Veterinary drug mixing production line and production method

Abstract

The veterinary drug mixing production line comprises an auxiliary material manufacturing module, a preliminary mixing module and a high-speed shearing mixing module, the auxiliary material manufacturing module comprises an auxiliary material tank and an auxiliary material stirring driving part, an auxiliary material inlet and an auxiliary material outlet are formed in the auxiliary material tank, and the auxiliary material stirring driving part is arranged on the auxiliary material tank and used for stirring auxiliary materials; the primary mixing module comprises a main material tank body, a main material stirring driving part and an auxiliary material extracting part, a main material inlet and a main material discharging pipe are arranged on the main material tank body, and the auxiliary material extracting part is used for connecting the auxiliary material outlet with the main material tank body and extracting auxiliary materials into the main material tank body; the main material stirring driving part is arranged on the main material tank body and is used for primarily stirring a mixed medicament of the auxiliary material and the main material; the high-speed shearing module comprises a shearing tank body and a shearing assembly, a shearing feeding opening is formed in the shearing tank body, the main material discharging pipe is connected with the shearing feeding opening, and the shearing assembly is used for conducting high-speed shearing on the mixed medicament so that solvent particles of the mixed medicament can reach the required size.

Description

Technical Field

[0001] This invention relates to the technical field of veterinary drug production, and in particular, to a veterinary drug mixing production line and production method. Background Technology

[0002] For veterinary drug production, whether it is Western or traditional Chinese medicine, the production process usually involves mixing and proportioning multiple materials in a tank. Existing production lines add multiple materials into the tank and then continuously stir to ensure that the materials are mixed evenly. After the mixture is evenly mixed, the drug is then filled into the container.

[0003] However, the above method has significant drawbacks. Whether the various raw materials in the tank are completely and evenly mixed, and whether the content of each component meets the standards after mixing, is unknown. Furthermore, if the raw materials added to the tank become damp and clump together, it will directly affect the content of each component and the uniformity of the material ratio, thus affecting the accuracy of the final composition of the veterinary drug powder during production. Moreover, to ensure good absorption of the drug, the solvent particles in the drug need to be below 5 micrometers to ensure rapid absorption after injection. Existing direct mixing methods often present the following problems: 1. It is difficult to completely and evenly mix the various raw materials; 2. The particle size of the mixed drug solution is difficult to meet the production requirement of 5 micrometers. Summary of the Invention

[0004] This invention provides a high-speed shearing machine to solve the technical problem of how to control the uniformity of drug mixing and the drug particles in the liquid.

[0005] According to the present invention, a veterinary drug mixing production line includes an excipient preparation module, a preliminary mixing module, and a high-speed shear mixing module. The excipient preparation module includes an excipient tank and an excipient stirring drive. The excipient tank has an excipient inlet and an excipient outlet. The excipient stirring drive is disposed on the excipient tank for stirring the excipients. The preliminary mixing module includes a main material tank, a main material stirring drive, and an excipient extraction component. The main material tank has a main material inlet and a main material outlet pipe. The excipient extraction component connects the excipient outlet to the main material tank and... The well-mixed excipients are extracted into the main material tank. The main material stirring drive is installed on the main material tank for preliminary mixing of the excipients and main material. The high-speed shearing module includes a shearing tank and a shearing assembly. The shearing tank has a shearing inlet, and the main material outlet pipe has a main material extraction component. The first end of the main material outlet pipe extends into the main material tank, and the second end of the main material outlet pipe is connected to the shearing inlet. The shearing assembly is used to perform high-speed shearing on the mixed agent to make the solvent particles of the mixed agent reach the required size.

[0006] Furthermore, the auxiliary material tank is also equipped with a heating pipe for heating the auxiliary material, which is used to introduce high-temperature steam into the auxiliary material tank.

[0007] Furthermore, the shearing tank includes an outer tank and an inner tank. The shearing assembly includes a first shearing member, a second shearing member, and a third shearing member for shearing particles, a drive motor, and a transmission shaft. The drive motor is connected to the transmission shaft and drives the transmission shaft to rotate at high speed. The transmission shaft is coaxially arranged with the shearing tank. The size of the particles sheared by the first shearing member, the second shearing member, and the third shearing member is progressively smaller and they are all connected to the transmission shaft and are arranged at intervals along the length of the transmission shaft. The first shearing member, the outer tank, and the inner tank enclose a first working chamber. The first shearing member, the second shearing member, and the inner tank enclose a second working chamber. The second shearing member, the third shearing member, and the inner tank enclose a third working chamber. The shearing inlet is located on the outer tank and communicates with the first working chamber. The outer tank has a shearing outlet that communicates with the third working chamber.

