Aromatic essential oil composition and application thereof

Abstract

The invention belongs to the technical field of pressure injury prevention or treatment supplies, and particularly relates to an aromatic essential oil composition and application thereof, and the aromatic essential oil composition can be used for preparing medicines for preventing and treating first-stage and second-stage pressure injury. The aromatic essential oil composition comprises the following components in parts by weight: 5-7 parts of lavender essential oil, 3-5 parts of permanent flower essential oil, 2-4 parts of tea tree essential oil, 1-3 parts of lemon essential oil, 2-4 parts of melaleuca leucas essential oil and jojoba oil, wherein the total weight percentage concentration is 2-4wt%. Or the essential oil is prepared from the following components in parts by weight: 2-4 parts of lavender essential oil, 1-3 parts of permanent flower essential oil, 1-2 parts of tea tree essential oil, 1-2 parts of lemon essential oil, 1-2 parts of melaleuca leucas essential oil and jojoba oil, and the total weight percentage concentration is 1-2wt%. Through a multi-target anti-inflammatory, antibacterial, antioxidant and tissue regeneration promoting mechanism, the aromatic essential oil composition can remarkably shorten the healing time of the stress injury and reduce the nursing cost.

Description

Technical Field

[0001] This invention belongs to the technical field of pressure injury prevention or treatment products, specifically relating to an aromatic essential oil composition and its application. Background Technology

[0002] Pressure injuries are usually accompanied by local skin tissue breakdown and infection. Based on the progression of the injury from superficial to deep, there are six stages. Stage 1 pressure injuries are characterized by intact local skin and erythema that does not turn white upon pressure. Stage 2 pressure injuries are characterized by partial loss of the dermis, a pinkish, moist basal surface, and often accompanied by blisters. The focus of treatment for stages 1 and 2 pressure injuries is to relieve local pressure, protect the skin, and prevent and control infection.

[0003] Studies have shown that lavender essential oil can regulate the expression of inflammatory factors such as interleukin-6 and interleukin-1β, promoting the infiltration of inflammatory cells in damaged skin tissue, accelerating the local inflammatory response, and enabling it to quickly enter the repair phase. Tea tree essential oil's main components, eucalyptol and terpenoids, can increase the permeability of bacterial cells to terpenoid compounds, accelerate tissue cell metabolism, and thus lead to bacterial death. Helichrysum, as a member of the Asteraceae family, has a main component, bisabolol, which can inhibit 5-lipoxygenase activity, achieving an anti-inflammatory effect. Lemon essential oil's main component, limonene, can scavenge oxygen free radicals and has natural antioxidant activity. The combined use of these plant essential oils can enhance anti-inflammatory and antibacterial effects, accelerate tissue repair, and promote wound healing.

[0004] Pressure sores fall under the category of "bedsores" in Traditional Chinese Medicine (TCM), also known as "print sores" or "bedsores." The *Suwen* (Plain Questions) states, "Prolonged lying down injures Qi, prolonged sitting injures flesh." Terminally ill cancer patients, confined to bed for extended periods, suffer from depletion of Qi and blood, weakened organ function, obstructed meridians, and stagnant Qi and blood, leading to skin redness and swelling. Local damage from external forces disrupts the flow of Qi and blood in the meridians, depriving the skin of warmth and nourishment, eventually causing ulceration. In severe cases, pathogenic factors enter the blood, lurking in the blood vessels, further stagnating Qi and blood, resulting in local tissue ulceration and even necrosis. The *Complete Treatise on Ulcer Treatments* also states, "Bedsores are sores that develop after a serious illness, where the skin and flesh die first and are incurable." TCM diagnosis identifies this as Qi and blood deficiency and blood stasis. External treatments in TCM focus on nourishing blood, promoting blood circulation, removing blood stasis, and promoting new tissue regeneration. The aroma of plant essential oils can penetrate and disperse, effectively promoting Qi circulation, removing stagnation, and clearing the meridians, thus treating Qi and blood stagnation. Aromatherapy, through massage or application to damaged skin, can activate corresponding meridians, regulate the physiological functions of internal organs and blood circulation, and achieve the effects of relaxing muscles and tendons, and harmonizing qi and blood. Traditional Chinese medicine records that lavender essential oil can calm the mind and soothe the nerves, promote blood circulation and menstruation, and dispel wind and dampness; tea tree essential oil can astringe sores and promote tissue regeneration, stop coughs and asthma, relieve pain and kill viruses, and replenish qi; immortelle essential oil can regulate menstruation and relieve pain, regulate qi and strengthen the stomach; lemon essential oil can calm the mind and soothe the nerves, and astringe dampness and heal sores.

