Injection water preparation system and control method thereof

Abstract

The invention relates to an injection water preparation system and a control method thereof.The injection water preparation system comprises a purified water system and an injection water system which are connected with each other, the purified water system is used for purifying raw material water to form purified water, and the injection water system is used for purifying the purified water to form injection water; the method comprises the following steps: acquiring a water quality key index of the water for injection; according to the water quality key indexes, a control strategy for the purified water system and / or the injection water system is adjusted. The water production quality of the water for injection can be improved.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of pharmaceutical engineering, in particular to a system for preparing water for injection and a control method thereof. BACKGROUND

[0002] Pharmaceutical water is the blood of the pharmaceutical industry and the public works of pharmaceutical engineering. The water quality directly affects the key quality of drugs. Based on online technology, the system quality is controlled in real time to reduce the risk of delayed detection of quality, which is the core quality control demand of the pharmaceutical industry. At the same time, with the increasing energy consumption and the requirement of green and low carbon, the public works of pharmaceutical water is also a core technical point of energy consumption, and the water quality function of the produced water is the core technical element of this type of product. The traditional technology prepares water for injection by distillation of purified water, and another type of water for injection is produced by using a purified water preparation process. The system detects related indicators manually. However, the water quality of the traditional water for injection preparation method is poor. SUMMARY

[0003] Therefore, it is necessary to provide a system for preparing water for injection and a control method thereof, which can improve the water quality of water for injection.

[0004] In a first aspect, the present application provides a control method of a system for preparing water for injection. The system for preparing water for injection comprises a purified water system and a water for injection system connected to each other. The purified water system is used to purify raw water to form purified water. The water for injection system is used to purify the purified water to form water for injection. The method comprises:

[0005] obtaining a water quality key indicator of water for injection;

[0006] adjusting a control strategy for the purified water system and / or the water for injection system according to the water quality key indicator.

[0007] In one embodiment, the control strategy comprises real-time adjustment of working parameters. The working parameters include circulating flow rate, ultraviolet lamp power, electric desalination current, disinfection mode and heat disinfection frequency. The water quality key indicator includes microbial load. Adjusting the control strategy for the purified water system and / or the water for injection system according to the water quality key indicator comprises:

[0008] analyzing the trend of the microbial load and adjusting the circulating flow rate, the ultraviolet lamp power, the electric desalination current, the disinfection mode and the heat disinfection frequency of the water for injection system.

[0009] In one embodiment, the water quality key indicator includes conductivity and total organic carbon content. Adjusting the control strategy for the purified water system and / or the water for injection system according to the water quality key indicator comprises:

[0010] If the conductivity and / or total organic carbon content of the water for injection are not up to standard, the water for injection preparation system shall be adjusted to enter the discharge mode until the conductivity of the water for injection is up to standard, and then the water for injection preparation system shall be adjusted to enter the production mode.

[0011] In one embodiment, the control strategy includes obtaining a production water data change model based on key water quality indicators, and making system predictions and strategy pre-executions based on the production water data change model.

[0012] Secondly, this application proposes a system for preparing water for injection, comprising:

[0013] A purified water system is used to purify raw water to produce purified water.

[0014] The water for injection system is connected to the purified water system and is used to purify purified water to form water for injection; the water for injection system includes a water quality detection module, which is used to acquire and output the key water quality indicators of the water for injection.

[0015] The control system is connected to the water quality detection module and is used to execute the above-described method.

[0016] In one embodiment, the purified water system includes a pretreatment system and a purification system connected to each other, wherein the raw water is purified by the pretreatment system and the purification system before entering the water for injection system.

[0017] In one embodiment, the water for injection system includes: a purified water tank, a return water purification system, and a product water tank. The return water purification system is connected to the purified water system through the purified water tank. After being purified by the purified water tank and the return water purification system, the purified water is converted into water for injection and enters the product water tank.