[0008] Furthermore, the outer tank and the inner tank are spaced apart to form cooling channels. The rapid shear mixing module also includes a cooling mechanism, which includes a water storage tank, an inlet pipe, an outlet pipe, and a cooling water pipe. The water storage tank is mounted on a support. The cooling water pipe is connected to the water storage tank and is used to inject coolant into the water storage tank. The inlet pipe is used to inject the coolant in the water storage tank into the cooling channels. The outlet pipe is used to recover the coolant in the cooling channels back into the water storage tank.

[0009] Furthermore, the first shearing member includes a first upper shearing ring and a first lower shearing ring. The first upper shearing ring is connected to the inner tank body, and the first lower shearing ring is connected to the drive shaft. The first upper shearing ring is provided with a plurality of first upper shearing teeth arranged in a circumferential direction, and the first lower shearing ring is provided with a plurality of first lower shearing teeth arranged in a circumferential direction. The first upper shearing teeth and the first lower shearing teeth are in clearance fit and form a first gap in the radial direction.

[0010] Further, the second shearing component includes a second upper shearing ring and a second lower shearing ring. The second upper shearing ring is connected to the inner tank body, and the second lower shearing ring is connected to the drive shaft. The second upper shearing ring is provided with a plurality of second upper shearing teeth arranged circumferentially, and the second lower shearing ring is provided with a plurality of second lower shearing teeth arranged circumferentially. The second upper shearing teeth and the second lower shearing teeth are in clearance fit and form a second gap in the radial direction. The second gap is smaller than the first gap. The second upper shearing teeth are arranged in multiple turns in the radial direction, and the second lower shearing teeth are arranged in multiple turns in the radial direction. The number of turns of the second upper shearing teeth corresponds to the number of turns of the second lower shearing teeth. The number of turns of the second upper shearing teeth is 2 to 3.

[0011] Furthermore, the third shearing component includes a third upper shearing ring and a third lower shearing ring. The third upper shearing ring is connected to the inner tank body, and the third lower shearing ring is connected to the drive shaft. The third upper shearing ring is provided with a plurality of third upper shearing teeth arranged circumferentially, and the third lower shearing ring is provided with a plurality of third lower shearing teeth arranged circumferentially. The third upper shearing teeth and the second lower shearing teeth are in clearance fit and form a third gap in the radial direction. The third gap is smaller than the second gap. The third upper shearing teeth are arranged in multiple circles in the radial direction, and the third lower shearing teeth are arranged in multiple circles in the radial direction. The number of circles of the third upper shearing teeth corresponds to the number of circles of the third lower shearing teeth, and the number of circles of the third upper shearing teeth is 3 to 5.

[0012] This invention also discloses a method for producing veterinary drugs according to the above-mentioned veterinary drug mixing production line, comprising the following steps: S100: The excipients, slow-release agents, and suspending agents are added to the excipient tank in the required proportions through the excipient inlet. The excipients are stirred evenly by the excipient stirring drive. At the same time, high-temperature water vapor is injected into the excipient tank through the heating pipe to maintain the temperature in the excipient tank at 130 degrees Celsius. The stirred excipients are suspended in the excipient tank for 3 days to allow the excipients, slow-release agents, and suspending agents to be fully mixed to form the initial material. S200: The mixed initial material is extracted through the auxiliary material extraction component, and the main material is added into the main material tank. The main material and the initial material are mixed and stirred by the main material stirring drive component to form the shearing agent. S300: The mixed agent to be sheared is injected into the shearing tank, and the agent particles in the agent are sheared by the shearing component to reduce the particle size to 5 micrometers and form the finished agent. Finally, it is discharged and collected through the shearing outlet. Furthermore, in step S200, the ratio of the main material to the initial material is 3:1.

[0013] Further, step S300 includes the following steps: S301: Open the cooling water pipe to allow the cooling water in the water storage tank to flow into the cooling channel; S302: Inject the mixed agent to be sheared into the first working chamber and turn on the drive motor so that the drive motor drives the first shearing component, the second shearing component and the third shearing component to work simultaneously, so that the mixed agent to be sheared is sheared in the first working chamber, the second working chamber and the third working chamber in sequence. S303: The finished drug after shearing is discharged and collected through the shearing outlet.

[0014] The present invention has the following beneficial effects: The veterinary drug mixing production line of the present invention first mixes the excipients in an excipient tank, then adds the mixed excipients and main ingredients into a main ingredient tank for secondary mixing, and finally uses a high-speed shearing module to filter and shear the drug particles in layers multiple times to ensure that the size of the sheared drug particles meets the usage requirements, so as to form the finished drug.