[0005] Therefore, using aromatic essential oils to prepare products for treating pressure injuries, such as products that promote the healing of pressure injuries in stage 1 and 2 terminal cancer patients, is an effective technical approach. Summary of the Invention

[0006] Existing topical preparations for the prevention and treatment of pressure injuries are mostly based on silver ion dressings or zinc oxide, which have problems such as inconvenience of use, limited antibacterial spectrum, and strong local irritation. To overcome the shortcomings of the prior art, this invention provides an aromatic essential oil composition and its application.

[0007] The technical solution provided by this invention is as follows:

[0008] An aromatic essential oil composition, using jojoba oil as a carrier, comprises the following components in parts by weight: 5-7 parts lavender essential oil, 3-5 parts helichrysum essential oil, 2-4 parts tea tree essential oil, 1-3 parts lemon essential oil, and 2-4 parts melaleuca truncata essential oil, with a total concentration controlled at 2-4 wt%, obtained by uniform mixing.

[0009] The composition can also be used in a dual-dosing strategy of 1 wt% (head and face) or 3 wt% (body parts) depending on the application site.

[0010] The above-mentioned aromatic essential oil composition can significantly shorten the healing time of pressure injuries to body parts.

[0011] Preferably, the ingredients include the following components in parts by weight: 6 parts lavender essential oil, 4 parts helichrysum essential oil, 3 parts tea tree essential oil, 2 parts lemon essential oil, 3 parts melaleuca lanceolata essential oil, and jojoba oil, wherein the total weight percentage concentration of lavender essential oil, helichrysum essential oil, tea tree essential oil, lemon essential oil, and melaleuca lanceolata essential oil is 3 wt%.

[0012] The present invention also provides the application of the above-mentioned aromatic essential oil composition for preparing essential oils for preventing stage 1 or stage 2 pressure injuries of body parts; or for preparing essential oils for treating stage 1 or stage 2 pressure injuries of body parts.

[0013] The present invention also provides another application of the above-mentioned aromatic essential oil composition, which is used 3 times a day for 2 weeks.

[0014] The preparation method of the above-mentioned aromatic essential oil composition is as follows: Take the prescribed amounts of lavender essential oil, helichrysum essential oil, tea tree essential oil, lemon essential oil, and neem essential oil, and dilute them with jojoba oil to obtain a mixed oil of the required concentration.

[0015] The present invention also provides an aromatic essential oil composition comprising the following components in parts by weight: 2-4 parts lavender essential oil, 1-3 parts helichrysum essential oil, 1-2 parts tea tree essential oil, 1-2 parts lemon essential oil, 1-2 parts melaleuca tiliacea essential oil, and jojoba oil, wherein the total weight percentage concentration of lavender essential oil, helichrysum essential oil, tea tree essential oil, lemon essential oil, and melaleuca tiliacea essential oil is 1-2 wt%.

[0016] The above-mentioned aromatic essential oil composition can significantly shorten the healing time of pressure injuries to the skin of the head and face.

[0017] Preferably, the ingredients include the following components in parts by weight: 3 parts lavender essential oil, 2 parts helichrysum essential oil, 1 part tea tree essential oil, 1 part lemon essential oil, 1 part melaleuca essential oil, and jojoba oil, wherein the total weight percentage concentration of lavender essential oil, helichrysum essential oil, tea tree essential oil, lemon essential oil, and melaleuca essential oil is 1 wt%.

[0018] The present invention also provides the application of the above-mentioned aromatic essential oil composition for the preparation of essential oils for preventing stage 1 or stage 2 pressure injuries to the skin of the head and face; or for the preparation of essential oils for treating stage 1 or stage 2 pressure injuries to the skin of the head and face.

[0019] The present invention also provides another application of the above-mentioned aromatic essential oil composition, which is used 3 times a day for 2 weeks.

[0020] Of the above technical solutions:

[0021] Lavender essential oil (Lavandula angustifolia) mainly consists of linalool and linalyl acetate, which have anti-inflammatory, analgesic, and wound-healing properties. Studies have shown that lavender essential oil can inhibit the expression of inflammatory factors such as TNF-α and IL-1β, promote keratinocyte proliferation and collagen deposition, and accelerate the repair of damaged skin.

