Chinese herbal medicine pain relieving formula and preparation process thereof
By combining the ingredients of *Gentiana scabra* and *Sinomenium acutum* and designing multiple dosage forms, the problem of complex and slow-acting traditional Chinese medicine analgesic formulas has been solved, providing a rapid and balanced analgesic effect, adapting to different pain needs, and improving the flexibility and quality stability of medication.
Patent Information
- Application Number
- CN202511175123.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-08-21
- Publication Date
- 2026-03-20
AI Technical Summary
Existing Chinese herbal pain relief formulas are complex, slow to take effect, and have limited dosage forms, making it difficult to meet patients' needs for rapid pain relief. Furthermore, quality control is challenging, leading to unstable efficacy.
This traditional Chinese medicine formula uses *Gentiana scabra* and *Symplocos rubra* as its main ingredients. It combines various dosage forms such as powders, capsules, pills, and decoctions. Through a refined preparation process, it ensures the rapid release and uniform absorption of the medicinal effects, including drying, pulverizing, and mixing steps. An ultra-micro pulverizer is used to improve bioavailability.
It achieves rapid, balanced, and stable efficacy, adapting to the needs of different pain courses and scenarios, and improving patient compliance and treatment effectiveness.
Abstract
Description
TECHNICAL FIELD
[0001] The application relates to the technical field of traditional Chinese medicines, in particular to a Chinese herbal medicine pain-relieving formula and a preparation process thereof. BACKGROUND
[0002] The application relates to the technical field of pain, which is one of the most common symptoms in clinical practice and is also the main reason for patients to seek medical treatment. Whether acute pain or chronic pain, it will seriously affect the quality of life, work efficiency and mental health of patients. At present, the clinical treatment for pain is mainly divided into two categories: modern Western medicine treatment and traditional Chinese medicine treatment. In the field of modern Western medicine, painkillers are the main treatment method, mainly including non-steroidal anti-inflammatory drugs, acetaminophen and opioid analgesics. Although Western medicine painkillers have a quick effect, their side effects and potential risks limit their long-term and safe use. Existing traditional Chinese medicine pain-relieving prescriptions also have some shortcomings: many traditional pain-relieving prescriptions contain a large number of medicinal herbs, and the compatibility of monarch, minister, assistant and guide is rigorous, but in actual application, for some specific pain symptoms such as sand-dust pain, the complex prescription may cause dispersion of medicinal power and make it difficult to quickly and centrally solve the core pathological problems. Traditional Chinese medicine dosage forms are mainly decoctions and pills. Decoctions need to be boiled for a long time, which is inconvenient to take and does not adapt to the fast-paced modern life. Traditional pill and powder dosage forms have a relatively slow dissolution and absorption of effective components due to the coarse particle size of medicinal materials, resulting in low bioavailability and slow effect, which is difficult to meet the demand of patients for rapid pain relief.
[0003] Large difficulty in quality control: the complex prescription and traditional processing and preparation process make it difficult to ensure the quality uniformity between batches of medicines, thereby affecting the stability of clinical efficacy.
[0004] In summary, the existing technical solutions have the technical problems of complex prescription, slow effect and single dosage form. INVENTION CONTENT
[0005] In view of the deficiencies of the prior art, the application provides a Chinese herbal medicine pain-relieving formula and a preparation process thereof, which solve the technical problems of complex prescription, slow effect and single dosage form of the existing technical solutions.
[0006] To achieve the above object, the present application is realized by the following technical scheme: A Chinese herbal medicine pain-relieving formula, characterized by comprising the following raw materials: Radix Sinomenii 1 part and Caulis Sinomenii 1 part; Radix Sinomenii is cold in nature and is good at clearing heat and detoxifying and relieving swelling and pain and can effectively target the inflammatory reaction that may exist in the pain site; Caulis Sinomenii is warm and is good at dispelling wind and dampness and promoting qi and relieving pain and is good at removing meridian obstruction caused by wind, cold, dampness evil or qi stagnation. The two are cold and warm respectively and are used together to clear heat without damaging yang and promote qi without consuming normal qi. Radix Sinomenii clears internal heat and Caulis Sinomenii dispels external evil, and the two treat internally and externally together to achieve the effects of clearing heat and detoxifying, dispelling wind and dampness, promoting qi and unblocking meridians, relieving swelling and pain, so that the formula has more comprehensive and balanced effects and can effectively deal with pain caused by complex causes.
