Medicinal and edible formula powder for regulating postpartum depression and physiological disorder and preparation method of medicinal and edible formula powder

Abstract

The invention relates to the technical field of functional food, and particularly discloses medicinal and edible formula powder for regulating postpartum depression and physiological disorder and a preparation method thereof, and the medicinal and edible formula powder comprises the following components in parts by mass: 115-125 parts of black sesame, 8-15 parts of an active extract, 55-65 parts of a tartary buckwheat compound, 55-65 parts of radix puerariae, 46-50 parts of radix rehmanniae, 5-9 parts of Chinese wolfberry and hawthorn polysaccharide, 32-38 parts of chrysanthemum and 45-50 parts of rock candy. The black sesame provides a nutrition basis, and the black sesame, the radix puerariae and the radix rehmanniae regulate postpartum estrogen fluctuation; the active extract and active ingredients in the tartary buckwheat compound form a synergistic effect, oxidative stress products are removed in a linkage manner, the serum MDA level is reduced, and cortisol is regulated; polysaccharide components of the Chinese wolfberry fruits and the hawthorn fruits synergistically improve immunity; the prepared formula powder can effectively improve the physiological function of postpartum people and improve postpartum depression.

Description

Technical Field

[0001] This invention relates to the field of functional food technology, specifically to a medicinal and edible formula powder for regulating postpartum depression and physiological disorders, and its preparation method. Background Technology

[0002] Postpartum depression and postpartum physiological disorders are common health problems among women in the perinatal period. The two often form a vicious cycle of "physiological imbalance-emotional disorder". The pathogenesis is directly related to the drastic fluctuations of estrogen and progesterone after childbirth, abnormal neurotransmitter metabolism, and nutritional consumption imbalance. Some patients also have symptoms of physiological disorders such as menstrual disorders, insufficient milk secretion, and deficiency of qi and blood, which threaten the physical and mental health of postpartum women.

[0003] Currently, clinical and market-based interventions for this problem have significant limitations. Western medicine antidepressants such as sertraline and fluvoxamine, selective serotonin reuptake inhibitors (SSRIs), are commonly used in clinical practice. While they can improve mood by inhibiting neurotransmitter reuptake, these drugs can cross the blood-milk barrier and enter breast milk, with a milk-to-plasma concentration ratio of 0.4-0.6. Newborns who ingest these drugs through breast milk may experience adverse reactions such as drowsiness, feeding difficulties, and abnormal muscle tone. Furthermore, Western medicines only target depressive symptoms and cannot address underlying physiological issues such as postpartum blood and qi deficiency and endocrine disorders; while traditional Chinese medicine formulas for soothing the liver carry the risk of contraindication to breastfeeding. Traditional Chinese medicine (TCM) treatment for postpartum depression often focuses on "soothing the liver and regulating qi, nourishing blood and calming the mind." Commonly used formulas contain ingredients such as Bupleurum, Cyperus, and Aurantium. However, Bupleurum saponins may affect the liver function of newborns through breast milk, and the "Guidelines for Medication Use in Lactating Women" explicitly lists them as "use with caution." Furthermore, traditional Chinese medicine is mostly in decoction form, which is bitter and inconvenient to prepare, making it difficult to adapt to the lifestyle of postpartum women. Commercially available meal replacement powders are mainly formulated with whey protein, dietary fiber, vitamins, and minerals, lacking active ingredients that regulate neurotransmitter metabolism and improve endocrine function. These products cannot improve mood by regulating precursors such as GABA and tryptophan, nor can they address symptoms like hot flashes and insomnia caused by the decline in postpartum estrogen levels. They only meet basic nutritional needs and are disconnected from the intervention goals for postpartum depression and physiological imbalances.

[0004] Currently, there are no dedicated medicinal and food-based formula powders specifically designed for postpartum depression and physiological disorders. Existing products are mostly general-purpose health powders that have not been optimized to address the specific physiological conditions such as postpartum hormonal changes and breastfeeding needs, making it difficult to achieve precise regulatory effects. Therefore, developing a medicinal and food-based formula powder that is safe and has no contraindications, highly targeted in function, and convenient in dosage form, to meet the core needs of postpartum women for "safe breastfeeding first and dual regulation of emotions and physiology" is of significant market importance. Summary of the Invention

[0005] The technical problem to be solved by the present invention is to provide a medicinal and edible formula powder for regulating postpartum depression and physiological disorders and its preparation method, so as to solve the problem of the lack of medicinal and edible formula powders for postpartum depression and physiological disorders in the prior art.

