Application of secoisolariciresinol diglucoside and flaxseed polysaccharide in preparation of health care product for improving osteoporosis

By preparing health products using a specific ratio of flaxseed lignans and flaxseed polysaccharides, the synergistic mechanism between flaxseed polysaccharides and flaxseed lignans in improving osteoporosis has been solved, resulting in significant improvements in bone density and biomechanical properties, regulation of gut microbiota, and providing a theoretical basis for the development of functional foods.

CN122162939APending Publication Date: 2026-06-09HEBEI AGRICULTURAL UNIV. +1
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Patent Information

Application Number
CN202610521456.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-04-20
Publication Date
2026-06-09

AI Technical Summary

Technical Problem

Existing technologies have failed to effectively explore the synergistic mechanism of flaxseed polysaccharides and flax lignans, resulting in a lack of reports and industrial applications regarding their combined application and synergistic effect in improving osteoporosis.

Method used

A flax lignan to flaxseed polysaccharide mass ratio of (1~4):1 was used to prepare a health product to improve osteoporosis. It can inhibit abnormal weight gain caused by ovariectomy, increase serum estrogen levels, reduce related bone metabolism indicators, improve femoral bone density and biomechanical properties, and regulate intestinal flora.

Benefits of technology

It significantly improves postmenopausal osteoporosis, increases bone mineral density, bone volume fraction, trabecular bone number and connectivity density, reduces trabecular bone separation, improves femoral biomechanical properties, and regulates gut microbiota, providing a theoretical basis for the development of flaxseed functional foods.

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Abstract

The invention discloses application of secoisolariciresinol diglucoside and flaxseed polysaccharide in preparation of health care products for improving osteoporosis. Belongs to the technical field of health-care function research. A postmenopausal osteoporosis model is established by ovariectomized rats, comparison of flaxseed polysaccharide and secoisolariciresinol diglucoside on rat bone metabolism, related bone transition indexes, bone microstructure, bone biomechanics and intestinal flora is systematically studied, and the invention aims to explore leading action substances of flaxseed polysaccharide and secoisolariciresinol diglucoside on osteoporosis improvement. Therefore, a more effective theoretical basis is provided for development of flaxseed functional food.
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