Anti-wrinkle firming care composition containing a plant extract and a process for preparing same

Abstract

The application discloses an anti-wrinkle firming repair composition containing plant extracts and a preparation method thereof, and belongs to the technical field of anti-wrinkle firming repair compositions. The anti-wrinkle firming repair composition contains white pool seed oil, gentian root extract, damask rose flower oil, acetyl tetrapeptide-9, palmitoyl pentapeptide-4, palmitoyl tetrapeptide-7 and sodium hyaluronate; the anti-wrinkle firming repair composition has a modified hydrophilic active skeleton as a core, precise compounding of plant extracts and polypeptides, and a customized lipid phase as a carrier, and thus achieves the effects of precise, efficient and mild anti-wrinkle firming repair.

Description

Technical Field

[0001] This invention belongs to the technical field of anti-wrinkle, firming and repairing compositions, specifically relating to an anti-wrinkle, firming and repairing composition containing plant extracts and its preparation method. Background Technology

[0002] Skin anti-wrinkle and firming has become one of the core research and development directions in the cosmetics industry. Skin aging problems such as wrinkles and decreased elasticity are essentially the result of multiple factors working together: reduced activity of dermal fibroblasts, decreased synthesis and accelerated degradation of type I and III collagen, and breakage of the elastic fiber network; impaired epidermal stratum corneum barrier function, increased transepidermal water loss, and dry, rough skin; simultaneously, oxidative stress and inflammatory responses continuously stimulate the skin, further exacerbating the damage to the dermal-epidermal junction structure, ultimately manifesting as skin laxity, deepened fine lines and wrinkles, and sagging contours. Currently, commercially available anti-wrinkle and firming cosmetics mostly achieve their effects by adding active ingredients such as plant extracts, bioactive peptides, sodium hyaluronate, and antioxidants. Related technologies have also conducted extensive research on ingredient formulations and carrier systems, such as using liposomes and microspheres to improve the transdermal efficiency of active ingredients, and using simple combinations of plant extracts and peptides to enhance anti-wrinkle effects. However, existing anti-wrinkle and firming compositions and preparation methods still face many technical bottlenecks, making it difficult to meet the requirements of efficacy, stability, safety, and process compatibility in practical applications. Specific problems are as follows: The core active ingredients are not sufficiently modified. Sodium hyaluronate, a classic moisturizing and skin conditioning ingredient, is widely used in anti-wrinkle compositions. However, conventional unmodified sodium hyaluronate only exerts a physical moisturizing effect, resulting in a single efficacy. Although antioxidant ingredients such as L-ascorbic acid can alleviate oxidative stress by scavenging free radicals, their chemical properties are highly reactive and easily oxidize, discolor, and become inactive in aqueous solutions. Existing technologies mostly use physical mixing methods for addition, which cannot solve their stability problems and make it difficult to achieve synergistic effects with sodium hyaluronate. At the same time, unmodified hydrophilic components have poor compatibility with lipid carriers, which can easily lead to system stratification and affect the encapsulation and delivery of active ingredients. The formulation design of plant extracts is unreasonable, and they are often simply mixed with multiple active ingredients, which can easily lead to a decrease in activity due to interactions between components. In order to improve the transdermal efficiency of active ingredients, existing technologies mostly use liposome carriers, without customized design for the hydrophilic-active ingredient system of anti-wrinkle and firming. They have poor compatibility with plant extracts and peptides, making it difficult to form a uniform and stable nano-dispersion system, resulting in low encapsulation rate of active ingredients.

