Double-enzyme anhydrous complex coupling acid-base fast-disintegrating porous toothpaste

Abstract

This invention discloses a dual-enzyme anhydrous compounded acid-base rapid-disintegration porous toothpaste, belonging to the field of oral care product technology. The toothpaste is composed of the following raw materials: 9.0 parts sodium bicarbonate, 4.5 parts anhydrous citric acid, 6.0 parts crospovidone, 27.5 parts microcrystalline cellulose, 1.5 parts embedded complex biological enzyme, 3.5 parts powdered sodium lauroyl sarcosinate, 1.5 parts powdered sodium cocoyl glutamate, 22.0 parts spherical micro-powdered hydrated silica, 0.75 parts sodium monofluorophosphate, 1.5 parts anhydrous sodium pyrophosphate, 7.0 parts low-hygroscopic sorbitol, 0.2 parts sucralose, 0.8 parts pre-adsorbed peppermint flavor, 0.75 parts magnesium stearate, and 0.5 parts powder-embedded phenoxyethanol. This invention utilizes an anhydrous powder formulation design, taking advantage of the synergistic disintegration effect of an acid-base effervescent system and cross-linked polyvinylpyrrolidone, combined with the chemical decomposition of plaque biofilm by microencapsulated dual enzymes, to achieve rapid disintegration of the lozenge in the mouth and release of micro-nano bubbles. It can complete oral cleaning without the need for toothbrush friction, and is characterized by being gentle, portable, rapid disintegration and leaving no residue.

Description

Technical Field

[0001] This invention relates to the field of oral care technology, specifically to a dual-enzyme anhydrous compound coupled acid-base rapid-disintegration porous toothpaste. Background Technology

[0002] Oral hygiene is an essential part of daily personal hygiene care, and effectively removing plaque is key to preventing tooth decay, gingivitis, and periodontal disease. Currently, most commercially available oral hygiene products are paste or gel toothpastes, which require the physical brushing of a toothbrush to achieve cleaning. However, traditional brushing methods have the following limitations in practical application:

[0003] Blind spots in cleaning are difficult to reach. Due to their physical shape and the angle of operation, toothbrush bristles cannot thoroughly clean areas such as interdental spaces, gingival sulci, and posterior tooth fissures. These areas easily become blind spots for plaque buildup, leading to interproximal caries and periodontal problems over time.

[0004] Mechanical friction poses a risk of damage. Some consumers, in pursuit of better cleaning results, tend to use hard-bristled toothbrushes or high-abrasion toothpaste. Long-term improper use can easily lead to enamel wear, dentin sensitivity, and even gum recession.

[0005] Limited usage scenarios. Due to liquid control restrictions, toothpaste is inconvenient to carry and is prone to problems such as leakage, drying out, or bristle contamination during travel, making it difficult to meet consumers' needs for oral hygiene anytime, anywhere.

[0006] Enzyme activity is unstable in liquid systems. Some functional toothpastes have attempted to add biological enzymes to enhance plaque-degrading capabilities, but enzyme activity decays rapidly in aqueous systems, making it difficult to guarantee efficacy within the shelf life. While anhydrous solid tablets can protect enzyme activity, existing tablet-based oral hygiene products generally suffer from drawbacks such as slow disintegration, a strong granular residue after ingestion, and a bitter taste. Summary of the Invention

[0007] To address the aforementioned technical deficiencies, the present invention aims to provide a dual-enzyme anhydrous compounded acid-base rapid-disintegration porous toothpaste to solve the problems mentioned in the background art.

[0008] To solve the above-mentioned technical problems, the present invention adopts the following technical solution: The present invention provides a dual-enzyme anhydrous compound coupled acid-base rapid-disintegration porous toothpaste, which is composed of the following raw materials in parts by weight, based on a total weight of 100 parts: The dual-enzyme anhydrous compounded acid-base rapid-disintegrating porous toothpaste provided by this invention is composed of the following raw materials in parts by weight, based on a total weight of 100 parts: sodium bicarbonate 9.0 parts, anhydrous citric acid 4.5 parts, crospovidone 6.0 parts, microcrystalline cellulose 27.5 parts, embedded compound bio-enzyme 1.5 parts, powdered sodium lauroyl sarcosinate 3.5 parts, powdered sodium cocoyl glutamate 1.5 parts, spherical micro-powdered toothpaste-grade hydrated silica 22.0 parts, sodium monofluorophosphate 0.75 parts, anhydrous sodium pyrophosphate 1.5 parts, low hygroscopic powdered sorbitol 7.0 parts, sucralose 0.2 parts, pre-adsorbed peppermint flavor 0.8 parts, magnesium stearate 0.75 parts, and powder-embedded phenoxyethanol 0.5 parts.

