Lipstick containing medicinal and edible components and preparation method thereof

Abstract

The invention relates to a lipstick containing medicinal and edible components and a preparation method thereof. The lipstick comprises the following components in parts by weight: 2-3 parts of freeze-dried almond extract powder, 3-4 parts of freeze-dried angelica sinensis extract powder, 3-4 parts of freeze-dried coix seed extract powder, 1-2 parts of freeze-dried amomum cardamomum extract powder, 50-55 parts of matrix materials and 6-7 parts of auxiliary materials, the matrix is preferably selected from natural beewax and olive oil, and the auxiliary material comprises oil-soluble cochineal or vitamin E essential oil; the preparation method comprises the following steps: soaking decoction pieces, decocting with water, extracting, merging filtrate, decolorizing with activated carbon, concentrating under reduced pressure, freeze-drying to prepare superfine freeze-dried powder, mixing with molten matrix and auxiliary materials, filling into a mold, cooling and molding. The lipstick is stable, cold-resistant, heat-resistant and low in irritation, has the functions of moistening lips and treating the lips, can clear heat, promote diuresis and relieve swelling and pain for the spleen and stomach damp-heat type lips, and is safe and edible in components, convenient to use and easy to popularize.

Description

Technical Field

[0001] The present invention belongs to the field of cosmetics and relates to a lip balm containing components of both medicine and food and a preparation method thereof. Background Art

[0002] Liu Xi in the Eastern Han Dynasty said in his work "Shi Ming · Shi Xing Ti": "The lip is the edge, the edge of the mouth." As the front guard of the oral cavity, as the saying goes, "if the lips are gone, the teeth will be cold", and the protection provided by the lips to the oral cavity cannot be underestimated. As one of the important image organs of the face, the lips play an irreplaceable role in functions such as chewing, sucking, swallowing, speaking, and expressing emotions. A healthy lip should be pink, soft, moist, bright, and have a proper opening and closing, giving people a comfortable and amiable feeling. Therefore, the lips are considered an important point in evaluating a person's appearance and attitude towards life in interpersonal communication.

[0003] In recent years, the clinical prevalence rate of chronic cheilitis has been increasing year by year. Since this disease will affect appearance and diet, it will have a great impact on the physical and mental health and daily life of patients. At present, Western medicine is not clear about the etiology and pathogenesis of chronic cheilitis, and there is no exact and effective targeted treatment drug. Clinically, local use of hormones or antibiotics for external application, local block, or physical therapies such as cryotherapy, laser, and microwave are mainly used. Local application of glucocorticoid drugs can effectively reduce lip inflammation and exudation, but long-term use will cause side effects such as local mucosal atrophy and pigmentation, which are difficult to accept for patients with high requirements for aesthetics; treatments such as cryotherapy, laser, and microwave are expensive, and the long-term curative effect is unstable and easy to relapse. It can be seen that modern medical technology still has certain limitations in the process of treating lip diseases. Traditional Chinese medicine advocates "treating the disease by seeking the root cause" and focuses more on syndrome differentiation and treatment in treating diseases, and has more flexible and targeted treatment methods for many diseases.

[0004] Cheilitis, the traditional Chinese medicine name is lip wind, also known as "lip dry cracking", "Shen lip", "tight lip", "lip stock", "lip swelling", "lip sore", "donkey mouth wind", "donkey lip wind", etc. The main clinical features of this disease are dry cracking, repeated desquamation, swelling, itching, pain or exudation and crusting of the lips, which can affect the upper and lower lips, mostly the lower lip is more serious, and the condition recurs and can last for a long time without healing. Among them, the spleen-stomach damp-heat type of lip wind is characterized by dry and cracked lips with erosion, purulent blood, bad breath, thirst without desire to drink, constipation or loose stools, red urine, red tongue, yellow and greasy tongue coating, and slippery and rapid pulse.

