Analyzer for simultaneous detection of multiple blood gas items

Abstract

This application discloses an analyzer for simultaneously detecting multiple blood gas parameters. The analyzer includes a main body, a microfluidic detection chip, and a detection component. The microfluidic detection chip is rotatably and replaceably mounted on the main body, and a blood gas detection slot is formed on the microfluidic detection chip. The detection component is disposed on the main body and has multiple detection channels spaced apart. Each detection channel corresponds to a blood gas detection slot. The detection component is used to emit light signals to the blood gas detection slot through the detection channels and to receive the light signals reflected from the blood gas detection slot through the detection channels, thereby performing blood gas detection on the sample in the blood gas detection slot. Different detection channels are used to transmit light signals for at least different blood gas detection parameters. This analyzer for simultaneously detecting multiple blood gas parameters solves the problem of low blood gas detection efficiency in related technologies.

Description

Technical Field

[0001] This application relates to the field of medical device technology, and more specifically, to an analyzer that can simultaneously detect multiple blood gas parameters. Background Technology

[0002] In related technologies, analyzers typically include microfluidic detection chips and detection components. The detection components are used to detect samples within the microfluidic detection chip to achieve rapid and efficient detection.

[0003] In related technologies, detection components can be used to perform blood gas detection on samples within microfluidic detection chips. However, when multiple blood gas parameters need to be detected, the analyzer needs to perform the detection sequentially, resulting in low blood gas detection efficiency. Summary of the Invention

[0004] The main objective of this application is to provide an analyzer that can simultaneously detect multiple blood gas parameters, thereby solving the problem of low blood gas detection efficiency in related technologies.

[0005] According to one aspect of this application, an analyzer is provided for simultaneously detecting multiple blood gas parameters, including: Organism; A microfluidic detection chip is rotatably and replaceably mounted on the body, and a blood gas detection groove is formed on the microfluidic detection chip; A detection component is disposed on the body. The detection component has multiple detection channels spaced apart, each detection channel corresponding to a blood gas detection slot. The detection component is used to emit light signals to the blood gas detection slot through the detection channels and receive the light signals reflected from the blood gas detection slot through the detection channels to perform blood gas detection on the sample in the blood gas detection slot. The light signals emitted by the detection component to different detection channels are different.

[0006] In some embodiments, the detection channel includes a first channel and a second channel, a first end of the first channel is connected to the second channel, a first end of the second channel is correspondingly disposed with the blood gas detection slot, and the second channel is used to transmit the light signal reflected in the blood gas detection slot to the detection component; The detection component also includes a light-emitting element, which comprises multiple light-emitting elements. The light-emitting elements are arranged one-to-one at the second end of the first channel. The light-emitting elements are used to emit light and allow the light to pass through the first channel and the second channel in sequence into the blood gas detection tank. The light emitted by different light-emitting elements has different wavelengths.

[0007] In some embodiments, a support frame is provided on the body, the support frame being located on top of the microfluidic detection chip, and the detection component includes: A light-emitting panel, the light-emitting panel being connected to the support frame, and a plurality of light-emitting elements being spaced apart on the light-emitting panel; A detection body is connected to the light-emitting plate, and multiple detection channels are spaced apart on the detection body; The second channel extends through the detection body along the height direction of the analyzer, and the first channel extends from the second channel toward the light-emitting plate.

[0008] In some embodiments, the detection component further includes a receiving plate disposed on the top of the detection body, and the second end of each of the second channels is disposed corresponding to the receiving plate.

[0009] In some embodiments, the detection body includes a first block and a second block that are detachably connected, with the first block located on top of the second block; The first channel is located in the second block, and the second channel includes a first segment and a second segment that are interconnected. The first segment passes through the first block along the height direction of the analyzer, and the second segment passes through the second block along the height direction of the analyzer.

[0010] In some embodiments, a first filter is disposed within the first channel; and / or, A second filter is provided within the first segment; and / or, A third filter is provided in the second segment.

[0011] In some embodiments, a connection port is provided between the first end and the second end of the second channel, the first end of the first channel is connected to the connection port, and a reflector is provided at the connection port.