[0003] In summary, given the problems of poor stability of active ingredients, insufficient synergistic effect of multiple targets, low compatibility of carrier systems, and poor efficacy specificity in existing anti-wrinkle and firming compositions, developing an anti-wrinkle, firming, and repairing composition with a modified hydrophilic active skeleton as the core, precise formulation of plant extracts and peptides, and customized lipid phase as the carrier to achieve precise, efficient, and gentle anti-wrinkle, firming, and repairing effects has become an urgent technical problem to be solved in this field. Summary of the Invention

[0004] The purpose of this invention is to provide an anti-wrinkle, firming, and repairing composition containing plant extracts and its preparation method. The anti-wrinkle, firming, and repairing composition uses a modified hydrophilic active skeleton as the core, plant extracts and peptides are precisely matched, and a customized lipid phase is used as the carrier to achieve precise, efficient, and gentle anti-wrinkle, firming, and repairing effects.

[0005] The objective of this invention can be achieved through the following technical solutions: An anti-wrinkle and firming repair composition containing plant extracts, including meadowfoam seed oil, gentian root extract, Rosa damascena flower oil, acetyl tetrapeptide-9, palmitoyl pentapeptide-4, palmitoyl tetrapeptide-7 and sodium hyaluronate.

[0006] As a preferred embodiment of the present invention, the mass ratio of meadowfoam seed oil, gentian root extract, Rosa damascena flower oil, acetyl tetrapeptide-9, palmitoyl pentapeptide-4, palmitoyl tetrapeptide-7, and sodium hyaluronate is 0.1-0.3:0.2-0.4:0.2-0.3:0.04-0.06:0.02-0.04:0.01-0.03:5-10.

[0007] As a preferred embodiment of the present invention, the sodium hyaluronate is L-ascorbic acid-grafted sodium hyaluronate.

[0008] A method for preparing an anti-wrinkle, firming, and repairing composition containing plant extracts includes the following steps: S1. Mix ceramide, polyglycerol-10 oleate and lecithin, heat to 55-65℃ in a water bath to dissolve, cool to 40-50℃, add meadowfoam seed oil and Rosa damascena flower oil, stir evenly to obtain material A; S2. Take gentian root extract, acetyl tetrapeptide-9, sodium hyaluronate and deionized water and mix them evenly to obtain material B; S3. Mix palmitoyl pentapeptide-4, palmitoyl tetrapeptide-7, and 1,3-propanediol evenly to obtain material C. S4. Take the materials B and C and mix them. Heat and stir in a water bath at 40-45℃ for 8-12 minutes. Then slowly add the mixture to the materials A and stir at 40-45℃ for 30-40 minutes. Vacuum freeze dry to obtain the anti-wrinkle and firming repair composition containing plant extracts.

[0009] As a preferred embodiment of the present invention, in step S1, the mass ratio of ceramide, polyglycerol-10 oleate, lecithin, meadowfoam seed oil and Rosa damascena flower oil is 5-6:0.2-0.3:3-4:0.1-0.3:0.2-0.3.

[0010] As a preferred embodiment of the present invention, in step S2, the mass ratio of the gentian root extract, acetyl tetrapeptide-9, sodium hyaluronate and deionized water is 0.2-0.4:0.04-0.06:5-10:89.54-94.76.

[0011] As a preferred embodiment of the present invention, in step S3, the mass ratio of palmitoyl pentapeptide-4, palmitoyl tetrapeptide-7, and 1,3-propanediol is 0.02-0.04:0.01-0.03:50.

[0012] As a preferred embodiment of the present invention, in step S4, the mass ratio of material A, material B, and material C is 10-20:65-75:5-25.

[0013] The beneficial effects of this invention are: (1) This invention uses a covalent grafting structure to chemically bind L-ascorbic acid to the molecular chain of sodium hyaluronate, which solves the problems of easy oxidation, discoloration and inactivation of the composition system, improves the anti-wrinkle and firming repair effect, and combines the high moisturizing and skin-targeting properties of sodium hyaluronate with the strong antioxidant effect of L-ascorbic acid. Furthermore, the hydrophilic skeleton formed after grafting can improve the transdermal absorption efficiency of lipid phase and peptides, laying the foundation for the subsequent delivery of active ingredients to the dermal layer.

