Multi-parameter feedback Chir99021 induced dental pulp stem cell differentiation intelligent regulation and control method

By employing a multi-parameter feedback intelligent regulation method, the problems of incomplete data and lack of dynamic adaptation of regulatory strategies during the differentiation of dental pulp stem cells have been solved. This has enabled multi-dimensional and precise assessment of the differentiation status of dental pulp stem cells and efficient utilization of drug release, thereby improving differentiation efficiency and stability.

CN122090920APending Publication Date: 2026-05-26FUJIAN PROVINCIAL HOSPITAL
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Patent Information

Application Number
CN202610223725.X
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-02-25
Publication Date
2026-05-26

AI Technical Summary

Technical Problem

Existing methods for regulating the differentiation of dental pulp stem cells induced by Chir99021 lack systematic data planning, incomplete data acquisition, lack of temporal alignment and noise filtering, and inability to achieve multimodal data fusion. This results in inaccurate assessment of differentiation status, lack of dynamic adaptability, and inability to optimize drug release parameters in real time, leading to low differentiation efficiency and low compound utilization.

Method used

By employing a multi-parameter feedback intelligent regulation method, a dataset of the dental pulp stem cell differentiation process is obtained. This dataset is then structured and fused with multimodal data. Multidimensional assessment and cross-modal correlation mining are performed, and targeted calibration is conducted in conjunction with historical trend data. A closed-loop iterative regulation strategy is then constructed to optimize drug release parameters and the culture microenvironment.

Benefits of technology

It enables multi-dimensional and precise assessment of the differentiation status of dental pulp stem cells, precise adaptation and efficient utilization of drug release, significantly improves differentiation efficiency and stability, and provides efficient differentiation support.

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Abstract

The invention relates to the technical field of cell regulation and control, and discloses a multi-parameter feedback Chir99021 induced dental pulp stem cell differentiation intelligent regulation and control method, which comprises the following steps: obtaining a differentiation process data set of dental pulp stem cells, and carrying out structured analysis to obtain a multi-parameter monitoring data set; performing multi-dimensional evaluation on the cell differentiation state to obtain differentiation state evaluation characterization; according to the differentiation state evaluation characterization and the historical differentiation trend data, obtaining drug release regulation and control parameters; performing multi-dimensional planning on the differentiation state evaluation characterization and drug release regulation and control parameters to obtain a regulation and control strategy, and performing coding reconstruction on the regulation and control strategy to obtain a microenvironment regulation instruction; applying the microenvironment adjusting instruction to obtain an optimized culture microenvironment, and monitoring cell state information in the optimized culture microenvironment; based on the cell state information, performing iterative regulation and control on the drug release regulation and control parameters to obtain a final regulation instruction; according to the invention, the regulation and control accuracy of the Chir99021 induced dental pulp stem cell differentiation can be improved.
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