[0012] In some embodiments, the analyzer further includes a heat dissipation component disposed on the body, the heat dissipation component being used to dissipate heat from the detection component.

[0013] In some embodiments, the blood gas detection slots include multiple slots, and each blood gas detection slot corresponds to a detection channel. Each of the blood gas detection cells is equipped with a different fluorescent reagent; or The same fluorescent reagent is provided in some of the blood gas detection cells.

[0014] In some embodiments, the analyzer further includes a reagent kit disposed on the microfluidic detection chip, the reagent kit having a clearance hole corresponding to the blood gas detection slot, the clearance hole penetrating the reagent kit along the height direction of the analyzer.

[0015] Unlike related technologies, the detection component of this application has multiple detection channels spaced apart, and the detection component emits different light signals to different detection channels. When multiple blood gas tests are required on a sample, the analyzer of this application, which can simultaneously detect multiple blood gas items, can transmit and emit different light signals to multiple detection channels through the detection component. This allows the sample in the blood gas detection chamber to receive different light signals and reflect the light signals of different blood gas detection items into different detection channels, which are then transmitted to the detection component. This enables the analyzer to simultaneously detect multiple blood gas items, thereby improving the analyzer's detection efficiency to a certain extent. Attached Figure Description

[0016] The accompanying drawings, which are included to provide a further understanding of this application and form part of this application, are illustrative and descriptive, serving to explain this application and do not constitute an undue limitation thereof. In the drawings: Figure 1 This is a connection diagram of an analyzer that simultaneously detects multiple blood gas parameters, as disclosed in an embodiment of this application. Figure 2 This is a structural diagram of an analyzer that simultaneously detects multiple blood gas parameters, as disclosed in an embodiment of this application. Figure 3 This is an exploded magnified view of a portion of the structure of an analyzer that simultaneously detects multiple blood gas parameters, as disclosed in an embodiment of this application. Figure 4 This is a cross-sectional view of the detection component disclosed in an embodiment of this application; Figure 5 This is an exploded structural diagram of the detection subject disclosed in the embodiments of this application.

[0017] The above figures include the following reference numerals: 10. Main body; 11. Support frame; 20. Microfluidic detection chip; 30. Detection component; 31. Detection body; 32. Light-emitting plate; 33. Receiving plate; 40. Reagent kit; 50. Heat dissipation component; 51. Cooling fan; 301. Detection channel; 311. First block; 312. Second block; 3011. First channel; 3012. Second channel; 30121. First segment; 30122. Second segment. Detailed Implementation

[0018] It should be noted that, unless otherwise specified, the embodiments and features described in this application can be combined with each other. This application will now be described in detail with reference to the accompanying drawings and embodiments.

[0019] It should be noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to limit the exemplary embodiments according to this application. As used herein, the singular form is intended to include the plural form as well, unless the context clearly indicates otherwise. Furthermore, it should be understood that when the terms "comprising" and / or "including" are used in this specification, they indicate the presence of features, steps, operations, devices, components, and / or combinations thereof.

[0020] Unless otherwise specifically stated, the relative arrangement, numerical expressions, and values ​​of the components and steps described in these embodiments do not limit the scope of this application. It should also be understood that, for ease of description, the dimensions of the various parts shown in the drawings are not drawn to actual scale. Techniques, methods, and devices known to those skilled in the art may not be discussed in detail, but where appropriate, such techniques, methods, and devices should be considered part of the specification. In all examples shown and discussed herein, any specific values ​​should be interpreted as merely exemplary and not as limitations. Therefore, other examples of exemplary embodiments may have different values. It should be noted that similar reference numerals and letters in the following drawings denote similar items; therefore, once an item is defined in one drawing, it need not be further discussed in subsequent drawings.

[0021] As described in the background section, in related technologies, the analyzer can only receive one blood gas detection signal at a time because its detection component can only perform one blood gas test at a time (blood gas tests include, for example, the pH value of the sample, the partial pressure of oxygen in the sample, the partial pressure of carbon dioxide in the sample, etc.). When multiple blood gas tests are required on a sample simultaneously, the analyzer in the related technology cannot perform simultaneous tests, resulting in excessively low detection efficiency.