[0005] Traditional Chinese medicine (TCM) is a complementary and alternative therapy that is gaining increasing attention both domestically and internationally, with satisfactory results. The application of Chinese herbal medicines in cosmetics is already widespread, and European and American countries are also beginning to value their use. The current global trend in cosmetics emphasizes green, environmentally friendly, and safe products while pursuing efficacy. Therefore, in the past decade or so, the use of mild yet effective Chinese herbal extracts as natural additives in cosmetics has become a hot topic in new product development. Adding Chinese herbal elements to traditional lip balms, specifically targeting the symptoms of spleen and stomach damp-heat type lip wind, allows for targeted treatment using corresponding Chinese herbs and preparations, reflecting the diagnostic and treatment characteristics of TCM. This approach can effectively treat lip wind patients, prevent recurrence, control the chronic and difficult-to-cure course of the disease, and truly solve a challenging clinical problem. At the same time, medicated lip balms also cater to the modern consumer's desire for convenience, speed, aesthetics, novelty, and comfort, making them easily accepted by patients and facilitating promotion.

[0006] In summary, this study combines traditional Chinese medicine with personal care products, integrating theory with practice, and has developed a novel lip balm that has both preventive and therapeutic effects, making it highly valuable for widespread application. Summary of the Invention

[0007] To address the shortcomings of existing technologies, this invention provides a lip balm containing ingredients that are both medicinal and edible, and a method for preparing the same.

[0008] To achieve the above objectives, the present invention adopts the following technical solution: a lip balm containing medicinal and edible ingredients, comprising the following components by weight:

[0009] 2-3 parts of freeze-dried almond extract powder;

[0010] 3-4 parts of freeze-dried Angelica sinensis extract powder;

[0011] 3-4 parts of freeze-dried coix seed extract powder;

[0012] 1-2 parts of freeze-dried white cardamom extract powder;

[0013] 50-55 parts of matrix material;

[0014] And 6-7 parts of auxiliary materials.

[0015] Preferably, the medicinal and edible component is an ultra-fine freeze-dried powder with a pore size of 90 micrometers (±4.6 micrometers) and a mesh size of 150 mesh.

[0016] Preferably, the excipients include at least one of oil-soluble carmine or vitamin E essential oil.

[0017] Preferably, the matrix material includes at least one of lanolin, natural beeswax, olive oil, camellia oil, shea butter, or petrolatum.

[0018] Preferably, the matrix material is natural beeswax and olive oil.

[0019] Preferably, the mass ratio of natural beeswax to olive oil is 167:100.

[0020] Preferably, the amount of oil-soluble carmine added is 5 parts by weight.

[0021] Preferably, the amount of vitamin E essential oil added is 50 mg by weight.

[0022] This invention also provides a method for preparing a lip balm containing ingredients that are both medicinal and edible, comprising the following steps:

[0023] 1) Soaking: Weigh out the almond slices according to the ratio, add 3 times the volume of purified water and soak; weigh out the coix seed slices according to the ratio, add 3 times the volume of purified water and soak; weigh out the angelica slices according to the ratio, add 3 times the volume of purified water and soak; weigh out the cardamom slices according to the ratio, add 3 times the volume of purified water and soak.

[0024] 2) Extraction: After soaking, the almond slices, coix seed slices, angelica slices, and cardamom slices were decocted separately, and the residue was filtered through a sieve to obtain the first extract. Three times the volume of water was added to the residue, and the decoctions were decocted separately again and filtered through a sieve to obtain the second extract. The two extracts of the four drugs were combined, and the decoction was poured into a pre-sterilized stainless steel sedimentation basin and allowed to stand to cool and settle. After sufficient sedimentation, the supernatant was taken and filtered through a stainless steel sieve. The filtrate was poured into a concentration container, activated carbon was added to the filtrate for decolorization, and then the solution was concentrated under low temperature and reduced pressure to obtain 280 ml. The concentrate was freeze-dried for 8 hours and then pulverized into an extremely fine freeze-dried powder to obtain the freeze-dried powder of the composition.

[0025] 3) Add base materials: Place natural beeswax in a beaker and heat it in a water bath to melt it. Then add olive oil and camellia oil and mix well. Then add vitamin E essential oil and oil-soluble carmine. After cooling, gradually add the ultra-fine freeze-dried powder of almond, coix seed, angelica and cardamom, and stir well to obtain lip balm liquid.

[0026] 4) Pouring into molds: Slowly pour the lipstick liquid into the pre-sterilized lipstick molds. Note that the liquid temperature should be maintained at 45-55℃ when pouring into the molds. After pouring into the molds, leave them open to allow water vapor to escape and cool naturally. After cooling completely, unmold, dispense, and cap.

[0027] 5) Demolding and Packaging: Remove the cooled and shaped lipstick from the mold and place it into a pre-sterilized medical PVC or medical PP lipstick box. Cover the box, affix a label, and store it upright in a cool, dark place.

