-held product, to solve the problem that existing sweeteners are relatively unstable at high temperatures, which affects their function.

[0004] This application discloses a method for preparing trifluorosucrose, comprising: in a first organic solvent, under the action of a first catalyst, sucralose and iodide undergo a first reaction to obtain triiodosucrose and chloride; in a second organic solvent, under the action of a second catalyst, the triiodosucrose and silver fluoride undergo a second reaction to obtain trifluorosucrose and silver iodide; wherein, both the first organic solvent and the second solvent are aprotic polar solvents; the reaction formula for the first reaction is shown below: Formula 1: nC 12 H 19 Cl3O8+3MI n →nC 12 H 19 I3O8+3MCl n M is a metal ion or an organic quaternary ammonium ion; the reaction formula for the second reaction is shown below: Formula 2: C 12 H 19 I3O8 + 3AgF → C 12 H 19 F3O8+3AgI↓.

[0005] In one implementation of this application, the first organic solvent comprises at least one of the following: N,N-dimethylformamide, N,N-dimethylacetamide, dimethyl sulfoxide, sulfolane, acetonitrile, propionitrile, acetone, and dichloromethane; and / or, the second organic solvent comprises at least one of the following: N,N-dimethylformamide, N,N-dimethylacetamide, dimethyl sulfoxide, sulfolane, acetonitrile, propionitrile, acetone, and dichloromethane; and / or, the amount of the first organic solvent used is 5 ml to 20 ml of the first organic solvent per gram of sucralose. An organic solvent; and / or, the amount of the second organic solvent used is 5 ml to 20 ml of the second organic solvent per gram of the triiodinated sucrose; and / or, the first catalyst comprises at least one of the following: a quaternary ammonium salt compound, a crown ether compound; and / or, the molar ratio of the first catalyst to the triiodinated sucrose is 0.003 to 0.02; and / or, the second catalyst comprises a Lewis acid; and / or, the molar ratio of the second catalyst to the triiodinated sucrose is 0.001 to 0.005.

[0006] In one implementation of this application, the iodide includes at least one of the following: potassium iodide, sodium iodide, cesium iodide, lithium iodide, and tetrabutylammonium iodide; and / or, in the first reaction, the molar ratio of sucralose to the iodide is 1:5 to 9; and / or, in the second reaction, the molar ratio of sucralose triiodosucrose to silver fluoride is 1:5 to 9.

[0007] In one implementation of this application, the quaternary ammonium salt compound includes at least one of the following: trioctylmethylammonium chloride, tetramethylammonium chloride, tetrabutylammonium bromide, dodecyltrimethylammonium chloride, benzyltriethylammonium chloride; and / or, the crown ether compound includes at least one of the following: 18-crown-6, 15-crown-5, 12-crown-4; and / or, the Lewis acid includes at least one of the following: aluminum trichloride, ferric trichloride, titanium tetrachloride, dichlorobis(triphenylphosphine)palladium, tri(triphenylphosphine)rhodium chloride.

[0008] In one implementation of this application, the reaction temperature of the first reaction is 50°C to 80°C; and / or, the reaction temperature of the second reaction is 20°C to 30°C; and / or, the reaction time of the first reaction is 12 hours to 24 hours; and / or, the reaction time of the second reaction is 18 hours to 48 hours.

[0009] In one implementation of this application, the first reaction and / or the second reaction are carried out in an inert gas atmosphere, wherein the inert gas includes at least one of the following: nitrogen, helium, neon, argon, krypton, and xenon.

[0010] This application also discloses a trifluorosucrose, which is obtained by the preparation method described above.

[0011] This application also discloses a sweetener comprising sucrose trifluoroacetate as described above or sucrose trifluoroacetate prepared by the method described above.

[0012] This application also discloses an atomizing matrix comprising sucrose trifluoroacetate as described above, sucrose trifluoroacetate prepared by the method described above, or a sweetener as described above.

[0013] This application also discloses a mouth-sucking article comprising sucrose trifluoroacetate as described above, or sucrose trifluoroacetate prepared by the method described above, or a sweetener as described above.