[0022] To address the problems existing in the relevant technologies, see [link to relevant documentation]. Figures 1 to 5As shown in the figure, this application embodiment provides an analyzer for simultaneously detecting multiple blood gas parameters. The analyzer includes a body 10, a microfluidic detection chip 20, and a detection component 30. The microfluidic detection chip 20 is rotatably and replaceably mounted on the body 10, and a blood gas detection slot (not shown in the figure) is formed on the microfluidic detection chip 20. The detection component 30 is mounted on the body 10, and multiple detection channels 301 are spaced apart on the detection component 30. Each detection channel 301 corresponds to a blood gas detection slot. The detection component 30 is used to emit light signals to the blood gas detection slot through the detection channels 301 and receive the light signals reflected from the blood gas detection slot through the detection channels 301 to perform blood gas detection on the sample in the blood gas detection slot. The detection component 30 emits different light signals to different detection channels 301.

[0023] When the analyzer performs blood gas analysis, it first selects and installs a compatible microfluidic detection chip 20 on the body 10. Then, it activates the detection component 30, which emits a light signal that enters the blood gas detection chamber through the detection channel 301. The sample in the blood gas detection chamber receives the light signal and reflects a corresponding light signal. The reflected light signal is then received by the detection component 30 after passing through the detection channel 301, thus performing blood gas analysis on the sample in the blood gas detection chamber. Unlike related technologies, the detection component 30 of this application has multiple detection channels 301 spaced apart, and the light signals emitted by the detection component 30 to different detection channels 301 are different. When multiple blood gas tests are required on a sample, the analyzer of this application can transmit different light signals to multiple detection channels 301 through the detection component 30. This allows the sample in the blood gas detection chamber to receive different light signals and reflect light signals for different blood gas tests into different detection channels 301, which are then transmitted to the detection component 30. This enables the analyzer to detect multiple blood gas tests simultaneously, thereby improving the analyzer's detection efficiency to a certain extent.

[0024] In some embodiments, the detection channel 301 includes a first channel 3011 and a second channel 3012. A first end of the first channel 3011 is connected to the second channel 3012, and a first end of the second channel 3012 is correspondingly disposed with respect to the blood gas detection chamber. The second channel 3012 is used to transmit the reflected light signal from the blood gas detection chamber to the detection component 30. The detection component 30 also includes multiple light-emitting elements (not shown in the figure), each corresponding to the second end of the first channel 3011. The light-emitting elements emit light, which then sequentially passes through the first channel 3011 and the second channel 3012 into the blood gas detection chamber. Different light-emitting elements emit light with different wavelengths.

[0025] Specifically, when different blood gas tests need to be performed simultaneously, multiple light-emitting elements are activated. Since each element emits light of a different wavelength, when light of each wavelength enters the blood gas detection chamber through the first channel 3011 and the second channel 3012 respectively, each wavelength of light acts on the sample within the chamber, causing the sample to reflect different light signals. These different light signals then reach the detection unit 30 through the second channel 3012, allowing the detection unit 30 to analyze the detection parameters for different blood gas tests in the sample. Furthermore, when only a single blood gas test is required, the light-emitting elements can be selectively activated, using an appropriate wavelength to excite the sample. In some embodiments, the light-emitting elements include LEDs.

[0026] In some embodiments, a support frame 11 is provided on the body 10, and the support frame 11 is located on top of the microfluidic detection chip 20. The detection component 30 includes a light-emitting plate 32 and a detection body 31. The light-emitting plate 32 is connected to the support frame 11, and multiple light-emitting elements are spaced apart on the light-emitting plate 32. The detection body 31 is connected to the light-emitting plate 32, and multiple detection channels 301 are spaced apart on the detection body 31. Among them, the second channel 3012 is along the height direction of the analyzer (as shown in the attached figure). Figure 2 The first channel 3011 extends from the second channel 3012 toward the light-emitting plate 32 in the Z direction through the detection body 31.