[0006] To solve the above-mentioned technical problems, this invention provides a medicinal and edible formula powder for regulating postpartum depression and physiological disorders, comprising the following components by weight: 115-125 parts black sesame, 8-15 parts active extract, 55-65 parts buckwheat complex, 55-65 parts kudzu root, 46-50 parts rehmannia root, 5-9 parts wolfberry and hawthorn polysaccharide, 32-38 parts chrysanthemum, and 45-50 parts rock sugar. The buckwheat complex is obtained by soaking buckwheat in a polysaccharide solution, baking it, cooling and pulverizing it, and then adding lysine hydrochloride for grinding. The active extract is obtained by compound extraction of kumquat and grape seed; The wolfberry and hawthorn polysaccharide was obtained by enzymatic hydrolysis of hawthorn and wolfberry with enzyme solution followed by ultrasonic extraction; The aforementioned medicinal and edible formula powder for regulating postpartum depression and physiological disorders comprises the following components by weight: 120 parts black sesame, 12 parts active extract, 60 parts buckwheat complex, 60 parts kudzu root, 48 parts rehmannia root, 7 parts wolfberry and hawthorn polysaccharide, 36 parts chrysanthemum, and 48 parts rock sugar.

[0007] The preparation of the buckwheat complex involves washing and draining buckwheat, then immersing it in a polysaccharide solution at a material-to-liquid ratio of 1:3-5 g / mL for 4-6 minutes. Afterward, it is removed and baked at 50-60℃ for 25-30 minutes. After cooling, it is pulverized to 80-100 mesh, and then lysine hydrochloride is added and ground at 300-350 rpm for 10-15 minutes. This process effectively reduces the caffeine and oxalic acid content of buckwheat, enhances the activity of active ingredients, and allows tyrosine to form a soluble complex with buckwheat flavonoids, thereby improving the intestinal absorption rate of the antidepressant active ingredients. The mass of the added lysine hydrochloride is 1-3% of that of tartary buckwheat; The polysaccharide solution is an aqueous solution containing 5-8 wt% brown algae polysaccharide and 1-2 wt% fructooligosaccharide; The active extract is obtained by freeze-drying kumquats, mixing them with grape seeds at a mass ratio of 1:2-3, extracting with steam heat for 8-12 minutes, then condensing at 70-80℃ to obtain the active extract, then increasing the temperature to 200-280℃ for steam heat extraction for 8-12 minutes, and condensing at 30-40℃ to obtain the active extract. The active extracts are combined, centrifuged, and then β-cyclodextrin is added and stirred evenly before concentration and drying. By using steam heat extraction at different temperature ranges, the terpenes in kumquats and vitamin E and other active substances in grape seeds can be effectively extracted. The β-cyclodextrin added is 0.1-0.3% by mass; The conditions for steam heat transfer are 120-200℃ and 0.015MPa; The preparation of the wolfberry and hawthorn polysaccharide involves mixing wolfberry and peeled, sliced ​​hawthorn in a 1-3:1 ratio, drying and pulverizing to 100 mesh, then enzymatically hydrolyzing with an enzyme solution at a 1:8-10 material-to-liquid ratio at 40-50℃ for 40-50 minutes, followed by ultrasonic soaking at 20-30kHz for 10-15 minutes, centrifuging, sterilization, and spray drying. The wolfberry and hawthorn polysaccharide can synergistically enhance the effects of the buckwheat complex and kumquat-grape seed active extract in the formula. Its immunomodulatory activity can strengthen the immune system of postpartum women. Simultaneously, the prebiotic properties of the polysaccharide can help improve the postpartum gut microbiota, promote the intestinal absorption of core active ingredients such as flavonoids and terpenes in the formula, and indirectly enhance the overall efficacy of the formula in regulating postpartum depression and repairing physiological imbalances. The enzyme solution contains 0.06%-0.08% of a complex enzyme, which is trypsin and tanninase in a mass ratio of 1:2-3. Tanninase can specifically degrade tannins in hawthorn, effectively reducing the risk of polysaccharide products irritating the sensitive postpartum gastrointestinal tract and avoiding problems such as bloating and discomfort caused by tannins. Trypsin can efficiently decompose protein impurities in the raw materials. This invention also provides a method for preparing a medicinal and edible homologous formula powder for regulating postpartum depression and physiological disorders, comprising the following steps: Step 1: Prepare the components according to their mass percentages; Step 2: After inactivating the enzymes in black sesame seeds, grind them together with kudzu root and rehmannia root, and vacuum freeze-dry goji berries, hawthorn, and chrysanthemum. Step 3: Mix all components thoroughly, sterilize, and then package with nitrogen. The enzyme inactivation is performed at 110-130℃ for 18-22 seconds.