[0028] Preferably, the base is refined before lipstick preparation to remove impurities and excess moisture, and to kill microorganisms and enzymes.

[0029] Preferably, in step 1), 10 parts of almond extract, 6 parts of cardamom extract, 18 parts of coix seed extract, and 14 parts of angelica extract are weighed and soaked for 4 hours; the concentration of the concentrated solution is 1g / ml.

[0030] Further, in step 1), weigh out 20g of almonds, 36g of coix seed, 28g of angelica root, and 12g of white cardamom, and soak them for 4 hours;

[0031] Preferably, in step 2), the decoction is simmered for 1 hour to obtain 150 ml of the first extract, and then simmered again for 1 hour to obtain 150 ml of the second extract; the supernatant is then filtered through an 80-100 mesh stainless steel sieve.

[0032] Preferably, in step 3), take 50g of natural beeswax, mix it with 20ml of olive oil, and then add one vitamin E essential oil and oil-soluble carmine.

[0033] The beneficial effects of this invention are:

[0034] 1) The appearance has a good gloss and is brownish-yellow. There are no bubbles on the surface. A small amount of uniform and extremely fine freeze-dried Chinese medicine powder particles can be seen in the paste. However, there is no discomfort when using it, no oil stains spread, and the properties are stable. It effectively and evenly preserves the medicinal and food homologous components.

[0035] 2) It has a moderate consistency, is resistant to cold and heat, has low skin irritation, is non-allergenic, contains no drug-derived pigments, is safe to consume without risk, and has appropriate cosmetic properties, which can cover up unhealthy lip conditions.

[0036] 3) The paste is stable under dynamic conditions without deformation or layering; the preparation method is freeze-drying to ensure the concentration and quality of the medicinal and edible components. Under this technology, the decomposition rate and loss rate of the active ingredients of the medicinal and edible components in the lipstick can be minimized, thereby ensuring its effective bioavailability.

[0037] 4) The main active ingredients in commercially available lip balms are beeswax, petrolatum, vitamins, and other oils. This invention uses natural Chinese herbal medicines as active ingredients. Compared to lip balms containing antibiotics and hormones, which require subsequent laser treatments and are prone to relapse after discontinuation, and can cause adverse reactions such as pigmentation, local skin atrophy, and drug dependence with long-term use, the medicinal and edible components of this invention not only have fewer side effects in the adjunctive treatment of lip eczema, but also act directly on the affected skin lesions, making it highly targeted. Long-term use can nourish the affected lip area, eliminate pigmentation, reduce the probability of scar formation, and lower the probability of recurrence of lip eczema, making it gentler on the human body.

[0038] This invention uses ingredients that are both medicinal and edible as active ingredients, reducing the amount of oil added. The formulation is simple, yet it treats both the symptoms and the root cause, achieving the effects of clearing heat and dampness, reducing swelling and relieving pain. It can effectively alleviate many symptoms such as swelling, pain, exudation, and erosion caused by spleen and stomach damp-heat type lip wind, thus playing a very good therapeutic role in spleen and stomach damp-heat type lip wind. Moreover, all the drugs can be used as both medicine and food, making it safe, effective, and easily accepted by patients. The lip balm of this invention also meets the modern people's pursuit of convenience, speed, beauty, novelty, and comfort, and has strong promotion potential. Attached Figure Description

[0039] Figure 1 This is a picture of the actual lipstick product.

[0040] Figure 2 This is a flowchart of the preparation process. Detailed Implementation

[0041] The present invention will be further described below through specific embodiments. To make the inventive objectives, technical solutions, and beneficial technical effects of the present invention clearer, the present invention will be further described in detail below with reference to the embodiments. It should be understood that the embodiments described in this specification are merely for explaining the present invention and are not intended to limit the present invention.

[0042] Experimental tools and materials

[0043] TD5102 electronic balance, manufactured by Tianjin Tianma Instrument Factory;

[0044] Medical casserole, models 17, 18, and 19, manufactured by Shanxi Pingding Liangjingjing Casserole Co., Ltd.

[0045] Model 202-00A Vacuum Freeze Drying Oven, manufactured by Senya Experimental Instrument Wholesale Center;

[0046] The lipstick molds are made of glass, which are stable and easy to clean. The lipstick containers (commercially available) are made of medical-grade PVC (polyvinyl chloride), medical-grade PP (polypropylene), constant temperature water bath, Chinese medicine liquid dispensing bags, filters, and activated carbon, all of which are commercially available.