[0018] In one embodiment, the purification system includes a medium-pressure ultraviolet system, a reverse osmosis membrane system, and a degassing membrane; the medium-pressure ultraviolet system is used to irradiate the feed water with the medium-pressure ultraviolet spectrum, the reverse osmosis membrane system is used to desalinate the feed water, and the degassing membrane is used to reduce the carbon dioxide concentration in the feed water.

[0019] In one embodiment, the water purification system includes: a clean heat exchanger, an ultraviolet lamp, and a continuous electrochemical desalination device; the clean heat exchanger is connected to the continuous electrochemical desalination device via the ultraviolet lamp, and the clean heat exchanger is also connected to the purified water tank via the ultraviolet lamp for circulating the purified water back; the continuous electrochemical desalination device is connected to the product water tank; the ultraviolet lamp is used to stimulate the purified water to generate hydroxyl radicals.

[0020] In one embodiment, the water quality testing module includes at least one of a pressure transmitter, an online conductivity monitor, an online total organic carbon monitor, and an online microbial detector installed on the product water pipeline of the water for injection; the product water pipeline of the water for injection is located between the continuous electrochemical desalination device and the product water tank.

[0021] The aforementioned water-to-injection preparation system and its control method comprise an interconnected purified water system and a water-to-injection system. The purified water system purifies the raw water to form purified water, and the water-to-injection system further purifies the purified water to form water for injection. The method includes: obtaining key water quality indicators for the water for injection; and adjusting the control strategies for the purified water system and / or the water-to-injection system based on the key water quality indicators, thereby improving the quality of the produced water for injection. Attached Figure Description

[0022] To more clearly illustrate the technical solutions in the embodiments of this application or the conventional technology, the drawings used in the description of the embodiments or the conventional technology will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0023] Figure 1 This is a schematic flowchart of the control method for a water-to-injection preparation system in one embodiment;

[0024] Figure 2 This is a detailed flowchart illustrating the control method of the water for injection preparation system in one embodiment;

[0025] Figure 3 This is a schematic diagram of the structure of a water-for-injection preparation system in one embodiment;

[0026] Figure 4 This is a detailed structural schematic diagram of a water-to-injection preparation system in one embodiment.

[0027] Figure reference numerals: Purified water system 100, Water for injection system 200, Water quality testing module 300, Control module 400; Pretreatment system 101, Medium-pressure ultraviolet system 102, Reverse osmosis membrane system 103, Degassing membrane 104, First PW permeate pipeline 105, Conductivity meter 106, First pressure transmitter 107, Clean check valve 108, First valve 109, Second valve 110, Third valve 111, Second PW permeate pipeline 112, Third PW permeate pipeline 113; Sixth valve 214, Temperature transmitter 215, Float valve 2 16. Purified water tank 217. Fourth valve 218. Fifth valve 219. Pump 220. Clean heat exchanger 221. First ultraviolet lamp 222. Second ultraviolet lamp 223. Continuous electrochemical desalination device 224. Circulation reflux pipeline 225. Spray ball 226. Water production pipeline for water for injection 227. First dual water supply 228. Second dual water supply 229. Second pressure transmitter 230. Online conductivity monitor 231. Online total organic carbon monitor 232. Online microbial detector 233. Seventh valve 234. Product water tank or point of use 235. Detailed Implementation

[0028] To facilitate understanding of this application, a more complete description will be provided below with reference to the accompanying drawings, which illustrate embodiments of the present application. However, the present application can be implemented in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided so that the disclosure of this application will be thorough and complete.

[0029] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the application.

[0030] It is understood that the terms “first,” “second,” etc., used in this application may be used herein to describe various elements, but these elements are not limited by these terms. These terms are only used to distinguish one element from another.

[0031] Spatial relation terms such as “below,” “under,” “below,” “below,” “above,” “above,” etc., are used herein to describe the relationship between one element or feature shown in the figure and other elements or features. It should be understood that, in addition to the orientation shown in the figure, spatial relation terms also include different orientations of the device in use and operation. For example, if the device in the figure is flipped, an element or feature described as “below,” “below,” or “below” will be oriented “above” the other element or feature. Therefore, the exemplary terms “below” and “under” can include both above and below orientations. Furthermore, the device may also include other orientations (e.g., rotated 90 degrees or other orientations), and the spatial descriptive terms used herein will be interpreted accordingly.