[0014] (2) This invention addresses the inflammatory causes of wrinkle formation by using gentian root extract to reduce inflammation, reduce allergies, and strengthen the skin barrier; acetyl tetrapeptide-9 inhibits inflammatory factors and repairs the dermal-epidermal junction; palmitoyl pentapeptide-4 promotes type I collagen synthesis; palmitoyl tetrapeptide-7 reduces collagen degradation; and tripleteptide provides anti-wrinkle and firming effects from multiple dimensions, including promoting synthesis, inhibiting degradation, and reducing inflammation; the four work together to achieve full-chain anti-wrinkle and firming effects from barrier repair to collagen regeneration; meadowfoam seed oil and Rosa damascena flower oil not only provide moisturizing properties to the lipid phase but also have antioxidant and skin-soothing effects, working synergistically with gentian root extract to strengthen barrier repair.

[0015] (3) By preparing the lipid phase, hydrophilic plant phase and peptide phase independently and then combining them, this invention can avoid the inactivation and aggregation problems caused by direct contact between peptides and plant extracts and lipid components. At the same time, it allows the active ingredients to be released gradually on the skin surface: the lipid phase first repairs the stratum corneum, sodium hyaluronate carries plant essences to penetrate the epidermis, and peptides are delivered to the dermis to promote collagen synthesis, thereby achieving layered repair from the epidermis to the dermis and exerting long-lasting anti-wrinkle and firming effects. Detailed Implementation

[0016] To further illustrate the technical means and effects of the present invention in achieving its intended purpose, the following detailed description of the specific implementation methods, structures, features, and effects of the present invention, in conjunction with embodiments, is provided below.

[0017] A sodium hyaluronate, wherein the sodium hyaluronate is L-ascorbic acid-grafted sodium hyaluronate, and the preparation method of the L-ascorbic acid-grafted sodium hyaluronate includes the following steps: Add 0.2-0.3g of sodium hyaluronate to 200mL of deionized water and place it in a 500mL three-necked flask. Turn on the stirring at low speed (150-200r / min) and stir at room temperature (25±2℃) for 30min until the sodium hyaluronate is completely dissolved and a colorless, transparent, viscous solution is formed. Under light-protected conditions, slowly add 0.4-0.5g of L-ascorbic acid powder and continue stirring for 20-40 minutes to ensure that L-ascorbic acid is evenly dispersed in the sodium hyaluronate aqueous solution without obvious particle precipitation. Nitrogen gas (flow rate 50-100 mL / min) is introduced into the three-necked flask and continuously purged for 10 min to remove air from the reaction system. Nitrogen gas is then introduced and stirring is continued for 30-40 min (activation temperature 25±2℃) to allow the sodium hyaluronate molecular chains to fully extend and expose the active sites of carboxyl and hydroxyl groups. At the same time, nitrogen gas protects L-ascorbic acid from oxidation throughout the process. Under a nitrogen atmosphere and in the dark, 1 mL of 5% hydrogen peroxide solution was added dropwise using a pipette. After the addition was complete, the stirring speed was increased to 300-350 r / min, the reaction temperature was controlled at 30±2℃, and the stirring was continued for 8-12 h. Hydrogen peroxide decomposed in the aqueous solution to generate hydroxyl radicals, which triggered the generation of carbon radicals on the methylene group of sodium hyaluronate molecular chain. These radicals then combined with the active hydrogen in the L-ascorbic acid structure, thus achieving the grafting of L-ascorbic acid onto the sodium hyaluronate molecular chain. After the reaction is complete, the reaction solution is transferred to a centrifuge tube and centrifuged at 8000-10000 r / min for 10-15 min. The clear, viscous supernatant is collected and transferred to a dialysis bag with a molecular weight cutoff of 3500 Da. The dialysis bag is sealed at both ends with dialysis clamps and placed in 5 L of deionized water for dialysis for 48 h. Fresh deionized water is replaced every 6-8 h during this period to remove free L-ascorbic acid, unreacted hydrogen peroxide, and small molecule impurities, ensuring product purity (conductivity of the solution after dialysis ≤20 μS / cm). The dialyzed sodium hyaluronate-gL-ascorbic acid solution was transferred to a lyophilization bottle and pre-frozen in an ultra-low temperature freezer at -40℃ for 2-4 hours to ensure complete freezing. The pre-frozen sample was then placed in a freeze dryer with a vacuum of 10-50 Pa and a shelf temperature of -50℃ for 24-36 hours until the sample was completely dry, thus obtaining the L-ascorbic acid-grafted sodium hyaluronate.