[0014] The beneficial effects of this application are as follows:

[0015] This application provides a method for preparing sucralose. Sucralose has better high-temperature resistance than sucralose, and its sweetness is comparable to that of sucralose. As a sweetener, it is particularly suitable for applications in high-temperature environments. For example, it can be used as a component of an atomizing matrix to improve the user experience. Attached Figure Description

[0016] Figure 1 The nuclear magnetic resonance spectrum of a product of an embodiment of this application is shown.

[0017] Figure 2 The liquid chromatography-mass spectra of the product of an embodiment of this application are shown.

[0018] Figure 3 The thermogravimetric analysis results of sucralose are shown in the figure.

[0019] Figure 4 The thermogravimetric analysis results of trifluorosucrose are shown in the figure. Detailed Implementation

[0020] The present invention will now be described in further detail with reference to specific embodiments and accompanying drawings. In the following embodiments, many details are described to facilitate a better understanding of the present application. However, those skilled in the art will readily recognize that some features may be omitted in different situations, or may be replaced by other materials or methods. In some cases, certain operations related to the present application are not shown or described in the specification. This is to avoid obscuring the core parts of the present application with excessive description. For those skilled in the art, detailed description of these related operations is not necessary; they can fully understand the related operations based on the description in the specification and general technical knowledge in the art.

[0021] Furthermore, the features, operations, or characteristics described in the specification can be combined in any suitable manner to form various embodiments. At the same time, the steps or actions in the method description can be rearranged or adjusted in a manner obvious to those skilled in the art. Therefore, the various orders in the specification and drawings are only for the clear description of a particular embodiment and do not imply a necessary order, unless otherwise stated that a particular order must be followed.

[0022] The serial numbers assigned to components in this article, such as "first" and "second", are used only to distinguish the objects being described and have no sequential or technical meaning.

[0023] Currently, sucralose is frequently used as a sweetener in the field of electronic atomization devices. However, sucralose is unstable at high temperatures, while trifluorosucrose has a relatively higher bond energy and is more stable. Therefore, the use of trifluorosucrose as a sweetener could be considered. However, no literature on the synthetic route of trifluorosucrose has been found to date.

[0024] In view of this, this application provides a method for preparing sucralose, a sweetener, and an atomizing matrix, which utilizes the reaction of sucralose to generate sucralose, thereby obtaining a sweetener with higher stability and reducing its decomposition at high temperatures during the atomization process of the atomizing matrix.

[0025] In one specific embodiment, this application relates to a method for preparing trifluorosucrose (hereinafter sometimes simply referred to as the "preparation method").

[0026] In one specific embodiment, the preparation method includes: in a first organic solvent, sucralose and iodide undergo a first reaction to obtain sucralose triiodosucrose and chloride; in a second organic solvent, sucralose triiodosucrose and silver fluoride undergo a second reaction to obtain sucralose trifluoroethylene and silver iodide. The reaction formula for the first reaction can be as follows: nC 12 H 19 Cl3O8+3MI n →nC 12 H 19 I3O8+3MCl n The reaction equation for the second reaction can be shown below: C 12 H 19 I3O8 + 3AgF → C 12 H 19 F3O8 + 3AgI↓. It should be noted that in this application, the nucleophilicity of iodide ions is utilized to first convert sucralose to triiodose through a first reaction, and then the insolubility of silver iodide drives the second reaction (silver iodide (AgI) has an extremely high lattice energy (Ksp = 8.52 × 10⁻⁶)). -17 ( ), which has a much lower solubility in most solvents than silver fluoride (AgF), converts triiodose into trifluorosucrose.

[0027] In one specific embodiment, the first organic solvent is an aprotic polar solvent. It should be noted that an aprotic solvent refers to a solvent whose molecules do not contain protons (H+). + The hydrogen atoms in iodide ions cannot donate protons through hydrogen bonding, nor can they act as hydrogen bond donors. The polarity of these solvents primarily derives from the dipole moment of the molecules; they can dissolve polar compounds but do not form hydrogen bonds with the solute (or the bond is very weak). In the first reaction, iodide ions (I... - It has strong nucleophilicity and readily forms strong hydrogen bonds with proton solvents (such as water and alcohol). If a proton solvent is used, the solvent molecules will "wrap" the iodide ion, greatly reducing its activity and hindering the first reaction.