[0015] In practice, the liquid medicine to be processed is first injected into the shearing tank through the feed inlet. At the same time, the cooling mechanism and the drive mechanism are activated. The drive mechanism drives the transmission shaft to rotate at high speed, which in turn drives the shearing assembly to rotate at high speed. Specifically, the liquid medicine first enters the first working chamber, where it undergoes the first large-particle crushing under the centrifugal shearing of the high-speed rotating first shearing component. The crushed medicine particles pass through the obstruction of the first shearing component and enter the second working chamber. The medicine particles crushed by the first shearing are then subjected to a second shearing under the left and right sides of the second shearing component, further reducing the size of the medicine particles. The further reduced medicine particles then pass through the obstruction of the second shearing component and enter the third working chamber. In the third working chamber, the medicine particles are further crushed under the operation of the third shearing component, so that the size of the medicine particles meets the production requirements. During the process of medicine particle shearing, the medicine is simultaneously cooled down. Specifically, the coolant enters the cooling channel of the shearing tank, carrying away the large amount of heat generated by the crushing of the medicine particles, thereby ensuring the rapid cooling of the medicine particles and improving the production efficiency of the medicine.

[0016] In addition to the objectives, features, and advantages described above, the present invention has other objectives, features, and advantages. The invention will now be described in further detail with reference to the figures. Attached Figure Description

[0017] The accompanying drawings, which form part of this application, are used to provide a further understanding of the invention. The illustrative embodiments of the invention and their descriptions are used to explain the invention and do not constitute an improper limitation of the invention.

[0018] In the attached diagram: Figure 1 This is a schematic diagram showing the connection between the excipient preparation module and the preliminary mixing module of the veterinary drug mixing production line according to a preferred embodiment of the present invention; Figure 2 This is a schematic diagram of the high-speed shear mixing module in a veterinary drug mixing production line according to a preferred embodiment of the present invention; Figure 3 This is a schematic diagram of the shearing component according to a preferred embodiment of the present invention; Figure 4 This is a schematic diagram of the structure of the second shearing upper ring in a preferred embodiment of the present invention.

[0019] Legend: 100, Auxiliary material tank; 101, Auxiliary material stirring drive; 102, Auxiliary material inlet; 103, Auxiliary material outlet; 104, Heating pipe; 200, Shearing tank; 201, Outer tank; 202, Inner tank; 203, Cooling channel; 204, Support sleeve; 205, Rolling bearing; 206, Shearing inlet; 207, Discharge channel; 300. Drive motor; 301. Connecting shaft; 302. Transmission shaft; 400. First shearing component; 401. First upper shearing ring; 402. First upper shearing tooth; 403. First lower shearing ring; 404. First lower shearing tooth; 405. First working chamber; 500. Second shearing component; 501. Second upper shearing ring; 502. Second upper shearing tooth; 503. Second lower shearing ring; 504. Second lower shearing tooth; 505. Second working chamber; 600. Third shearing component; 601. Third upper shear ring; 602. Third upper shear tooth; 603. Third lower shear ring; 604. Third lower shear tooth; 605. Third working chamber; 700. Water storage tank; 701. Water inlet pipe; 702. Water outlet pipe; 703. Cooling water pipe; 704. Drain valve; 705. Pressure gauge; 800. Main material tank; 801. Main material stirring drive; 802. Main material inlet; 803. Main material outlet pipe; 804. Auxiliary material extraction component; 805. Main material extraction component. Detailed Implementation

[0020] The embodiments of the present invention will be described in detail below with reference to the accompanying drawings. However, the present invention can be implemented in many different ways as defined and covered below.

[0021] like Figures 1-3 As shown, this invention discloses a veterinary drug mixing production line, including an excipient preparation module, a preliminary mixing module, and a high-speed shear mixing module. The excipient preparation module includes an excipient tank 100 and an excipient stirring drive 101. The excipient tank 100 has an excipient inlet 102 and an excipient outlet 103. The excipient stirring drive 101 is mounted on the excipient tank 100 for stirring the excipients. The preliminary mixing module includes a main material tank 800, a main material stirring drive 801, and an excipient extraction component 804. The main material tank 800 has a main material inlet 802 and a main material outlet pipe 803. The excipient extraction component 804 is used to extract the excipients from the excipient outlet 103 and the main material tank. The main body 800 is connected to and extracts the uniformly mixed auxiliary materials into the main material tank 800. The main material stirring drive 801 is installed on the main material tank 800 for preliminary stirring of the mixture of auxiliary materials and main materials. The high-speed shearing module includes a shearing tank 200 and a shearing assembly. The shearing tank 200 is provided with a shearing inlet 206. The main material outlet pipe 803 is provided with a main material extraction component 805. The first end of the main material outlet pipe 803 extends into the main material tank 800, and the second end of the main material outlet pipe 803 is connected to the shearing inlet 206. The shearing assembly is used to perform high-speed shearing of the mixed materials so that the solvent particles of the mixed materials reach the required size.

[0022] In this embodiment, both the excipient tank 100 and the main ingredient tank 800 are made of high-temperature resistant metal materials. To ensure thorough mixing of the excipients, a slow-release agent and a suspending agent can be added to the excipients. Simultaneously, the excipient tank 100 is heated, specifically maintaining the heating temperature below 130 degrees Celsius, to accelerate the mixing of the excipients with the slow-release agent and suspending agent, thereby obtaining a relatively stable concentration. When mixing the excipients and main ingredient subsequently, an appropriate amount of purified water can be added to the main ingredient tank 800 as a solution to facilitate mixing and stirring of the excipients and main ingredient.