[0047] The prepared slices of Chinese medicinal herbs were purchased from Chenyu Chinese Medicinal Materials Co., Ltd.; the oil-soluble carmine was purchased from Foshan Kangneng Biotechnology Co., Ltd.

[0048] In addition, all materials and reagents used in the examples are commercially available or synthesized using conventional methods and can be used directly without further processing, and the instruments used in the examples are also commercially available.

[0049] Experimental methods:

[0050] (1) Appearance stability check

[0051] Observe whether the gloss of the lipstick is good, the color of the lipstick, the amount of bubbles on the surface, and whether the texture of the lipstick is uniform; take a small amount of the finished lipstick and apply it to a tissue to observe whether there is any oil stain spreading; observe how comfortable it is to apply and whether there is any obvious graininess.

[0052] (2) Lipstick consistency measurement

[0053] Referring to the consistency determination method for ointments, at room temperature of 20℃, a 15g, 25cm long glass rod was vertically fixed 5.5cm above a horizontal tabletop. An appropriate amount of lipstick liquid (not yet in a mold, with the base and liquid in optimal ratio) was poured into a glass beaker. After the lipstick cooled and set in the beaker, it was placed under the glass rod. In each experiment, the distance between the end of the glass rod and the surface of the lipstick was kept consistent. The glass rod was then released and dropped vertically into the lipstick. After 5 seconds, the glass rod was removed, and the insertion depth was measured.

[0054] The standard is that the deeper the insertion, the lower the sample consistency, and vice versa, the lower the insertion depth, thus evaluating the consistency of the lipstick.

[0055] To ensure accurate determination of lipstick consistency, the lipsticks to be tested will be placed at room temperature of 20°C for 1 day, 5 days, 10 days, 15 days, and 30 days, and then consistency tests will be conducted on each test to obtain more accurate experimental results.

[0056] (3) Lipstick spreadability test

[0057] Take 1g of the finished lipstick and spread it evenly on the bottom of a 100g weight with a diameter of 2.6cm. Gently place the weight on the upper part of a glass plate at a 30° angle, allowing the lipstick to spread on the glass plate under the pressure of the weight until the bottom of the weight is completely covered. Measure the spreading distance; the shorter the distance, the worse the spreading performance, and vice versa.

[0058] Considering that the lipstick sample is ultimately applied to the human lips, which are relatively dry and smooth with low permeability, a clean, smooth glass plate was selected as the tool for testing the spreadability of the lipstick.

[0059] (4) Light Illumination Experiment

[0060] Take an appropriate amount of sample and place it in a colorless, transparent, sealed container. Illuminate the container under a light intensity of 3000 lx and observe the color change at 1, 4, 7, and 10 days. If no significant color change occurs within 10 days, the sample quality is considered stable.

[0061] (5) Cold and heat resistance tests

[0062] 10g of sample was evenly poured into the lipstick case and placed in a 45℃ constant temperature incubator for 6 hours and a -16℃ refrigerator for 24 hours for observation. The results showed that the lipstick did not leak water, deform, or separate, indicating stable quality.

[0063] (6) Centrifugation experiment

[0064] A lipstick sample was taken and centrifuged for 15 minutes. The sample showed no deformation or layering, indicating that the centrifugation test was successful. A miniature medical exfoliator was then used, with the speed set to 10,000 rpm, to conduct the centrifugation experiment and obtain the results.

[0065] (7) Safety and lip moisturizing effect experiment

[0066] The study was conducted using a single-blind, parallel-controlled method. Clinical trial subjects were selected strictly according to the inclusion and exclusion criteria of this study. Under the premise of adhering to medical ethics, a controlled experiment was conducted with the standard group using the lip balm of this invention, the positive control group using erythromycin ointment, and the blank control group using petroleum jelly lip balm. The lip balm underwent acute skin toxicity tests, skin irritation tests, sensitization tests, and drug-induced pigmentation tests. Based on the results and data of each experiment, the safety of the ingredients of Lanyu Lip Balm was evaluated.

[0067] Sampling criteria for experimental subjects: Western medicine diagnostic criteria (referring to the diagnostic criteria for "chronic cheilitis" in "Integrated Traditional Chinese and Western Medicine Oral Mucosal Diseases"): recurrent course of disease, sometimes mild and sometimes severe, more common in cold and dry seasons. Symptoms include dry, peeling, painful, swollen, itchy, oozing, and crusting lips.

