Blood separation workstation

Abstract

The invention relates to the technical field of biomedical equipment, and particularly provides a blood separation workstation. Specifically, the blood separation workstation comprises a blood separation system and an intelligent control system, the blood separation system is used for executing blood separation operation, and the intelligent control system can collect voice instructions of a user and control the blood separation system to execute corresponding blood separation operation according to the voice instructions of the user. According to the blood separation work station, the intelligent control system is arranged, and the intelligent control system can collect the voice instruction of the user and control the blood separation system to execute the corresponding blood separation operation according to the voice instruction of the user, so that the user can directly control the blood separation work station to perform blood separation work through voice; manual control is not needed any more, the working efficiency and convenience are greatly improved, and the user experience is improved.

Description

Technical Field

[0001] This invention relates to the field of biomedical equipment technology, specifically providing a blood separation workstation. Background Technology

[0002] In hospitals or biomedical experiments, it is often necessary to separate blood and extract the required components, such as peripheral blood mononuclear cells (PBMCs). Although some blood centrifugation and stratification equipment has achieved partial automation, existing equipment mostly relies on physical buttons, touch screens or professional software interfaces for operation. The operation is cumbersome and not convenient for experimental personnel to quickly and intuitively input instructions in specific environments such as sterile conditions or when wearing gloves.

[0003] Therefore, a new technical solution is needed in this field to solve the above problems. Summary of the Invention

[0004] The present invention aims to solve the above-mentioned technical problems, namely, to solve the problem that existing blood separation equipment relies heavily on manual operation by staff, which is inconvenient to use.

[0005] In a first aspect, the present invention provides a blood separation workstation, the blood separation workstation comprising a blood separation system and an intelligent control system, the blood separation system being used to perform blood separation operations, and the intelligent control system being able to collect user voice commands and control the blood separation system to perform corresponding blood separation operations according to the user's voice commands.

[0006] In the preferred embodiment of the aforementioned blood separation workstation, the blood separation system includes a pipetting device, a centrifuge device, an image acquisition device, and a capping device. The centrifuge device is used to centrifuge blood samples in centrifuge tubes to separate the blood into layers. The image acquisition device is used to acquire layered images of the blood samples after centrifugation. The pipetting device can remove different components of the blood sample from the centrifuge tubes separately. The capping device is used for opening and closing the caps of the centrifuge tubes. The intelligent control system can automatically arrange the workflow sequence of the centrifuge device, the pipetting device, the image acquisition device, and the capping device according to user needs and control the centrifuge device, the pipetting device, the image acquisition device, and the capping device to perform corresponding blood separation operations according to the arranged workflow sequence.

[0007] In the preferred embodiment of the blood separation workstation described above, the intelligent control system can automatically set the operating parameters of the centrifugation device according to the type of blood sample.

[0008] In the preferred technical solution of the blood separation workstation described above, the intelligent control system can record the data and results of the blood separation operation for continuous training and optimization.

[0009] In the preferred technical solution of the blood separation workstation described above, the intelligent control system can make anomaly judgments based on the images acquired by the image acquisition device and provide corresponding processing suggestions when an anomaly occurs.

[0010] In the preferred embodiment of the blood separation workstation described above, the pipetting device includes a pump body and a plurality of pipettes connected to the pump body.

[0011] In the preferred embodiment of the blood separation workstation described above, the centrifugation device includes a centrifuge, a centrifugation adapter, and a balancing adapter. The centrifugation adapter is used to hold centrifuge tubes for centrifugation, and the balancing adapter is used to hold balancing tubes. During centrifugation, the centrifugation adapter and the balancing adapter are symmetrically placed in the centrifuge. The number of centrifuge tubes in the centrifugation adapter is the same as the number of balancing tubes in the balancing adapter, and the weight of the blood in the centrifuge tubes is equal to the weight of the liquid in the balancing tubes.