[0032] It should be noted that when one element is considered to be "connected" to another element, it can be directly connected to the other element or connected to the other element through an intermediary element. Furthermore, in the following embodiments, "connection" should be understood as "electrical connection," "communication connection," etc., if there is transmission of electrical signals or data between the connected objects.

[0033] When used herein, the singular forms of “a,” “an,” and “the” may also include the plural forms unless the context clearly indicates otherwise. It should also be understood that the terms “comprising / including” or “having,” etc., specify the presence of the stated features, wholes, steps, operations, components, parts, or combinations thereof, but do not preclude the possibility of the presence or addition of one or more other features, wholes, steps, operations, components, parts, or combinations thereof. Meanwhile, the term “and / or” as used in this specification includes any and all combinations of the associated listed items.

[0034] As described in the background section, one method for producing water for injection involves distillation of purified water. Another method uses a similar process, but relies on manual monitoring of relevant indicators, which typically lags behind the actual water quality by 5-7 days. Furthermore, the disinfection strategies are manually controlled, leading to significant deviations. In addition, current processes for producing water for injection suffer from the following problems: the conventional distillation method requires industrial steam heating, resulting in high production costs and poor environmental friendliness; current membrane-based processes lack effective control over microorganisms and endotoxins, relying on frequent disinfection, which reduces system lifespan; and for both distillation and membrane-based processes, key indicators such as microbial indicators require offline culture and monitoring for 4-7 days. By this time, the produced water has already been used, and if problems arise during monitoring, the drug faces the risk of spoilage and market recall, threatening patient safety.

[0035] Based on the above reasons, this invention provides a novel continuous endotoxin and microbial removal process based on trend judgment, self-diagnosis, and self-control: Through online monitoring of microorganisms, TOC (Total Organic Carbon), and conductivity, the system's water quality and operating status are analyzed in real time, and the data is fed back to the main control system. This allows for real-time adjustment of parameters such as circulation flow rate, UV lamp power, electro-desalination current, disinfection method, and thermal disinfection frequency, ensuring continuous water quality. Endotoxins and microorganisms are converted into ionic organic matter by hydroxyl radicals and removed by adsorption from a continuous electrochemical desalination device. Furthermore, a cross-flow control process increases the circulation frequency, effectively treating microorganisms and endotoxins.

[0036] In one exemplary embodiment, such as Figure 1 As shown, a control method for a water-for-injection preparation system is provided. The water-for-injection preparation system includes a purified water system and a water-for-injection system connected to each other. The purified water system is used to purify raw water to form purified water, and the water-for-injection system is used to purify the purified water to form water for injection. The method includes steps 302 to 304, wherein:

[0037] Step 302: Obtain key water quality indicators for water for injection.

[0038] For example, key water quality indicators for water for injection are obtained through a water quality testing device.

[0039] Step 304: Adjust the control strategy for the purified water system and / or water for injection system based on key water quality indicators.

[0040] For example, based on the obtained key water quality indicators of water for injection, the control strategy for the purified water system and / or the water for injection system is adjusted by adjusting the working status of relevant components of the water for injection preparation system.

[0041] The above-mentioned control method for the preparation system of water for injection obtains key water quality indicators of water for injection and adjusts the control strategy for the purified water system and / or the water for injection system based on these key water quality indicators. The preparation system of water for injection includes an interconnected purified water system and a water for injection system. The purified water system is used to purify the raw water to form purified water, and the water for injection system is used to purify the purified water to form water for injection. This allows the control strategy to be adjusted in real time according to the quality of the water produced by the system, thereby ensuring continuous water production quality and further improving the quality of the water for injection.

