Preservative for external skin preparation containing hinokitiol, and cosmetic composition containing same

Abstract

The present invention provides a preservative for an external preparation for skin and a use thereof. The preservative comprises: hinokitiol; and one or more solvents selected from the group consisting of alkantriol having 3 to 6 carbon atoms, dipropylene glycol, glycerol caprylate, ethylhexylglycerin, and phenoxyethanol. According to one aspect of the present invention, the preservative for an external preparation for skin can be stably held in a liquid state at room temperature and under cold storage conditions, and can exhibit an excellent antibacterial effect after being formed into a dosage form.

Description

Technical Field

[0001] This application claims priority to Korean Patent Application No. 10-2023-0124816, filed on September 19, 2023, and Korean Patent Application No. 10-2024-0036722, filed on March 15, 2024, the disclosures of which are incorporated herein by reference.

[0002] This application relates to a preservative for topical skin preparations containing juniper alcohol and a cosmetic composition containing the same. Background Technology

[0003] Because cosmetics are inevitably susceptible to microbial contamination during preparation and use, preservatives that enhance product preservation must be added during the manufacturing process. Widely used preservatives include parabens, imidazolidinyl ureas, and phenoxyethanol. However, while these preservatives possess excellent preservation capabilities due to their strong antibacterial properties, they are also known for their potential to cause toxicity, skin irritation, and allergies. Therefore, there is an urgent need to develop a safe preservative that does not cause skin irritation and offers high preservation capabilities.

[0004] As part of this research, studies on developing preservatives using diols with antibacterial properties have been ongoing. However, due to the known drawbacks of alkyldiols, such as causing toxicity, skin irritation, or allergies, their usage needs to be kept to a minimum. In doing so, however, a reduction in preservative efficacy is inevitable.

[0005] Therefore, there is an urgent need to develop a preservative for topical skin medications that does not cause skin irritation, has excellent preservation capabilities, and is stable.

[0006] Against this backdrop, the inventors conducted in-depth research on developing preservatives for topical skin preparations with excellent dosage form stability. The results showed that by combining juniper alcohol with various compounds, preservatives for topical skin preparations with excellent dosage form stability and superior antiseptic capabilities can be prepared, thus completing this application. Summary of the Invention

[0007] Technical issues

[0008] One aspect provides a preservative for topical skin preparations, comprising: juniper alcohol; and one or more solvents selected from the group consisting of alkyldiols having 3 to 10 carbon atoms, alkyltriols having 3 to 6 carbon atoms, dipropylene glycol, glyceryl caprylate, ethylhexylglycerin, and phenoxyethanol.

[0009] On the other hand, a cosmetic composition comprising the preservative for the topical skin agent is provided.

[0010] Another aspect provides a pharmaceutical composition for a skin application containing the preservative for the skin application.

[0011] Another aspect provides a method for preparing a cosmetic composition, which includes the step of adding a preservative for the topical skin agent.

[0012] Another method is provided for antibacterial, preservation, or preservative treatment of a cosmetic composition, comprising the step of adding a preservative to the topical skin agent.

[0013] Another aspect provides an use for antibacterial, preservation, or preservative treatment of a skin topical or cosmetic composition, wherein the composition comprises: juniper alcohol; and one or more solvents selected from the group consisting of alkyldiols having 3 to 10 carbon atoms, alkyltriols having 3 to 6 carbon atoms, dipropylene glycol, glyceryl caprylate, ethylhexylglycerin, and phenoxyethanol.

[0014] Other objects and advantages of this application will become clearer in conjunction with the appended claims and drawings, as well as the detailed description below. Regarding matters not described in this specification, which can be fully understood and deduced by those skilled in the art or similar fields, their descriptions are omitted.

[0015] Technical solution

[0016] The various descriptions and embodiments disclosed in this application can also be applied to various other descriptions and embodiments. That is, all combinations of the various elements disclosed in this application fall within the scope of this application. Furthermore, it cannot be determined that the scope of this application is limited to the specific descriptions set forth below.

[0017] One aspect provides a preservative for topical skin preparations, comprising: hinokitiol; and

[0018] One or more solvents selected from the group consisting of alkanediols having 3 to 10 carbon atoms, alkanetriols having 3 to 6 carbon atoms, dipropylene glycol, glyceryl caprylate, ethylhexylglycerin, and phenoxyethanol.

[0019] The term "topical skin preparation" in this specification is a concept that encompasses all compositions applied to the skin, including various cosmetics such as basic cosmetics, color cosmetics, and hair care cosmetics; as well as topical pharmaceutical compositions including ointments, creams, lotions, and other pharmaceutical and medical external products.

[0020] The term "preservative for topical skin preparations" in this specification may be used interchangeably with "antibacterial agent," "preservative," "antibacterial preservative," "preservative for preservation," "antibacterial composition," "preservative composition," "antibacterial or preservative composition," "antibacterial cosmetic composition," "preservative cosmetic composition," and "antibacterial or preservative cosmetic composition."

[0021] In this manual, the term "antimicrobial" refers to resistance to all contaminating microorganisms such as bacteria, mold, and yeast; "antimicrobial capacity" or "antimicrobial effect" refers to the ability or effect of defense against these contaminating microorganisms; and "antiseptic capacity" or "antiseptic effect" refers to the ability or effect of defense against spoilage caused by microbial contamination, which includes the concept of antimicrobial capacity or antimicrobial effect.

[0022] In this manual, the term "preservative" refers to a substance that has anti-corrosion or antioxidant properties and can prevent the product from deteriorating and maintain its original state over a long period of time; "preservation capacity" refers to the protective ability that can prevent the product from deteriorating and maintain its original state over a long period of time.

[0023] Although existing preservatives possess effective antibacterial activity, they face challenges in large-scale production and processing due to instability induced during storage, such as solidification and deterioration. Therefore, there is an urgent need to develop a preservative that possesses effective antibacterial activity while maintaining high stability under room temperature or refrigeration conditions.

[0024] Based on considerations of processing convenience and management, the inventors aim to develop a preservative for natural-derived topical skin agents that is in a liquid state, especially under room temperature and refrigeration conditions, and has superior antibacterial and preservative capabilities compared to existing preservatives.

