A chitosan intelligent hemostatic gauze doped with cerium-based nanozyme based on molecular sieve effect and a preparation method and application thereof

By introducing Ce-MOF nanozymes into chitosan gauze to form a cross-linked structure, the problems of poor mechanical strength and heavy metal toxicity of traditional hemostatic materials are solved, and a smart hemostatic gauze with rapid hemostasis, strong antibacterial and anti-inflammatory properties is realized.

CN122376818APending Publication Date: 2026-07-14李昊宸
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Patent Information

Application Number
CN202610514097.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-04-17
Publication Date
2026-07-14

AI Technical Summary

Technical Problem

Traditional chitosan gauze has poor mechanical strength after absorbing blood and is prone to sticking to the wound. Traditional silver-containing gauze has heavy metal toxicity and cannot actively eliminate wound inflammation.

Method used

A three-dimensional network cross-linked structure is formed by doped cerium-based nanozymes (Ce-MOF nanozymes) based on the molecular sieve effect and chitosan. Combining the oxidase-like activity of Ce-MOF and the positive charge effect of chitosan, rapid hemostasis, antibacterial and anti-inflammatory functions are achieved.

Benefits of technology

It achieves rapid hemostasis, non-toxic and highly effective antibacterial properties, intelligent anti-inflammatory and wound-healing effects, and does not adhere to the wound, thus improving the mechanical strength and biological safety of hemostatic materials.

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Abstract

This invention relates to a chitosan-based smart hemostatic gauze doped with cerium-based nanozymes based on the molecular sieve effect, its preparation method, and its applications, belonging to the field of biomedical materials. The hemostatic gauze comprises a medical gauze substrate and a composite hemostatic coating loaded thereon. The coating consists of chitosan, Ce-MOF nanozymes, and a cross-linking agent. This invention is the first to introduce Ce-MOF, which possesses ultra-high porosity and enzyme-like catalytic activity, into a chitosan matrix. Utilizing its "molecular sieve" effect, it rapidly absorbs blood moisture, achieving second-level procoagulation. Simultaneously, the Ce-MOF nanozymes not only catalyze the generation of reactive oxygen species (ROS) in the bacterial microenvironment, achieving broad-spectrum bactericidal action without heavy metal toxicity, but also intelligently remove excess ROS from wound tissue, reducing inflammatory responses. Furthermore, the coordination-physical dual cross-linking network formed by Ce-MOF and chitosan significantly enhances the wet mechanical strength of the gauze, preventing wound adhesion. This invention has extremely high clinical translational value in trauma emergency care, massive bleeding control, and infected wound repair.
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