Pancreatic cancer specific binding peptide and preparation method and application thereof

Abstract

The application belongs to the technical field of biological medicine, and particularly relates to a pancreatic cancer specific binding peptide and a preparation method and application thereof. The pancreatic cancer specific binding peptide is a chelator-mediated radionuclide labeled HFL2c peptide; the radionuclide includes an imaging radionuclide or a therapeutic radionuclide; and the amino acid sequence of the HFL2c peptide is shown in SEQ ID NO. 1. Test results show that the polypeptide can be targeted to combine with the extracellular region of CLDN18.2, and the radionuclide labeled HFL2c peptide prepared by using the polypeptide can be used for nuclide imaging, realizes precise positioning, quantitative monitoring and high-sensitivity in-vivo imaging of CLDN18.2 expression, and is suitable for early screening, diagnosis and treatment monitoring of pancreatic cancer. Meanwhile, the therapeutic radionuclide labeled HFL2c peptide prepared by using the polypeptide can inhibit the growth of pancreatic cancer tumors.

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