[0042] In one exemplary embodiment, such as Figure 3As shown, a water-for-injection preparation system is provided, comprising: a purified water system 100 for purifying raw water to form purified water; a water-for-injection system 200 connected to the purified water system 100 for purifying the purified water to form water for injection; wherein the water-for-injection system 200 includes a water quality detection module 300 for acquiring and outputting key water quality indicators of the water for injection; and a control system 400 connected to the water quality detection module 300 for executing the above-described control method for the water-for-injection preparation system.

[0043] In one exemplary embodiment, refer to Figure 4 The purified water system 100 includes a pretreatment system 101 and a purification system connected to each other. The raw water is purified by the pretreatment system 101 and the purification system before entering the water for injection system.

[0044] In one exemplary embodiment, refer to Figure 4 The water for injection system 200 includes: a purified water tank 217, a return water purification system, and a product water tank 235. The return water purification system is connected to the purified water system 100 through the purified water tank 217. After being purified by the purified water tank 217 and the return water purification system, the purified water is converted into water for injection and enters the product water tank 235.

[0045] In an exemplary embodiment, the purification system includes a medium-pressure ultraviolet system 102, a reverse osmosis membrane system 103, and a degassing membrane 104; the medium-pressure ultraviolet system is used to irradiate the feed water with the medium-pressure ultraviolet spectrum, the reverse osmosis membrane system 103 is used to desalinate the feed water, and the degassing membrane 104 is used to reduce the carbon dioxide concentration in the feed water.

[0046] In an exemplary embodiment, the water purification system includes: a clean heat exchanger 221, an ultraviolet lamp, and a continuous electrochemical desalination device 224; the clean heat exchanger 221 is connected to the continuous electrochemical desalination device 224 via the ultraviolet lamp, and the clean heat exchanger 221 is also connected to the purified water tank 217 via the ultraviolet lamp for circulating purified water back; the continuous electrochemical desalination device is connected to the product water tank 235; the ultraviolet lamp is used to excite the purified water to generate hydroxyl radicals.

[0047] In an exemplary embodiment, the water quality testing module 300 includes at least one of a pressure transmitter (i.e., a second pressure transmitter 230), an online conductivity monitor 227, an online total organic carbon monitor 232, and an online microbial detector 233 disposed on the product water pipeline 227 for water for injection; the product water pipeline 227 for water for injection is disposed between the continuous electrochemical desalination device 224 and the product water tank 235.

[0048] Exemplarily, in one specific embodiment, reference is made to Figure 4The purified water system 100 includes: a pretreatment system 101, a medium-pressure ultraviolet system 102, an RO reverse osmosis system 103, a degassing membrane 104, a first PW permeate pipeline 105, a conductivity meter 106, a first pressure transmitter 107, a clean one-way valve 108, a first valve 109, a second valve 110, a third valve 111, a second PW permeate pipeline 112, and a third PW permeate pipeline 113; wherein, the purification system includes: a medium-pressure ultraviolet system 102, a reverse osmosis membrane system 103, and a degassing membrane 104.

[0049] The water for injection system includes: a sixth valve 214, a temperature transmitter 215, a float valve 216, a purified water tank 217, a fourth valve 218, a fifth valve 219, a pump 220, a clean heat exchanger 221, a first ultraviolet lamp 222, a second ultraviolet lamp 223, a continuous electrochemical desalination device 224, a circulating return pipeline 225, a spray ball 226, a product water pipeline for water for injection 227, a first dual-line water supply 228, a second dual-line water supply 229, a second pressure transmitter 230, an online conductivity monitor 231, an online total organic carbon monitor 232, an online microbial detector 233, a seventh valve 234, and a product water tank or point of use 235; wherein, the return water purification system includes: a clean heat exchanger 221, ultraviolet lamps and a continuous electrochemical desalination device 224; the ultraviolet lamps may include a first ultraviolet lamp 222 and a second ultraviolet lamp 223.

[0050] Optionally, the water for injection preparation system operates in three main states: normal operation, circulation, and disinfection.