[0023] Specifically, the excipients are first stirred and mixed in the excipient tank 100. Then, the mixed excipients and main materials are added to the main material tank 800 for secondary mixing. Finally, the mixed main material and excipients are fed into the high-speed shearing module through the main material extraction component 805. The high-speed shearing module performs layered and multiple filtration and shearing of the drug particles to ensure that the size of the sheared drug particles meets the usage requirements, thus forming the finished drug.

[0024] In practice, the liquid medicine to be processed is first injected into the shearing tank 200 through the feed inlet 206. Simultaneously, the cooling mechanism and drive mechanism are activated. The drive mechanism drives the transmission shaft 302 to rotate at high speed, which in turn drives the shearing assembly to rotate at high speed. Specifically, the liquid medicine first enters the first working chamber 405, where it undergoes initial large-particle crushing under the centrifugal shearing of the high-speed rotating first shearing member 400. The crushed medicine particles pass through the obstruction of the first shearing member 400 and enter the second working chamber 505. The medicine particles crushed after the initial shearing are then subjected to further crushing under the left and right sides of the second shearing member 500. The second shearing and crushing process further reduces the size of the drug particles. These smaller particles then pass through the obstruction of the second shearing element 500 and enter the third working chamber 605. In the third working chamber 605, the drug particles are further crushed by the third shearing element 600, ensuring that the particle size meets production requirements. During the shearing process, the drug is simultaneously cooled. Specifically, the coolant enters the cooling channel 203 of the shearing tank 200, carrying away the large amount of heat generated by the crushing of the drug particles, thereby ensuring rapid cooling of the drug particles and improving the production efficiency of the drug.

[0025] Furthermore, the excipient tank 100 is also equipped with a heating pipe 104 for heating the excipients. The heating pipe 104 is used to introduce high-temperature steam into the excipient tank 100. Adding high-temperature steam into the excipient tank 100 can accelerate the mixing of the excipients with the slow-release agent and suspending agent. In order to ensure that the activity of the excipients is not affected, the high-temperature steam needs to be stably controlled at 130 degrees Celsius.

[0026] Further, the shearing tank 200 includes an outer tank 201 and an inner tank 202. The shearing assembly includes a first shearing member 400, a second shearing member 500, and a third shearing member 600 for shearing particles, a drive motor 300, and a transmission shaft 302. The drive motor 300 is connected to the transmission shaft 302 and drives the transmission shaft 302 to rotate at high speed. The transmission shaft 302 is coaxially arranged with the shearing tank 200. The size of the particles sheared by the first shearing member 400, the second shearing member 500, and the third shearing member 600 decreases sequentially. The first shearing member 400, the second shearing member 500, and the third shearing member 600 are all connected to the transmission shaft 302. The components are connected and arranged sequentially at intervals along the length of the drive shaft 302. The first shearing member 400, the outer tank 201, and the inner tank 202 enclose a first working chamber 405. The first shearing member 400, the second shearing member 500, and the inner tank 202 enclose a second working chamber 505. The second shearing member 500, the third shearing member 600, and the inner tank 202 enclose a third working chamber 605. The shearing inlet 206 is provided on the outer tank 201 and communicates with the first working chamber 405. The outer tank 201 has a shearing outlet 207 that communicates with the third working chamber 605.

[0027] In this embodiment, a support sleeve 204 is provided inside the shearing tank 200, and the drive shaft 302 is sleeved on the support sleeve 204. A rolling bearing 205 is provided between the drive shaft 302 and the support sleeve 204. A connecting shaft 301 is also provided on the output shaft of the drive motor 300. The output shaft of the drive motor 300 is connected to the first end of the connecting shaft 301, and the second end of the connecting shaft 301 is connected to the drive shaft 302.

[0028] Furthermore, the outer tank 201 and the inner tank 202 are spaced apart to form a cooling channel 203. The rapid shear mixing module also includes a cooling mechanism, which includes a water storage tank 700, an inlet pipe 701, an outlet pipe 702, and a cooling water pipe 703. The water storage tank 700 is mounted on a support. The cooling water pipe 703 is connected to the water storage tank 700 and is used to inject coolant into the water storage tank 700. The inlet pipe 701 is used to inject the coolant in the water storage tank 700 into the cooling channel 203. The outlet pipe 702 is used to recover the coolant in the cooling channel 203 back into the water storage tank 700.