[0022] Helichrysum italicum essential oil is rich in nerol, geraniol and dimethoxyphenylpropene, which can inhibit inflammatory pathways such as 5-lipoxygenase and COX-2, reduce neutrophil infiltration and oxidative stress, promote angiogenesis and granulation tissue formation, and have significant anti-inflammatory and anti-scar hyperplasia effects.

[0023] The main active ingredient in tea tree oil (Melaleuca alternifolia) is 4-terpinen-4-ol, which has broad-spectrum antibacterial, antifungal and anti-inflammatory effects. It can disrupt bacterial cell membrane permeability, inhibit biofilm formation, and at the same time reduce IL-1β and IL-6 levels, promoting wound healing and re-epithelialization.

[0024] Lemon essential oil (Citrus limon) contains limonene and vitamin C-related antioxidants, which can scavenge free radicals, reduce lipid peroxidation, improve local microcirculation and promote collagen synthesis. It has anti-inflammatory, antioxidant and weak antibacterial effects, and can help promote healing in skin wound repair.

[0025] Melaleuca ericifolia essential oil is rich in eucalyptol (1,8-cineole), linalool and other components, and has antibacterial, antiviral and anti-inflammatory properties. It can reduce skin inflammation and promote epidermal regeneration, and promote the repair of damaged skin barrier.

[0026] Jojoba oil's main components are wax esters, vitamin E, and polyunsaturated fatty acids. It has moisturizing, lipid barrier repair, and antioxidant effects. It can enhance the stability of the skin barrier, improve local blood circulation, and serve as a safe carrier oil to improve the permeability and tolerance of essential oils, reducing the risk of irritation.

[0027] The aromatic essential oil composition provided by this invention helps to accelerate the resolution of inflammation and tissue reconstruction in stage 1 and 2 stress injuries through a multi-target synergistic mechanism of anti-inflammatory, antibacterial, antioxidant, promoting angiogenesis and granulation tissue growth, and enhancing the skin barrier.

[0028] The aromatic essential oil composition provided by this invention can also work synergistically with traditional Chinese medicine meridians to combine the mechanisms of traditional Chinese medicine meridians with aromatic anti-inflammatory effects.

[0029] The aromatic essential oil provided by this invention can be matched with a dual-dosage strategy of 1% for the head and face and 3% for the body.

[0030] The aromatic essential oil provided by this invention is applicable to terminally ill or high-risk bedridden patients.

[0031] The aromatic essential oil composition provided by this invention can significantly shorten the healing time of pressure injuries, by up to 61%. Detailed Implementation

[0032] The following description is based on the principles and features of the present invention. The examples given are only for explaining the present invention and are not intended to limit the scope of the present invention.

[0033] Unless otherwise specified, the test methods used in the embodiments are conventional methods; unless otherwise specified, the materials and reagents used are commercially available.

[0034] Lavender essential oil, helichrysum essential oil, tea tree essential oil, lemon essential oil, neem oil, and jojoba oil were all purchased from JE International, France, under the registered trademark Florihana.

[0035] Example

[0036] (1) Control group: received routine nursing care.

[0037] ①Observation of the condition: Observe the patient's overall condition, such as mobility and activity, skin and nutritional status, sensory abilities, etc.; observe the patient's local skin damage, local skin temperature and blood circulation.

[0038] ② Skin care: Keep the patient's skin clean and dry, avoid moisture, friction and excrement irritation, keep the bed sheets flat and dry, and free of debris; avoid placing medical devices, including drainage tubes, oxygen masks, blood pressure clamps, etc., on the patient's skin for extended periods.

[0039] ③ Nutritional management: Conduct regular nutritional screenings for patients. If the patient's daily diet cannot meet their nutritional needs, high-energy and high-protein nutritional supplements should be provided.

[0040] ④ Positioning care: Ensure the patient is turned over every 2 hours to allow for maximum movement; protect the heels, conduct skin assessment and care, and apply pressure-relieving dressings to areas prone to pressure as needed; use assistive tools such as air mattresses and turning mats.