[0025] In one specific embodiment, the preservative may contain the juniper alcohol and the solvent in a weight ratio of 1:19 to 1:1000. For example, the weight ratio may be 1:19 to 1:1000, 1:19 to 1:500, 1:19 to 1:300, 1:19 to 1:200, 1:19 to 1:100, 1:19 to 1:99, 1:19 to 1:89, 1:20 to 1:1000, 1:20 to 1:500, 1:20 to 1:300, 1:20 to 1:200, 1:20 to 1:100, 1:20 to 1:99, 1:20, or 1:89. Specifically, it may be 1:19 to 1:99. If the range is exceeded, the antibacterial or preservative effect of the preservative may be reduced, and it may cause a decrease in stability, such as solidification, precipitation, sedimentation, reduced solubility, reduced emulsifying or solubilizing power.

[0026] According to one experimental example, a preservative containing juniper alcohol and solvent in the weight ratio within the range remained in a liquid state at room temperature and also exhibited excellent antibacterial ability (see Experimental Examples 2, 3, 4 and 5).

[0027] The preservative for the topical skin preparation may contain juniper alcohol in an amount of 0.1 to 5% by weight relative to the total weight. For example, it may contain 0.1 to 5% by weight, 0.1 to 3% by weight, 0.1 to 2% by weight, 0.1 to 1% by weight, 0.5 to 5% by weight, 0.5 to 3% by weight, 0.5 to 2% by weight, 0.5 to 1% by weight, 1 to 5% by weight, 1 to 3% by weight, or 1 to 2% by weight. If the range is exceeded, the antibacterial or preservative effect of the preservative may be reduced, and problems such as solidification, precipitation, reduced solubility, reduced emulsifying power, or reduced solubilizing power may occur.

[0028] The preservative for the topical skin preparation may contain alkyl glycols with 3 to 10 carbon atoms, alkyltriols with 3 to 6 carbon atoms, dipropylene glycol, glyceryl caprylate, ethylhexylglycerin, or phenoxyethanol in an amount of 85 to 99.9% by weight relative to the total weight. For example, it may contain 85 to 99.9% by weight, 85 to 99% by weight, 85 to 97% by weight, 85 to 95% by weight, or 85 to 90% by weight. If the range is exceeded, the antibacterial or preservative effect of the preservative may be reduced, and problems such as solidification, precipitation, reduced solubility, reduced emulsifying power, or reduced solubilizing power may occur.

[0029] The preservative for the topical skin preparation may comprise: 0.1 to 5 wt%, 0.1 to 3 wt%, 0.1 to 2 wt%, 0.1 to 1 wt%, 0.5 to 5 wt%, 0.5 to 3 wt%, 0.5 to 2 wt%, 0.5 to 1 wt%, 1 to 5 wt%, 1 to 3 wt%, or 1 to 2 wt% of juniper alcohol relative to the total weight; and one or more compounds selected from the group consisting of alkylene glycols having 3 to 10 carbon atoms, alkyltriols having 3 to 6 carbon atoms, dipropylene glycol, glyceryl caprylate, ethylhexylglycerin, or phenoxyethanol, relative to the total weight.

[0030] The preservative for the topical skin preparation may further contain caprylhydroxamic acid or raspberry ketone.

[0031] In one specific embodiment, the preservative for the topical skin preparation may comprise, in a weight ratio of 1:19 to 1:1000: juniper alcohol; one or more solvents selected from the group consisting of alkyldiols having 3 to 10 carbon atoms, alkyltriols having 3 to 6 carbon atoms, dipropylene glycol, glyceryl caprylate, ethylhexylglycerin, and phenoxyethanol; and capryloyl hydroxamic acid or raspberry ketone. For example, the weight ratio can be 1:19 to 1:1000, 1:19 to 1:500, 1:19 to 1:300, 1:19 to 1:200, 1:19 to 1:100, 1:19 to 1:99, 1:19 to 1:89, 1:20 to 1:1000, 1:20 to 1:500, 1:20 to 1:300, 1:20 to 1:200, 1:20 to 1:100, 1:20 to 1:99, 1:20, or 1:89. If the range is exceeded, the antibacterial or preservative effect of the preservative may be reduced, and stability may decrease, such as problems like solidification, precipitation, sedimentation, reduced solubility, reduced emulsifying power, or reduced solubilizing power.

[0032] In one specific embodiment, the preservative for the topical skin preparation may comprise, in a weight ratio of 1 to 5: 80 to 94: 1 to 15: juniper alcohol; one or more solvents selected from the group consisting of alkyldiols having 3 to 10 carbon atoms, alkyltriols having 3 to 6 carbon atoms, dipropylene glycol, glyceryl caprylate, ethylhexylglycerin, and phenoxyethanol; and capryloyl hydroxamic acid or raspberry ketone. For example, the weight ratio can be 1 to 5:80 to 94:1 to 15, 1 to 5:80 to 93:2 to 15, 1 to 5:80 to 92:3 to 15, 1 to 5:80 to 91:4 to 15, 1 to 5:80 to 90:5 to 15, 1 to 5:80 to 89:6 to 15, 1 to 5:80 to 88:7 to 15, 1 to 5:80 to 87:8 to 15, 1 to 5:80 to 86:9 to 15, 1 to 5:80 to 85:10 to 15, 5:85:10, or 5:80:15. Specifically, it can be 5:80 to 85:10 to 15.

[0033] The preservative for the topical skin preparation may contain juniper alcohol in an amount of 0.1 to 5% by weight relative to the total weight. For example, it may contain 0.1 to 5% by weight, 0.1 to 3% by weight, 0.1 to 2% by weight, 0.1 to 1% by weight, 0.5 to 5% by weight, 0.5 to 3% by weight, 0.5 to 2% by weight, 0.5 to 1% by weight, 1 to 5% by weight, 1 to 3% by weight, or 1 to 2% by weight. If the range is exceeded, the antibacterial or preservative effect of the preservative may be reduced, and problems such as solidification, precipitation, reduced solubility, reduced emulsifying power, or reduced solubilizing power may occur.

[0034] The preservative for the topical skin preparation may contain alkyl glycols with 3 to 10 carbon atoms, alkyltriols with 3 to 6 carbon atoms, dipropylene glycol, glyceryl caprylate, ethylhexylglycerin, or phenoxyethanol in an amount of 75 to 94.9% by weight relative to the total weight. For example, it may contain 75 to 94.9% by weight, 80 to 94% by weight, 80 to 92% by weight, 80 to 90% by weight, or 80 to 85% by weight. If it exceeds the range, the antibacterial or preservative effect of the preservative may be reduced, and problems such as solidification, precipitation, reduced solubility, reduced emulsifying power, or reduced solubilizing power may occur.