[0008] The beneficial effects of this invention are as follows: This invention provides a method for preparing a medicinal and edible formula powder for regulating postpartum depression and physiological disorders. The method involves removing impurities and complexing tartary buckwheat to obtain highly active substances such as flavonoids. The added active extracts are extracted from kumquat and grape seeds at different temperature ranges, and stability is improved with β-cyclodextrin. Complex polysaccharides are removed using an enzymatic solution. The medicinal and edible formula powder provided by this invention uses black sesame as a nutritional base. Black sesame, kudzu root, and rehmannia root regulate postpartum estrogen fluctuations. The active ingredients in the active extract, such as kumquat terpenes and grape seed vitamin E, synergistically interact with the active ingredients in the tartary buckwheat complex, such as flavonoid-lysine complexes. This reduces collagen degradation by inhibiting collagenase activity and simultaneously eliminates oxidative stress products, lowers serum MDA levels, and regulates cortisol. The polysaccharides from wolfberry and hawthorn synergistically enhance immunity and increase peripheral blood lymphocyte transformation rate. The prepared formula powder can effectively improve the physiological functions of postpartum women and alleviate postpartum depression. Detailed Implementation

[0009] The present invention will be further described in detail below through specific implementation examples. It should be understood that these embodiments are only used to illustrate the present invention and are not intended to limit the scope of protection of the present invention. After reading the present invention, any modifications of the present invention in various equivalent forms by those skilled in the art fall within the scope of the appended claims.

[0010] Unless otherwise specified, all raw materials and reagents used in this invention are from the conventional market.

[0011] Example 1 A method for preparing a medicinal and edible homologous formula powder for regulating postpartum depression and physiological disorders includes the following steps: Step 1: Prepare the ingredients by weight: 120 parts black sesame, 12 parts active extract, 60 parts buckwheat complex, 60 parts kudzu root, 48 parts rehmannia root, 7 parts wolfberry and hawthorn polysaccharide, 35 parts chrysanthemum, and 48 parts rock sugar. The preparation of the buckwheat complex is as follows: after washing and draining the buckwheat, it is immersed in a polysaccharide solution at a material-to-liquid ratio of 1:4 g / mL for 5 min, then taken out and baked at 55℃ for 28 min, cooled and pulverized to 80-100 mesh, and then lysine hydrochloride is added and ground at 300 rpm for 13 min to obtain the complex. The added lysine hydrochloride is 2% of the weight of tartary buckwheat; The polysaccharide solution is an aqueous solution containing 7 wt% brown algae polysaccharide and 1 wt% oligofructose; The active extract was obtained by freeze-drying kumquats, mixing them with grape seeds at a mass ratio of 1:3, extracting with steam heat for 10 minutes, then condensing at 75°C to obtain the active extract, then increasing the temperature to 240°C for steam heat extraction for 10 minutes, and condensing at 35°C to obtain the active extract. The active extracts were combined, centrifuged, and then β-cyclodextrin was added and stirred evenly, followed by concentration and drying. The mass of β-cyclodextrin added was 0.2%. The steam heat transfer conditions were 160°C and 2 MPa. The preparation of the wolfberry and hawthorn polysaccharide involves mixing wolfberry and peeled and sliced ​​hawthorn in a 2:1 ratio, drying and pulverizing to 100 mesh, enzymatically hydrolyzing with an enzyme solution at a 1:9 material-to-liquid ratio at 45°C for 45 min, then ultrasonically soaking at 25 kHz for 10 min, centrifuging, sterilizing, and then spray drying to obtain the product. The enzyme solution contains 0.07% of a complex enzyme, which is trypsin and tannin enzyme in a mass ratio of 1:2. Step 2: After inactivating the enzymes in black sesame seeds, grind them together with kudzu root and rehmannia root, and vacuum freeze-dry goji berries, hawthorn, and chrysanthemum. Step 3: Mix all components thoroughly, sterilize, and then package with nitrogen. The enzyme inactivation is performed at 120°C for 20 seconds.