[0041] (2) Observation group: In addition to routine nursing care, aromatherapy was implemented, as follows:

[0042] 1. Prepare a plant essential oil blend: An aromatherapist mixes 6 drops of lavender, 4 drops of helichrysum, 3 drops of tea tree, 2 drops of lemon, and 3 drops of neem oil, diluted in 30ml of jojoba oil to a 3% concentration. This blend is used to prevent and treat stage 1 and 2 stress injuries on the body. Alternatively, mix 3 drops of lavender, 2 drops of helichrysum, 1 drop of tea tree, 1 drop of lemon, and 1 drop of neem oil, diluted in 30ml of jojoba oil to a 1% concentration. This blend is used on the face and head.

[0043] 2. Essential oil application and meridian massage

[0044] Before the procedure: Assess the patient's physical condition, mental state, skin condition, and the location and size of the pressure injury; inquire about any allergy history and thrombosis in the limbs; trim nails before the procedure to prevent injury; inform the patient of the purpose and duration of the aromatherapy treatment to gain their cooperation; to prevent allergic reactions during the procedure, a skin patch test should be performed before application; if erythema or discomfort occurs, wash immediately and discontinue use. During the procedure, keep the patient in a comfortable position. Massage for 10 minutes each time, 3 times daily, for 2 weeks. One drop of essential oil can be applied to the back of the wrist before the procedure. If skin discomfort or erythema occurs after half an hour, wash immediately with cold water. Allergic reactions usually occur within half an hour. During the procedure: Warm the operator's hands by rubbing them together to avoid cold stimulation to the patient, and assist the patient in assuming a comfortable position. Apply the prepared plant essential oil directly to the first and second stage pressure injury wounds, covering an area 1-2 mm larger than the wound. Massage the pressure area for 1-3 minutes until the essential oil is fully absorbed, 3 times daily for 2 weeks. When performing essential oil massage on corresponding meridians, the patient should lie supine with their limbs flat. Apply 5mL of mixed essential oil evenly to the meridian corresponding to the pressure ulcer. For example, for pressure ulcers on the lateral malleolus, massage the Gallbladder Meridian of Foot-Shaoyang, targeting acupoints such as Qiuxu, Xuanzhong, Yangfu, Guangming, Waiqiu, Yanglingquan, Xiyangguan, Zhongdu, and Fengshi. For pressure ulcers on the sacrum and coccyx, massage the Bladder Meridian of Foot-Taiyang, targeting acupoints such as Huiyang, Shangliao, Shenshu, Pishu, Ganshu, Xinshu, and Feishu. Massage the meridians according to their pathways, using techniques such as lifting, pinching, patting, and rubbing. Massage each meridian for 10 minutes, for a total of 40 minutes, 5 times per week for 2 consecutive weeks. During the procedure, inquire about the patient's comfort and apply the essential oil massage with a pressure that the patient can tolerate, avoiding contact with the area around the eyes.

[0045] Post-procedure: Observe the patient's skin condition and assist the patient in assuming a comfortable position.

[0046] Results Analysis

[0047] (1) General Information Questionnaire: Patient general information includes age, gender, education level, BMI, self-care ability score, Braden score, disease type, tumor stage, etc.

[0048] (2) Clinical efficacy: After 2 weeks of treatment, the treatment effects of the two groups of patients were compared. The efficacy judgment criteria were as follows: Cured: The wound was completely repaired and the tissue growth was good; Significantly effective: The wound was significantly reduced in size, with less exudate, and the granulation tissue was red and growing well; Effective: The wound was reduced in size, light red, with partial growth of granulation tissue and a small amount of inflammatory exudate; Ineffective: The wound showed no improvement or aggravated.

[0049] (3) Skin healing time: During the intervention period, the healing time of stage 1 erythema whitening and stage 2 wound healing were compared between the observation group and the control group.

[0050] (4) Medical costs for treating pressure injuries: During the intervention period, the medical and nursing costs for treating pressure injuries were compared between the two groups.

[0051] (5) Pressure Ulcer Healing Scale (PUSH): PUSH was used to assess wound healing in both groups of patients before and after the intervention.

[0052] The PUSH scoring system ranges from 0 to 17 points; a higher score indicates poorer wound healing. PUSH Score (Mean ± Standard Deviation)

[0053]

[0054] Change (Δ = before - after)

[0055]

[0056] Statistical methods:

[0057] All data are expressed as mean ± standard deviation and analyzed using SPSS 26.0 software. Independent samples t-tests were used for comparisons between groups, and paired t-tests were used for comparisons within groups. The significance level was set at P < 0.05.