[0027] In other words, the support frame 11 provides support for the light-emitting plate 32 and the detection body 31, thereby improving their stability and preventing them from loosening after long-term use of the analyzer. On the other hand, in this embodiment, the first channel 3011 and the second channel 3012 are arranged perpendicularly or at an angle. This design can reduce the length of the detection body 31 in the height direction of the analyzer to a certain extent, and facilitates the centralized arrangement of the light-emitting components on the light-emitting plate 32.

[0028] In some embodiments, the detection component 30 further includes a receiving plate 33, which is disposed on the top of the detection body 31, and the second end of each second channel 3012 is disposed corresponding to the receiving plate 33.

[0029] Specifically, "each second end of the second channel 3012 is correspondingly configured with a receiving plate 33" means that different light signals reflected from the blood gas detection chamber can be transmitted to the receiving plate 33 through the second end of each second channel 3012, that is, the axis of the opening of the second end of the second channel 3012 extends to the receiving plate 33. In this embodiment, the receiving plate 33 is used to receive the light signals reflected from the blood gas detection chamber and to detect the blood gas parameters of the sample in the blood gas detection chamber by analyzing the light signals. On the other hand, in this application, multiple detection channels 301 share one receiving plate 33, without the need to configure a separate receiving plate 33 for each detection channel 301, thus improving the space utilization of the analyzer to a certain extent.

[0030] In some embodiments, the detection body 31 includes a first block 311 and a second block 312 that are detachably connected, with the first block 311 located on top of the second block 312. A first channel 3011 is formed in the second block 312, and the second channel 3012 includes a first segment 30121 and a second segment 30122 that are interconnected. The first segment 30121 penetrates the first block 311 along the height direction of the analyzer, and the second segment 30122 penetrates the second block 312 along the height direction of the analyzer.

[0031] Specifically, the first block 311 and the second block 312 can be detachably connected by bolts, and when the first block 311 and the second block 312 are connected, the first segment 30121 and the second segment 30122 form the second channel 3012. It is understood that after long-term use, dust may accumulate in the first channel 3011 or the second channel 3012, thus requiring regular cleaning to prevent a decrease in the analyzer's detection accuracy. In this embodiment, since the first block 311 and the second block 312 are detachably connected, and the second channel 3012 includes the first segment 30121 and the second segment 30122, with the first segment 30121 located on the first block 311 and the second segment 30122 located on the second block 312, and the first channel 3011 located in the second block 312, this design facilitates separate cleaning of the first channel 3011 and the second channel 3012. On the other hand, if either the first block 311 or the second block 312 is damaged, the first block 311 or the second block 312 can be replaced separately, avoiding the need to replace the entire detection body 31, thus reducing the maintenance cost of the analyzer to some extent.

[0032] In some embodiments, a first filter (not shown in the figure) is provided in the first channel 3011. The first filter is used to prevent light other than a specific wavelength emitted by the light-emitting element from entering the first channel 3011, so as to avoid astigmatism or other light interfering with the detection results of the analyzer.

[0033] In some embodiments, a second filter (not shown) is provided within the first segment 30121. In some embodiments, a third filter (not shown) is provided within the second segment 30122. Similarly, providing a second filter within the first segment 30121 prevents stray light from entering the blood gas detection chamber, or prevents stray light reflected from the blood gas detection chamber from entering the first segment 30121. Providing a third filter within the second segment 30122 prevents stray light from shining onto the receiving plate 33, thus preventing stray light from interfering with the detection results. That is, the detection accuracy of the analyzer can be improved by using the first filter, the second filter, and the third filter.

[0034] In some embodiments, a connection port (not shown in the figure) is provided between the first end and the second end of the second channel 3012, the first end of the first channel 3011 is connected to the connection port, and a reflector (not shown in the figure) is provided at the connection port.

[0035] Specifically, in this embodiment, the second channel 3012 is perpendicularly connected to the first channel 3011. Therefore, in order for the light energy in the first channel 3011 to pass through the second channel 3012 and enter the blood gas detection tank, a reflector needs to be installed at the connection point to reflect the light in the first channel 3011 and allow it to pass through the second channel 3012 into the blood gas detection tank. In this embodiment, the reflector is tilted at the connection point.