[0068] The TCM diagnostic criteria (referring to the "Standards for Diagnosis and Efficacy of TCM Diseases and Syndromes" promulgated by the State Administration of Traditional Chinese Medicine in 1994) conform to the characteristics of spleen and stomach damp-heat syndrome: red and swollen lips, dry and cracked with oozing, easy bleeding, burning pain, as if skinless, scabbing and itching. Dry mouth and tongue, red tongue with little saliva, thin tongue coating, and thready and rapid pulse.

[0069] Six Kunming mice (half male and half female), aged 0-2 weeks and weighing 25-30g, were used as experimental subjects. The product number was A11100_001, purchased from Jilin Jintai Meidi Biotechnology Co., Ltd., at a unit price of 17 yuan per mouse. Before the experiment, the mice were kept in cages and fed for 3-5 days. 45 minutes before the formal drug administration, different amounts of xylene were applied to the mice's ears to simulate human lip inflammation. The mice were then grouped and the results were measured.

[0070] The usage method is as follows:

[0071] The standard group used the lip balm of this invention applied to the affected area twice a day, morning and evening. All three groups underwent a 7-day treatment course. The lip-moisturizing effect was compared based on the recovery status of ear inflammation in mice.

[0072] Observation indicators:

[0073] Since there is currently no universally accepted diagnostic standard for chronic cheilitis, this study has developed its own standard.

[0074] Observation indicators: Symptoms such as pain, dryness, itching, congestion, swelling, scaling, and erosion were observed before and after treatment. A 5-point scoring method was used to quantify these symptoms in the experimental subjects.

[0075] Level 0 (0 points): No symptoms of discomfort;

[0076] Grade 1 (1 point): Mild pain, dry lips with itching, no congestion, swelling, erosion, or scaling;

[0077] Grade 2 (2 points): The main symptoms are congestion, swelling, pain, and a small amount of scaling, without erosion;

[0078] Grade 3 (3 points): Excessive scaling, erosion surface less than 2mm, accompanied by ulceration and purulent discharge, pain, and affecting diet;

[0079] Grade 4 (4 points): Scales are present throughout the entire area, and the erosion area is greater than 2 mm but less than half of the area;

[0080] Level 5 (5 points): Pain, scales all over the lips, and large areas of erosion.

[0081] Evaluation criteria:

[0082] ①Cure: Skin lesions completely disappear, symptoms are alleviated, and the index is ≥95%;

[0083] ②Significant effect: Most skin lesions subside, symptoms are significantly relieved, 95% > index ≥ 60%;

[0084] ③ Effective: Skin lesions partially subside, symptoms improve, 60% > index ≥ 20%;

[0085] ④ Ineffective: Skin lesions do not subside significantly, symptoms do not improve or even worsen, index <20%.

[0086] Index = (Pre-use rating - Post-use rating) / Pre-use rating × 100%;

[0087] Example 1:

[0088] Preparation steps: Weigh out 20g of almonds, 36g of coix seeds, 28g of angelica root, and 12g of cardamom.

[0089] 1) Soaking: Add 3 times the volume of purified water to almond slices and soak; add 3 times the volume of purified water to coix seed slices and soak; add 3 times the volume of purified water to angelica root slices and soak; add 3 times the volume of purified water to cardamom seed slices and soak.

[0090] 2) Extraction: After soaking, the almond slices, coix seed slices, angelica slices, and cardamom slices were decocted separately, and the residue was filtered through a sieve to obtain the first extract. Three times the volume of water was added to the residue, and the decoction was repeated. After filtration, the second extract was obtained. The two extracts of the four drugs were combined, and the decoction was poured into a pre-sterilized stainless steel sedimentation basin and allowed to stand to cool and settle. After sufficient sedimentation, the supernatant was collected, filtered through a stainless steel sieve, and the filtrate was poured into a concentration container. Activated carbon was added to the filtrate for decolorization, and then the solution was concentrated under low temperature and reduced pressure to obtain 280 ml of concentrate with a concentration of 1 g / ml. The concentrate was freeze-dried for 8 hours and then pulverized into an extremely fine freeze-dried powder to obtain the freeze-dried powder of the composition.