[0012] In the preferred embodiment of the blood separation workstation described above, the cap opening device includes a lifting mechanism and a clamping cap opening mechanism. The lifting mechanism can drive the clamping cap opening mechanism to move up and down in a vertical direction. The clamping cap opening mechanism includes a first clamping arm, a second clamping arm, and a driving mechanism. A first insert and a second insert are respectively provided on the sides of the first clamping arm and the second clamping arm that are far apart from each other. The blood separation workstation also includes an integrated tube cap. The integrated tube cap includes a plate-shaped body. The top surface of the plate-shaped body is provided with a first slot and a second slot that are respectively inserted and engaged with the first insert and the second insert. The bottom surface of the plate-shaped body is provided with a plurality of tube caps, each tube cap corresponding to a centrifuge tube. The driving mechanism can drive the first clamping arm and the second clamping arm to move away from each other, thereby allowing the first insert and the second insert to be inserted into the first slot and the second slot, respectively.

[0013] In the preferred embodiment of the blood separation workstation described above, the blood separation system further includes a reagent dispensing device, which is used to add reagents required for centrifugation into the centrifuge tubes.

[0014] In the preferred technical solution of the blood separation workstation described above, the intelligent control system includes a voice acquisition module and a large language model control module. The voice acquisition module is used to acquire the user's voice commands and translate the acquired voice commands into text commands before transmitting them to the large language model control module. The large language model control module is able to perform semantic understanding on the received text commands and control the blood separation system to perform corresponding blood separation operations based on the semantic understanding.

[0015] With the above technical solution adopted, the blood separation workstation of the present invention is equipped with an intelligent control system. The intelligent control system can collect the user's voice commands and control the blood separation system to perform corresponding blood separation operations according to the user's voice commands. This allows the user to directly control the blood separation workstation to perform blood separation work through voice, eliminating the need for manual control, which greatly improves work efficiency and convenience, and enhances the user experience.

[0016] Furthermore, the blood separation workstation of the present invention, through an intelligent control system, can automatically arrange the workflow sequence of the centrifuge device, pipetting device, image acquisition device, and cap opening device of the blood separation system according to user needs, and control the centrifuge device, pipetting device, image acquisition device, and cap opening device to perform corresponding blood separation operations according to the arranged workflow sequence, making the control of the blood separation workstation simpler and the user experience better.

[0017] Furthermore, the blood separation workstation of the present invention can automatically set the operating parameters of the centrifuge device according to the type of blood sample through the intelligent control system, eliminating the need for manual setting by personnel. This helps to avoid errors in the input of operating parameters and thus helps to ensure the quality of blood separation.

[0018] Furthermore, the blood separation workstation of the present invention can record the data and results of blood separation operations through an intelligent control system for continuous training and optimization, making the intelligent control system more intelligent and efficient, and further improving the quality and efficiency of blood separation.

[0019] Furthermore, the blood separation workstation of the present invention, by setting a balancing adapter and balancing tubes, can set the number of balancing tubes and the weight of liquid in the balancing tubes according to the number of centrifuge tubes and the weight of blood in the centrifuge tubes, thereby achieving automatic balancing.

[0020] Furthermore, the blood separation workstation of the present invention achieves higher pipetting efficiency by configuring the pipetting device as a multi-channel pipetting device.

[0021] Furthermore, the clamping mechanism of the blood separation workstation of the present invention has multiple clamping positions, which can clamp multiple centrifuge tubes at the same time. The rotating capping mechanism is correspondingly provided with multiple clamping modules, which can clamp the caps of multiple centrifuge tubes at the same time, so that the capping device of the present invention can open multiple centrifuge tubes at the same time, and the capping efficiency is higher. Attached Figure Description

[0022] The preferred embodiments of the present invention are described below with reference to the accompanying drawings, in which: Figure 1 This is a system schematic diagram of the blood separation workstation of the present invention; Figure 2 This is a schematic diagram of the opening device of the present invention; Figure 3 This is a schematic diagram of the image acquisition device of the blood separation workstation of the present invention.