[0029] In this embodiment, the cooling mechanism injects external coolant into the water storage tank 700 through the cooling water pipe 703. In order to ensure the cooling effect, the temperature of the coolant is usually set at -10 degrees Celsius. During operation, the coolant enters the cooling channel 203 through the inlet pipe 701, and after circulation, it flows out of the cooling channel 203 into the water storage tank 700 through the outlet pipe 702.

[0030] In another embodiment, the cooling mechanism further includes a pressure pump and a pressure gauge 705. The pressure pump is installed inside the water storage tank 700 to provide power for the flow of coolant, and the pressure gauge 705 is used to measure the flow channel pressure of the coolant. In this embodiment, to ensure smooth flow of coolant, a pressure pump is installed to drive the coolant flow, ensuring that the coolant continuously flows into the cooling channel 203 during operation to cool the first working chamber 405, the second working chamber 505, and the third working chamber 605. Simultaneously, the pressure gauge 705 is installed to detect the pressure inside the water storage tank 700 to ensure sufficient pressure. In another embodiment, a pressure boosting valve is installed on the water storage tank 700. Inert gas is introduced into the pressure boosting valve to pressurize the inside of the water storage tank 700, ensuring the pressure for liquid flow. In this case, the pressure gauge 705 is a gas pressure gauge. By observing the gas pressure gauge, it is ensured that the internal gas pressure of the tank is within the standard range. When the gas pressure is lower than the normal operating pressure, gas needs to be added promptly. The water storage tank 700 is also equipped with a drain valve 704. In this embodiment, the drain valve 704 can drain the coolant in the water storage tank 700, facilitating cleaning and maintenance of the water storage tank 700.

[0031] Further, the first shearing member 400 includes a first upper shearing ring 401 and a first lower shearing ring 403. The first upper shearing ring 401 is connected to the inner tank 202, and the first lower shearing ring 403 is connected to the drive shaft 302. The first shearing ring is provided with a plurality of first upper shearing teeth 402 arranged in a circumferential direction, and the second shearing ring is provided with a plurality of first lower shearing teeth 404 arranged in a circumferential direction. The first upper shearing teeth 402 and the first lower shearing teeth 404 are in clearance fit and form a first gap in the radial direction.

[0032] In this embodiment, the first upper shearing ring 401 and the first lower shearing ring 403 are mutually cooperating annular members. The first upper shearing teeth 402 on the first upper shearing ring 401 and the first lower shearing teeth 404 on the first lower shearing ring 403 can break up the drug particles under the action of centrifugal force. When the size of the broken drug particles is smaller than the first gap, they can pass through the first gap and enter the second working chamber 505. The first gap is usually set between 25 micrometers and 30 micrometers. In order to improve the shearing effect, multiple sets of the first upper shearing teeth 402 and the second upper shearing teeth 502 can be arranged in the radial direction.

[0033] Reference Figure 4 The second shearing member 500 includes a second upper shearing ring 501 and a second lower shearing ring 503. The second upper shearing ring 501 is connected to the inner tank 202, and the second lower shearing ring 503 is connected to the drive shaft 302. The second shearing ring is provided with a plurality of second upper shearing teeth 502 arranged circumferentially, and the second shearing ring is provided with a plurality of second lower shearing teeth 504 arranged circumferentially. The second upper shearing teeth 502 and the second lower shearing teeth 504 are in clearance fit and form a second gap in the radial direction. The second gap is smaller than the first gap. The second upper shearing teeth 502 are arranged in multiple turns in the radial direction, and the second lower shearing teeth 504 are arranged in multiple turns in the radial direction. The number of turns of the second upper shearing teeth 502 corresponds to the number of turns of the second lower shearing teeth 504. The number of turns of the second upper shearing teeth 502 is 2 to 3.

[0034] In this embodiment, the second upper shearing ring 501 and the second lower shearing ring 503 are mutually cooperating ring-shaped parts. The second upper shearing ring 501 is rotatably connected to the inner tank 202, specifically through a T-shaped ring groove on the inner tank 202 and a T-shaped ring block on the outer periphery of the second upper shearing ring 501. The second lower shearing ring 503 is engaged with the drive shaft 302 through a spline to ensure that the second lower shearing ring 503 rotates at high speed with the drive shaft 302. In specific operation, the drug particles after initial crushing and shearing enter the second working chamber 505 through the first gap. At this time, the drug particles are sheared and crushed by the second upper shearing teeth 502 and the second lower shearing teeth 504, so that the drug in the second working chamber 505 can pass through the second gap. Specifically, the first gap is usually set between 10 micrometers and 15 micrometers.