[0035] The preservative for the topical skin preparation may contain the capryloyl hydroxamic acid or raspberry ketone in an amount of 1 to 20% by weight relative to the total weight. For example, it may contain 1 to 20% by weight, 1 to 15% by weight, 1 to 10% by weight, 1 to 5% by weight, 1 to 3% by weight, 3 to 20% by weight, 3 to 15% by weight, 3 to 10% by weight, 3 to 5% by weight, 5 to 20% by weight, 5 to 15% by weight, 5 to 10% by weight, 10 to 20% by weight, or 10 to 15% by weight. If the range is exceeded, the antibacterial or preservative effect of the preservative may be reduced, and problems such as solidification, precipitation, reduced solubility, reduced emulsifying power, or reduced solubilizing power may occur.

[0036] According to one experimental example, preservatives containing octanoyl hydroxamic acid or raspberry ketone in the range described exhibited excellent preservative properties (see Experimental Example 8).

[0037] In one specific embodiment, the preservative for the topical skin preparation may comprise, by weight ratios of 1:19 to 1:1000, 1:19 to 1:500, 1:19 to 1:300, 1:19 to 1:200, 1:19 to 1:100, 1:19 to 1:99, 1:19 to 1:89, 1:20 to 1:1000, 1:20 to 1:500, 1:20 to 1:300, 1:20 to 1:200, 1:20 to 1:100, 1:20 to 1:99, 1:20, or 1:89: juniper alcohol; and a group selected from carbons having 3 to 10 carbon atoms. The solvent comprises one or more solvents from the group consisting of alkyldiol, alkyltriol having 3 to 6 carbon atoms, dipropylene glycol, glyceryl caprylate, ethylhexylglycerol, and phenoxyethanol, and capryloyl hydroxamic acid or raspberry ketone, wherein the capryloyl hydroxamic acid or raspberry ketone may be contained in amounts of 1 to 20 wt%, 1 to 15 wt%, 1 to 10 wt%, 1 to 5 wt%, 1 to 3 wt%, 3 to 20 wt%, 3 to 15 wt%, 3 to 10 wt%, 3 to 5 wt%, 5 to 20 wt%, 5 to 15 wt%, 5 to 10 wt%, 10 to 20 wt%, or 10 to 15 wt%. When the preservative simultaneously satisfies the following conditions: the weight ratio of the juniper alcohol (selected from one or more solvents in the group consisting of alkyldiols with 3 to 10 carbon atoms, alkyltriols with 3 to 6 carbon atoms, dipropylene glycol, glyceryl caprylate, ethylhexylglycerol, and phenoxyethanol) and capryloyl hydroxamic acid or raspberry ketone, and satisfies the content range of the capryloyl hydroxamic acid or raspberry ketone, its antibacterial ability and stability can be significantly improved.

[0038] The preservative for the topical skin preparation may comprise: 0.1 to 5 wt%, 0.1 to 3 wt%, 0.1 to 2 wt%, 0.1 to 1 wt%, 0.5 to 5 wt%, 0.5 to 3 wt%, 0.5 to 2 wt%, 0.5 to 1 wt%, 1 to 5 wt%, 1 to 3 wt%, or 1 to 2 wt% of juniper alcohol relative to the total weight; and 75 to 94.9 wt%, 80 to 94 wt%, 80 to 92 wt%, 80 to 90 wt%, or 80 to 85 wt% of a preservative selected from carbons 3 to 1. One or more compounds from the group consisting of 0 alkyldiol, 3 to 6 alkyltriol, dipropylene glycol, glyceryl caprylate, ethylhexylglycerol or phenoxyethanol; and caprylyl hydroxamic acid or raspberry ketone in amounts of 1 to 20 wt%, 1 to 15 wt%, 1 to 10 wt%, 1 to 5 wt%, 1 to 3 wt%, 3 to 20 wt%, 3 to 15 wt%, 3 to 10 wt%, 3 to 5 wt%, 5 to 20 wt%, 5 to 15 wt%, 5 to 10 wt%, 10 to 20 wt% or 10 to 15 wt% relative to the total weight.

[0039] In one specific embodiment, the alkanediol having 3 to 10 carbon atoms may be propylene glycol, methylpropylene glycol, butanediol, pentanediol, hexanediol, heptanediol, octanediol, or decanediol. More specifically, it may be one or more selected from the group consisting of 1,3-propanediol, methylpropylene glycol, 2,3-butanediol, 1,3-butanediol, 1,2-pentanediol, 1,5-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, and 1,2-decanediol.

[0040] In one specific embodiment, the alkyltriol having 3 to 6 carbon atoms can be glycerol, 1,2,6-hexanetriol, or a combination thereof.

[0041] In another specific embodiment, the solvent may be one or more selected from the group consisting of 1,3-propanediol, methylpropanediol, 2,3-butanediol, 1,3-butanediol, 1,2-pentanediol, 1,5-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-decanediol, glycerol, 1,2,6-hexanetriol, dipropylene glycol, glyceryl caprylate, ethylhexylglycerol, and phenoxyethanol. More specifically, the solvent may be 1,2-pentanediol, 1,5-pentanediol, 1,2-octanediol, glyceryl caprylate, or combinations thereof.

[0042] According to one experimental example, a preservative containing juniper alcohol; and alkyldiols with 3 to 10 carbon atoms, alkyltriols with 3 to 6 carbon atoms, dipropylene glycol, glyceryl caprylate, ethylhexylglycerol or phenoxyethanol can remain liquid at room temperature and exhibit excellent antibacterial activity against bacteria, yeast and mold.

[0043] Furthermore, an experimental example confirmed that 1,2-pentanediol, 1,5-pentanediol, 1,2-octanediol, or glyceryl caprylate exhibit a synergistic effect of antibacterial activity with juniper alcohol in the strain.

[0044] The compound can be obtained by those skilled in the art using well-known methods, for example, it can be derived from natural sources, and can be a substance obtained from sugarcane. Compounds derived from natural sources help to further reduce skin irritation.

[0045] Furthermore, in one specific embodiment, the preservative for the topical skin agent exhibits excellent antibacterial or antiseptic effects against a variety of microorganisms (specifically, contaminating microorganisms). Specifically, the preservative for the topical skin agent can inhibit or kill the growth of Gram-positive bacteria, Gram-negative bacteria, and fungi (such as yeasts and molds). Specifically, the preservative for the topical skin agent exhibits excellent antibacterial or antiseptic effects against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans, and Aspergillus brasiliensis, but is not limited thereto.