[0007] Preferably, the Radix Sinomenii is the dried root of Sinomenium acutum or the dried root of Khusiatha sieboldi; and the dried root is used for medical purposes. The root is selected for use in medicine because it is the enrichment area of effective plant components such as alkaloids and saponins. These components are the material basis for clearing heat and detoxifying, relieving swelling and pain.
[0008] Preferably, the Caulis Sinomenii is the dried root of Aristolochia debilis; and the dried root of Aristolochia debilis is used in traditional Chinese medicine theory to have the effects of promoting qi and relieving pain and detoxifying and relieving swelling and is often used to treat abdominal distension and pain, rheumatic arthralgia and the like. The qi-promoting effect of the Caulis Sinomenii can promote the movement of blood and relieve pain caused by qi stagnation and blood stasis.
[0009] Preferably, the formula has the dosage forms of powder, capsule, pill or decoction; the powder: simple preparation, fast drug dispersion, fast absorption, convenient to carry and dose adjustment; the capsule: can effectively mask the bad smell of Chinese herbal medicine, improve the patient's medication compliance, and at the same time protect the drug powder from moisture to ensure the accuracy of the dose; the pill: the drug effect is released slowly and durably, easy to store and carry, suitable for the conditioning of chronic pain; the decoction: the most traditional dosage form of Chinese medicine, the drug components are dissolved most fully, absorbed quickly, and have strong medicinal effect, especially suitable for acute pain or situations requiring rapid effect. The various dosage forms make the formula more flexible in clinical application.
[0010] A Chinese herbal medicine pain-relieving formula and a preparation process thereof, comprising the following steps:
[0011] Step 1: taking Radix Sinomenii 1 part and Caulis Sinomenii 1 part by weight ratio;
[0012] Step 2: washing and removing impurities from the raw medicinal materials of Radix Sinomenii and Caulis Sinomenii;
[0013] Step 3: drying the pretreated raw medicinal materials;
[0014] Step 4: mixing the dried raw medicinal materials and crushing them into fine powder;
[0015] Step 5: Sift the fine powder further to ensure even mixing of the medicinal powder.
[0016] Preferably, the drying process described in step 3 is carried out in an oven at 50-70°C until the moisture content of the raw material is below 10%. This temperature is sufficient to effectively remove moisture and kill most microorganisms, but it is relatively mild, which can minimize the decomposition or volatilization loss of heat-sensitive active ingredients in the medicinal material due to high temperature. Controlling the moisture content to below 10% can effectively ensure the physical, chemical, and microbiological stability of the medicinal material during its shelf life.
[0017] Preferably, the pulverization into fine powder in step 5 is performed using an ultrafine pulverizer until the particle size passes through a 100-mesh sieve. Using an ultrafine pulverizer can break down plant cell walls, allowing the drug components to dissolve and be absorbed more quickly and completely in the digestive tract, thereby improving the bioavailability of the drug and enabling it to exert its effects more rapidly. The finer powder also has a better taste, reducing the roughness experienced during consumption and increasing patient acceptance.
[0018] Preferably, it is used to prepare medicines or health products for the prevention, treatment or relief of stomach pain, headache or neck pain.