[0012] Example 2 A method for preparing a medicinal and edible homologous formula powder for regulating postpartum depression and physiological disorders includes the following steps: Step 1: Prepare the ingredients by weight: 115 parts black sesame, 8 parts active extract, 55 parts buckwheat complex, 55 parts kudzu root, 46 parts rehmannia root, 5 parts wolfberry and hawthorn polysaccharide, 32 parts chrysanthemum, and 45 parts rock sugar. The preparation of the buckwheat complex is as follows: after washing and draining the buckwheat, it is immersed in a polysaccharide solution at a material-to-liquid ratio of 1:3 g / mL for 4 min, then taken out and baked at 50℃ for 25 min, cooled and pulverized to 80-100 mesh, and then lysine hydrochloride is added and ground at 300 rpm for 10 min to obtain the product. The mass of the added lysine hydrochloride is 1% of that of tartary buckwheat; The polysaccharide solution is an aqueous solution containing 5 wt% brown algae polysaccharide and 1 wt% oligofructose; The active extract was obtained by freeze-drying kumquats, mixing them with grape seeds at a mass ratio of 1:2, extracting with steam heat for 8 minutes, then condensing at 70°C to obtain the active extract, then increasing the temperature to 200°C for steam heat extraction for 8 minutes, and condensing at 30°C to obtain the active extract. The active extracts were combined, centrifuged, and then β-cyclodextrin was added and stirred evenly, followed by concentration and drying. The mass of β-cyclodextrin added was 0.1%. The steam heat transfer conditions were 120°C and 0.01 MPa. The preparation of the wolfberry and hawthorn polysaccharide involves mixing wolfberry and peeled and sliced ​​hawthorn in a 1-3:1 ratio, drying and pulverizing to 100 mesh, enzymatically hydrolyzing with an enzyme solution at a 1:8 material-to-liquid ratio at 40°C for 40 min, then ultrasonically soaking at 20 kHz for 10 min, centrifuging, sterilizing, and then spray drying to obtain the polysaccharide. The enzyme solution contains 0.06% of a complex enzyme, which is trypsin and tannin in a mass ratio of 1:2. Step 2: After inactivating the enzymes in black sesame seeds, grind them together with kudzu root and rehmannia root, and vacuum freeze-dry goji berries, hawthorn, and chrysanthemum. Step 3: Mix all components thoroughly, sterilize, and then package with nitrogen. The enzyme inactivation was performed at 110°C for 18 seconds.

[0013] Example 3 A method for preparing a medicinal and edible homologous formula powder for regulating postpartum depression and physiological disorders includes the following steps: Step 1: Prepare the ingredients by weight: 125 parts black sesame, 15 parts active extract, 65 parts buckwheat complex, 65 parts kudzu root, 50 parts rehmannia root, 9 parts wolfberry and hawthorn polysaccharide, 38 parts chrysanthemum, and 50 parts rock sugar. The preparation of the buckwheat complex is as follows: after washing and draining the buckwheat, it is immersed in a polysaccharide solution at a material-to-liquid ratio of 1:5 g / mL for 6 min, then taken out and baked at 60℃ for 30 min, cooled and pulverized to 100 mesh, and then lysine hydrochloride is added and ground at 350 rpm for 15 min to obtain the complex. The added lysine hydrochloride is 3% of the weight of tartary buckwheat; The polysaccharide solution is an aqueous solution containing 8 wt% brown algae polysaccharide and 2 wt% oligofructose; The active extract is obtained by freeze-drying kumquats, mixing them with grape seeds at a mass ratio of 1:3, extracting with steam heat for 12 minutes, then condensing at 80°C to obtain the active extract, then increasing the temperature to 280°C for steam heat extraction for 12 minutes, and condensing at 40°C to obtain the active extract. The active extracts are combined, centrifuged, and then β-cyclodextrin is added and stirred evenly, followed by concentration and drying. The mass of β-cyclodextrin added is 0.3%. The steam heat transfer conditions are 200°C and 5 MPa. The preparation of the wolfberry and hawthorn polysaccharide involves mixing wolfberry and peeled and sliced ​​hawthorn in a 3:1 ratio, drying and pulverizing to 100 mesh, enzymatically hydrolyzing with an enzyme solution at a 1:10 material-to-liquid ratio at 50°C for 50 min, then ultrasonically soaking at 30 kHz for 15 min, centrifuging, sterilizing, and then spray drying to obtain the product. The enzyme solution contains 0.08% of a complex enzyme, which is trypsin and tannin in a mass ratio of 1:3. Step 2: After inactivating the enzymes in black sesame seeds, grind them together with kudzu root and rehmannia root, and vacuum freeze-dry goji berries, hawthorn, and chrysanthemum. Step 3: Mix all components thoroughly, sterilize, and then package with nitrogen. The enzyme inactivation was performed at 130°C for 22 seconds.

