Composite microspheres, and preparation method and application thereof

By combining doped hydroxyapatite, polylactic acid, and β-cyclodextrin with graphene oxide, a porous structure was constructed, which solved the problems of low drug encapsulation efficiency and poor interfacial compatibility of drug-loaded microspheres, and achieved long-lasting and controllable drug release and bone repair effects.

CN122376542APending Publication Date: 2026-07-14SHENZHEN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHENZHEN UNIV
Filing Date
2026-05-18
Publication Date
2026-07-14

AI Technical Summary

Technical Problem

Existing drug-loaded microspheres suffer from low drug encapsulation efficiency, severe burst release effects, poor material interfacial compatibility, and rapid degradation of mechanical properties, making it difficult to meet the long-term drug delivery requirements for orthopedic bone defect repair.

Method used

A porous structure was constructed by combining doped hydroxyapatite (Ce/Zn-HA) with polylactic acid (PLA) and β-cyclodextrin (β-CD) and enhancing interfacial compatibility with graphene oxide (GO). A stable drug sustained-release system was formed by utilizing the host-guest specific recognition of β-CD and the coordination cross-linking reaction of metal ions.

Benefits of technology

It significantly improves drug encapsulation performance, inhibits initial drug release, constructs a long-lasting and controllable drug sustained-release system, optimizes the bone repair microenvironment, provides continuous mechanical support and biocompatibility, and meets the needs of bone tissue regeneration.

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Abstract

The application relates to the technical field of high polymer composite materials, and provides a composite microsphere, which comprises a core body and a coating layer covering the core body, the core body comprises doped hydroxyapatite doped with zinc ions and cerium ions, the coating layer comprises polylactic acid and beta-cyclodextrin, and graphene oxide is distributed between the core body and the coating layer; the composite microsphere has a porous structure, and beta-cyclodextrin is filled in at least part of the porous structure. The composite microsphere provided by the application can significantly improve the drug encapsulation performance of the composite microsphere by utilizing the synergistic effect among the Ce / Zn co-doped doped hydroxyapatite, polylactic acid, graphene oxide and beta-cyclodextrin, can effectively inhibit and reduce the initial burst release phenomenon of the drug, and can construct a stable, long-acting and controllable drug sustained-release system.
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