[0035] Further, the third shearing member 600 includes a third upper shearing ring 601 and a third lower shearing ring 603. The third upper shearing ring 601 is connected to the inner tank 202, and the third lower shearing ring 603 is connected to the drive shaft 302. The third shearing ring is provided with a plurality of third upper shearing teeth 602 arranged circumferentially, and the third shearing ring is provided with a plurality of third lower shearing teeth 604 arranged circumferentially. The third upper shearing teeth 602 and the second lower shearing teeth 604 are in clearance fit and form a third gap in the radial direction. The third gap is smaller than the second gap. The third upper shearing teeth 602 are arranged in multiple turns in the radial direction, and the third lower shearing teeth 604 are arranged in multiple turns in the radial direction. The number of turns of the third upper shearing teeth 602 corresponds to the number of turns of the third lower shearing teeth 604. The number of turns of the third upper shearing teeth 602 is 3 to 5.

[0036] In this embodiment, the third upper shear ring 601 and the third lower shear ring 603 are mutually cooperating ring-shaped parts. The third upper shear ring 601 is rotatably connected to the inner tank 202, specifically through the T-shaped ring groove on the inner tank 202 and the T-shaped ring block on the outer periphery of the third upper shear ring 601. The third lower shear ring 603 is engaged with the drive shaft 302 through a spline to ensure that the third lower shear ring 603 rotates at high speed with the drive shaft 302. In specific operation, the drug particles after the initial crushing and shearing enter the third working chamber 605 through the first gap. At this time, the drug particles are sheared and crushed by the third upper shearing tooth 602 and the third lower shearing tooth 604, so that the drug in the third working chamber 605 can pass through the third gap. The first gap is usually set between 3 micrometers and 5 micrometers.

[0037] This invention also discloses a method for producing veterinary drugs according to the above-mentioned veterinary drug mixing production line, comprising the following steps: S100, the excipients, slow-release agents, and suspending agents are added to the excipient tank 100 in the required proportions through the excipient inlet 102, and the excipients are stirred evenly by the excipient stirring drive 101. At the same time, high-temperature water vapor is injected into the excipient tank 100 through the heating pipe 104 to maintain the temperature inside the excipient tank 100 at 130 degrees Celsius. The stirred excipients are suspended in the excipient tank 100 for 3 days to allow the excipients, slow-release agents, and suspending agents to be fully mixed to form the initial material. S200, the mixed initial material is extracted through the auxiliary material extraction component 804, the main material is added into the main material tank 800, and the main material and initial material are mixed and stirred by the main material stirring drive component 801 to form the shearing agent. S300: The mixed agent to be sheared is injected into the shearing tank 200, and the agent particles in the agent to be sheared are sheared under the action of the shearing component so that the agent particles in the agent to be sheared reach 5 micrometers and form a finished agent. Finally, it is discharged and collected through the shearing outlet 207.

[0038] In this embodiment, the excipients are first stirred and mixed in the excipient tank 100. Then, the mixed excipients and main ingredients are added to the main ingredient tank 800 for secondary mixing. Finally, the mixed main ingredients and excipients are filtered and sheared multiple times by a high-speed shearing module to ensure that the size of the sheared drug particles meets the usage requirements, thus forming the finished drug.

[0039] For step S100, to ensure thorough mixing of the excipients, a slow-release agent and a suspending agent can be added. Simultaneously, the excipient container 100 is heated, specifically maintaining the heating temperature below 130 degrees Celsius. This allows the excipients to mix more quickly with the slow-release agent and suspending agent, thereby achieving a relatively stable concentration.

[0040] In step S200, when mixing the auxiliary materials and the main materials, an appropriate amount of purified water can be added to the main material tank 800 as a solution to facilitate the mixing and stirring of the auxiliary materials and the main materials.

[0041] In step S300, the liquid medicine to be processed is first injected into the shearing tank 200 through the feed inlet 206. Simultaneously, the cooling mechanism and drive mechanism are activated. The drive mechanism drives the transmission shaft 302 to rotate at high speed, which in turn drives the shearing assembly to rotate at high speed. Specifically, the liquid medicine first enters the first working chamber 405, where it undergoes initial large-particle crushing under the centrifugal shearing of the high-speed rotating first shearing member 400. The crushed medicine particles pass through the obstruction of the first shearing member 400 and enter the second working chamber 505. The medicine particles crushed after the initial shearing are then moved to the left and right sides of the second shearing member 500. A second shearing and crushing process further reduces the size of the drug particles. These smaller particles then pass through the obstruction of the second shearing element 500 and enter the third working chamber 605. In the third working chamber 605, the drug particles are further crushed by the third shearing element 600, ensuring that the particle size meets production requirements. During the shearing process, the drug is simultaneously cooled. Specifically, the coolant enters the cooling channel 203 of the shearing tank 200, carrying away the large amount of heat generated by the crushing of the drug particles, thereby ensuring rapid cooling of the drug particles and improving the production efficiency of the drug.

[0042] Furthermore, in step S200, the ratio of the main material to the initial material is 3:1. In this embodiment, the mixing ratio of the main material and the initial material is determined according to actual production needs; in other embodiments, the mixing ratio of the main material and the initial material can be adjusted according to specific circumstances.