[0091] 3) Add matrix material:

[0092] Take 50g of natural beeswax as a base. Melt the beeswax in a beaker using a water bath. Mix it with 20ml of olive oil and 10ml of camellia oil. Then add one vitamin E capsule (50mg) and oil-soluble carmine. After slightly cooling, gradually add a finely freeze-dried powder of a traditional Chinese medicine combination of almond, coix seed, angelica, and cardamom, and stir until well mixed to obtain the lip balm liquid.

[0093] 4) Molding: Slowly pour the lipstick liquid into the pre-sterilized lipstick mold. Note that the liquid temperature should be kept at 50℃ when pouring into the mold. After pouring into the mold, leave it open to allow water vapor to escape and cool naturally. After it has cooled completely, unmold, dispense, and cap it. It is temporarily named Lanyu Lip Wind Lipstick.

[0094] The finished product, with an average weight of 7g per lipstick in the same batch, contains 15% medicinal powder, or 1.05g of medicinal powder, including 0.2205g of almond extract freeze-dried powder, 0.3045g of angelica extract freeze-dried powder, 0.39375g of coix seed extract freeze-dried powder, 0.13125g of cardamom extract freeze-dried powder, 3.31g of natural beeswax, 0.66g of carmine, and 1.98g of olive oil.

[0095] Comparative Example 1: Lanolin as a Single Matrix Material

[0096] Lanolin was melted in a water bath in a beaker. After cooling slightly, a fine freeze-dried powder of a traditional Chinese medicine combination of almonds, coix seeds, angelica, and cardamom was gradually added and stirred evenly to obtain lipstick liquid. The lipstick liquid was slowly poured into a pre-sterilized lipstick mold and allowed to cool naturally. After it had cooled completely, it was unmolded, packaged, and capped to produce lipstick No. 1.

[0097] Comparative Example 2: Natural Beeswax as a Single Matrix Material

[0098] Natural beeswax is melted in a water bath in a beaker. After slightly cooling, a fine freeze-dried powder of a traditional Chinese medicine combination of almonds, coix seeds, angelica, and cardamom is gradually added and stirred evenly to obtain lipstick liquid. The lipstick liquid is then slowly poured into a pre-sterilized lipstick mold and allowed to cool naturally. After it has cooled completely, it is unmolded, packaged, and capped, resulting in Lipstick No. 2.

[0099] Comparative Example 3: Olive Oil as a Single Matrix Material

[0100] After placing olive oil in a beaker, gradually add the ultra-fine freeze-dried powder of the Chinese herbal combination of almonds, coix seeds, angelica, and cardamom, and stir evenly to obtain lipstick liquid. Slowly pour the lipstick liquid into a pre-sterilized lipstick mold, let it cool naturally, and after it has cooled completely, unmold, dispense, and cap it to obtain lipstick No. 3.

[0101] Comparative Example 4: Single Matrix Material Shea Butter

[0102] Shea butter is placed in a beaker and heated in a water bath to melt it. After slightly cooling, a fine freeze-dried powder of a traditional Chinese medicine combination of almond, coix seed, angelica, and cardamom is gradually added and stirred evenly to obtain lipstick liquid. The lipstick liquid is slowly poured into a pre-sterilized lipstick mold, allowed to cool naturally, and then unmolded, packaged, and capped to produce lipstick No. 4.

[0103] Comparative Example 5: Vaseline as a single matrix material

[0104] Place Vaseline in a beaker and heat it in a water bath to melt it. After slightly cooling, gradually add the ultra-fine freeze-dried powder of the Chinese herbal combination of almonds, coix seeds, angelica, and cardamom, and stir evenly to obtain lipstick liquid. Slowly pour the lipstick liquid into a pre-sterilized lipstick mold, let it cool naturally, and after it has cooled completely, unmold, dispense, and cap it to obtain lipstick No. 5.

[0105] The above experiments were performed on Example 1 and Comparative Examples 1-5, and the results are shown in the table below:

[0106] Acute dermal toxicity experiment Skin irritation experiment Sensitization experiment Drug-induced pigmentation Recovery status Example 1 Safe Safe Safe No 99% Comparative Example 1 Safe Safe Mildly allergenic No 78% Comparative Example 2 Safe Safe Safe No 88% Comparative Example 3 Safe Safe Safe No 90% Comparative Example 4 Safe Safe Mildly allergenic No 79% Comparative Example 5 Safe Safe Safe No 83%

[0107] For comparisons of other texture stability, Example 1 was named Lanyu Lip Wind Lipstick, and Comparative Example 3 was named Traditional Chinese Medicine Liquid Lipstick. The results are as follows:

[0108] Lanyu Lip Balm: Its appearance shows good gloss and a brownish-yellow color. No bubbles appear on the surface, and a small amount of fine, evenly distributed freeze-dried herbal powder particles are visible in the balm. There is no discomfort. A small amount of the lip balm was then applied to a tissue, and no oil stains were observed.