[0018] Preparation Example 1 A method for preparing L-ascorbic acid-grafted sodium hyaluronate includes the following steps: Add 0.25g of sodium hyaluronate to 200mL of deionized water and place it in a 500mL three-necked flask. Turn on the stirring at low speed (200r / min) and stir at room temperature (25℃) for 30min until the sodium hyaluronate is completely dissolved to form a colorless, transparent, viscous solution. Under light-protected conditions, slowly add 0.45g of L-ascorbic acid powder and continue stirring for 30min to ensure that L-ascorbic acid is uniformly dispersed in the sodium hyaluronate aqueous solution without obvious particle precipitation. Nitrogen gas (flow rate 100 mL / min) is introduced into a three-necked flask and continuously purged for 10 min to remove air from the reaction system. Nitrogen gas is introduced and stirring is continued for 40 min (activation temperature 25℃) to allow the sodium hyaluronate molecular chains to fully expand and expose the active sites of carboxyl and hydroxyl groups. At the same time, nitrogen gas protects L-ascorbic acid from oxidation throughout the process. Under a nitrogen atmosphere and in the dark, 1 mL of 5% hydrogen peroxide solution was added dropwise using a pipette. After the addition was complete, the stirring speed was increased to 300 r / min, the reaction temperature was controlled at 30℃, and stirring was continued for 8 hours. The solution was then transferred to a centrifuge tube and centrifuged at 10000 r / min for 15 minutes. The clear, viscous supernatant was collected and transferred to a dialysis bag with a molecular weight cutoff of 3500 Da. The dialysis bag was sealed at both ends with dialysis clips and placed in 5 L of deionized water for dialysis for 48 hours, with fresh deionized water replaced every 8 hours. The dialyzed sodium hyaluronate-gL-ascorbic acid solution was transferred to a lyophilization bottle and pre-frozen in an ultra-low temperature freezer at -40℃ for 4 hours to ensure complete freezing. The pre-frozen sample was then placed in a freeze dryer with a vacuum of 10 Pa and a shelf temperature of -50℃ and freeze-dried for 24 hours to obtain the L-ascorbic acid-grafted sodium hyaluronate. Example 1

[0019] A method for preparing an anti-wrinkle, firming, and repairing composition containing plant extracts includes the following steps: S1. Ceramide, polyglycerol-10 oleate and lecithin are mixed and dissolved in a water bath at 55°C. The mixture is then cooled to 40°C, and meadowfoam seed oil and Rosa damascena flower oil are added. The mixture is stirred until homogeneous to obtain material A. The mass ratio of ceramide, polyglycerol-10 oleate, lecithin, meadowfoam seed oil and Rosa damascena flower oil is 5:0.2:3:0.1:0.2. S2. Take gentian root extract, acetyl tetrapeptide-9, L-ascorbic acid-grafted sodium hyaluronate and deionized water and mix them evenly to obtain material B; the mass ratio of gentian root extract, acetyl tetrapeptide-9, sodium hyaluronate and deionized water is 0.2:0.04:5:94.76. S3. Take palmitoyl pentapeptide-4, palmitoyl tetrapeptide-7, and 1,3-propanediol and mix them evenly to obtain material C; the mass ratio of palmitoyl pentapeptide-4, palmitoyl tetrapeptide-7, and 1,3-propanediol is 0.02:0.01:50. S4. Take the materials B and C, mix them, heat and stir in a water bath at 40°C for 8 minutes, then slowly add them dropwise to the materials A, stir at 40°C for 30 minutes, and freeze-dry at a vacuum of 10 Pa and a temperature of -45°C for 20 hours to obtain the anti-wrinkle, firming and repairing composition containing plant extracts; the mass ratio of the materials A, B and C is 10:65:25. Example 2