[0023] List of reference numerals in the attached figures: 1. Intelligent control system; 2. Pipette; 3. Centrifuge device; 31. Centrifuge adapter; 311. Observation opening; 312. Column; 32. Centrifuge tube; 4. Image acquisition device; 41. Image acquisition component; 411. Support frame; 412. Camera; 42. Rotating component; 421. Rotating mechanism; 422. Mounting frame; 5. Cap opening device; 51. Lifting mechanism; 52. Rotating cap opening mechanism; 521. First gripper; 522. Second gripper; 53. Clamping mechanism; 531. Fixed base; 532. Fixed clamping plate; 533. Moving clamping plate; 534. Drive mechanism; 6. Reagent dispensing device. Detailed Implementation

[0024] Preferred embodiments of the present invention will now be described with reference to the accompanying drawings. Those skilled in the art should understand that these embodiments are merely illustrative of the technical principles of the present invention and are not intended to limit the scope of protection of the present invention.

[0025] It should be noted that in the description of this invention, terms such as "upper," "lower," "top," "bottom," "left," "right," "front," and "rear," which indicate direction or positional relationships, are based on the direction or positional relationships shown in the accompanying drawings. These are used merely for ease of description and do not indicate or imply that the device or element must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this invention. Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0026] Furthermore, it should be noted that, in the description of this invention, unless otherwise explicitly specified and limited, the terms "set," "connect," and "install" should be interpreted broadly, for example, referring to a fixed connection, a detachable connection, or an integral connection. Those skilled in the art can understand the specific meaning of the above terms in this invention according to the specific circumstances.

[0027] Specifically, the present invention provides a blood separation workstation that can realize the automated separation and processing of blood samples.

[0028] like Figure 1 As shown, the blood separation workstation of the present invention includes a blood separation system for performing blood separation operations. The blood separation system of the present invention includes a pipetting device 2, a centrifugation device 3, an image acquisition device 4, and a cap opening device 5.

[0029] The centrifuge device 3 includes a centrifuge tube 32, in which a blood sample is placed. The centrifuge device 3 is used to centrifuge the blood sample in the centrifuge tube 32 to separate the blood into layers.

[0030] Using heparin-anticoagulated whole blood as the blood sample, centrifuging the blood sample in centrifuge tube 32 can separate the blood sample in centrifuge tube 32 into 3 layers, from top to bottom: plasma, peripheral blood mononuclear cells (PBMCs) and red blood cells.

[0031] The image acquisition device 4 of the blood separation workstation of the present invention is used to acquire layered images of blood samples in centrifuge tubes 32 to provide data support for subsequent pipetting operations. The pipetting device 2 can remove different components of the blood sample in centrifuge tubes 32 separately. The capping device 5 is used for opening and closing the cap of the centrifuge tube.

[0032] After centrifuging the blood sample in centrifuge tube 32 using centrifuge device 3, centrifuge tube 32 is removed from centrifuge device 3 and transferred to image acquisition device 4. Image acquisition device 4 takes pictures of centrifuge tube 32 to acquire layered images of the blood sample in centrifuge tube 32. Based on the layered images of the blood, the position of each layer is determined. The centrifuge tube is then transferred to pipetting device 2. The cap of centrifuge tube 32 is opened using cap opening device 5. Then, the different components of the blood sample are removed separately using pipetting device 2, thereby achieving blood separation.

[0033] The centrifugation, layered image acquisition, pipetting, transfer of centrifuge tubes, and opening and closing of caps described above all fall under the category of blood separation operations.

[0034] Preferably, such as Figure 1 As shown, the blood separation workstation of the present invention also includes an intelligent control system 1, which can collect the user's voice commands and control the blood separation system to perform corresponding blood separation operations according to the user's voice commands.

[0035] The blood separation workstation of the present invention, by setting up an intelligent control system 1, allows users to directly control the blood separation workstation to perform blood separation work through voice, eliminating the need for manual control, which greatly improves work efficiency and convenience, and enhances the user experience.

[0036] For example, when a blood sample needs to be centrifuged, the user can say "Start centrifugation." After receiving the voice command "Start centrifugation," the intelligent control system controls the centrifugation device of the blood separation system to start operation and centrifuge the blood sample in the centrifuge tube. When centrifugation needs to be stopped, the user can say "Stop centrifugation, transfer the centrifuge tube to the image acquisition device, and acquire blood layer images." After receiving the voice command "Stop centrifugation, transfer the centrifuge tube to the image acquisition device, and acquire blood layer images," the intelligent control system shuts down the centrifugation device, controls the robotic arm to transfer the centrifuge tube from the centrifugation device to the image acquisition device, and controls the image acquisition device to acquire blood layer images. After acquiring the blood layer images, the user can say "Separate PBMCs, extract 2 ml." After receiving the voice command "Separate PBMCs, extract 2 ml," the intelligent control system first controls the robotic arm to transfer the centrifuge tube to the pipette, then controls the capping device to open the cap of the centrifuge tube, and then controls the pipette to extract 2 ml of PBMCs.