[0051] The normal operating mode is as follows: municipal drinking water is pretreated and then enters the PW (Purified Water) main unit system, i.e., the purification system. It enters the RO (Reverse Osmosis) membrane system 103 through medium-pressure ultraviolet spectral irradiation control to remove microorganisms and residual chlorine from the raw water. The RO system desalinates the water and reduces the carbon dioxide concentration in the water through the degassing membrane. After passing through the PW main unit system, the municipal drinking water is produced as purified water that meets the pharmacopoeia requirements. The purified water produced is supplied through the first PW product water pipeline 105. The system monitors the conductivity of the product water. When the conductivity is not up to standard or when the equipment is started for the first time, the second valve 110 and the third valve 111 are closed. Then the second valve 110 is opened, and the PW product water flows through the first PW product water pipeline 105, through the second PW product water pipeline 112 and the third PW product water pipeline 113, and through the first valve 109 for flushing and discharge. After the system product water index is up to standard, the system enters the normal water supply state. The first valve 109 is closed, the second valve 110 is opened, and the third valve 111 is opened. The system product water flows through the first PW product water pipeline 105 and is divided into two paths. One path flows through the third valve 111 into the second PW product water pipeline 112, and the other path flows directly into the third PW product water pipeline 113. The two paths converge and then flow through the float valve 216 into the PW water tank, i.e., the purified water tank 217. This part of the water supply process is called dual-path water supply.

[0052] Purified water in the PW water tank enters the clean heat exchanger 221 via pump 220, then enters the first UV lamp 222 and the second UV lamp 223. One path enters the continuous electrochemical desalination device 224, and the other path returns to the purified water tank 217 via spray ball 226. The return water process design considers increasing the number of times the UV lamp device treats the PW water by increasing the number of system cycles, thereby improving the treatment effect. Typically, the return pipeline calculation, pipeline design, and pump selection are based on 2-3 times the water volume entering 24 to achieve 2-3 times return. The water produced by the continuous electrochemical desalination device 224 meets the WFI (Water for Injection) injection water index. It is divided into two paths through the injection water production pipeline 227. One path enters the second dual-path water supply 229 through the fourth valve 218, and the other path directly enters the first dual-path water supply 228. The two water supply paths converge at the seventh valve 234 and enter the product water tank 235 or the WFI usage point. When the system is initially flushed and discharged, valves 218, 219, and 234 are closed, and valve 214 is open. Water for injection (WFI) enters the first dual-line water supply 228 through the product water pipeline 227, returns from the second dual-line water supply 229, and is discharged through valve 214. During normal operation, valve 214 is closed, valve 219 is closed, and valve 218 is open, with water supplied through the first dual-line water supply 228 and the second dual-line water supply 229.

[0053] The clean heat exchanger 221 in the system has two functions. First, when the system is running normally, the PW water is located in the tube side of the heat exchanger. The temperature of the water entering the downstream device is regulated by the shell side cooling water or industrial steam to maintain a constant temperature, usually in the range of 20-25℃. Second, the system is periodically subjected to thermal disinfection. The system is heated by introducing heat medium through the shell side of the clean heat exchanger 221.

[0054] Microorganism removal typically employs two methods: direct killing and reducing the content of nutrients and organic matter in the water. The TOC (Total Organic Carbon) indicator for organic matter in water is used for monitoring. In this process, the first UV lamp 222 is typically configured with a wavelength of 185nm. This wavelength effectively stimulates the generation of hydroxyl radicals in the water. These radicals have strong oxidizing properties and can react with organic matter and microorganisms in the water, killing microbial activity. Simultaneously, it triggers the breaking of chemical bonds in large organic molecules and their gradual degradation, ultimately converting the organic matter into smaller organic molecules, as well as CO2 and H2O. These substances are then adsorbed and removed by the downstream continuous electrochemical desalination unit 224. However, due to its wavelength, the first UV lamp 222 also generates a small amount of ozone in the water. The second UV lamp 223, typically with a wavelength of 254nm, is used to further control the microbial indicators in the water and simultaneously remove the small amount of ozone generated by the upstream first UV lamp 222. Ozone in the water has strong oxidizing properties and will damage the downstream continuous electrochemical desalination unit 224.