[0028] In one specific embodiment, the second organic solvent is an aprotic polar solvent.

[0029] In one specific embodiment, the first organic solvent includes at least one of the following: N,N-dimethylformamide, N,N-dimethylacetamide, dimethyl sulfoxide, sulfolane, acetonitrile, propionitrile, acetone, and dichloromethane. Thus, the first organic solvent can dissolve the reactants (sucralose and iodide) and also provide a favorable reaction environment for the first reaction.

[0030] In one specific embodiment, the second organic solvent includes at least one of the following: N,N-dimethylformamide, N,N-dimethylacetamide, dimethyl sulfoxide, sulfolane, acetonitrile, propionitrile, acetone, and dichloromethane.

[0031] In one specific embodiment, the first organic solvent and the second organic solvent may be the same or different. Thus, the second organic solvent can provide a reaction environment for the second reaction, and the product silver iodide is insoluble or only slightly soluble in the second solvent, which can facilitate the progress of the second reaction.

[0032] In one specific embodiment, the amount of the first organic solvent used is 5 to 20 milliliters per gram of sucralose. For example, the amount of the first organic solvent used can be 5, 8, 10, 12, 15, 18, or 20 milliliters per gram of sucralose. For instance, assuming the mass of sucralose used in the first reaction is 5g, the amount of the first organic solvent used can be 25 mL to 100 mL.

[0033] In one specific embodiment, the amount of the second organic solvent used is 5 to 20 ml per gram of sucrose. For example, the amount of the second organic solvent used can be 5, 8, 10, 12, 15, 18, or 20 ml per gram of sucrose. For instance, assuming the mass of sucrose used in the second reaction is 5 g, the amount of the second organic solvent used can be 25 mL to 100 mL.

[0034] In one specific embodiment, M is a metal ion or an organic quaternary ammonium ion.

[0035] In one specific embodiment, the iodide may include at least one of the following: potassium iodide, sodium iodide, cesium iodide, lithium iodide, and tetrabutylammonium iodide.

[0036] In one specific embodiment, the molar ratio (molar ratio) of sucralose to iodide in the first reaction is 1:5 to 9. For example, the molar ratio of sucralose to iodide in the first reaction can be 1:5, 1:6, 1:7, 1:8, or 1:9. Thus, an excess of iodide can facilitate the complete conversion of sucralose to triiodosucrose.

[0037] In one specific embodiment, in the second reaction, the molar ratio (molar ratio) of sucrose triiodide to silver fluoride is 1:2 to 9. For example, in the second reaction, the molar ratio of sucrose triiodide to silver fluoride can be 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, or 1:9. Thus, an excess of iodide can facilitate the complete conversion of sucrose triiodide to sucrose trifluorosulfonate.

[0038] In one specific embodiment, the first reaction is carried out under the conditions of a first catalyst.

[0039] In one specific embodiment, the first catalyst includes at least one of the following: a quaternary ammonium salt compound or a crown ether compound. It should be noted that the crown ether compound can react with metal cations (such as K+). + (etc.) form stable complexes through coordination, thereby enhancing the properties of fluorides (MF). n The nucleophilicity of fluorine promotes the substitution reaction of chlorine atoms in sucralose molecules by fluorine atoms. Quaternary ammonium compounds can act as phase transfer catalysts, enabling efficient reactions between nucleophiles and substrates in organic phases and promoting the reaction process.

[0040] In one specific embodiment, the quaternary ammonium salt compound includes at least one of the following: trioctylmethylammonium chloride, tetramethylammonium chloride, tetrabutylammonium bromide, dodecyltrimethylammonium chloride, and benzyltriethylammonium chloride.