[0014] Comparative Example 1 The difference between Comparative Example 1 and Example 1 is that the buckwheat complex in Comparative Example 1 is prepared by using an aqueous solution instead of a polysaccharide solution, while the rest remains the same.

[0015] Comparative Example 2 The difference between Comparative Example 2 and Example 1 is that the buckwheat complex in Comparative Example 2 does not contain lysine hydrochloride, while all other aspects remain the same.

[0016] Comparative Example 3 The difference between Comparative Example 3 and Example 1 is that in Comparative Example 3, equal amounts of kumquat water extract and grape seed water extract in a mass ratio of 2.6:1 are used instead of the active extract, while other aspects remain unchanged.

[0017] Comparative Example 4 The difference between Comparative Example 4 and Example 1 is that in the preparation of Lycium barbarum and hawthorn polysaccharide in Comparative Example 4, cellulase was used instead of complex enzyme, while everything else remained the same.

[0018] 1. Six- to eight-week-old SPF-grade female SD rats were selected and housed individually after fertilization until parturition. Female rats with normal lactation within 48 hours after parturition were selected as experimental subjects.

[0019] Establishment of a rat model of postpartum depression: A combined approach of chronic unpredictable mild stress and isolation was used to induce the model. From day 15 of gestation to day 7 postpartum, 135 successfully modeled rats were selected and randomly divided into 7 groups (n=15 per group) according to their weight and behavioral scores. An additional 15 normally pregnant female rats served as a blank control group (no stress treatment, group housing). There were no statistically significant differences in baseline data among the groups (P>0.05). Experimental group: administered the powder suspension of the food-medicine homology formula of this regimen by gavage; Positive control group: administered commercially available postpartum depression treatment powder suspension by gavage; Model control group: administered an equal volume of physiological saline by gavage; Feeding conditions: All groups were kept at a temperature of 22-25℃ and a humidity of 45%-55%, with a 12-hour light-dark cycle. The model group, experimental group, and positive control group were kept in isolation until the end of the experiment. The blank control group was kept in groups of 3 animals per cage, with free access to food and water. The formula powder was prepared into a homogeneous suspension with physiological saline (prepared fresh for use) by oral gavage at a dosage of 1 mL / 100g body weight for 21 days. Serum: 3 mL of blood was collected from the abdominal aorta of rats after anesthesia, centrifuged at 3000 rpm for 10 min, and stored at -80℃; 5-HT was measured by ELISA and MDA was measured by TBA colorimetric method, both according to the kit instructions. GraphPad Prism 9.0 and SPSS 26.0 software were used. Quantitative data are expressed as mean ± standard deviation (x ± s). The data of the example and comparative examples are the increase (serum 5-HT) / decrease (MDA oxidation index) compared with the model control group, while the data of the model control group and positive control group are the increase (serum 5-HT) / decrease (MDA oxidation index) compared with their own pre-intervention values.

[0020] Table 1 Biochemical indicators of rats As shown in Table 1, the medicinal and edible formula powder prepared in this invention can effectively improve the pathological state of postpartum depression in rats, increase serum 5-HT and reduce MDA levels.

[0021] II. Ninety-five volunteers were selected from 42 days to 6 months postpartum (the peak period for postpartum depression) and met the following criteria: EPDS score of 13-20 (moderate depression), exclusively breastfed / mixed fed, and without underlying diseases such as abnormal liver or kidney function or diabetes. They were randomly divided into 9 groups and took the formula powder prepared in the examples and comparative examples twice a day, 15g each time, mixed with 40℃ warm water, after breakfast and dinner, for 30 days. One group took commercially available conditioning powder, and the other group served as a blank control, without taking any functional products. The volunteers' physiological function scores were recorded. Emotional symptoms: Blind assessment using the EPDS scale (operated by a professional obstetrician), recording scores for symptoms such as low mood, insomnia, and anxiety; (Postpartum depression scale, 0-30 points, ≤5 points is normal, the lower the score, the better the improvement in depression) Physiological repair: Record milk production (daily milk pumping volume); Safety: Record gastrointestinal reactions daily (bloating, diarrhea, etc., 0-10 points, 0 points for no irritation, the higher the score, the more obvious the gastrointestinal discomfort).