[0037] Preferably, such as Figure 1 As shown, the intelligent control system 1 of the present invention includes a voice acquisition module and a large language model control module. The voice acquisition module is used to acquire the user's voice commands and translate the acquired voice commands into text commands before transmitting them to the large language model control module. The large language model control module is able to perform semantic understanding on the received text commands and control the blood separation system to perform corresponding blood separation operations based on the semantic understanding.

[0038] The large language model is an artificial intelligence technology based on deep learning. It is trained with a large-scale dataset and can understand and generate natural language text. The large language model control module of the intelligent control system of this invention is based on the large language model. Through prior training, it can accurately understand the user's voice commands and thus complete the corresponding blood separation operation.

[0039] Preferably, the intelligent control system 1 of the present invention can automatically arrange the workflow sequence of the centrifuge device, pipetting device, image acquisition device and cap opening device of the blood separation system according to user needs, and control the centrifuge device, pipetting device, image acquisition device and cap opening device to perform corresponding blood separation operations according to the arranged workflow sequence.

[0040] By setting the intelligent control system 1 to automatically arrange the workflow of the centrifuge device, pipetting device, image acquisition device and capping device, the control of the blood separation workstation is made simpler and the user experience is better.

[0041] It should be noted that user requirements may include the target components in the blood sample to be extracted, the quantity of the target components, the purity of the target components, etc. Different user requirements may result in different workflow sequences for each device. For example, if the user requires higher purity of the target components, multiple centrifugation operations and multiple pipetting operations are required for the blood sample. In order for the large language model control module of the intelligent control system to reasonably arrange the workflow sequence of the centrifugation device, pipetting device, image acquisition device, and capping device, the large language model needs to be fully trained for each user requirement during the initial training, and the large language model control module needs to fully master the operating specifications of each device of the blood separation system.

[0042] Preferably, training can also incorporate some principles of blood separation biology. For example, the PBMC layer is extremely thin and fragile, and must be aspirated slowly to prevent damage to the interface. The aspiration speed of the pipette needs to be controlled at a preset speed. The tip of the pipette needs to be positioned below the target liquid surface, for example, 0.5 mm below the target liquid surface. By combining the principles of blood separation biology to train the large language model, the quality of blood separation can be improved.

[0043] Preferably, the intelligent control system 1 of the present invention can automatically set the operating parameters of the centrifugation device 3 according to the type of blood sample.

[0044] The operating parameters of centrifuge device 3 mainly include relative centrifugal force (RCF), centrifugation time, acceleration / deceleration rate, and temperature. RCF determines the separation efficiency, centrifugation time determines the integrity of the layer separation, temperature affects cell viability, and acceleration / deceleration rate affects the stability of the layer interface. The type of blood sample (e.g., heparin-anticoagulated whole blood, serum, animal blood, etc.) can be input by the user. Different types of blood samples are centrifuged using corresponding operating parameters by controlling the centrifuge device, resulting in better centrifugation quality.

[0045] Preferably, the intelligent control system 1 of the present invention can record the data and results of blood separation operations for continuous training and optimization.

[0046] In later stages of use, a large amount of data and results are accumulated. By recording this data and results, the large language model can be continuously trained and optimized, making the large language model control module more intelligent and efficient, and further improving the quality and efficiency of blood separation.

[0047] Preferably, the intelligent control system 1 of the present invention can make anomaly judgments based on the images acquired by the image acquisition device 4, and provide corresponding processing suggestions when an anomaly occurs.

[0048] For example, if the blood layer images acquired by the image acquisition device 4 show that the thickness of the PBMC layer is significantly higher than the historical average and the interface is blurry, the large language model control module will suggest that the centrifugation is insufficient and that the centrifugation operation should be repeated or the PBMC should be discarded. If the blood layer images acquired by the image acquisition device show that air bubbles or clots are present, the large language model control module will suggest that high-precision separation is not possible and that the PBMC should be discarded or that the clots should be removed.