[0041] In one specific embodiment, the crown ether compound includes at least one of the following: 18-crown-6, 15-crown-5, and 12-crown-4.

[0042] In one specific embodiment, the molar ratio of the first catalyst to sucralose in the first reaction is 0.003 to 0.02. For example, the molar ratio of the first catalyst to sucralose in the first reaction is 0.003, 0.005, 0.008, 0.01, 0.015, 0.018, or 0.02.

[0043] In one specific embodiment, the second reaction is carried out under the conditions of a second catalyst.

[0044] In one specific embodiment, the second catalyst comprises a Lewis acid. It should be noted that Lewis acids (electron docking acceptors) can lower the activation energy of the reaction and promote the second reaction by coordinating with iodine atoms (leaving groups) in the substrate or by interacting with fluoride ions (nucleophiles) in the fluoride.

[0045] In one specific embodiment, Lewis acid includes at least one of the following: aluminum trichloride, ferric trichloride, titanium tetrachloride, dichlorobis(triphenylphosphine)palladium [PdCl2(PPh3)2], and tri(triphenylphosphine)rhodium chloride [RhCl(PPh3)3].

[0046] In one specific embodiment, the molar ratio of the second catalyst to sucrose in the second reaction is 0.001 to 0.005. For example, the molar ratio of the second catalyst to sucrose in the second reaction is 0.001, 0.002, 0.003, 0.004, or 0.005.

[0047] In one specific embodiment, the first reaction can be carried out in an inert gas atmosphere. This helps to avoid interference from oxygen, moisture, etc., on the reaction.

[0048] In one specific embodiment, the second reaction can be carried out in an inert gas atmosphere. This helps to avoid interference from oxygen, moisture, etc., on the reaction.

[0049] In one specific embodiment, the inert gas includes at least one of the following: nitrogen, helium, neon, argon, krypton, and xenon.

[0050] In one specific embodiment, the reaction temperature of the first reaction is 50°C to 80°C. For example, the reaction temperature of the first reaction can be 50°C, 55°C, 60°C, 65°C, 70°C, 75°C, or 80°C.

[0051] In one specific embodiment, the reaction time of the first reaction is 12 to 24 hours. For example, the reaction time of the first reaction can be 12 hours, 16 hours, 18 hours, 20 hours, 22 hours, or 24 hours.

[0052] In one specific embodiment, the reaction temperature of the second reaction is 20°C to 30°C. For example, the reaction temperature of the second reaction can be 20°C, 21°C, 22°C, 23°C, 24°C, 25°C, 26°C, 27°C, 28°C, 29°C, or 30°C.

[0053] In one specific embodiment, the reaction time of the second reaction is 18 to 48 hours. For example, the reaction time of the second reaction can be 18 hours, 24 hours, 30 hours, 36 hours, 42 hours, or 48 hours.

[0054] In one specific embodiment, the first reaction is carried out under stirring. The stirring rate can be 10–150 rpm. This facilitates the complete progress of the reaction.

[0055] In one specific embodiment, the second reaction is carried out under stirring. The stirring rate can be 10–150 rpm. This facilitates the complete progress of the reaction.

[0056] In one specific embodiment, after the first reaction is completed, water can be added to the resulting reaction mixture to quench the reaction. Thus, the unreacted iodide can dissolve in water, a protic solvent, which helps to prevent the first reaction from continuing.

[0057] This application also provides a sweetener. The sweetener includes sucralose obtained by the above-described synthesis method. It should be noted that the sweetness of sucralose is close to that of sucralose, and sucralose has better heat resistance.

[0058] This application also provides an atomizing matrix. The atomizing matrix includes sucrose obtained by the above-described synthesis method; or, the atomizing matrix includes the above-described sweetener. An atomizing matrix refers to a substance used to carry and transport active ingredients during atomization, and refers to a reagent used to generate aerosols through atomization. In the field of electronic atomization, the atomizing matrix may include active ingredients, solvents, and flavoring agents. Active ingredients may include nicotine and / or nicotine derivatives. Solvents may include propylene glycol, glycerin, etc. Flavoring agents may include sweeteners, flavoring agents, cooling agents, etc. The atomizing matrix of this application contains sweeteners with higher thermal stability.

