Chelerythrine bactericide and preparation method thereof

By combining chelidonine with N-aryl-3,4-dihydroisoquinoline derivatives with Bacillus amyloliquefaciens and Pseudomonas fluorescens, a slow-release bactericide was prepared, solving the problem of coexistence between chemical substances and microorganisms, and achieving efficient disease control and protection of beneficial bacteria.

CN122320045APending Publication Date: 2026-07-03NORTHEAST FORESTRY UNIV
View PDF 0 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NORTHEAST FORESTRY UNIV
Filing Date
2026-06-05
Publication Date
2026-07-03

AI Technical Summary

Technical Problem

In existing technologies, it is difficult to achieve synergistic effects of chemical and biological control in the same product by combining plant-derived antibacterial substances and live microbial agents. Furthermore, it is difficult to balance the concentration of chemical substances and the activity of microorganisms, making it challenging to achieve long-term stable coexistence in commercial formulations.

Method used

An antibacterial active ingredient composed of celandine and N-aryl-3,4-dihydroisoquinoline derivatives is prepared as a bactericide with a sustained-release unit by coexisting with functional microbial agents in a carrier through physical isolation. Controlled release is achieved by using microcapsules or porous materials, combined with the synergistic effect of Bacillus amyloliquefaciens and Pseudomonas fluorescens.

Benefits of technology

It achieves highly efficient sterilization of pathogens at extremely low concentrations, protects the activity of beneficial bacteria, maintains long-term prevention and control effects, avoids the inhibition of microorganisms by chemical substances, and achieves a balance between drug efficacy and bacterial activity and a lasting prevention and control effect.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure SMS_1
    Figure SMS_1
  • Figure SMS_2
    Figure SMS_2
  • Figure SMS_3
    Figure SMS_3
Patent Text Reader

Abstract

This invention relates to the field of bactericide technology, specifically to a celandine bactericide and its preparation method. The bactericide is composed of the following parts by weight: antibacterial active ingredient: 0.1-0.5 parts; functional microbial agent: 2-20 parts; carrier: 70-90 parts; wherein the antibacterial active ingredient is composed of celandine and N-aryl-3,4-dihydroisoquinoline derivative in a mass ratio of 1:(0.2-5). This application introduces iodine and bromohalogen atoms at specific positions of N-aryl-3,4-dihydroisoquinoline, enabling it to produce a significant synergistic antibacterial effect with celandine. Beneficial bacteria such as Bacillus amyloliquefaciens and Pseudomonas fluorescens can resist the effects of sub-inhibitory drug concentrations by secreting cyclic lipopeptides and upregulating efflux pumps. The technology of encapsulating the antibacterial active ingredient into a sustained-release unit and combining it with a carrier that adsorbs live bacteria significantly improves the retention rate of live bacteria, achieving a long-term balance between stable drug release and beneficial bacterial activity.
Need to check novelty before this filing date? Find Prior Art