[0020] A method for preparing an anti-wrinkle, firming, and repairing composition containing plant extracts includes the following steps: S1. Ceramide, polyglycerol-10 oleate and lecithin are mixed and dissolved in a water bath at 60°C. The mixture is then cooled to 45°C, and meadowfoam seed oil and Rosa damascena flower oil are added. The mixture is stirred until homogeneous to obtain material A. The mass ratio of ceramide, polyglycerol-10 oleate, lecithin, meadowfoam seed oil and Rosa damascena flower oil is 5.5:0.25:3.5:0.2:0.25. S2. Take gentian root extract, acetyl tetrapeptide-9, L-ascorbic acid-grafted sodium hyaluronate and deionized water and mix them evenly to obtain material B; the mass ratio of gentian root extract, acetyl tetrapeptide-9, sodium hyaluronate and deionized water is 0.3:0.05:8:91.65. S3. Take palmitoyl pentapeptide-4, palmitoyl tetrapeptide-7, and 1,3-propanediol and mix them evenly to obtain material C; the mass ratio of palmitoyl pentapeptide-4, palmitoyl tetrapeptide-7, and 1,3-propanediol is 0.03:0.02:50. S4. Take the materials B and C, mix them, heat and stir in a water bath at 45°C for 10 minutes, then slowly add them dropwise to the materials A, stir at 45°C for 35 minutes, and freeze-dry at a vacuum of 10 Pa and a temperature of -45°C for 25 hours to obtain the anti-wrinkle, firming and repairing composition containing plant extracts; the mass ratio of the materials A, B and C is 15:70:15. Example 3

[0021] A method for preparing an anti-wrinkle, firming, and repairing composition containing plant extracts includes the following steps: S1. Ceramide, polyglycerol-10 oleate and lecithin are mixed and dissolved in a water bath at 65°C. The mixture is then cooled to 50°C, and meadowfoam seed oil and Rosa damascena flower oil are added. The mixture is stirred until homogeneous to obtain material A. The mass ratio of ceramide, polyglycerol-10 oleate, lecithin, meadowfoam seed oil and Rosa damascena flower oil is 6:0.3:4:0.3:0.3. S2. Take gentian root extract, acetyl tetrapeptide-9, L-ascorbic acid-grafted sodium hyaluronate and deionized water and mix them evenly to obtain material B; the mass ratio of gentian root extract, acetyl tetrapeptide-9, sodium hyaluronate and deionized water is 0.4:0.06:10:94.76. S3. Take palmitoyl pentapeptide-4, palmitoyl tetrapeptide-7, and 1,3-propanediol and mix them evenly to obtain material C; the mass ratio of palmitoyl pentapeptide-4, palmitoyl tetrapeptide-7, and 1,3-propanediol is 0.04:0.03:50. S4. Take the materials B and C, mix them, heat and stir in a water bath at 45°C for 12 minutes, then slowly add them dropwise to the materials A, stir at 45°C for 40 minutes, and freeze-dry at a vacuum of 10 Pa and a temperature of -45°C for 30 hours to obtain the anti-wrinkle, firming and repairing composition containing plant extracts; the mass ratio of materials A, B and C is 20:75:5.

[0022] Comparative Example 1 The difference from Example 2 is that meadowfoam seed oil is not added during the preparation process, while the rest of the operations and dosages remain unchanged.

[0023] Comparative Example 2 The difference from Example 2 is that no Rosa damascena flower oil is added during the preparation process, while the rest of the operations and dosages remain unchanged.