[0022] Table 2. Physiological Functions of Volunteers As shown in Table 2, the medicinal and edible formula powder prepared by this invention can more effectively alleviate postpartum depression in volunteers, improve physiological functions, and does not affect gastrointestinal function, while also increasing milk production. The examples are superior to the comparative examples, and the solution of this invention has outstanding effects. The product of this invention is suitable for postpartum women.

[0023] The embodiments described above are merely illustrative of several implementations of the present invention, and while the descriptions are specific and detailed, they should not be construed as limiting the scope of the present invention. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of the present invention, and these modifications and improvements all fall within the scope of protection of the present invention. Therefore, the scope of protection of this patent should be determined by the appended claims.

Claims

1. A medicinal and edible homologous formula powder for regulating postpartum depression and physiological disorders, characterized in that, The following components by mass parts: black sesame 115-125 parts, active extract 8-15 parts, tartary buckwheat compound 55-65 parts, 55-65 parts of radix puerariae, 46-50 parts of raw land, 5-9 parts of medlar hawthorn polysaccharide, 32-38 parts of chrysanthemum, 45-50 parts of granulated sugar; The tartary buckwheat compound is baked after tartary buckwheat is immersed in a polysaccharide solution, cooled, crushed, and then ground with lysine hydrochloride; The active extract is obtained by complex extraction of gold orange and grape seeds; The medlar hawthorn polysaccharide is obtained by ultrasonic extraction after enzymolysis of hawthorn and medlar with enzyme solution.

2. The phyo-phonutrient formulation as claimed in claim 1, wherein, The following components by mass parts: black sesame 120 parts, active extract 12 parts, tartary buckwheat compound 60 parts, 60 parts of radix puerariae, 48 parts of raw land, 7 parts of medlar hawthorn polysaccharide, 35 parts of chrysanthemum, 48 parts of granulated sugar.

3. The phyo-phytochemical composition as claimed in claim 1, wherein, The preparation of the tartary buckwheat compound is as follows: after the tartary buckwheat is washed and drained, it is immersed in a polysaccharide solution with a solid-liquid ratio of 1:3-5 g / mL for 4-6 min, then taken out and baked at 50-60℃ for 25-30 min, cooled and crushed to 80-100 mesh, and then ground with lysine hydrochloride at 300-350 rpm for 10-15 min.

4. The phyo-phytochemical composition as claimed in claim 1, wherein, The addition amount of lysine hydrochloride is 1-3% of the tartary buckwheat.

5. The phyo-phytochemical composition as claimed in claim 1, wherein, The polysaccharide solution is an aqueous solution containing 5-8 wt% of fucoidan and 1-2 wt% of fructooligosaccharide.

6. The phyo-phytochemical composition as claimed in claim 1, wherein, The active extract is obtained by complex extraction of gold orange and grape seeds; 7. The phyo-phytochemical composition as claimed in claim 1, wherein, The preparation of the medlar hawthorn polysaccharide is as follows: medlar and peeled and sliced hawthorn are mixed in a mass ratio of 1-3:1, dried and crushed to 100 mesh, then enzymolysis is carried out with enzyme solution at a solid-liquid ratio of 1:8-10 at 40-50℃ for 40-50 min, followed by ultrasonic immersion at 20-30 kHz for 10-15 min, centrifugation, sterilization, and then spray drying.

8. The phyo-phonutrient formulation as claimed in claim 1 wherein, The enzyme solution contains 0.06%-0.08% of complex enzyme, and the complex enzyme is a mixture of trypsin and tannase in a mass ratio of 1:2-3.

9. A process for the preparation of a pharmacological and nutritional formulation for the treatment of postpartum depression and physiological disorders, for recovering a pharmacological and nutritional formulation for the treatment of postpartum depression and physiological disorders, prepared according to any one of the processes described in claims 1-8, characterized by, The following steps are included: Step 1: prepare each component according to the mass parts; Step 2: after the black sesame is inactivated, it is broken and crushed together with the radix puerariae and raw land, and the medlar, hawthorn and chrysanthemum are vacuum freeze-dried; Step 3: all components are mixed and sterilized, then packaged under nitrogen.

10. A process for preparing the pharmacological and nutriceutical composition powder as claimed in claim 9, wherein, The inactivation is carried out at 110-130℃ for 18-22 s.

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