[0009] In the above-mentioned raw materials, both sodium bicarbonate and anhydrous citric acid are food-grade or cosmetic-grade anhydrous powders that have passed through an 80-mesh sieve. In this invention, they are mixed in a 1:2 acid-base weight ratio, maintaining isolation and stability in an anhydrous state. Upon contact with saliva in the mouth, the product rapidly undergoes an acid-base reaction, generating dense micro-nano bubbles that physically impact plaque in the gaps between teeth and the gingival sulcus, simultaneously driving the tablet to rapidly disintegrate within 30 seconds.

[0010] The cross-linked polyvinylpyrrolidone is a cosmetic-grade disintegrating powder that passes through an 80-mesh sieve. It has extremely strong capillary water absorption and swelling properties, and its volume expands rapidly upon contact with water. This forms a dual-mechanism synergistic disintegration effect with the aforementioned acid-base effervescent reaction, effectively solving the problems of solid tablets not dissolving properly in the mouth and having a hard core residue.

[0011] The microcrystalline cellulose used is tablet-grade MCC PH102, a low-hygroscopic powder that passes through an 80-mesh sieve. Its function is to provide sufficient forming hardness to the tablets, ensuring that the product is not easily broken during transportation and storage, while its porous structure does not affect the disintegration rate of the tablet after it enters the mouth.

[0012] The encapsulated composite bioenzyme is composed of glucanase and protease in a 1:1 weight ratio and is processed using microencapsulation technology. This microencapsulation technology involves encapsulating enzyme molecules within microcapsules using natural or synthetic polymer wall materials, isolating them from an anhydrous environment to maintain long-term stability of enzyme activity under solid-state storage conditions. Upon contact with saliva, the wall material dissolves or ruptures, rapidly releasing the active enzyme components. This enzyme specifically decomposes the glucan backbone and protein matrix in dental plaque biofilm, breaking down and peeling away stubborn plaque, achieving chemical cleaning without the need for toothbrush friction.

[0013] Both the powdered sodium lauroyl sarcosinate and the powdered sodium cocoyl glutamate are cosmetic-grade amino acid powder surfactants. When used in combination, they can penetrate bacterial biofilms for deep cleaning, producing a fine, dense foam that is gentle and non-irritating to the oral mucosa. Furthermore, they effectively mask the bitter taste of the surfactants themselves, enhancing the user experience.

[0014] The spherical micro-powdered toothpaste-grade hydrated silica is a toothpaste-specific abrasive. It is spherical with a particle size controlled within the 5-8μm range and is classified as low-abrasion. During use, it gently removes stains from the tooth surface through natural oral peristalsis and a light sweeping motion of the tongue, avoiding the damage to tooth enamel caused by the hard bristles and high-abrasion abrasives of traditional toothbrushes, and leaving no gritty feeling in the mouth.

[0015] The sodium monofluorophosphate is a toothpaste-grade anhydrous powder that provides free fluoride ions to exert its anti-caries and tooth-strengthening effects. Its addition ensures the total fluoride content is controlled within the range of 0.05%-0.15% specified in national toothpaste standards, and it exhibits excellent stability in anhydrous systems. The anhydrous sodium pyrophosphate is a cosmetic-grade anhydrous powder that removes extrinsic stains from the tooth surface through chelation, brightens tooth color, and inhibits tartar formation.

[0016] The low-hygroscopic powdered sorbitol is a cosmetic-grade powder used to adjust the sweetness of the product, replacing the liquid moisturizer in traditional toothpaste. This reduces the hygroscopicity of the powder system from the source, preventing the product from absorbing moisture and clumping during storage. The sucralose is a high-intensity sweetener used to further mask the sour aftertaste of anhydrous citric acid and the slightly bitter aftertaste of amino acid surfactants, improving the mouthfeel.