[0019] Beneficial effects
[0020] This invention provides a traditional Chinese medicine pain-relieving formula and its preparation process. The formula is refined, with each component having a clear pharmacological effect. *Gentiana scabra* clears heat and detoxifies, reduces swelling and relieves pain; *Ilex chinensis* dispels wind and dampness, promotes qi circulation and unblocks the meridians. The two herbs, one cold and one warm, work together to clear heat without harming yang, and promote qi circulation without depleting vital energy. Together, they achieve the dual effects of clearing heat and detoxifying, and promoting qi circulation and unblocking the meridians. This scientific combination not only avoids potential antagonism or adverse reactions between components in complex formulas, but also enhances the synergistic effect of the medicine, making the target more concentrated, thus achieving... The invention achieves optimal analgesic effect with minimal ingredients. It offers a variety of dosage forms, including powders, capsules, pills, and decoctions, allowing the formula to flexibly adapt to the needs of different disease stages, scenarios, and patient groups. For example, decoctions are suitable for acute attacks and aim for rapid onset of action; capsules are convenient to carry, provide precise dosage, and can mask unpleasant odors; pills have a mild and long-lasting effect, making them more suitable for long-term management of chronic pain. The diverse dosage form options greatly facilitate patients, improve medication compliance, and help ensure the achievement of therapeutic effects. Detailed Implementation
[0021] To further illustrate the technical means and effects adopted by the present invention to achieve the intended purpose of the invention, it is obvious that the described embodiments are only some embodiments of the present invention, and not all embodiments, as detailed below.
[0022] This invention provides a technical solution: a traditional Chinese medicine analgesic formula, characterized by comprising the following raw materials: 1 part of *Gentiana scabra* and 1 part of *Symplocos buergeriana*; *Gentiana scabra* is cold in nature and is used to clear heat and detoxify.
[0023] It excels at reducing swelling and relieving pain, effectively targeting potential inflammatory reactions at the site of pain. *Symplocos edulis* is warm in nature, effective in dispelling wind and dampness, promoting qi circulation and relieving pain. It excels at traversing the meridians, clearing blockages caused by wind-cold-dampness or qi stagnation. The two ingredients, one cold and one warm, work together to clear heat without harming yang, and promote qi circulation without depleting vital energy. *Gastrodia elata* clears internal heat, while *Symplocos edulis* disperses external pathogens. Together, they treat both internal and external ailments, achieving the combined effects of clearing heat and detoxifying, dispelling wind and dampness, promoting qi circulation and unblocking meridians, reducing swelling and relieving pain. This makes the formula more comprehensive and balanced, effectively addressing pain caused by complex etiologies.
[0024] In this embodiment, the *Gentiana scabra* is further configured as follows: the dried tuberous root of *Gentiana scabra* or *Gentiana scabra*, both belonging to the Menispermaceae family, is used medicinally. The tuberous root is chosen for medicinal use because this part is a rich area of plant active ingredients, such as alkaloids and saponins. These components are the material basis for its effects of clearing heat and detoxifying, reducing swelling and dissipating nodules, and relieving pain.
[0025] In this embodiment, the *Aristolochia debilis* is a dried root of the Aristolochia plant (family Aristolochiaceae). In traditional Chinese medicine, *Aristolochia debilis* is indeed believed to have the effects of promoting qi circulation, relieving pain, detoxifying, and reducing swelling; it is commonly used to treat abdominal distension and pain, and rheumatic pain. Its qi-regulating effect can promote the flow of qi and blood, relieving pain caused by qi stagnation and blood stasis.
[0026] This embodiment further specifies that the dosage form of the formula is a powder, capsule, pill, or decoction; Powder: simple to prepare, the drug can be quickly dispersed, absorbed rapidly, and is convenient to carry and adjust dosage. Capsules: can effectively mask the unpleasant odor of Chinese herbal medicines, improve patient medication compliance, and protect the powder from moisture, ensuring accurate dosage. Pills: the drug release is relatively slow and long-lasting, easy to store and carry, and suitable for the management of chronic pain. Decoction: the most traditional dosage form of Chinese medicine, with the most complete dissolution of drug components, rapid absorption, and strong efficacy, especially suitable for acute pain or situations requiring rapid onset of action. The variety of dosage form options makes this formula more flexible in clinical application.
[0027] A traditional Chinese medicine pain-relieving formula and its preparation process include the following steps:
[0028] Step 1: Take 1 part of bitter gall and 1 part of fragrant vine according to the weight ratio;
[0029] Step 2: Clean the raw materials of *Gentiana scabra* and *Sinomenium acutum* to remove impurities;
[0030] Step 3: Dry the pretreated raw materials;
[0031] Step 4: Mix the dried raw materials and grind them into a fine powder;
[0032] Step 5: Sift the fine powder further to ensure even mixing of the medicinal powder.