[0024] Comparative Example 3 The difference from Example 2 is that gentian root extract is not added during the preparation process, while the rest of the operations and dosages remain unchanged.

[0025] Comparative Example 4 The difference from Example 2 is that acetyl tetrapeptide-9 is not added during the preparation process, while the rest of the operations and dosages remain unchanged.

[0026] Comparative Example 5 The difference from Example 2 is that palmitoyl pentapeptide-4 is not added during the preparation process, while the rest of the operations and dosages remain unchanged.

[0027] Comparative Example 6 The difference from Example 2 is that palmitoyl tetrapeptide-7 is not added during the preparation process, while the rest of the operations and dosages remain unchanged.

[0028] Comparative Example 7 The difference from Example 2 is that, in the preparation process, a physical mixture of sodium hyaluronate and L-ascorbic acid is used instead of L-ascorbic acid to graft sodium hyaluronate, while the other operations and dosages remain unchanged.

[0029] Performance testing 1. In vitro type I collagen secretion promotion test Experimental samples: The compositions prepared in Examples 1, 2, 3, Comparative Examples 1, 2, 3, 4, 5, 6, and 7 were reconstituted with deionized water to form a uniform dispersion with a mass fraction of 5% as the experimental group; the blank group contained only deionized water; the positive control group was 100 ng / mL LTGF-β1 working solution.

[0030] Experimental cells: human dermal fibroblasts (HDF, purchased from ATCC); Experimental steps: HDF cells were loaded at 5 × 10 3 Seeds were inoculated into 96-well plates and cultured at 37°C and 5% CO2 for 24 h. The original culture medium was discarded, and 100 μL of sample solution from the experimental group, blank group, and positive control group were added to each well. Six parallel wells were set up for each group. After culturing for another 48 hours, the supernatant was collected, and the ColⅠ content was determined using a human type I collagen (ColⅠ) ELISA kit (COAB Biotech, catalog number CB10152-Hu). Calculation method: Collagen upregulation rate (%) = (T / C-1)×100%, where T is the average ColⅠ content of the test group and C is the average ColⅠ content of the blank group; The test results are shown in Table 1 below: Table 1 2. Human skin efficacy test Subject criteria: 100 healthy women aged 35-55, all with sensitive skin that tested positive for lactic acid stinging, had obvious dry lines / fine lines on their faces, and had no history of skin diseases or allergies; Grouping method: Randomly divided into 10 groups (Example 1-Example 3, Comparative Example 1-Comparative Example 7), with 10 people in each group;

[0031] Experimental period: TEWL value measurement period was 14 days, and skin elasticity and wrinkle measurement period was 28 days; Instructions for use: Apply the reconstituted sample evenly to the test area (3cm x 3cm) on the subject's face twice daily, morning and evening. Single application dose: 2.0 mg / cm². 2 ; Testing instruments and specifications: TEWL value: The 14-day change rate was calculated by measuring the test area (3cm×3cm) on the inner side of the arm using a German CKMPA580 transepidermal water loss tester. Skin elasticity: The CKCutometer MPA580 from Germany was used to measure the facial zygomatic region. The elasticity index R2 was used as the evaluation index to calculate the 28-day change rate. Wrinkle improvement: Using the American VISIA-CR skin image analyzer, the area of ​​wrinkles around the eyes was measured, the number and average depth of wrinkles were counted, and the 28-day reduction rate was calculated. The test results are shown in Table 2 below: Table 2 The test results above show that the compositions prepared in Examples 1-3 of this invention have good anti-wrinkle, firming and repairing effects. Compared with the comparative examples, the collagen upregulation rate of Example 2 (45.2%) is significantly higher than that of other groups because the distribution ratio of each group is optimal, and the covalent structure of L-ascorbic acid grafted with sodium hyaluronate promotes the synergistic effect of active ingredients. The upregulation rate of Comparative Example 7 (physical mixing) is only 24.8%, which verifies the improvement of stability and synergy by grafting modification. Example 2 showed the best results in terms of elasticity improvement, TEWL improvement, and wrinkle reduction, while the comparative example showed a significant decrease in efficacy due to the lack of key ingredients.