[0109] Take an appropriate amount of Lanyu Lipstick liquid and pour it into a glass beaker. After the liquid has cooled and set in the beaker, place it under a glass rod. Keep the distance between the end of the glass rod and the surface of the liquid 15cm, release the glass rod and drop it vertically into the liquid. After 5 seconds, remove the glass rod and measure the insertion depth. Repeat this process 3 times and take the average value to obtain the consistency of Lanyu Lipstick as 3mm.

[0110] Take 1g of Lanyu Lipstick and spread it evenly on the bottom of a 100g weight with a diameter of 2.6cm. Gently place the weight on the upper part of a glass plate at a 30° angle, allowing the lipstick to spread on the glass plate under the pressure of the weight until the bottom of the weight is completely covered. The spread of the Lanyu Lipstick is 3.8cm.

[0111] A small amount of the finished Lanyu Chunfeng lipstick was placed in a colorless, sealed container and exposed to natural light for 1, 4, 7, and 10 days to observe the changes and ensure stability.

[0112] The prepared Lanyu Lip Wind lipsticks were placed in a 45℃ constant temperature chamber for 6 hours and in a -16℃ refrigerator for 24 hours for observation. The lipsticks showed no softening or cracking, indicating that the cold and heat resistance tests were qualified.

[0113] After centrifuging the Lanyu Chunfeng lipstick sample for 15 minutes, the lipstick showed no deformation or layering, indicating that the centrifugation test was qualified.

[0114] The traditional Chinese medicine liquid lipstick exhibits good gloss and a brownish-yellow color, slightly lighter than the Lanyu Lip Feng lipstick. No bubbles appear on the surface, and the translucency is slightly higher than that of the Lanyu Lip Feng lipstick. A small amount of the finished lipstick was applied to a tissue, and slight oil stains were observed spreading, with the outer edge of the oil stains 1mm from the outer edge of the lipstick. The consistency of the traditional Chinese medicine liquid lipstick is 5mm, and its spreadability is 3.4cm. A small amount of the finished traditional Chinese medicine liquid lipstick was placed in a colorless, sealed container and exposed to natural light for 1, 4, 7, and 10 days, and observed to ensure stability. The prepared traditional Chinese medicine liquid lipstick was placed in a 45℃ constant temperature incubator for 6 hours and in a -16℃ refrigerator for 24 hours. The lipstick showed slight softening in the 45℃ incubator without cracking. After centrifugation for 15 minutes, the traditional Chinese medicine liquid lipstick sample showed slight oil-water separation.

[0115] In summary, the lipstick of this invention has a good gloss and is brownish-yellow in color. There are no bubbles on the surface. A small amount of uniform and extremely fine freeze-dried Chinese medicine powder particles can be seen in the lipstick. However, it does not cause any discomfort when used, and there is no oil stain diffusion. It is stable in nature, effectively and evenly retains the medicinal and edible homologous components, has a moderate consistency, is cold and heat resistant, and has strong stability. It is significantly superior to similar lipstick products on the market.

[0116] Note: During the preparation process, it was found that the initial process of preparing Lanyu Chunfeng lipstick (sample) was simple; at the same time, the medicinal liquids of the parallel comparison samples were all boiled, decolorized and filtered in the same batch, which minimized the difference in raw materials between the comparison samples.

[0117] Based on the above experiments and data verification, it can be seen that the Lanyu Chunfeng lipstick (sample) provided by this invention has certain advantages over traditional Chinese medicine liquid clear lipstick (sample) in terms of appearance stability, lipstick spreadability, lipstick consistency, lipstick stability under light, cold and heat resistance, and centrifugation conditions.