[0033] In this embodiment, the drying process described in step 3 is further configured to be carried out in an oven at 50-70°C until the moisture content of the raw material is below 10%. This temperature is sufficient to effectively remove moisture and kill most microorganisms, but it is relatively mild, which can minimize the decomposition or volatilization loss of heat-sensitive active ingredients in the medicinal material due to high temperature. Controlling the moisture content to below 10% can effectively ensure the physical, chemical, and microbiological stability of the medicinal material during its shelf life.
[0034] In this embodiment, the pulverization into fine powder in step 5 is performed using an ultrafine pulverizer until the particle size passes through a 100-mesh sieve. Using an ultrafine pulverizer can break down plant cell walls, allowing the drug components to dissolve and be absorbed more quickly and completely in the digestive tract, thereby improving the bioavailability of the drug and enabling it to exert its effects more rapidly. The finer powder also has a better taste, reducing the roughness experienced during consumption and increasing patient acceptance.
[0035] This embodiment is further configured to be used in the preparation of medicines or health products for the prevention, treatment, or relief of stomachache, epigastric pain, headache, or neck pain.
[0036] The method used is a well-known technique in the field. Basic raw material preparation: All the following examples are based on the completed "pre-mixed fine powder" as the starting material. The preparation process of this fine powder is as follows: Accurately weigh 1 part of *Gentiana scabra* and 1 part of *Clematis chinensis*. Select and wash the above raw materials to remove mud and impurities. Place the clean raw materials in an oven at 50-70℃ to dry until the moisture content is below 10%. Mix the two dried raw materials and pulverize them using an ultrafine pulverizer until the powder particle size can pass through a 100-mesh sieve. Sieving and homogenization: Sieve the pulverized fine powder again to ensure uniform mixing, obtaining the "pre-mixed fine powder".
[0037] Example 1: Preparation of Powder
[0038] Powders are the most direct form of application, and their subsequent processing mainly involves repackaging. The prepared "pre-mixed fine powder" is quantitatively packaged using an automatic packaging machine. The dosage for each dose is set, for example, 3 grams per packet. A moisture-proof and light-proof composite film (such as aluminum-plastic composite film) is used as the packaging material to heat-seal the quantitatively packaged powder, creating individual small packages. The finished product is inspected, and after passing inspection, labels are affixed indicating the product name, specifications, usage and dosage, production date, and expiration date, before being stored in the warehouse.
[0039] Take one packet of powder and dissolve it in warm water before drinking. This dosage form is absorbed quickly and has a rapid onset of action.
[0040] Example 2: Preparation of Capsules
[0041] Capsules mask the taste of the medicine and make it easier to swallow. Prepare the "pre-mixed fine powder" and empty capsules that meet pharmaceutical standards. Filling: Load the "pre-mixed fine powder" into a fully automatic or semi-automatic capsule filling machine. The machine will automatically complete the steps of capsule separation, powder filling, and capsule locking to form capsules. The filling amount needs to be precisely controlled to ensure accurate dosage in each capsule. Send the filled capsules to a capsule polishing machine to remove trace amounts of powder adhering to the capsule shell surface, making it clean and smooth. Pack the polished capsules in aluminum-plastic blister packs or seal them in pharmaceutical plastic bottles. Inspect the finished products, and package and store them after passing the inspection.
[0042] Directions for use: Take the prescribed dose with warm water. This dosage form is accurate and easy to carry.
[0043] Example 3: Preparation of Pills
[0044] The pills have a mild and long-lasting effect, making them suitable for chronic conditioning. High-quality honey is selected and refined through heating. First, it is heated to boiling over high heat to remove surface foam, then simmered over low heat until it forms a firm, round bead when dropped into cold water – this indicates the honey has the strongest binding force. The pre-mixed fine powder is then thoroughly mixed with an appropriate amount of warm refined honey in a pharmaceutical machine according to a predetermined ratio, forming a uniform, moderately firm clump. The mixed clump is fed into an automatic pill-making machine, where it is extruded into strips and then cut into uniformly sized pills. For example, large honey pills weighing 9 grams each are made. The finished honey pills are individually packaged in waxed paper or plastic shells to prevent sticking and spoilage. The finished products are inspected for appearance, weight variation, moisture content, and other indicators; those that pass inspection are then boxed and stored.