[0046] Furthermore, in one specific embodiment, the skin preservative used in the topical preparation exhibits significantly reduced skin irritation compared to preservatives commonly used in existing cosmetics (e.g., parabens, imidazolidinyl urea, phenoxyethanol, etc.), or compared to the use of octanediol, octylglycerol ether, or ethylhexylglycerin alone, thus demonstrating excellent skin safety.

[0047] The preservative for topical skin preparations may further include purified water, a carrier, emulsifiers, moisturizers, skin conditioning agents, surfactants, chelating agents, antioxidants, preservatives, bactericides, stabilizers, preservatives, pH adjusters, lubricants, solubilizers, solvents, and other additives. Furthermore, the preservative for topical skin preparations may further include substances that can help provide essential nutrients to the skin or improve skin condition, such as functional substances that improve wrinkles or whiten the skin. Additionally, the preservative for topical skin preparations may further include adjuvants, including but not limited to natural fragrances, cosmetic fragrances, or plant extracts.

[0048] On the other hand, a cosmetic composition comprising the preservative for topical skin preparations is provided. Terms or elements already mentioned in the description of the preservative for topical skin preparations, if identical to those described above, shall be as stated above.

[0049] The cosmetic composition, by including the preservative for topical skin application, can be provided as a cosmetic composition with excellent preservation ability and stability. There is no particular limitation on the amount of the preservative for topical skin application used in the cosmetic composition, as long as the desired preservation ability is ensured; those skilled in the art can appropriately determine this amount based on the required preservation ability.

[0050] In one specific embodiment, the preservative for topical skin preparations may be included in an amount of 0.0001 to 50% by weight relative to the total weight of the cosmetic composition. For example, the preservative for topical skin preparations may be included in amounts of 0.0001 to 0.001% by weight, 0.001 to 0.01% by weight, 0.01 to 0.1% by weight, 0.1 to 1% by weight, 1 to 10% by weight, 10 to 20% by weight, 20 to 30% by weight, 30 to 40% by weight, or 40 to 50% by weight. If these ranges are exceeded, the antibacterial or preservative effects may be reduced, and decreased stability may occur, such as problems like solidification, precipitation, reduced solubility, reduced emulsifying power, or reduced solubilizing power.

[0051] The cosmetic composition may further include additives selected from, but not limited to, purified water, carriers, emulsifiers, moisturizers, skin conditioning agents, surfactants, chelating agents, antioxidants, preservatives, bactericides, stabilizers, preservatives, pH adjusters, lubricants, solubilizers, solvents, and combinations thereof. Furthermore, the cosmetic composition may further include substances capable of assisting in the provision of essential nutrients to the skin or improving skin condition, such as functional substances with wrinkle-improving or whitening effects. Additionally, the cosmetic composition may further include excipients, including but not limited to natural fragrances, cosmetic fragrances, or plant extracts.

[0052] The cosmetic composition can be formulated into any dosage form commonly prepared in the art. Specifically, the dosage form of the cosmetic composition can be a solution, emulsion, suspension, softening lotion, nourishing lotion, massage cream, nourishing cream, mask, gel, skin-adhesive cosmetic, lipstick, powder, makeup base, foundation, shampoo, conditioner, scalp cleanser, scalp lotion, scalp cream, scalp mask, scalp gel, scalp ointment, scalp gel, body cleanser, soap, toothpaste, oral cleanser, paste, lotion, ointment, gel, cream, patch, spray, or atomizer, but is not limited thereto.

[0053] The carrier contained in the cosmetic composition may be selectively used depending on the dosage form of the cosmetic. For example, when preparing cosmetics in the form of ointments, pastes, creams, or gels, waxes, paraffin wax, starch, tragacanth gum, cellulose derivatives, polyethylene glycol, silicone, bentonite, silica, talc, zinc oxide, etc., may be used as carrier components, alone or in combination. When preparing cosmetics in the form of powders or sprays, lactose, talc, silica, aluminum hydroxide, calcium silicate, polyamide powder, chlorofluorocarbons, propane / butane, dimethyl ether, etc., may be used as carrier components, alone or in combination. When preparing cosmetics in the form of solutions or emulsions, water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3-butanediol oil, cottonseed oil, peanut oil, corn germ oil, olive oil, castor oil, sesame oil, glycerol aliphatic esters, polyethylene glycol, or sorbitan fatty acid esters, etc., may be used as carrier components, alone or in combination. In the preparation of cosmetics in suspension form, water, ethanol or propylene glycol, ethoxylated isostearyl alcohol, polyoxyethylene sorbitan ester, polyoxyethylene sorbitan ester, microcrystalline cellulose, aluminum hydroxide, bentonite, agar, tragacanth gum, etc., can be used alone or in combination as carrier components. In the preparation of cosmetics in soap form, fatty acid alkali metal salts, fatty acid half-ester salts, fatty acid protein hydrolysates, ethanesulfonates, lanolin derivatives, aliphatic alcohols, vegetable oils, glycerin, sugars, etc., can be used alone or in combination as carrier components.

[0054] Another aspect provides a pharmaceutical composition for a topical application comprising the aforementioned preservative for a topical application. Terms or elements already mentioned in the description of the preservative for a topical application, if identical to those described above, shall be as stated above.

[0055] There is no particular limitation on the content of the preservative used in the topical pharmaceutical composition, as long as the desired preservation ability can be ensured. Those skilled in the art can appropriately determine the content based on the required preservation ability. For example, the preservative may be included in an amount of 0.0001 to 50% by weight relative to the total weight of the topical pharmaceutical composition. For example, the preservative may be included in amounts of 0.0001 to 0.001% by weight, 0.001 to 0.01% by weight, 0.01 to 0.1% by weight, 0.1 to 1% by weight, 1 to 10% by weight, 10 to 20% by weight, 20 to 30% by weight, 30 to 40% by weight, or 40 to 50% by weight.

[0056] The pharmaceutical composition for topical skin application can be any dosage form known as a topical skin application agent, such as, but not limited to, a dosage form selected from the group consisting of liniments, ointments, pastes, poultices, suspensions, oils, lotions, aerosols, and suppositories.

[0057] The pharmaceutical composition for topical application can be used to achieve systemic action of the active ingredient through skin application, or to achieve local action of the active ingredient through skin application. In one specific embodiment, the pharmaceutical composition is used to achieve local action of the active ingredient through skin application.