[0049] It should be noted that, in practical applications, those skilled in the art can configure the cap-opening device 5 to open only one centrifuge tube 32 at a time, or it can be configured to open multiple centrifuge tubes 32 at a time, etc. Such flexible adjustments and changes do not deviate from the principles and scope of the present invention and should all be limited to the protection scope of the present invention. Of course, the present invention preferably configures the cap-opening device 5 to open multiple centrifuge tubes 32 simultaneously, thereby improving work efficiency.

[0050] Preferably, the centrifugation device 3 of the present invention includes a centrifuge, a centrifugation adapter 31, and a balancing adapter. The centrifugation adapter 31 is used to hold centrifuge tubes 32 that need to be centrifuged, and the balancing adapter is used to hold balancing tubes. During centrifugation, the centrifugation adapter 31 and the balancing adapter are symmetrically placed in the centrifuge. The number of centrifuge tubes 32 in the centrifugation adapter 31 is the same as the number of balancing tubes in the balancing adapter, and the weight of the blood in the centrifuge tubes 32 is equal to the weight of the liquid in the balancing tubes.

[0051] By setting a balancing adapter and a balancing tube, the number of balancing tubes and the weight of the liquid in the balancing tubes can be set according to the number of centrifuge tubes 32 and the weight of the blood in the centrifuge tubes 32, thereby achieving automatic balancing. Preferably, the centrifuge adapter 31 and the balancing adapter have the same structure, and the centrifuge tubes 32 and the balancing tubes are also preferably identical.

[0052] For example, blood samples from eight blood collection tubes are separated simultaneously. The volumes of the blood samples in the eight blood collection tubes are 10ml, 9.8ml, 10.1ml, 9.9ml, 10.2ml, 9.8ml, 10ml, and 9.8ml, respectively. Taking the smallest volume of 9.8ml as the baseline, the blood from the eight blood collection tubes is transferred to eight centrifuge tubes 32, with each centrifuge tube containing a volume of 9.8ml. The eight centrifuge tubes 32 are placed on the same centrifuge adapter 31, and eight balancing tubes are also placed in the balancing adapter. The volume of liquid in each balancing tube is also 9.8ml, and the density of the liquid in the balancing tubes is basically the same as the density of the blood samples, so that the weight of the liquid in the balancing tubes is the same as the weight of the blood samples in the centrifuge tubes 32. The centrifuge adapter 31 and the balancing adapter are symmetrically placed in the centrifuge, and the centrifuge is started for centrifugation.

[0053] Preferably, the pipetting device 2 of the present invention includes a pump body and a plurality of pipettes communicating with the pump body. That is, the pipetting device 2 of the present invention is a multi-channel pipetting device 2, which has higher pipetting efficiency.

[0054] For example, the pipetting device 2 of the present invention is a four-channel pipetting device, specifically including four pipettes arranged in a row, capable of simultaneously transferring blood samples from four centrifuge tubes. The pump of the pipetting device 2 is communicatively connected to an intelligent control system, which can control the pump to achieve precise pipetting.

[0055] It should be noted that the number of pipettes is not limited to the four mentioned above. For example, it can also be set to three, six or more, etc. Such adjustments and changes to the specific number of pipettes do not deviate from the principles and scope of the present invention and should be limited to the protection scope of the present invention.

[0056] Preferably, such as Figure 2 As shown, the cap-opening device 5 of the present invention includes a lifting mechanism 51, a rotating cap-opening mechanism 52, and a clamping mechanism 53. The clamping mechanism 53 is provided with a plurality of clamping positions, each clamping position being able to clamp the tube body of a centrifuge tube 32. The rotating cap-opening mechanism 52 includes a plurality of clamping modules, each clamping module being able to clamp the cap of a centrifuge tube 32, and each clamping module is provided with a cap-opening driving component for driving the clamping module to rotate. The lifting mechanism 51 is connected to the rotating cap-opening mechanism 52, and the lifting mechanism 51 can lift the rotating cap-opening mechanism 52 while the cap-opening driving component drives the clamping module to rotate and open the cap.