[0045] Take one pill each time, chew it and swallow it with warm water, or cut it into small pieces and swallow it in several doses.
[0046] Example 4: Preparation of Decoction
[0047] Decoctions are a traditional dosage form, ensuring full dissolution and rapid absorption of active ingredients. This section introduces a modern, pre-prepared decoction-free process. This process eliminates the use of pre-mixed powders, instead using cleaned raw medicinal materials directly. Single-dose doses are prepared and packaged in dedicated non-woven fabric medicine bags. These bags are placed in the decoction pot of an intelligent decoction machine, and the prescribed amount of purified water is added to fully moisten the herbs. The decoction program is then started. The machine automatically heats to boiling, then reduces to a simmer. The entire process is conducted in a sealed environment to minimize the loss of volatile components. After decoction, the machine automatically squeezes the medicine bag to extract the liquid from the dregs and performs preliminary filtration. The filtered, hot liquid is then piped into an automatic liquid packaging machine, sealed in a high-temperature resistant composite film medicine bag, and vacuum-sealed. High-temperature filling and vacuum sealing sterilize and preserve the product. The finished liquid undergoes tests for appearance, pH value, and microbial limits; once qualified, it is ready for delivery to patients.
[0048] To take the medicine, warm the medicine bag in hot water, tear it open, and drink directly. This process retains the advantages of decoctions while making it convenient to carry and consume.
[0049] It should be noted that in this paper, relational terms such as first and second are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations.
[0050] The above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention in any way. Although the present invention has been disclosed above with reference to preferred embodiments, it is not intended to limit the present invention. Any person skilled in the art can make some modifications or alterations to the above-disclosed technical content to create equivalent embodiments without departing from the scope of the present invention. Any simple modifications, equivalent changes and alterations made to the above embodiments based on the technical essence of the present invention without departing from the scope of the present invention shall still fall within the scope of the present invention.
Claims
1. A traditional Chinese medicine analgesic formula, characterized in that, It is made from the following ingredients: 1 part bitter gall and 1 part green vine fragrance.
2. The herbal analgesic formula according to claim 1, characterized in that, The bitter root of the plant is made from the dried tuberous root of the Menispermaceae plant *Gentiana scabra* or *Gentiana scabra*.
3. The herbal analgesic formula according to claim 1, characterized in that, The Qing Teng Xiang is the dried root of Aristolochia debilis, a plant in the Aristolochiaceae family.
4. A traditional Chinese medicine analgesic formula according to any one of claims 1-3, characterized in that, The dosage form of the formula is powder, capsule, pill or decoction.
5. The preparation process of a traditional Chinese medicine analgesic formula according to claims 1-4, characterized in that, Includes the following steps: Step 1: Take 1 part of bitter gall and 1 part of fragrant vine according to the weight ratio; Step 2: Clean the raw materials of *Gentiana scabra* and *Sinomenium acutum* to remove impurities; Step 3: Dry the pretreated raw materials; Step 4: Mix the dried raw materials and grind them into a fine powder; Step 5: Sift the fine powder further to ensure even mixing of the medicinal powder.
6. The preparation process of the herbal analgesic formula according to claim 5, characterized in that, The drying process described in step 3 is carried out in an oven at 50-70°C until the moisture content of the raw material is less than 10%.
7. The herbal pain-relieving formula and its preparation process according to claim 5, characterized in that, The grinding into fine powder mentioned in step 5 refers to grinding the particles into fine powder using an ultra-micro pulverizer until the particle size passes through a 100-mesh sieve.
8. A traditional Chinese medicine analgesic formula according to claims 1-4, characterized in that, It is used to prepare medicines or health products for the prevention, treatment or relief of stomach pain, headache or neck pain.