[0059] In one specific embodiment, the atomizing matrix can refer to the atomizing matrix of an electronic atomizing device. An electronic atomizing device is a device that can convert an atomizing matrix into an inhalable aerosol.

[0060] This application also provides an electronic atomizing device, which may include sucralose obtained by the above-described synthesis method; or, the electronic atomizing device may contain the above-described sweetener; or, the electronic atomizing device may include the above-described atomizing matrix. The electronic atomizing device of this application contains a sweetener with higher thermal stability.

[0061] This application also provides a lozenge. The lozenge may contain an active substance. For example, it can be a nicotine lozenge, which is a product containing nicotine and / or nicotine derivatives. The lozenge can be placed in the oral cavity in the form of powder, tablets, sachets, chewing gum, etc., where it dissolves and releases the active ingredient, which is absorbed through the oral mucosa. It has advantages such as precise dosage, rapid onset of action, and portability. Nicotine lozenges include nicotine lozenges, nicotine sachets, nicotine dissolving films, nicotine chewing gum, and other product forms.

[0062] In one specific embodiment, the active substance may be nicotine and / or nicotine derivatives. Nicotine may include natural nicotine and synthetic nicotine. Nicotine derivatives may include one or more of the following: nicotine salts, nicotine in a matrix such as a glycobase or an organometallic complex, nicotine-resin combinations, nicotine inclusion complexes, and non-covalently bound nicotine. Non-covalently bound nicotine includes nicotine lactate, nicotine malate, nicotine salicylate, nicotine cyclodextrin-encapsulated complexes, nicotine hydrochloride, nicotine dihydrochloride, nicotine tartrate, nicotine tartrate dihydrate, nicotine sulfate, nicotine zinc chloride, and nicotine benzoate. Nicotine derivatives also include nicotine containing substituents, such as one or more mixtures of hexamethylnicotine, hexamethylnicotine lactate, hexamethylnicotine malate, hexamethylnicotine salicylate, hexamethylnicotine cyclodextrin encapsulated complex, hexamethylnicotine hydrochloride, hexamethylnicotine dihydrochloride, hexamethylnicotine tartrate, hexamethylnicotine tartrate dihydrate, hexamethylnicotine sulfate, hexamethylnicotine zinc chloride, and hexamethylnicotine benzoate.

[0063] In one specific embodiment, the active substance may also be selected from other substances with medical or other specific uses, such as vitamins, capsaicin, caffeine, etc., to meet the needs of different users.

[0064] In one specific embodiment, the active substance may also be selected from other alkaloids or amino acids. For example, alkaloids such as tobacco, coffee, and tea.

[0065] The present application will be further described in detail below through specific experimental procedures and experimental data examples. The following examples are for further illustration only and should not be construed as limiting the present application. In these examples, unless otherwise specified, all reagents and instruments used are commercially available, and all experimental operations are performed in accordance with product instructions and standard experimental procedures.

[0066] (1) Preparation of trifluorosucrose:

[0067] Example 1:

[0068] Synthesis of triiodinated sucrose: 0.1 mol sucralose, 0.5 mol sodium iodide, and 0.001 mol 18-crown-6 were mixed in 200 mL of acetonitrile and heated to 50 °C. The mixture was stirred (50 rpm) for 24 hours, during which the degree of chlorine substitution was monitored by thin-layer chromatography (TLC). After the reaction was completed, the reaction mixture was cooled to room temperature and quenched with 200 mL of water. The organic phase was extracted with dichloromethane, dried, and then distilled to obtain crude triiodinated sucrose.