[0057] The clamping mechanism 53 of the cap-opening device 5 of the present invention is provided with multiple clamping positions, which can simultaneously clamp multiple centrifuge tubes 32. The rotating cap-opening mechanism 52 is correspondingly provided with multiple clamping modules, which can simultaneously clamp the caps of multiple centrifuge tubes 32, so that the cap-opening device 5 of the present invention can open multiple centrifuge tubes 32 at the same time, resulting in higher cap-opening efficiency. Among them, the lifting mechanism 51, the rotating cap-opening mechanism 52, and the clamping mechanism 53 are communicatively connected to the intelligent control system. The intelligent control system can control the lifting mechanism 51, the rotating cap-opening mechanism 52, and the clamping mechanism 53 to realize the cap-opening and cap-closing operations of the centrifuge tubes.

[0058] For example, the clamping mechanism 53 of the cap-opening device 5 is located at the bottom, and the lifting mechanism 51 and the rotating cap-opening mechanism 52 are located above the clamping mechanism 53. The clamping mechanism 53 is provided with four clamping positions, and the rotating cap-opening mechanism 52 of the cap-opening device 5 is provided with four clamping modules. When performing the cap-opening operation, four centrifuge tubes 32 are first placed on the clamping mechanism 53, and one centrifuge tube 32 is clamped at each clamping position. Then, the lifting mechanism 51 drives the rotating cap-opening mechanism 52 to move downward, so that the four clamping modules of the rotating cap-opening mechanism 52 clamp the cap of one centrifuge tube 32 respectively. Then, the cap-opening driving component drives the corresponding clamping module to rotate, so that the clamping module rotates with the cap, and at the same time, the lifting mechanism 51 drives the rotating cap-opening mechanism 52 to rise, thereby opening the cap of the centrifuge tube 32.

[0059] Preferably, such as Figure 2 As shown, the clamping mechanism 53 of the present invention is provided with a rubber pad at the clamping position, and the rubber pad can fit against the outer wall of the centrifuge tube 32.

[0060] By placing a rubber pad on the clamping position of the clamping mechanism 53 to fit against the wall of the centrifuge tube 32, the friction between the clamping mechanism 53 and the centrifuge tube 32 can be increased, and the centrifuge tube 32 can be prevented from being damaged by the buffer of the rubber pad.

[0061] Preferably, such as Figure 2 As shown, the clamping mechanism 53 of the present invention includes a fixed base 531 and a fixed clamping plate 532, a movable clamping plate 533 and a driving mechanism 534 mounted on the fixed base 531. The fixed clamping plate 532 is provided with a plurality of first clamping grooves and the movable clamping plate 533 is provided with a plurality of second clamping grooves. The first clamping grooves and the second clamping grooves are arranged opposite to each other and together form a clamping position. The driving mechanism 534 is connected to the movable clamping plate 533 and can drive the movable clamping plate 533 to move toward / away from the fixed clamping plate 532.

[0062] First, the centrifuge tube 32 is placed into the first clamping groove of the fixed clamping plate 532. Then, the moving clamping plate 533 is driven by the driving mechanism 534 to move towards the fixed clamping plate 532, so that the second clamping groove and the first clamping groove together clamp the body of the centrifuge tube 32. When it is necessary to remove the centrifuge tube 32, the moving clamping plate 533 is driven by the driving mechanism 534 to move away from the fixed clamping plate 532, releasing the body of the centrifuge tube 32.

[0063] For example, the fixing base 531 of the clamping mechanism 53 includes a horizontally arranged first mounting plate and a vertically arranged second mounting plate. The fixing clamping plate 532 is vertically arranged on the first mounting plate and is arranged opposite to the second mounting plate. The driving mechanism 534 includes a motor and a lead screw connected to the drive shaft of the motor. The motor is installed on the side of the second mounting plate away from the fixing clamping plate 532. The drive shaft of the motor passes through the second mounting plate. The lead screw is horizontally arranged. The movable clamping plate 533 is vertically arranged and located between the fixing clamping plate 532 and the second mounting plate. The movable clamping plate 533 is provided with a threaded hole that cooperates with the lead screw. When the motor drives the lead screw to rotate, it can drive the movable clamping plate 533 to move.