[0017] The pre-adsorption treated peppermint flavoring is a powdered flavoring obtained by pre-adsorbing and mixing liquid peppermint flavoring with porous silica powder at a weight ratio of 1:2 and then passing the mixture through an 80-mesh sieve. This treatment method can avoid the problem of local agglomeration caused by uneven distribution of liquid flavoring in the powder system, ensuring uniform release of aroma from the tablets and fresh breath.

[0018] The magnesium stearate is a cosmetic-grade tableting lubricant, added last before tableting to prevent sticking during compression, and its addition amount does not affect the disintegration performance of the tablets. The powder-encapsulated phenoxyethanol is a cosmetic-grade anhydrous powder preservative used to inhibit microbial growth, ensuring that the product meets microbial standards within its shelf life, and is highly compatible with anhydrous solid systems.

[0019] In this invention, the toothpaste is preferably in tablet form, manufactured by direct compression of powder. The weight of a single tablet can be adjusted according to actual usage requirements and mold specifications, typically ranging from 0.5g to 1.0g, preferably 0.6g or 0.8g. As long as the relative weight proportions of the ingredients in the formula remain constant, they are all within the scope of protection of this invention.

[0020] This invention employs anhydrous powder direct compression technology, organically coupling an acid-base effervescent system, a hyperdisintegration system, and a microencapsulated dual-enzyme system. Upon ingestion, triggered by saliva, the micro-nano bubble bursting effect generated by the acid-base reaction synergistically with the water-absorbing swelling effect of cross-linked povidone, causing the tablet to rapidly disintegrate into a fine foam emulsion carrying active enzymes and a gentle abrasive within 30 seconds. The micro-nano bubbles can penetrate deep into the interdental spaces and gingival sulcus for physical cleaning, while the embedded dual enzymes chemically decompose the plaque biofilm matrix. Combined with the gentle polishing effect of spherical silica, this achieves highly efficient and gentle cleaning of the entire oral cavity without the need for a toothbrush.

[0021] The beneficial effects of this invention are as follows: This invention, through anhydrous powder formulation design, organically couples an acid-base effervescent system, a superdisintegration system, and a microencapsulated dual-enzyme system, achieving multi-dimensional synergistic cleaning. First, the dextranase and protease treated with microencapsulation technology can maintain enzyme activity stability for a long time in an anhydrous solid environment, releasing instantly upon contact with saliva. They specifically decompose the dextran backbone and protein bridges in the dental plaque biofilm, achieving "chemical plaque removal," loosening and peeling off plaque without the need for strong toothbrush friction. Second, anhydrous citric acid and sodium bicarbonate are mixed in a 1:2 weight ratio. Upon contact with saliva in the mouth, they generate dense micro-nano bubbles. The cavitation effect generated by the bursting of these bubbles can impact areas difficult to reach with a toothbrush, such as between teeth and the gingival sulcus, achieving physical self-cleaning. Simultaneously, the compounded cross-linked povidone utilizes its extremely strong capillary water absorption and swelling properties to form a dual-mechanism disintegration with the acid-base effervescent system, causing the tablet to rapidly disintegrate into porous fragments from the inside, completely solving the problems of conventional tablets not dissolving properly in the mouth and leaving a hard core residue. In addition, spherical hydrated silica with a specific particle size of 5-8μm is selected as an abrasive, which can be gently polished by stirring with the tongue, avoiding damage to the enamel and without a gritty feeling during use.