[0069] Synthesis of trifluorosucrose: The reaction must be carried out in an anhydrous environment using dichloromethane. 0.1 mol of synthesized triiodinated sucrose, 0.5 mol of silver fluoride, and 0.0002 mol of dichlorobis(triphenylphosphine)palladium [PdCl2(PPh3)2] were added to 200 mL of dichloromethane. The reaction was carried out at 25 °C with stirring (50 rpm) for 24 hours. The reaction progress could be monitored by thin-layer chromatography (TLC). After the reaction was complete, insoluble matter was removed by filtration, and the organic solvent was removed by vacuum distillation or rotary evaporation to obtain trifluorosucrose.

[0070] Example 2:

[0071] Compared with Example 1, the reaction temperature for the synthesis of triiodinated sucrose was 60°C and the reaction time was 18 hours; the reaction temperature for the synthesis of trifluorosucrose was 30°C and the reaction time was 18 hours; the rest were the same as in Example 1.

[0072] Example 3:

[0073] Compared with Example 1, the reaction temperature for the synthesis of triiodinated sucrose was 70°C and the reaction time was 12 hours; the reaction temperature for the synthesis of trifluorosucrose was 20°C and the reaction time was 48 hours; the rest were the same as in Example 1.

[0074] (2) Product structure identification, yield and purity analysis:

[0075] The structures of the products of each example were identified by nuclear magnetic resonance spectroscopy (NMR) and liquid chromatography-mass spectrometry (LC-MS). Figure 1The nuclear magnetic resonance spectrum of a product of one embodiment of this application is shown. Figure 2 The liquid chromatography-mass spectrometry (LC-MS) spectrum of a product of an embodiment of this application is shown, and the characterization results indicate that the product is trifluorosucrose.

[0076] Yield (%) = Mass of the target product actually obtained / Mass of the target product theoretically obtainable × 100%.

[0077] Purity (%) = Mass of target product / Total mass of product × 100%. The purity of the product was analyzed by liquid chromatography (HPLC) under the following conditions: HILIC column (4.6 mm × 250 mm, 5 μm); mobile phase: A phase: acetonitrile, B phase: water; gradient elution: starting from 80% A phase, linear transition to 50% A phase within 10-15 minutes; detector: ELSD (nebulization temperature: 40℃, evaporation temperature: 100℃, gas flow rate: 1.5 L / min); column temperature: 35℃; flow rate: 1.0 mL / min).

[0078] Analysis showed that the yield of Example 1 was 90.6% and the purity was 96.1%; the yield of Example 2 was 89.3% and the purity was 95.8%; and the yield of Example 3 was 91.2% and the purity was 96.8%.

[0079] (3) Sweetness analysis of sucrose:

[0080] Sensory testing was conducted, with different concentrations of sucralose and trifluorosucrose solutions prepared. Participants rinsed their mouths with pure water after each test, with a 30-second interval between tests. Results showed that sucralose was approximately 500 times sweeter than sucrose, and its sweetness was close to that of sucralose.

[0081] (4) Thermal stability analysis of sucralose and trifluorosucrose:

[0082] Thermogravimetric analysis (TGA) was performed on sucralose and trifluorosucrose at a heating rate of 10 °C / min, heating to 650 °C, and the mass changes at different temperatures were recorded. The results are as follows: Figure 3 and Figure 4 , Figure 3 The thermogravimetric analysis results of sucralose are shown in the figure. Figure 4 The thermogravimetric analysis results of trifluorosucrose are shown in the figure. Figure 3 and Figure 4 The solid line in the graph represents the thermogravimetric variation, and the dashed line represents the endothermic peak. It shows that sucralose exhibits a strong absorption peak near 143℃, indicating the breakage of the carbon-chlorine bond; sucralose exhibits a strong absorption peak at 184℃, also indicating the breakage of the carbon-fluorine bond. This suggests that sucralose has improved thermal stability compared to sucralose.

[0083] The above description, in conjunction with specific embodiments, provides a further detailed explanation of this application and should not be construed as limiting the specific implementation of this application to these descriptions. Those skilled in the art to which this application pertains can make several simple deductions or substitutions without departing from the concept of this application.