[0032] The above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention in any way. Although the present invention has been disclosed above with reference to preferred embodiments, it is not intended to limit the present invention. Any person skilled in the art can make some modifications or alterations to the above-disclosed technical content to create equivalent embodiments without departing from the scope of the present invention. Any simple modifications, equivalent changes and alterations made to the above embodiments based on the technical essence of the present invention without departing from the scope of the present invention shall still fall within the scope of the present invention.

Claims

1. A wrinkle-reducing and firming repair composition containing plant extracts, characterized in that, It includes meadowfoam seed oil, gentian root extract, Rosa damascena flower oil, acetyl tetrapeptide-9, palmitoyl pentapeptide-4, palmitoyl tetrapeptide-7 and sodium hyaluronate.

2. The anti-wrinkle, firming, and repairing composition containing plant extracts according to claim 1, characterized in that, The mass ratio of meadowfoam seed oil, gentian root extract, Rosa damascena flower oil, acetyl tetrapeptide-9, palmitoyl pentapeptide-4, palmitoyl tetrapeptide-7, and sodium hyaluronate is 0.1-0.3: 0.2-0.4: 0.2-0.3: 0.04-0.06: 0.02-0.04: 0.01-0.03: 5-10.

3. The anti-wrinkle, firming, and repairing composition containing plant extracts according to claim 1, characterized in that, The sodium hyaluronate is L-ascorbic acid-grafted sodium hyaluronate.

4. A method for preparing the anti-wrinkle, firming, and repairing composition containing plant extracts as described in claim 3, characterized in that, Includes the following steps: S1. Mix ceramide, polyglycerol-10 oleate and lecithin, heat to 55-65℃ in a water bath to dissolve, cool to 40-50℃, add meadowfoam seed oil and Rosa damascena flower oil, stir evenly to obtain material A; S2. Take gentian root extract, acetyl tetrapeptide-9, sodium hyaluronate and deionized water and mix them evenly to obtain material B; S3. Mix palmitoyl pentapeptide-4, palmitoyl tetrapeptide-7, and 1,3-propanediol evenly to obtain material C. S4. Take the materials B and C and mix them. Heat and stir in a water bath at 40-45℃ for 8-12 minutes. Then slowly add the mixture to the materials A and stir at 40-45℃ for 30-40 minutes. Vacuum freeze dry to obtain the anti-wrinkle and firming repair composition containing plant extracts.

5. The method for preparing the anti-wrinkle, firming, and repairing composition containing plant extracts according to claim 4, characterized in that, In step S1, the mass ratio of ceramide, polyglycerol-10 oleate, lecithin, meadowfoam seed oil and Rosa damascena flower oil is 5-6:0.2-0.3:3-4:0.1-0.3:0.2-0.

3.

6. The method for preparing the anti-wrinkle, firming, and repairing composition containing plant extracts according to claim 4, characterized in that, In step S2, the mass ratio of the gentian root extract, acetyl tetrapeptide-9, sodium hyaluronate, and deionized water is 0.2-0.4:0.04-0.06:5-10:89.54-94.

76.

7. The method for preparing the anti-wrinkle, firming, and repairing composition containing plant extracts according to claim 4, characterized in that, In step S3, the mass ratio of palmitoyl pentapeptide-4, palmitoyl tetrapeptide-7, and 1,3-propanediol is 0.02-0.04:0.01-0.03:

50.

8. The method for preparing the anti-wrinkle, firming, and repairing composition containing plant extracts according to claim 4, characterized in that, In step S4, the mass ratio of material A, material B, and material C is 10-20:65-75:5-25.

Images