[0064] The first clamping groove is located on the side of the fixed clamping plate 532 facing the movable clamping plate 533, and the second clamping groove is located on the side of the movable clamping plate 533 facing the fixed clamping plate 532. Both the first clamping groove and the second clamping groove extend in the vertical direction. The cross-section of the first clamping groove and the second clamping groove is approximately U-shaped. Both the first clamping groove and the second clamping groove are provided with rubber pads.

[0065] Preferably, such as Figure 2 As shown, the clamping module of the rotating opening mechanism 52 of the present invention includes a first clamping jaw 521 and a second clamping jaw 522 disposed opposite to each other, and a clamping drive member for driving the first clamping jaw 521 and the second clamping jaw 522 to clamp / separate.

[0066] For example, the first gripper 521 and the second gripper 522 are both vertically arranged. The clamping drive component includes an electromagnetic component and an elastic reset component disposed between the first gripper 521 and the second gripper 522. When it is necessary to clamp the cap of the centrifuge tube 32, the electromagnetic component is energized to clamp the first gripper 521 and the second gripper 522, and the elastic reset component is compressed. When the electromagnetic component is de-energized, the first gripper 521 separates from the second gripper 522 under the action of the elastic reset component, and the cap of the centrifuge tube 32 is released.

[0067] Preferably, such as Figure 1 As shown, the blood separation workstation of the present invention also includes a reagent dispensing device 6, which is used to add reagents required for centrifugation into the centrifuge tube 32.

[0068] For example, reagents such as buffered saline (PBS) and density centrifugation media (e.g., Ficoll or Percoll solution) may be used during centrifugation. The buffer protects the blood from damage during centrifugation, while the density centrifugation media separates the different components of the blood to facilitate extraction of the target component. For instance, when Ficoll solution is added to a blood sample during centrifugation, peripheral blood mononuclear cells will be on top of the Ficoll solution after centrifugation, while red blood cells will be on the bottom, thus better separating the peripheral blood mononuclear cells.

[0069] The reagent dispensing device 6 of the present invention is also controlled by the intelligent control system 1, and the intelligent control system 1 is also able to arrange the workflow of the reagent dispensing device 6.

[0070] Preferably, such as Figure 3 As shown, the image acquisition device 4 of the present invention includes an image acquisition component 41 and a rotation component 42, wherein the rotation component 42 is used to place the centrifuge tube 32 and is capable of rotating the centrifuge tube 32, and the image acquisition component 41 is used to acquire blood layer images in the centrifuge tube 32.

[0071] For example, the image acquisition component 41 includes a support frame 411 and a camera 412 mounted on the support frame 411. The rotation component 42 includes a rotation mechanism 421 and a mounting bracket 422 mounted on top of the rotation mechanism 421. The centrifuge adapter 31 can be directly placed on the mounting bracket 422. The centrifuge adapter 31 is provided with eight receiving slots for accommodating centrifuge tubes 32. The eight receiving slots are divided into two rows of four receiving slots each. The receiving slots have observation openings 311 extending in the vertical direction to expose the centrifuge tubes 32 in the receiving slots. The camera 412 can acquire blood layering images in the centrifuge tubes 32 through the observation openings 311. The blood layering images of four centrifuge tubes 32 can be acquired first. After the acquisition is completed, the mounting bracket 422 is driven by the rotation mechanism 421 to rotate the centrifuge adapter 31 180 degrees, and then the blood layering images of the other four centrifuge tubes 32 are acquired.

[0072] In addition, in order to improve the acquisition effect of blood layer images, it is preferable to set a light-illuminating component in the centrifuge adapter 31 to illuminate the centrifuge tube 32. For example, a light guide plate can be set in the middle of the two rows of receiving slots of the centrifuge adapter 31, and light sources can be set at both ends of the light guide plate.

[0073] Those skilled in the art will understand that although some embodiments herein include certain features included in other embodiments but not others, combinations of features from different embodiments are intended to be within the scope of this application and form different embodiments. For example, any of the claimed embodiments in the claims of this application can be used in any combination.