Claims

1. A method for preparing trifluorosucrose, characterized in that, include: In a first organic solvent, under the action of a first catalyst, sucralose and iodide react in a first reaction to yield sucralose triiodosucrose and chloride. In a second organic solvent, under the action of a second catalyst, the triiodose and silver fluoride undergo a second reaction to yield trifluorosucrose and silver iodide. Wherein, both the first organic solvent and the second solvent are aprotic polar solvents; The reaction formula for the first reaction is shown below: Formula 1: nC 12 H 19 Cl3O8+3MI n →nC 12 H 19 I3O8+3MCl n M is a metal ion or an organic quaternary ammonium ion; The reaction formula for the second reaction is shown below: Formula 2: C 12 H 19 I3O8 + 3AgF → C 12 H 19 F3O8+3AgI↓.

2. The preparation method according to claim 1, characterized in that, The first organic solvent includes at least one of the following: N,N-dimethylformamide, N,N-dimethylacetamide, dimethyl sulfoxide, sulfolane, acetonitrile, propionitrile, acetone, and dichloromethane; And / or, the second organic solvent comprises at least one of the following: N,N-dimethylformamide, N,N-dimethylacetamide, dimethyl sulfoxide, sulfolane, acetonitrile, propionitrile, acetone, and dichloromethane; And / or, the amount of the first organic solvent used is 5 ml to 20 ml of the first organic solvent per gram of sucralose; And / or, the amount of the second organic solvent used is 5 ml to 20 ml of the second organic solvent per gram of the triiodinated sucrose; And / or, the first catalyst comprises at least one of the following: quaternary ammonium salt compounds, crown ether compounds; And / or, the molar ratio of the first catalyst to the sucralose is 0.003 to 0.02; And / or, the second catalyst comprises a Lewis acid; And / or, the molar ratio of the second catalyst to the triiodose is 0.001 to 0.

005.

3. The preparation method according to claim 2, characterized in that, The quaternary ammonium salt compound includes at least one of the following: trioctylmethylammonium chloride, tetramethylammonium chloride, tetrabutylammonium bromide, dodecyltrimethylammonium chloride, and benzyltriethylammonium chloride; And / or, the crown ether compounds include at least one of the following: 18-crown-6, 15-crown-5, 12-crown-4; And / or, the Lewis acid includes at least one of the following: aluminum trichloride, ferric trichloride, titanium tetrachloride, dichlorobis(triphenylphosphine)palladium, and tri(triphenylphosphine)rhodium chloride.

4. The preparation method according to claim 1, characterized in that, The iodide includes at least one of the following: potassium iodide, sodium iodide, cesium iodide, lithium iodide, and tetrabutylammonium iodide; And / or, in the first reaction, the molar ratio of the sucralose to the iodide is 1:5 to 9; And / or, in the second reaction, the molar ratio of the triiodose sucrose to the silver fluoride is 1:5 to 9.

5. The preparation method according to claim 1, characterized in that, The reaction temperature of the first reaction is 50℃~80℃; And / or, the reaction temperature of the second reaction is 20℃~30℃; And / or, the reaction time of the first reaction is 12 hours to 24 hours; And / or, the reaction time of the second reaction is 18 to 48 hours.

6. The preparation method according to claim 1, characterized in that, The first reaction and / or the second reaction are carried out in an inert gas atmosphere, wherein the inert gas includes at least one of the following: nitrogen, helium, neon, argon, krypton, and xenon.

7. A type of sucrose, characterized in that, The trifluorosucrose is obtained by the preparation method according to any one of claims 1 to 6.

8. An atomizing matrix, characterized in that, It includes sucrose trifluoroacetate obtained by the preparation method according to any one of claims 1 to 6, or sucrose trifluoroacetate as described in claim 7.

9. An electronic atomizing device, characterized in that, It includes sucrose trifluoroacetate obtained by the preparation method according to any one of claims 1 to 6, or sucrose trifluoroacetate as described in claim 7, or atomizing matrix as described in claim 8.

10. A mouth-held product, characterized in that, The oral product comprises sucrose trifluoroacetate obtained by the preparation method according to any one of claims 1 to 6, or sucrose trifluoroacetate as described in claim 7.

Images