[0118] The above description of the disclosed embodiments enables those skilled in the art to make or use the invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the invention. Therefore, the invention is not to be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A lip balm containing ingredients that are both medicinal and edible, characterized in that, By weight, it contains the following components: 2-3 parts of freeze-dried almond extract powder; 3-4 parts of freeze-dried Angelica sinensis extract powder; 3-4 parts of freeze-dried coix seed extract powder; 1-2 parts of freeze-dried white cardamom extract powder; 50-55 parts of matrix material; And 6-7 parts of auxiliary materials.

2. The lip balm containing medicinal and edible ingredients according to claim 1, characterized in that, The medicinal and edible components are ultra-fine freeze-dried powders with a pore size of 85-95 micrometers and a mesh size of 150 mesh.

3. The lip balm containing medicinal and edible ingredients according to claim 1, characterized in that, The excipients include at least one of the following: oil-soluble carmine or vitamin E essential oil.

4. A lip balm containing medicinal and edible ingredients according to claim 1, characterized in that, The base material includes at least one of lanolin, natural beeswax, olive oil, camellia oil, shea butter, or petrolatum.

5. A lip balm containing a medicinal and edible ingredient according to claim 4, characterized in that, The base materials are natural beeswax and olive oil.

6. A lip balm containing a medicinal and edible ingredient according to claim 5, characterized in that, The mass ratio of natural beeswax to olive oil is 167:

100.

7. A lip balm containing medicinal and edible ingredients according to claim 3, characterized in that, The amount of oil-soluble carmine added, by weight, is 5 parts.

8. A lip balm containing a medicinal and edible ingredient according to claim 3, characterized in that, The amount of vitamin E essential oil added, by weight, is 50 mg.

9. A method for preparing a lip balm containing a medicinal and edible ingredient as described in any one of claims 1-8, characterized in that, Includes the following steps: 1) Soaking: Weigh out the almond slices according to the ratio, add 3 times the volume of purified water and soak; weigh out the coix seed slices according to the ratio, add 3 times the volume of purified water and soak; weigh out the angelica slices according to the ratio, add 3 times the volume of purified water and soak; weigh out the cardamom slices according to the ratio, add 3 times the volume of purified water and soak. 2) Extraction: After soaking, the almond slices, coix seed slices, angelica slices, and cardamom slices were decocted separately, and the residue was filtered through a sieve to obtain the first extract. Three times the volume of water was added to the residue, and the decoctions were decocted separately again and filtered through a sieve to obtain the second extract. The two extracts of the four drugs were combined, and the decoction was poured into a pre-sterilized stainless steel sedimentation basin and allowed to stand to cool and settle. After sufficient sedimentation, the supernatant was taken and filtered through a stainless steel sieve. The filtrate was poured into a concentration container, activated carbon was added to the filtrate for decolorization, and then the solution was concentrated under low temperature and reduced pressure to obtain a concentrated solution. The concentrated solution was freeze-dried for 8 hours and then pulverized into an extremely fine freeze-dried powder to obtain the freeze-dried powder of the composition. 3) Add base materials: Place natural beeswax in a beaker and heat it in a water bath to melt it. Then add olive oil and camellia oil and mix well. Then add vitamin E essential oil and oil-soluble carmine. After cooling, gradually add the ultra-fine freeze-dried powder of almond, coix seed, angelica and cardamom, and stir well to obtain lip balm liquid. 4) Pouring into molds: Slowly pour the lipstick liquid into the pre-sterilized lipstick molds. Note that the liquid temperature should be maintained at 45-55℃ when pouring into the molds. After pouring into the molds, leave them open to allow water vapor to escape and cool naturally. After cooling completely, unmold, dispense, and cap. 5) Demolding and Packaging: Remove the cooled and shaped lipstick from the mold and place it into a pre-sterilized medical PVC or medical PP lipstick box. Cover the box, affix a label, and store it upright in a cool, dark place.

10. A method for preparing a lipstick containing ingredients that are both medicinal and edible, as described in claim 9, characterized in that, In step 1), weigh out 10 portions of almond slices, 6 portions of white cardamom slices, 18 portions of coix seed slices, and 14 portions of angelica slices, and soak them for 4 hours; the concentration of the concentrated solution is 1g / ml; In step 2), the decoction is 1 hour to obtain 150 ml of the first extract. The decoction is then 1 hour to obtain 150 ml of the second extract. The supernatant is then filtered through an 80-100 mesh stainless steel sieve. In step 3), take 50g of natural beeswax, mix it with 20ml of olive oil, and then add vitamin E essential oil and oil-soluble carmine.

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