[0074] The technical solution of the present invention has been described above with reference to the preferred embodiments shown in the accompanying drawings. However, it will be readily understood by those skilled in the art that the scope of protection of the present invention is obviously not limited to these specific embodiments. Without departing from the principles of the present invention, those skilled in the art can make equivalent changes or substitutions to the relevant technical features, and the technical solutions after such changes or substitutions will all fall within the scope of protection of the present invention.

Claims

1. A blood separation station, characterized in that, The blood separation workstation comprises a blood separation system for performing blood separation operations and an intelligent control system (1) capable of collecting voice instructions of a user and controlling the blood separation system to perform corresponding blood separation operations according to the voice instructions of the user.

2. The blood separation workstation according to claim 1, wherein the blood separation system comprises a pipetting device (2), a centrifugal device (3), an image acquisition device (4) and a cap opening device (5), the centrifugal device (3) is used for centrifuging blood samples in centrifugal tubes to separate the blood, the image acquisition device (4) is used for acquiring images of the separated blood after centrifuging, the pipetting device (2) is capable of moving different components of the blood samples in the centrifugal tubes respectively, and the cap opening device is used for opening and closing the caps of the centrifugal tubes; the intelligent control system (1) is capable of automatically arranging the work flow sequence of the centrifugal device (3), the pipetting device (2), the image acquisition device (4) and the cap opening device (5) according to user requirements and controlling the centrifugal device (3), the pipetting device (2), the image acquisition device (4) and the cap opening device (5) to perform corresponding blood separation operations according to the arranged work flow sequence.

3. The blood separation station of claim 2, wherein, The intelligent control system (1) is capable of automatically setting the operating parameters of the centrifugal device (3) according to the type of the blood samples.

4. The blood separation station of claim 2, wherein, The intelligent control system (1) is capable of recording data and results of blood separation operations for continuous training and optimization.

5. The blood separation station of claim 2, wherein, The intelligent control system (1) is capable of performing abnormality judgment according to images acquired by the image acquisition device (4) and giving corresponding processing suggestions when abnormal conditions occur.

6. The blood separation station of claim 2, wherein, The pipetting device (2) comprises a pump body and a plurality of pipetting guns in communication with the pump body.

7. The blood separation station of claim 2, wherein, The centrifugal device (3) comprises a centrifuge, a centrifugal adapter (31) for placing centrifugal tubes (32) requiring centrifugation and a balancing adapter for placing balancing tubes, when performing centrifugation, the centrifugal adapter (31) and the balancing adapter are symmetrically placed in the centrifuge, the number of the centrifugal tubes (32) in the centrifugal adapter (31) is the same as the number of the balancing tubes in the balancing adapter, and the weight of the blood in the centrifugal tubes (32) is equal to the weight of the liquid in the balancing tubes.

8. The blood separation station of claim 2, wherein, The cap opening device (5) comprises a lifting mechanism (51), a rotary cap opening mechanism (52) and a clamping mechanism (53), the clamping mechanism (53) is provided with a plurality of clamping positions, each of which can clamp a tube body of a blood collection tube (8), the rotary cap opening mechanism (52) comprises a plurality of clamping modules, each of which can clamp a cap of a centrifugal tube, and each of which is provided with a cap opening driving member for driving the clamping module to rotate, The lifting mechanism (51) is connected with the rotating cover opening mechanism (52), and the lifting mechanism (51) can ascend with the rotating cover opening mechanism (52) in the process that the cover opening driving member drives the clamping module to rotate and open the cover.

9. The blood separation station of claim 2, wherein, The blood separation system further comprises a reagent filling device (6) for filling a reagent required for centrifugal operation into the centrifugal tube (32).

10. The blood separation station according to any one of claims 1 to 9, characterized in that, The intelligent control system (1) comprises a voice acquisition module and a large language model control module, the voice acquisition module is used for acquiring voice instructions of a user and transmitting the acquired voice instructions to the large language model control module after translating the voice instructions into text instructions, and the large language model control module can perform semantic understanding on the received text instructions and control the blood separation system to perform corresponding blood separation operations based on the semantic understanding.

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