Lactobacillus buchneri with hypoglycemic activity and application of lactobacillus buchneri in fermented milk

By mixing Lactobacillus PB6 isolated from Guizhou sour soup with traditional starter cultures, a fermented milk with hypoglycemic activity was prepared. This solved the problem of insufficient application of Lactobacillus PB6 in existing technologies and achieved efficient blood sugar regulation and intestinal health effects.

CN122168474APending Publication Date: 2026-06-09SOUTH CHINA UNIV OF TECH
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Patent Information

Application Number
CN202610322325.4
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-03-17
Publication Date
2026-06-09

AI Technical Summary

Technical Problem

Existing research on the hypoglycemic function of Lactobacillus brucellosis is relatively limited, and its application in dairy products is also limited. Most studies focus on a single mechanism and have not conducted comprehensive research. Existing drugs have side effects when treating type 2 diabetes.

Method used

Lactobacillus brucellosis PB6 was isolated from Guizhou sour soup. It has a high inhibition rate of α-amylase and α-glucosidase and can promote GLP-1 secretion. When it is mixed with Streptococcus thermophilus and Lactobacillus delbrueckii in fermented milk, fermented milk with hypoglycemic activity is prepared.

Benefits of technology

Fermented milk exhibits high inhibition rates of α-amylase and α-glucosidase, promotes GLP-1 secretion, improves liver glycogen metabolism, maintains intestinal flora balance, and possesses excellent antioxidant and antibacterial capabilities. It also boasts superior sensory quality and rheological properties, is safe and non-toxic, and is suitable as a raw material for functional foods.

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Abstract

The invention discloses lactobacillus buchneri with hypoglycemic activity and application of the lactobacillus buchneri in fermented milk, the strain is lactobacillus buchneri PB6, is preserved in Guangdong Microbiological Culture Collection Center on May 19, 2025, and has the preservation number of GDMCC No: 66352, the strain has hypoglycemic activity, has both safety and prebiotics, has good tolerance to gastrointestinal tract environment, and can be used for preparing fermented milk. The feed additive has excellent self-coacervation capability and oxidation resistance, can inhibit the growth of common pathogenic bacteria, and is helpful for maintaining the balance of intestinal flora. The lactobacillus buchneri PB6 is applied to the fermented milk, the sensory quality and rheological property of the fermented milk can be improved, the lactobacillus buchneri PB6 has hypoglycemic activity and rich organic acid and volatile flavor substances, and a basis is provided for application of the lactobacillus buchneri PB6 in functional food.
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