[0058] In addition to the preservative for the topical skin application, the cosmetic composition and the pharmaceutical composition for topical skin application may further include various known additives, depending on the dosage form, to the extent that the efficacy of the preservative for the topical skin application is not impaired. In one specific embodiment, it may further include additives from the group consisting of cobalt free carriers, emulsifiers, moisturizers, skin conditioning agents, surfactants, chelating agents, antioxidants, bactericides, stabilizers, and any combination thereof.

[0059] Another aspect provides a method for preparing a cosmetic composition, which includes the step of adding a preservative for the topical skin agent.

[0060] Terms or elements already mentioned in the description of the preservatives and cosmetic compositions for topical skin preparations shall be as stated above if they are the same as those mentioned above.

[0061] The preservative for the topical skin agent may be used in an amount of 0.0001 to 50% by weight relative to the cosmetic composition.

[0062] Another method is provided for antibacterial, preservation, or preservative treatment of a cosmetic composition, comprising the step of adding a preservative to the topical skin agent.

[0063] Another aspect provides an use for antibacterial, preservation, or preservative treatment of a skin topical or cosmetic composition, wherein the composition comprises: juniper alcohol; and one or more solvents selected from the group consisting of alkyldiols having 3 to 10 carbon atoms, alkyltriols having 3 to 6 carbon atoms, dipropylene glycol, glyceryl caprylate, ethylhexylglycerin, and phenoxyethanol.

[0064] Beneficial effects

[0065] Based on the fact that the skin preservative has significant and excellent antibacterial, preservative and safety properties, it can be used as a skin-safe preservative, preservative or preservative adjuvant when applied to cosmetic compositions.

[0066] Furthermore, the preservative for topical skin preparations exhibits excellent dosage form stability, remaining stably liquid without discoloration, odor change, or precipitation under various temperature conditions, specifically at room temperature and under refrigeration. This addresses the potential stability reduction issues arising from the inclusion of juniper alcohol and at least one solvent selected from the group consisting of alkyldiols (3 to 10 carbon atoms), alkyltriols (3 to 6 carbon atoms), dipropylene glycol, glyceryl caprylate, ethylhexylglycerin, and phenoxyethanol. This allows for stable application in cosmetic compositions. Moreover, compared to preservatives commonly used in existing cosmetics (e.g., parabens, imidazolidinyl urea, phenoxyethanol, etc.), or compared to the use of alkyldiols, alkyltriols, dipropylene glycol, glyceryl caprylate, or ethylhexylglycerin alone, the preservative for topical skin preparations shows significantly reduced skin irritation, thus demonstrating excellent skin safety. Detailed Implementation

[0067] The present invention will now be described in more detail through embodiments. However, these embodiments are merely illustrative of the invention, and the scope of the invention is not limited to these embodiments.

[0068] Experimental Example 1: Evaluation of the stability of preservative formulations based on solvent type

[0069] In this experimental example, the formulation stability of the preservative, depending on the solvent type, was evaluated; specifically, whether it could maintain a liquid state. For this purpose, the preservative was prepared according to the components and amounts described in Tables 1 and 2 below, and stirred at room temperature.

[0070] Table 1

[0071] Table 2

[0072] The results are shown in Tables 1 and 2. Preservatives using alkyldiols with 3 to 10 carbon atoms, alkyltriols with 3 to 6 carbon atoms, dipropylene glycol, glyceryl caprylate, ethylhexylglycerin, or phenoxyethanol (Examples 1 to 16) were able to remain in a liquid state at room temperature (25°C), while Comparative Examples 1 to 3 solidified.

[0073] Experimental Example 2: Evaluation of antibacterial ability based on solvent type

[0074] In this experimental example, the antimicrobial activity of preservatives using different solvents against *Escherichia coli* (ATCC 8739), *Pseudomonas aeruginosa* (ATCC 9027), *Staphylococcus aureus* (ATCC 6538), *Candida albicans* (ATCC 10231), and *Aspergillus brasiliensis* (ATCC 16404) strains was evaluated. For this purpose, preservatives were prepared according to the components and concentrations described in Tables 3 and 4 below, and experiments were conducted using the minimum inhibitory concentration (MIC) method. Specifically, the preservatives were diluted to 0.0025% to 5% (w / w) for later use. At this point, *Escherichia coli*, *Pseudomonas aeruginosa*, and *Staphylococcus aureus* were diluted using tryptic soy broth (TSB), while *Candida albicans* and *Aspergillus brasiliensis* were diluted using potato dextrose broth (PDB). 200 μL of each was then aliquoted into 96-well plates. For strains aliquoted into tryptic soy broth (TSB), they were incubated in liquid medium at 37°C. After culturing under aerobic conditions for 18 hours to activate the strain, the resulting bacterial culture was inoculated to achieve a concentration greater than 10. 6 CFU / mL, while for strains dispensed into potato dextrose agar (PDB), the concentration was increased to 25 CFU / mL. After activation by culturing under aerobic conditions, the resulting bacterial strain is inoculated to achieve a concentration greater than 10. 5 CFU / mL.

[0075] The samples were then cultured under their respective conditions, and absorbance was measured at 600 nm to confirm the minimum inhibitory concentration (MIC). The MIC is the lowest concentration (w / w%) of a sample that can inhibit the growth of approximately 95% or more of the bacterial strains.

[0076] Table 3

[0077] Table 4

[0078] Table 5

[0079] The results are shown in Table 5. Compared with Comparative Examples 4 to 6, the preservatives using alkyldiols with 3 to 10 carbon atoms, alkyltriols with 3 to 6 carbon atoms, dipropylene glycol, glyceryl caprylate, ethylhexylglycerin or phenoxyethanol (Examples 17 to 32) showed significantly lower minimum inhibitory concentrations, thus demonstrating excellent antibacterial ability.

[0080] Based on the results of Experimental Example 1 and Experimental Example 2, it can be seen that the preservative containing juniper alcohol exhibits excellent formulation stability and antibacterial ability when using alkyldiols with 3 to 10 carbon atoms, alkyltriols with 3 to 6 carbon atoms, dipropylene glycol, glyceryl caprylate, ethylhexylglycerol, or phenoxyethanol as solvents.

[0081] Experimental Example 3: Evaluation of dosage form stability based on the weight ratio of preservative components

[0082] In this experimental example, the formulation stability of the preservative based on the solvent weight ratio of juniper alcohol was evaluated, specifically, whether it could maintain a liquid state. For this purpose, the preservative was prepared according to the components and contents described in Tables 6 and 7 below, and was prepared by stirring at room temperature.