[0043] Further, step S300 includes the following steps: S301: Open the cooling water pipe 703 so that the cooling water in the water storage tank 700 flows into the cooling channel 203; S302: Inject the mixed shearing agent into the first working chamber 405 and turn on the drive motor 300, so that the drive motor 300 drives the first shearing member 400, the second shearing member 500 and the third shearing member 600 to work simultaneously, so that the mixed shearing agent is sheared sequentially in the first working chamber 405, the second working chamber 505 and the third working chamber 605. S303: The finished drug after shearing is discharged and collected through the shearing outlet 207.

[0044] In this embodiment, for the first working chamber 405, the first upper shearing tooth 402 on the first upper shearing ring 401 and the first lower shearing tooth 404 on the first lower shearing ring 403 can break the drug particles under the action of centrifugal force. When the size of the broken drug particles is smaller than the first gap, they can pass through the first gap and enter the second working chamber 505. The specific first gap is usually set between 25 micrometers and 30 micrometers. For the second working chamber 505, the drug particles after initial crushing and shearing enter the second working chamber 505 through the first gap. At this time, the drug particles are sheared and crushed by the second upper shearing tooth 502 and the second lower shearing tooth 504, so that the drug in the second working chamber 505 can pass through the second gap. Specifically, the first gap is usually set between 10 micrometers and 15 micrometers. For the third working chamber 605, during operation, the drug particles after initial crushing and shearing enter the third working chamber 605 through the first gap. At this time, the drug particles are sheared and crushed by the third upper shearing tooth 602 and the third lower shearing tooth 604, so that the drug in the third working chamber 605 can pass through the third gap. Specifically, the first gap is usually set between 3 micrometers and 5 micrometers.

[0045] The above description is merely a preferred embodiment of the present invention and is not intended to limit the invention. Various modifications and variations can be made to the present invention by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A veterinary drug mixing production line, characterized in that, include: An auxiliary material preparation module includes an auxiliary material tank (100) and an auxiliary material stirring drive (101). The auxiliary material tank (100) is provided with an auxiliary material inlet (102) and an auxiliary material outlet (103). The auxiliary material stirring drive (101) is disposed on the auxiliary material tank (100) for stirring the auxiliary material. The preliminary mixing module includes a main material tank (800), a main material stirring drive (801), and an auxiliary material extraction component (804). The main material tank (800) is provided with a main material inlet (802) and a main material outlet pipe (803). The auxiliary material extraction component (804) is used to connect the auxiliary material outlet (103) and the main material tank (800) and extract the uniformly stirred auxiliary material into the main material tank (800). The main material stirring drive (801) is provided on the main material tank (800) for preliminary stirring of the mixture of auxiliary material and main material. A high-speed shearing mixing module includes a shearing tank (200) and a shearing assembly. The shearing tank (200) is provided with a shearing inlet (206), and the main material outlet pipe (803) is provided with a main material extraction component (805). The first end of the main material outlet pipe (803) extends into the main material tank (800), and the second end of the main material outlet pipe (803) is connected to the shearing inlet (206). The shearing assembly is used to perform high-speed shearing on the mixed agent so that the solvent particles of the mixed agent reach the required size.

2. The veterinary drug mixing production line according to claim 1, characterized in that, The auxiliary material tank (100) is also provided with a heating pipe (104) for heating the auxiliary material, and the heating pipe (104) is used to introduce high temperature water vapor into the auxiliary material tank (100).

3. The veterinary drug mixing production line according to claim 1, characterized in that, The shearing tank (200) includes an outer tank (201) and an inner tank (202). The shearing assembly includes a first shearing member (400), a second shearing member (500), and a third shearing member (600) for shearing particles, a drive motor (300), and a transmission shaft (302). The drive motor (300) is connected to the transmission shaft (302) and drives the transmission shaft (302) to rotate at high speed. The transmission shaft (302) is coaxially arranged with the shearing tank (200). The size of the particles sheared by the first shearing member (400), the second shearing member (500), and the third shearing member (600) decreases sequentially, and all are connected to the transmission shaft (302) along the length of the transmission shaft (302). The components are arranged sequentially at intervals. The first shearing component (400), the outer tank (201), and the inner tank (202) enclose a first working chamber (405). The first shearing component (400), the second shearing component (500), and the inner tank (202) enclose a second working chamber (505). The second shearing component (500), the third shearing component (600), and the inner tank (202) enclose a third working chamber (605). The shearing inlet (206) is located on the outer tank (201) and communicates with the first working chamber (405). The outer tank (201) has a shearing outlet (207) that communicates with the third working chamber (605).

4. The veterinary drug mixing production line according to claim 3, characterized in that, The outer tank (201) and the inner tank (202) are spaced apart to form a cooling channel (203). The rapid shear mixing module also includes a cooling mechanism, which includes a water storage tank (700), an inlet pipe (701), an outlet pipe (702), and a cooling water pipe (703). The water storage tank (700) is mounted on a support. The cooling water pipe (703) is connected to the water storage tank (700) and is used to inject coolant into the water storage tank (700). The inlet pipe (701) is used to inject the coolant in the water storage tank (700) into the cooling channel (203). The outlet pipe (702) is used to recover the coolant in the cooling channel (203) back into the water storage tank (700).