[0022] The anhydrous formulation system of this invention eliminates the risk of microbial growth and component hydrolysis. Sodium monofluorophosphate exhibits superior stability in an anhydrous system and requires no liquid humectant, preventing the tablets from absorbing moisture and clumping. Its portability and shelf life are significantly superior to traditional toothpaste. Furthermore, the combination of amino acid powder surfactants and the high-intensity sweetener sucralose effectively masks the astringent aftertaste of citric acid and the slightly bitter aftertaste of surfactants. The powder-encapsulated phenoxyethanol preservative is compatible with the anhydrous solid system, ensuring the product meets microbiological standards. The pre-adsorption process for the peppermint flavor ensures uniform aroma release. Overall, this invention provides an oral care product that requires no toothbrush, disintegrates rapidly in the mouth, provides excellent cleaning, and has a gentle and comfortable taste. Detailed Implementation

[0023] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0024] The dual-enzyme anhydrous compounded acid-base rapid-disintegrating porous toothpaste provided by this invention allows for adjustment of the weight proportions of each raw material within a certain range. Specifically, the preferred weight proportions of sodium bicarbonate are 7.0-11.0 parts; anhydrous citric acid is 3.5-5.5 parts; crospovidone is 4.0-8.0 parts; microcrystalline cellulose is 22.0-32.0 parts; the embedded compound bio-enzyme is 1.0-2.5 parts; powdered sodium lauroyl sarcosinate is 2.5-5.0 parts; and powdered sodium cocoyl glutamate is 1.0 parts. -2.5 parts; the preferred weight range of spherical micronized toothpaste-grade hydrated silica is 18.0-26.0 parts; the preferred weight range of sodium monofluorophosphate is 0.5-1.0 parts; the preferred weight range of anhydrous sodium pyrophosphate is 1.0-2.5 parts; the preferred weight range of low hygroscopic powdered sorbitol is 5.0-10.0 parts; the preferred weight range of sucralose is 0.1-0.4 parts; the preferred weight range of pre-adsorbed peppermint flavor is 0.5-1.2 parts; the preferred weight range of magnesium stearate is 0.5-1.0 parts; the preferred weight range of powder-embedded phenoxyethanol is 0.3-0.8 parts.

[0025] Example 1 Weigh out the following parts by weight, based on a total weight of 100 parts: Sodium bicarbonate 9.0 parts, anhydrous citric acid 4.5 parts, crospovidone 6.0 parts, microcrystalline cellulose 27.5 parts, encapsulated complex bio-enzyme 1.5 parts (glucanase and protease are compounded in a 1:1 weight ratio and microencapsulated), powdered sodium lauroyl sarcosinate 3.5 parts, powdered sodium cocoyl glutamate 1.5 parts, spherical micro-powdered toothpaste-grade hydrated silica (particle size 5-8μm) 22.0 parts, sodium monofluorophosphate 0.75 parts, anhydrous sodium pyrophosphate 1.5 parts, low hygroscopic powdered sorbitol 7.0 parts, sucralose 0.2 parts, pre-adsorbed peppermint flavor 0.8 parts (liquid peppermint flavor and porous silica are pre-adsorbed in a 1:2 ratio and then passed through an 80-mesh sieve), powder-encapsulated phenoxyethanol 0.5 parts, magnesium stearate 0.75 parts.

[0026] Preparation method: Add all raw materials except magnesium stearate into a mixer and mix evenly. Finally, add magnesium stearate and mix briefly. Compress the powder into tablets using a direct compression process, controlling the weight of each tablet to be 0.8g.

[0027] The tablets obtained in this embodiment have moderate hardness, completely disintegrate within 30 seconds of ingestion, produce fine and dense foam, and leave the mouth feeling refreshed and without residue after cleaning.

[0028] Example 2 Weigh out the following parts by weight, based on a total weight of 100 parts: 7.0 parts sodium bicarbonate, 3.5 parts anhydrous citric acid, 4.0 parts crospovidone, 32.0 parts microcrystalline cellulose, 1.0 part encapsulated complex bio-enzyme (glucanase and protease are compounded in a 1:1 weight ratio and microencapsulated), 2.5 parts powdered sodium lauroyl sarcosinate, 1.0 part powdered sodium cocoyl glutamate, 26.0 parts spherical micro-powdered toothpaste-grade hydrated silica (particle size 5-8μm), 0.5 parts sodium monofluorophosphate, 2.5 parts anhydrous sodium pyrophosphate, 10.0 parts low hygroscopic powdered sorbitol, 0.1 parts sucralose, 1.2 parts pre-adsorbed peppermint flavor (liquid peppermint flavor and porous silica are pre-adsorbed in a 1:2 ratio and then passed through an 80-mesh sieve), 0.8 parts powder-encapsulated phenoxyethanol, and 0.5 parts magnesium stearate.