[0083] Table 6

[0084] Table 7

[0085] The results are shown in Tables 6 and 7. The preservatives containing solvent at a weight ratio of 1:19 relative to hinoki alcohol (Examples 33 to 48) were able to remain in a liquid state at room temperature; while the preservatives containing solvent at a weight ratio of less than 1:19 relative to hinoki alcohol (Comparative Examples 7 to 22) exhibited precipitation.

[0086] Experiment Example 4: Evaluation of antibacterial ability based on the weight ratio of preservative components

[0087] In this experimental example, the antibacterial activity of each strain was evaluated based on the solvent weight ratio to hinoki alcohol. For this purpose, a preservative was prepared according to the components and contents of the examples (Examples 33 to 48) and comparative examples (Comparative Examples 7 to 22) in Experimental Example 3, and the minimum inhibitory concentration (MIC) method was performed using the same method as in Experimental Example 2.

[0088] Table 8

[0089] Table 9

[0090] The results are shown in Tables 8 and 9. Compared with the preservatives containing solvent at a weight ratio of less than 1:19 relative to hinoki alcohol (Comparative Examples 4 to 19), the preservatives containing solvent at a weight ratio of 1:19 relative to hinoki alcohol (Examples 33 to 48) showed a significant decrease in minimum inhibitory concentration, thereby exhibiting excellent antibacterial ability.

[0091] Based on the results of Experiments 3 and 4, it can be seen that when the weight ratio of juniper alcohol to solvent in the preservative containing juniper alcohol is less than 1:19, its formulation stability and antibacterial ability are significantly reduced.

[0092] Experimental Example 5: Evaluation of the synergistic effect of antibacterial ability based on solvent type

[0093] In this experimental example, the synergistic effect of chinaberry alcohol with different solvents on the antibacterial activity against *Escherichia coli* (ATCC 8739), *Pseudomonas aeruginosa* (ATCC 9027), *Staphylococcus aureus* (ATCC 6538), *Candida albicans* (ATCC 10231), and *Aspergillus brasiliensis* (ATCC 16404) was evaluated. For this purpose, the checkerboard method was used to calculate the fractional inhibitory concentration (FIC) index.

[0094] Specifically, 100 μL of TSB or PDB medium, 50 μL of juniper alcohol (concentration of 0.04 to 2.5%) and 50 μL of solvent (adjusted to the following concentration) were dispensed into 96-well plates to bring the total volume to 200 μL.

[0095] Dilute glycerol, 1,3-propanediol, dipropylene glycol, methylpropanediol, 2,3-butanediol, and 1,3-butanediol to 1.25 to 40% (w / w); dilute 1,2-pentanediol, 1,5-pentanediol, 1,2-hexanediol, 1,2,6-hexanetriol, and 1,2-heptanediol to 0.125 to 4% (w / w); and dilute 1,2-octanediol, 1,2-decanediol, ethylhexylglycerol, glyceryl caprylate, and phenoxyethanol to 0.03 to 1% (w / w). Inoculate the strain culture, which has been pre-cultured and activated in liquid medium for 18 hours, with a concentration greater than 10 for *Escherichia coli*, *Pseudomonas aeruginosa*, and *Staphylococcus aureus*. 6 CFU / mL, while for Candida albicans and Aspergillus brasiliensis, the concentration should be greater than 10. 5 CFU / mL. The cells were then cultured under their respective conditions, and absorbance was measured at 600 nm to confirm the minimum inhibitory concentration (MIC). The fractional inhibitory concentration (FIC) index was then calculated using the following mathematical formula 1. In the FIC index, 0.5 or less indicates a synergistic effect, greater than 0.5 and less than or equal to 1.0 indicates an additive effect, greater than 1.0 and less than or equal to 4.0 indicates an irrelevant effect, and greater than 4.0 indicates an antagonistic effect.

[0096]

Mathematical Formula 1

[0097] FIC index = FICa + FICb

[0098] (FICa = MICa in combination / MICa, FICb = MICb in combination / MICb)

[0099] Table 10

[0100] –: Antagonistic, 0: Irrelevant, +: Additive, ++: Synergistic

[0101] The results, as shown in Table 10, indicate that when alkyldiols with carbon numbers 3 to 10, alkyltriols with carbon numbers 3 to 6, dipropylene glycol, glyceryl caprylate, ethylhexylglycerol, or phenoxyethanol were used, one or more strains exhibited additive or synergistic effects with hinoki alcohol. Conversely, when the aforementioned solvents were not used, all strains exhibited irrelevant or antagonistic effects. In particular, 1,2-pentanediol, 1,5-pentanediol, 1,2-octanediol, and glyceryl caprylate showed significant synergistic effects with hinoki alcohol.

[0102] The results confirm that when a specific solvent is used, it exhibits a synergistic effect with the antibacterial ability of hinoki alcohol.

[0103] Experimental Example 6: Preparation and Preservative Evaluation of Topical Skin Compositions

[0104] In this experimental example, a skin-applied composition containing a preservative was prepared, and the preservative ability was evaluated by confirming the number of surviving bacteria after inoculating a certain number of bacteria into it.

[0105] First, to prepare a composition for topical skin application, a preservative was prepared according to the composition shown in Table 11 below. The preservatives of dosage forms 1 to 12 contain both juniper alcohol and a solvent, while the preservative of dosage form 13 contains only juniper alcohol as a single component.

[0106] Subsequently, phases A to D were prepared according to the components and contents shown in Table 12 below, and were respectively mixed with 1% by weight of a preservative (dosage form examples 1 to 12) or 0.05% by weight of a single component of juniper alcohol (dosage form example 13) to prepare a topical skin composition.

[0107] Table 11

[0108] Table 12

[0109] Subsequently, to evaluate the antiseptic ability of the topical skin composition, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus were inoculated at the same concentration in a 1:1:1 ratio to achieve an initial bacterial concentration of approximately 10 in each sample. 6 CFU / g. For yeast and mold, *Candida albicans* and *Aspergillus brasiliensis* were inoculated separately to achieve an initial concentration of approximately 10. 5 CFU / g. The sample was then subjected to temperature control at room temperature (25°C). Store the samples under the specified conditions for 4 weeks, and take 1 g of each sample at 7-day intervals to confirm the number of surviving bacteria. In particular, for molds, confirm whether the samples have developed an off-flavor and whether hyphae or spores have appeared on the sample surface.