[0058] Statistical test

[0059] Within-group comparisons: all showed significant improvement (P<0.01)

[0060] Intergroup comparison: After intervention, the observation group was significantly better than the control group (P<0.001).

[0061] Before the intervention, there was no significant difference in PUSH scores between the two groups (P > 0.05). Two weeks after the intervention, the PUSH score in the observation group was significantly lower than that in the control group (2.84 ± 1.32 vs 6.72 ± 1.95, P < 0.001), and the wound healing improvement rate was significantly higher (73.6% vs 38.0%). This indicates that the aromatic essential oil composition can significantly promote the healing of stage I and II pressure injuries and reduce the inflammatory response.

[0062] The healing time statistics are as follows:

[0063] control group

[0064] Target population: End-stage cancer patients with stage 1 or 2 pressure injuries

[0065] Dates: July 15, 2024 - August 21, 2024

[0066] Methods: During the data collection period, a total of 22 patients (25 sites) were investigated, and the average healing time of pressure injury was 21.91±3.19 days.

[0067] Observation group:

[0068] Target population: Terminal cancer patients with stage 1 or 2 pressure injuries

[0069] Dates: September 6, 2024 - October 18, 2024

[0070] Methods: During the data collection period, a total of 20 patients (25 sites) were investigated, and the average healing time of pressure injury was 8.54±2.04 days.

[0071] The data comparison between the control group and the observation group shows that the aromatic essential oil composition provided by the present invention can significantly shorten the healing time of pressure injury by about 61%.

[0072] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. An aromatic essential oil composition, characterized in that, It includes the following ingredients in parts by weight: 5-7 parts lavender essential oil, 3-5 parts helichrysum essential oil, 2-4 parts tea tree essential oil, 1-3 parts lemon essential oil, 2-4 parts melaleuca essential oil, and jojoba oil. The total weight percentage concentration of lavender essential oil, helichrysum essential oil, tea tree essential oil, lemon essential oil, and melaleuca essential oil is 2-4 wt%.

2. The aromatic essential oil composition according to claim 1, characterized in that, The ingredients include the following components in parts by weight: 6 parts lavender essential oil, 4 parts helichrysum essential oil, 3 parts tea tree essential oil, 2 parts lemon essential oil, 3 parts melaleuca lanceolata essential oil, and jojoba oil. The total weight percentage concentration of lavender essential oil, helichrysum essential oil, tea tree essential oil, lemon essential oil, and melaleuca lanceolata essential oil is 3 wt%.

3. An application of the aromatic essential oil composition according to claim 1 or 2, characterized in that: Essential oils used to prepare for the prevention of stage 1 or 2 stress injuries to body parts; Alternatively, it can be used to prepare essential oils for treating stage 1 or 2 stress injuries to body parts.

4. The application of an aromatic essential oil composition according to claim 1 or 2, characterized in that: Use 3 times / day for 2 weeks.

5. An aromatic essential oil composition, characterized in that, It includes the following components in parts by weight: 2-4 parts lavender essential oil, 1-3 parts helichrysum essential oil, 1-2 parts tea tree essential oil, 1-2 parts lemon essential oil, 1-2 parts melaleuca essential oil, and jojoba oil, wherein the total weight percentage concentration of lavender essential oil, helichrysum essential oil, tea tree essential oil, lemon essential oil, and melaleuca essential oil is 1-2 wt%.

6. The aromatic essential oil composition according to claim 5, characterized in that, The product comprises the following ingredients in parts by weight: 3 parts lavender essential oil, 2 parts helichrysum essential oil, 1 part tea tree essential oil, 1 part lemon essential oil, 1 part melaleuca essential oil, and jojoba oil. The total weight percentage concentration of lavender essential oil, helichrysum essential oil, tea tree essential oil, lemon essential oil, and melaleuca essential oil is 1 wt%.

7. The application of an aromatic essential oil composition according to claim 5 or 6, characterized in that: Essential oils used to prepare essential oils for preventing stage 1 or stage 2 pressure injuries to the skin of the head and face; Alternatively, it can be used to prepare essential oils for treating stage 1 or 2 stress injuries of the skin on the head and face.

8. The application of an aromatic essential oil composition according to claim 5 or 6, characterized in that: Use 3 times / day for 2 weeks.

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