[0055] The continuous electrochemical desalination unit 224 in the system mainly utilizes high-purity resin to adsorb small molecule organic matter and ions in the water, thereby reducing the TOC and conductivity of the water to meet the relevant regulatory requirements of WFI water for injection.

[0056] Circulation Mode: When there is no short-term demand for WFI in the WFI product tank / point of use 235, the system cannot be directly shut down according to relevant regulations on microbial control. The system switches to circulation mode. At this time, the fifth valve 219 is open, the fourth valve 218 is closed, the sixth valve 214 is closed, and the seventh valve 234 is closed. The WFI product water enters the first dual-line water supply 228 through the self-circulation return pipeline 225, and returns to the purified water tank 217 through the second dual-line water supply 229 via the fifth valve 219, forming a circulation pipeline. The design meets the requirement that the return water flow velocity is not less than 1m / s, and a turbulent state is formed in the pipeline, which is conducive to controlling the formation of microbial film. In the circulation state, the purified water tank 217 experiences minimal liquid level consumption. The float valve 216 closes based on the liquid level. At this time, the pressure in the upstream PW system's permeable pipeline increases to the opening pressure of the check valve 108. The check valve 108 opens, the first pressure transmitter 107 detects the system pressure change, the third valve 111 closes, the first valve 109 remains open, and the second valve 110 remains closed. PW permeable water flows from the first PW permeable pipeline 105, the third PW permeable pipeline 113, the second PW permeable pipeline 112, the first valve 109, and the clean check valve 108 into the inlet of the medium-pressure ultraviolet system 102, circulating at this point. The upstream PW system then enters a low-pressure circulation state. When the product water tank or the downstream end of the usage point 235 is not in use for a short period, the PW system (i.e., the purified water system) and the WFI system (i.e., the water for injection system) enter their respective circulation states.

[0057] Disinfection Mode: To control microbial load, the system undergoes periodic thermal disinfection, typically pasteurization. Due to differing risk control strategies, the PW and WFI systems will implement different disinfection frequencies, with the WFI segment generally having a higher disinfection frequency than the PW segment. For the PW segment, the pretreatment system has an industrial steam heater. After heating, the raw water enters the RO system, following the same process and low-pressure circulation mode, circulating and heating to 80 degrees Celsius for 30-60 minutes. The WFI system uses a clean heat exchanger 221 for disinfection, with the same process flow and circulation mode. A temperature transmitter (15) monitors the system return water temperature, recording the time when it reaches 80 degrees Celsius. Disinfection is maintained for 30-60 minutes. Discharge is performed after disinfection, following the same process flow and pre-start discharge mode.

[0058] In one exemplary embodiment, the control strategy includes real-time adjustment of operating parameters; the operating parameters include circulation flow rate, UV lamp power, electro-desalination current, disinfection method, and thermal disinfection frequency, and key water quality indicators include microbial load; based on the key water quality indicators, the control strategy for the purified water system and / or water for injection system is adjusted, including: analyzing the trend of microbial load and adjusting the circulation flow rate, UV lamp power, electro-desalination current, disinfection method, and thermal disinfection frequency of the water for injection system.

[0059] In one exemplary embodiment, key water quality indicators include conductivity and total organic carbon content. Based on these key water quality indicators, the control strategy for the purified water system and / or water for injection system is adjusted, including:

[0060] If the conductivity and / or total organic carbon content of the water for injection are not up to standard, the water for injection preparation system shall be adjusted to enter the discharge mode until the conductivity of the water for injection is up to standard, and then the water for injection preparation system shall be adjusted to enter the production mode.

[0061] In one exemplary embodiment, the control strategy includes obtaining a production water data change model based on key water quality indicators, and making system predictions and strategy pre-executions based on the production water data change model.