[0110] Table 13

[0111] –: Normal condition with no off-odor, no mycelium, and no spores; +: Localized mold growth on the sample surface; ++: Off-odor and mold growth on the sample surface.

[0112] The results are shown in Table 13. When the weight ratio of juniper alcohol to solvent was equal to or greater than 1:19 (Dosage Forms 1 to 5), the number of viable bacteria, yeasts, and molds was significantly reduced compared to the case where the weight ratio was less than 1:19 (Dosage Forms 6 to 10). On the other hand, in the topical skin formulations (preservatives containing 1,6-hexanediol, 1,10-decanediol, and undecenoic acid glyceride) (Dosage Forms 11 to 13), the number of bacteria and yeasts did not decrease, nor did mold grow on the sample surface. Furthermore, the preservative containing only juniper alcohol without solvent (Dosage Form 13) also showed a significant reduction in preservative ability.

[0113] Therefore, based on the results, it can be seen that the preservative ability of a preservative containing juniper alcohol and a solvent is determined by the type of solvent and the weight ratio of juniper alcohol to solvent.

[0114] Furthermore, it can be seen that specific solvents with antibacterial properties can produce a synergistic effect with juniper alcohol in terms of antibacterial properties.

[0115] Experimental Example 7: Preparation and antiseptic efficacy evaluation of topical skin formulations containing capryloyl hydroxamic acid or raspberry ketone

[0116] In this experimental example, a topical skin composition further comprising capryloyl hydroxamic acid or raspberry ketone was prepared, and its antiseptic ability was evaluated by confirming the number of surviving bacteria after inoculating a certain number of bacteria therein.

[0117] First, to prepare a composition for topical skin application, a preservative was prepared according to the composition shown in Table 14 below. The preservatives of Examples 49 to 58 contained juniper alcohol, a solvent, and capryloyl hydroxamic acid or raspberry ketone, while the preservatives of Comparative Examples 23 to 24 contained only capryloyl hydroxamic acid or raspberry ketone as a single component.

[0118] Subsequently, phases A to D were prepared according to the components and contents shown in Table 15 below, and were respectively mixed with 1% by weight of a preservative (Examples 49 to 58) or 0.1% by weight of a single component of capryloyl hydroxamic acid or raspberry ketone (Comparative Examples 23 to 24) to prepare a composition for topical skin application.

[0119] Table 14

[0120] Table 15

[0121] Subsequently, to evaluate the antiseptic ability of the topical skin composition, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus were inoculated at the same concentration in a 1:1:1 ratio to achieve an initial bacterial concentration of approximately 10 in each sample. 6 CFU / g. For yeast and mold, *Candida albicans* and *Aspergillus brasiliensis* were inoculated separately to achieve an initial concentration of approximately 10. 5 CFU / g. The sample was then subjected to temperature control at room temperature (25°C). Store the samples under the specified conditions for 4 weeks, and take 1 g of each sample at 7-day intervals to confirm the number of surviving bacteria. In particular, for molds, confirm whether the samples have developed an off-flavor and whether hyphae or spores have appeared on the sample surface.

[0122] Table 16

[0123] –: Normal condition with no off-odor, no mycelium, and no spores; +: Localized mold growth on the sample surface; ++: Off-odor and mold growth on the sample surface.

[0124] The results are shown in Table 16. When the preservative contained juniper alcohol, a solvent, and capryloyl hydroxamic acid or raspberry ketone (Examples 49 to 58), the number of bacteria and yeast was significantly reduced, and no mold was generated on the sample surface, thus confirming that the preservative ability was significantly excellent. On the other hand, when the preservative contained only capryloyl hydroxamic acid or raspberry ketone (Comparative Examples 23 to 24), the effect of reducing the number of bacteria and yeast was relatively limited, and mold was generated on the sample surface, thus confirming that the preservative ability was significantly reduced.

[0125] Furthermore, in Formulation Example 1 of Experimental Example 6, Examples 49 and 54, which added capryloyl hydroxamic acid or raspberry ketone, showed a more significant reduction in bacterial and yeast counts in the first and second weeks compared to Formulation Example 1. Additionally, in Formulation Example 3 of Experimental Example 6, Examples 51 and 56, which added capryloyl hydroxamic acid or raspberry ketone, showed a more significant reduction in bacterial and yeast counts in the first week compared to Formulation Example 1. Furthermore, in Formulation Example 5 of Experimental Example 6, Examples 53 and 58, which added capryloyl hydroxamic acid or raspberry ketone, showed a more significant reduction in bacterial counts in the first week compared to Formulation Example 1.

[0126] Based on the results, it was confirmed that when octanoyl hydroxamic acid or raspberry ketone is further included in the preservative, a synergistic effect of preservative ability is generated between it and juniper alcohol and solvent.

[0127] Example 8: Evaluation of preservative ability based on octanoyl hydroxamic acid content

[0128] In this experimental example, the preservative effect was evaluated based on the amount of capryloyl hydroxamic acid.

[0129] Therefore, preservatives were prepared by changing the weight ratio according to the composition shown in Table 17 below. For the preservatives in each dosage form example, the weight ratio of juniper alcohol:solvent and capryloyl hydroxamic acid was kept at 1:19, and only the content of capryloyl hydroxamic acid was changed during preparation.

[0130] Subsequently, phases A to D were prepared according to the ingredients and contents shown in Table 18 below, and were mixed with 1% by weight of a preservative (dosage form examples 14 to 20) to prepare a topical skin composition.

[0131] Table 17

[0132] Table 18

[0133] Subsequently, to evaluate the antiseptic ability of the topical skin composition, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus were inoculated at the same concentration in a 1:1:1 ratio to achieve an initial bacterial concentration of approximately 10 in each sample. 6 CFU / g. For yeast and mold, *Candida albicans* and *Aspergillus brasiliensis* were inoculated separately to achieve an initial concentration of approximately 10. 5 CFU / g. The sample was then subjected to temperature control at room temperature (25°C). Store the samples under the specified conditions for 4 weeks, and take 1 g of each sample at 7-day intervals to confirm the number of surviving bacteria. In particular, for molds, confirm whether the samples have developed an off-flavor and whether hyphae or spores have appeared on the sample surface.

[0134] Table 19

[0135] –: Normal condition with no off-odor, no mycelium, and no spores; +: Localized mold growth on the sample surface; ++: Off-odor and mold growth on the sample surface.

