Use of cyclic dipeptides for the preparation of a medicament for the prevention / treatment of metabolic-related inflammatory diseases

Abstract

This invention discloses the use of cyclic dipeptides in the preparation of drugs for the prevention / treatment of metabolism-related inflammatory diseases, belonging to the field of biomedical technology. The cyclic dipeptide has the following structural formula and molecular formula C1. 18 H 18 N2O2, with a molecular weight of 294.35 Da, is an ADCY7 inhibitor. It inhibits ADCY7 protein expression by binding to ADCY7, thereby playing a role in the prevention / treatment of diseases such as fatty liver associated with metabolic dysfunction. It is composed of natural amino acids, has good biocompatibility, low immunogenicity, and few toxic side effects, and has good safety. It overcomes the defect of easy degradation in vivo of traditional linear peptide drugs and has broad prospects for the development of indications.

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