[0036] It is understood that, since the detection component 30 includes a light-emitting element, a reflector, and a filter, in order to prevent the light-emitting element, reflector, and filter from overheating and being damaged due to prolonged operation of the analyzer, in some embodiments, the analyzer also includes a heat dissipation component 50. The heat dissipation component 50 is disposed on the body 10 and is used to dissipate heat from the detection component 30.

[0037] Specifically, the heat dissipation component 50 includes a cooling fan 51. When the analyzer is started, the cooling fan 51 blows air onto the detection body 31, the light-emitting plate 32, and the receiving plate 33, thereby removing the heat from the detection body 31, the light-emitting plate 32, and the receiving plate 33, and preventing the light-emitting element, reflector, filter, and receiving plate 33 inside the detection component 30 from being damaged due to excessive temperature.

[0038] In some embodiments, the blood gas detection cell includes multiple cells, each corresponding to a detection channel 301, wherein each blood gas detection cell contains a different fluorescent reagent.

[0039] In one specific embodiment, the blood gas detection cells include three cells, each containing a different fluorescent reagent. Specifically, one cell contains a pH fluorescent dye, one cell contains a CO2 fluorescent dye, and the other cell contains an O2 fluorescent dye. When the analyzer is operating, the samples in the three cells react with the pH, CO2, and O2 fluorescent dyes respectively, and after receiving light of a predetermined wavelength incident through the second channel 3012, they reflect light of a specific wavelength that passes through the second channel 3012 and enters the detection component 30. This allows the analyzer to simultaneously detect the sample's pH value, carbon dioxide partial pressure, and oxygen partial pressure.

[0040] In some embodiments, the same fluorescent reagent is provided in some blood gas detection cells. It is understood that since the light emitted by each light-emitting element has a different wavelength, when the same fluorescent reagent is provided in some blood gas detection cells, different wavelengths of light will reflect different light signals after irradiating the blood gas detection cells containing the same fluorescent reagent. Analyzing and comparing these light signals can be used to calibrate the analyzer's detection results. In other words, the blood gas detection performed by the detection component 30 on the blood gas detection cells containing the same fluorescent reagent is the same detection, but different wavelengths of light are used for excitation. Analyzing the difference between the reflected light can be used to calibrate the analyzer's detection accuracy.

[0041] In some embodiments, the analyzer further includes a reagent kit 40, which is disposed on the microfluidic detection chip 20. The reagent kit 40 is provided with a clearance hole (not shown in the figure) corresponding to the blood gas detection slot, and the clearance hole penetrates the reagent kit 40 along the height direction of the analyzer.

[0042] Specifically, the reagent kit 40 is used to release reagents into the microfluidic detection chip 20. In order to avoid the reagent kit 40 from blocking the blood gas detection slot, an obstacle hole is provided on the reagent kit 40 in this embodiment so that the light energy reflected in the blood gas detection slot can enter the second channel 3012 through the obstacle hole.

[0043] For ease of description, spatial relative terms such as "above," "on top of," "on the upper surface of," "above," etc., are used herein to describe the spatial positional relationship of a device or feature as shown in the figures to other devices or features. It should be understood that spatial relative terms are intended to encompass different orientations in use or operation beyond the orientation of the device as described in the figures. For example, if the device in the figures were inverted, a device described as "above" or "on top of" other devices or structures would subsequently be positioned as "below" or "under" other devices or structures. Thus, the exemplary term "above" can include both "above" and "below." The device may also be positioned in other different ways (rotated 90 degrees or in other orientations), and the spatial relative descriptions used herein will be interpreted accordingly.

[0044] Furthermore, it should be noted that the use of terms such as "first" and "second" to define components is merely for the purpose of distinguishing the corresponding components. Unless otherwise stated, the above terms have no special meaning and therefore cannot be construed as limiting the scope of protection of this application.

[0045] The above are merely preferred embodiments of this application and are not intended to limit this application. Various modifications and variations can be made to this application by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this application should be included within the protection scope of this application.