[0136] The results are shown in Table 19. When capryloyl hydroxamic acid was included at a content of 1 to 15% by weight relative to the total weight of the preservative (dosage form examples 14 to 18), the viable counts of bacteria, yeast, and mold were significantly reduced. In contrast, when capryloyl hydroxamic acid was included at a content of 0.1% by weight relative to the total weight of the preservative (dosage form example 19), the effect on reducing the number of bacteria and yeast was limited in the first and second weeks, and mold appeared locally on the sample surface in the fourth week. Furthermore, when capryloyl hydroxamic acid was included at a content of 20% by weight relative to the total weight of the preservative (dosage form example 20), the effect on reducing the number of bacteria and yeast was limited in the first to fourth weeks, and mold appeared locally on the sample surface in the third week, and the sample surface became moldy in the fourth week.

[0137] Based on the results, it was confirmed that when octanoyl hydroxamic acid is included in the preservative at a specific concentration, the preservative can exhibit significantly superior preservative properties.

[0138] Experimental Example 9: Evaluation of preservative ability based on raspberry ketone content

[0139] In this experimental example, the preservative effect was evaluated based on the raspberry ketone content.

[0140] Therefore, preservatives were prepared by varying the weight ratios according to the compositions shown in Table 20 below. For the preservatives in each dosage form example, the weight ratio of juniper alcohol:solvent and raspberry ketone was maintained at 1:19, and only the content of raspberry ketone was varied during preparation.

[0141] Subsequently, phases A to D were prepared according to the components and contents shown in Table 21 below, and were mixed with 1% by weight of a preservative (dosage form examples 21 to 27) to prepare a topical skin composition.

[0142] Table 20

[0143] Table 21

[0144] Subsequently, to evaluate the antiseptic ability of the topical skin composition, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus were inoculated at the same concentration in a 1:1:1 ratio to achieve an initial bacterial concentration of approximately 10 in each sample. 6 CFU / g. For yeast and mold, *Candida albicans* and *Aspergillus brasiliensis* were inoculated separately to achieve an initial concentration of approximately 10. 5 CFU / g. The sample was then subjected to temperature control at room temperature (25°C). Store the samples under the specified conditions for 4 weeks, and take 1 g of each sample at 7-day intervals to confirm the number of surviving bacteria. In particular, for molds, confirm whether the samples have developed an off-flavor and whether hyphae or spores have appeared on the sample surface.

[0145] Table 22

[0146] –: Normal condition with no off-odor, no mycelium, and no spores; +: Localized mold growth on the sample surface; ++: Off-odor and mold growth on the sample surface.

[0147] The results are shown in Table 22. When raspberry ketone was included at a content of 1 to 15% by weight relative to the total weight of the preservative (dosage form examples 21 to 25), the viable counts of bacteria, yeast, and mold were significantly reduced. In contrast, when raspberry ketone was included at a content of 0.1% by weight relative to the total weight of the preservative (dosage form example 26), the reduction effect on the number of bacteria and yeast was limited in the first and second weeks, and mold appeared locally on the sample surface in the fourth week. Furthermore, when raspberry ketone was included at a content of 20% by weight relative to the total weight of the preservative (dosage form example 27), the reduction effect on the number of bacteria and yeast was limited in the first to fourth weeks, and mold appeared locally on the sample surface in the third week, and off-flavor and mold appeared on the sample surface in the fourth week.

[0148] Based on the results, it was confirmed that when raspberry ketone is included in the preservative at a specific concentration, the preservative can exhibit significantly superior preservative properties.

[0149] The description of this invention is for illustrative purposes only, and those skilled in the art should understand that the invention can be readily modified into other specific forms without changing the technical concept or essential features of the invention. Therefore, the embodiments described above should be understood as exemplary in all respects, and not as limiting.

Claims

1. A preservative for topical skin preparations, comprising: Hinoki alcohol; and The solvent is selected from at least one solvent selected from the group consisting of alkyldiols having 3 to 10 carbon atoms, alkyltriols having 3 to 6 carbon atoms, dipropylene glycol, glyceryl caprylate, ethylhexylglycerol, and phenoxyethanol.

2. The preservative for topical skin preparations according to claim 1, wherein, The juniper alcohol and the solvent are contained in a weight ratio of 1:19 to 1:1000.

3. The preservative for topical skin preparations according to claim 1, wherein, The alkyldiol having 3 to 10 carbon atoms is selected from one or more of the group consisting of 1,3-propanediol, methylpropanediol, 2,3-butanediol, 1,3-butanediol, 1,2-pentanediol, 1,5-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, and 1,2-decanediol.

4. The preservative for topical skin preparations according to claim 1, wherein, The alkyltriol having 3 to 6 carbon atoms is glycerol, 1,2,6-hexanetriol, or a combination thereof.

5. The preservative for topical skin preparations according to claim 1, wherein, The solvent is one or more selected from the group consisting of 1,3-propanediol, methylpropanediol, 2,3-butanediol, 1,3-butanediol, 1,2-pentanediol, 1,5-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-decanediol, glycerol, 1,2,6-hexanetriol, dipropylene glycol, glyceryl caprylate, ethylhexylglycerol, and phenoxyethanol.

6. The preservative for topical skin preparations according to claim 1, wherein, The solvent is 1,2-pentanediol, 1,5-pentanediol, 1,2-octanediol, glyceryl caprylate, or a combination thereof.

7. The preservative for topical skin preparations according to claim 1, further comprising capryloyl hydroxamic acid or raspberry ketone.

8. The preservative for topical skin preparations according to claim 7, wherein, The weight ratio of the juniper alcohol to the solvent and the total amount of the octanoyl hydroxamic acid or raspberry ketone is 1:19 to 1:1000.

9. The preservative for topical skin preparations according to claim 7, wherein, The octanoyl hydroxamic acid or raspberry ketone is contained in an amount of 1 to 20% by weight relative to the total weight of the preservative.

10. A cosmetic composition comprising a preservative for topical skin preparations according to any one of claims 1 to 9.

11. The cosmetic composition according to claim 10, wherein, The preservative for topical skin preparation is contained in an amount of 0.0001 to 50% by weight relative to the total weight of the cosmetic composition.

12. A pharmaceutical composition for topical skin application comprising a preservative for topical skin application according to any one of claims 1 to 9.

13. The pharmaceutical composition according to claim 12, wherein, The preservative for topical skin preparation is contained in an amount of 0.0001 to 50% by weight relative to the total weight of the pharmaceutical composition.

Images