[0029] Preparation method: Add all raw materials except magnesium stearate into a mixer and mix evenly. Finally, add magnesium stearate and mix briefly. Compress the powder into tablets using a direct powder compression process, controlling the weight of each tablet to 0.5g.

[0030] In this embodiment, the acid and alkaline components are relatively low, and the disintegration process is gentler, making it suitable for people with sensitive mouths; the added hydrated silica and sorbitol ensure both cleaning power and taste.

[0031] Example 3 Weigh out the following parts by weight, based on a total weight of 100 parts: Sodium bicarbonate 11.0 parts, anhydrous citric acid 5.5 parts, crospovidone 8.0 parts, microcrystalline cellulose 22.0 parts, encapsulated complex bio-enzyme 2.5 parts (glucanase and protease compounded in a 1:1 weight ratio and microencapsulated), powdered sodium lauroyl sarcosinate 5.0 parts, powdered sodium cocoyl glutamate 2.5 parts, spherical micro-powdered toothpaste-grade hydrated silica (particle size 5-8μm) 18.0 parts, sodium monofluorophosphate 1.0 part, anhydrous sodium pyrophosphate 1.0 part, low hygroscopic powdered sorbitol 5.0 parts, sucralose 0.4 parts, pre-adsorbed peppermint flavor 0.5 parts (liquid peppermint flavor and porous silica pre-adsorbed in a 1:2 ratio and then passed through an 80-mesh sieve), powder-encapsulated phenoxyethanol 0.3 parts, magnesium stearate 1.0 part.

[0032] Preparation method: Add all raw materials except magnesium stearate into a mixer and mix evenly. Finally, add magnesium stearate and mix briefly. Compress the powder into tablets using a direct compression process, controlling the weight of each tablet to 1.0g.

[0033] In this embodiment, the content of effervescent ingredients and disintegrants is relatively high, the disintegration speed is faster, the bubble impact is stronger, and the increased enzyme content makes the plaque decomposition effect more significant, which is suitable for consumers who pursue a deep cleaning experience.

[0034] Obviously, those skilled in the art can make various modifications and variations to this invention without departing from its spirit and scope. Therefore, if these modifications and variations fall within the scope of the claims of this invention and their equivalents, this invention also intends to include these modifications and variations.

Claims

1. A dual-enzyme anhydrous compounded acid-base rapidly disintegrating porous toothpaste, characterized in that, Based on a total weight of 100 parts, it consists of the following parts by weight of raw materials: Sodium bicarbonate 9.0 parts; 4.5 parts anhydrous citric acid; Cross-linked polyvinylpyrrolidone 6.0 parts; 27.5 parts of microcrystalline cellulose; 1.5 parts of encapsulated complex bio-enzyme; 3.5 parts of powdered sodium lauroyl sarcosinate; 1.5 parts of powdered sodium cocoyl glutamate; 22.0 parts of spherical micronized toothpaste-grade hydrated silica; Sodium monofluorophosphate 0.75 parts; 1.5 parts of anhydrous sodium pyrophosphate; 7.0 parts of low-hygroscopic powdered sorbitol; 0.2 parts of sucralose; Peppermint flavoring 0.8 parts; 0.75 parts magnesium stearate; 0.5 parts of powder-encapsulated phenoxyethanol.

2. The dual-enzyme anhydrous compounded acid-base rapid-disintegration porous toothpaste as described in claim 1, characterized in that, The encapsulated complex bioenzyme is composed of glucanase and protease in a weight ratio of 1:

1.

3. The dual-enzyme anhydrous compounded acid-base rapid-disintegration porous toothpaste as described in claim 2, characterized in that, The encapsulated composite bioenzyme is processed using microencapsulation technology.

4. The dual-enzyme anhydrous compounded acid-base rapid-disintegration porous toothpaste as described in claim 1, characterized in that, The peppermint flavoring is a powdered flavoring obtained by pre-adsorbing liquid peppermint flavoring with porous silica powder at a weight ratio of 1:2 and then sieving it.