Claims

1. An analyzer for simultaneously detecting multiple blood gas parameters, characterized in that, include: Body (10); A microfluidic detection chip (20) is rotatably and replaceably disposed on the body (10), and a blood gas detection groove is provided on the microfluidic detection chip (20); A detection component (30) is disposed on the body (10). The detection component (30) has multiple detection channels (301) spaced apart. Each detection channel (301) is correspondingly disposed to the blood gas detection tank. The detection component (30) is used to emit light signals to the blood gas detection tank through the detection channels (301) and receive the light signals reflected in the blood gas detection tank through the detection channels (301) to perform blood gas detection on the sample in the blood gas detection tank. The light signals emitted by the detection component (30) to different detection channels (301) are different.

2. The analyzer for simultaneously detecting multiple blood gas parameters according to claim 1, characterized in that, The detection channel (301) includes a first channel (3011) and a second channel (3012). The first end of the first channel (3011) is connected to the second channel (3012). The first end of the second channel (3012) is correspondingly arranged with the blood gas detection slot. The second channel (3012) is used to transmit the light signal reflected in the blood gas detection slot to the detection component (30). The detection component (30) also includes a light-emitting element, which includes multiple light-emitting elements. The light-emitting elements are arranged one-to-one at the second end of the first channel (3011). The light-emitting elements are used to emit light and allow the light to pass through the first channel (3011) and the second channel (3012) in sequence into the blood gas detection tank. The light emitted by different light-emitting elements has different wavelengths.

3. The analyzer for simultaneously detecting multiple blood gas parameters according to claim 2, characterized in that, A support frame (11) is provided on the body (10), the support frame (11) is located on top of the microfluidic detection chip (20), and the detection component (30) includes: A light-emitting plate (32) is connected to the support frame (11), and a plurality of light-emitting elements are spaced apart on the light-emitting plate (32). The detection body (31) is connected to the light-emitting plate (32), and a plurality of detection channels (301) are spaced apart on the detection body (31). The second channel (3012) extends through the detection body (31) along the height direction of the analyzer that simultaneously detects multiple blood gas items, and the first channel (3011) extends from the second channel (3012) toward the light-emitting plate (32).

4. The analyzer for simultaneously detecting multiple blood gas parameters according to claim 3, characterized in that, The detection component (30) also includes a receiving plate (33), which is disposed on the top of the detection body (31), and the second end of each of the second channels (3012) is correspondingly disposed with the receiving plate (33).

5. The analyzer for simultaneously detecting multiple blood gas parameters according to claim 3, characterized in that, The detection body (31) includes a first block (311) and a second block (312) that are detachably connected, and the first block (311) is located on top of the second block (312); The first channel (3011) is located in the second block (312). The second channel (3012) includes a first segment (30121) and a second segment (30122) that are connected to each other. The first segment (30121) passes through the first block (311) along the height direction of the analyzer, and the second segment (30122) passes through the second block (312) along the height direction of the analyzer.

6. The analyzer for simultaneously detecting multiple blood gas parameters according to claim 5, characterized in that, A first filter is disposed within the first channel (3011); and / or, A second filter is provided within the first segment (30121); and / or, A third filter is provided in the second segment (30122).

7. The analyzer for simultaneously detecting multiple blood gas parameters according to claim 2, characterized in that, A connection port is provided between the first end and the second end of the second channel (3012), and the first end of the first channel (3011) is connected to the connection port. A reflector is provided at the connection port.

8. The analyzer for simultaneously detecting multiple blood gas parameters according to any one of claims 1 to 7, characterized in that, The analyzer also includes a heat dissipation component (50), which is disposed on the body (10) and is used to dissipate heat from the detection component (30).

9. The analyzer for simultaneously detecting multiple blood gas parameters according to any one of claims 1 to 7, characterized in that, The blood gas detection slots include multiple slots, and each blood gas detection slot corresponds to one detection channel (301). Each of the blood gas detection cells is equipped with a different fluorescent reagent; or The same fluorescent reagent is provided in some of the blood gas detection cells.

10. The analyzer for simultaneously detecting multiple blood gas parameters according to any one of claims 1 to 7, characterized in that, The analyzer also includes a reagent kit (40), which is disposed on the microfluidic detection chip (20). The reagent kit (40) is provided with a clearance hole corresponding to the blood gas detection slot, and the clearance hole penetrates the reagent kit (40) along the height direction of the analyzer.

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