[0062] Optionally, the system can monitor key water quality indicators of the WFI produced water in real time, such as microorganisms, TOC, and conductivity, by configuring a conductivity meter (i.e., an online conductivity monitor 231), an online TOC (i.e., an online total organic carbon monitor 232), and an online microbial detector 233. This monitoring enables the release of water quality indicators, prediction of water production trends, and system control. An example of this logic is as follows:

[0063] The system uses an online conductivity monitor 231 to detect water production indicators. If the indicators are not up to standard, the system switches to discharge mode and discharges water until the indicators are up to standard, at which point it switches back to water production mode.

[0064] The system monitors the water production indicators using an online total organic carbon monitor 232. If the indicators are not up to standard, the system switches to discharge mode and discharges the water until the indicators are up to standard, at which point it switches back to water production mode.

[0065] The system monitors the microbial load trend in the produced water in real time using an online microbial detector. The data is uploaded to the control system, which analyzes long-term operational data trends, adjusts the control methods of relevant system components, and re-records and analyzes the data to ensure the long-term stability of the system's produced water parameters. For example, if the microbial detector detects a recent increase in microbial load, it initially judges that the system's microbial load is increasing, mainly considering two possibilities: first, the microbial content in the system's influent may be high; second, there may be microbial attachment in the system. For the first possibility, the system increases the frequency of pump 220 and the system's circulation flow rate, thereby enhancing its ability to circulate and treat organic matter and microorganisms. At the same time, it increases the irradiation power of the first ultraviolet lamp 222 and the second ultraviolet lamp 223 by frequency conversion, increasing the irradiation intensity. It also appropriately increases the current of the continuous electrochemical desalination device 224 to enhance its adsorption capacity. Combined with the real-time detection of the TOC index decline trend by the online total organic carbon monitor 232, the data after the online microbial detector 233 detects the executed actions and feeds back to the main control system to provide the next execution strategy. The second possibility is that the system has microbial adhesion, i.e., a microbial film. In this case, cyclic heat disinfection and chemical disinfection are required. After the system makes a judgment, it issues a heat disinfection execution command and performs heat disinfection. After the treatment, the operating data is monitored by the online microbial detector 233 to see if the situation has improved. If the situation has not improved, the system issues a predictive alarm to prompt the operator to perform chemical cleaning.

[0066] Through this preventative monitoring and control strategy, the system can determine its own operating status in real time and provide appropriate adjustment and control strategies, greatly improving the accuracy of the automated system and reducing the lag and errors associated with manual judgment and operation in traditional systems. Optionally, the specific control logic can be as follows: Figure 2 As shown.

[0067] It should be understood that, although Figure 1 and Figure 2 The steps in the flowchart are shown sequentially as indicated by the arrows, but these steps are not necessarily executed in the order indicated by the arrows. Unless otherwise specified herein, there is no strict order in which these steps are executed, and they can be performed in other orders. Figure 1 and Figure 2 At least some of the steps in the process may include multiple steps or multiple stages. These steps or stages are not necessarily completed at the same time, but may be executed at different times. The execution order of these steps or stages is not necessarily sequential, but may be executed in turn or alternately with other steps or at least some of the steps or stages in other steps.

[0068] In one embodiment, a computer device is provided, including a memory and a processor, wherein the memory stores a computer program, and the processor executes the computer program to implement the steps of the method described above.

[0069] In one embodiment, a computer-readable storage medium is provided having a computer program stored thereon, which, when executed by a processor, implements the steps of the above-described method.

[0070] Those skilled in the art will understand that all or part of the processes in the methods of the above embodiments can be implemented by a computer program instructing related hardware. The computer program can be stored in a non-volatile computer-readable storage medium, and when executed, it can include the processes of the embodiments of the methods described above. Any references to memory, storage, databases, or other media used in the embodiments provided in this application can include at least one of non-volatile and volatile memory. Non-volatile memory can include read-only memory (ROM), magnetic tape, floppy disk, flash memory, or optical storage, etc. Volatile memory can include random access memory (RAM) or external cache memory. By way of illustration and not limitation, RAM can be in various forms, such as static random access memory (SRAM) or dynamic random access memory (DRAM), etc.