5. The veterinary drug mixing production line according to claim 4, characterized in that, The first shearing member (400) includes a first upper shearing ring (401) and a first lower shearing ring (403). The first upper shearing ring (401) is connected to the inner tank (202), and the first lower shearing ring (403) is connected to the drive shaft (302). The first upper shearing ring (401) is provided with a plurality of first upper shearing teeth (402) arranged in a circumferential direction, and the first lower shearing ring (403) is provided with a plurality of first lower shearing teeth (404) arranged in a circumferential direction. The first upper shearing teeth (402) and the first lower shearing teeth (404) are in clearance fit and form a first gap in the radial direction.

6. The veterinary drug mixing production line according to claim 4, characterized in that, The second shearing component (500) includes a second upper shearing ring (501) and a second lower shearing ring (503). The second upper shearing ring (501) is connected to the inner tank (202), and the second lower shearing ring (503) is connected to the drive shaft (302). The second upper shearing ring (501) is provided with a plurality of second upper shearing teeth (502) arranged in a circumferential direction, and the second lower shearing ring (503) is provided with a plurality of second lower shearing teeth (504) arranged in a circumferential direction. The second upper shearing teeth (502) and the second lower shearing teeth (504) are in clearance fit and form a second gap in the radial direction. The second gap is smaller than the first gap. The second upper shearing teeth (502) are arranged in multiple turns in the radial direction, and the second lower shearing teeth (504) are arranged in multiple turns in the radial direction. The number of turns of the second upper shearing teeth (502) corresponds to the number of turns of the second lower shearing teeth (504). The number of turns of the second upper shearing teeth (502) is 2 to 3 turns.

7. The veterinary drug mixing production line according to claim 4, characterized in that, The third shearing component (600) includes a third upper shearing ring (601) and a third lower shearing ring (603). The third upper shearing ring (601) is connected to the inner tank (202), and the third lower shearing ring (603) is connected to the drive shaft (302). The third upper shearing ring (601) is provided with a plurality of third upper shearing teeth (602) arranged circumferentially, and the third lower shearing ring (603) is provided with a plurality of third lower shearing teeth (604) arranged circumferentially. The third upper shearing tooth (602) and the third lower shearing tooth (604) are in clearance fit and form a third gap in the radial direction. The third gap is smaller than the second gap. The third upper shearing tooth (602) is arranged in multiple circles in the radial direction. The third lower shearing tooth (604) is arranged in multiple circles in the radial direction. The number of circles of the third upper shearing tooth (602) corresponds to the number of circles of the third lower shearing tooth (604). The number of circles of the third upper shearing tooth (602) is 3 to 5.

8. A production method for a veterinary drug mixing production line according to any one of claims 1 to 7, characterized in that, Includes the following steps: S100, the excipients, slow-release agents and suspending agents are added to the excipient tank (100) in the required proportions through the excipient inlet (102), and the mixed excipients are stirred evenly by the excipient stirring drive (101). At the same time, high-temperature water vapor is injected into the excipient tank (100) through the heating pipe (104) to maintain the temperature in the excipient tank (100) at 130 degrees Celsius. The stirred excipients are suspended in the excipient tank (100) for 3 days to allow the excipients, slow-release agents and suspending agents to be fully mixed to form the initial material. S200, the mixed initial material is extracted through the auxiliary material extraction component (804), the main material is added into the main material tank (800), the main material and the initial material are mixed, and the mixture is stirred by the main material stirring drive component (801) to form the shearing agent; S300, the mixed agent to be sheared is injected into the shearing tank (200), and the agent particles in the agent to be sheared are sheared under the action of the shearing component so that the agent particles in the agent to be sheared reach 5 micrometers and form a finished agent, which is finally discharged and collected through the shearing outlet (207).

9. The production method of the veterinary drug mixing production line according to claim 8, characterized in that, In step S200, the ratio of the main material to the initial material is 3:

1.

10. The production method of the veterinary drug mixing production line according to claim 8, characterized in that, Step S300 includes the following steps; S301: Open the cooling water pipe (703) so that the cooling water in the water storage tank (700) flows into the cooling channel (203); S302: The mixed shearing agent is injected into the first working chamber (405), and the drive motor (300) is turned on, so that the drive motor (300) drives the first shearing component (400), the second shearing component (500) and the third shearing component (600) to work simultaneously, so that the mixed shearing agent is sheared sequentially in the first working chamber (405), the second working chamber (505) and the third working chamber (605); S303: The finished drug after shearing is discharged and collected through the shearing outlet (207).

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