[0071] In the description of this specification, references to terms such as "some embodiments," "other embodiments," and "ideal embodiments" indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the invention. In this specification, the illustrative descriptions of the above terms do not necessarily refer to the same embodiments or examples.

[0072] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0073] The embodiments described above are merely illustrative of several implementation methods of this application, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the invention patent. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of this application, and these all fall within the protection scope of this application. Therefore, the protection scope of this patent application should be determined by the appended claims.

Claims

1. A water-for-injection preparation system control method characterized by, The water for injection preparation system comprises a purified water system and a water for injection system connected with each other, the purified water system is used for purifying raw water to form purified water, and the water for injection system is used for purifying the purified water to form water for injection; the method comprises: obtaining a water quality key indicator of the water for injection; adjusting a control strategy of the purified water system and / or the water for injection system according to the water quality key indicator.

2. The method of claim 1, wherein, The control strategy comprises real-time adjustment of working parameters, the working parameters comprise circulating flow rate, ultraviolet lamp power, electric desalination current, disinfection mode and heat disinfection frequency, and the water quality key indicator comprises microbial load; the adjusting of the control strategy of the purified water system and / or the water for injection system according to the water quality key indicator comprises: analyzing a trend of the microbial load and adjusting the circulating flow rate, the ultraviolet lamp power, the electric desalination current, the disinfection mode and the heat disinfection frequency of the water for injection system.

3. The method of claim 1, wherein, The water quality key indicator comprises conductivity and total organic carbon content, and the adjusting of the control strategy of the purified water system and / or the water for injection system according to the water quality key indicator comprises: when the conductivity and / or the total organic carbon content of the water for injection is unqualified, adjusting the water for injection preparation system to enter a discharge mode until the conductivity of the water for injection is qualified and then adjusting the water for injection preparation system to enter a water production mode.

4. The method according to any one of claims 1 to 3, characterized in that, The control strategy comprises obtaining a water production data change model according to the water quality key indicator, and performing system prediction and strategy pre-execution according to the water production data change model.

5. A system for preparing water for injection, characterized in that comprise: a purified water system used for purifying raw water to form purified water; a water for injection system connected with the purified water system and used for purifying the purified water to form water for injection; wherein the water for injection system comprises a water quality detection module used for obtaining a water quality key indicator of the water for injection and outputting the water quality key indicator; a control system connected with the water quality detection module and used for executing the method of any one of claims 1 to 4.

6. The system of claim 5, wherein, The purified water system comprises a pretreatment system and a purification system connected with each other, and the raw water is purified by the pretreatment system and the purification system and then enters the water for injection system.

7. The system of claim 5, wherein, The water for injection system comprises a purified water tank, a backwater purification system and a product water tank, the backwater purification system is connected with the purified water system through the purified water tank; and the purified water is purified by the purified water tank and the backwater purification system to form the water for injection and then enters the product water tank.

8. The system of claim 6, wherein, The purification system comprises a medium-pressure ultraviolet system, a reverse osmosis membrane system and a degassing membrane; the medium-pressure ultraviolet system is used for irradiating the raw water in a medium-pressure ultraviolet spectrum range, the reverse osmosis membrane system is used for desalting the raw water, and the degassing membrane is used for reducing the carbon dioxide concentration in the raw water.

9. The system of claim 7, wherein, The backwater purification system comprises a clean heat exchanger, an ultraviolet lamp and a continuous electrochemical desalination device; the clean heat exchanger is connected with the continuous electrochemical desalination device through the ultraviolet lamp, the clean heat exchanger is also connected with the purified water tank through the ultraviolet lamp, and is used for circulating backflow of the purified water; the continuous electrochemical desalination device is connected with the product water tank; the ultraviolet lamp is used for exciting the purified water to generate hydroxyl radicals.

10. The system of claim 9, wherein, The water quality detection module comprises at least one of a pressure transmitter, an online conductivity monitor, an online total organic carbon monitor and an online microorganism detector arranged on a water production pipeline of the water for injection; the water production pipeline of the water for injection is arranged between the continuous electrochemical desalination device and the product water tank.

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