Toothpaste against oral helicobacter pylori and its preparation method
By combining quaternized chitosan and zinc gluconate, the shortcomings of existing toothpastes in killing Helicobacter pylori are overcome, achieving effective killing and inhibition of Helicobacter pylori and prolonging its action time in the oral cavity.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Filing Date
- 2026-04-08
- Publication Date
- 2026-07-17
AI Technical Summary
Existing toothpastes are significantly inadequate in killing Helicobacter pylori in the oral cavity.
Quaternized chitosan was used as an antibacterial agent. It was adsorbed onto the surface of bacterial cells through electrostatic interactions, disrupting the membrane arrangement, increasing membrane permeability, and causing leakage of cell contents. At the same time, the p-coumaric acid structural unit of the antibacterial agent interfered with the electron transport process of the bacterial respiratory chain, and adhered to the tooth surface through the chitosan backbone to prolong the action time. Meanwhile, zinc gluconate was used to inhibit the urease activity secreted by Helicobacter pylori.
It effectively kills Helicobacter pylori, inhibits its growth and reproduction, and prolongs its action time in the oral cavity.
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Abstract
Citation Information
Patent Citations
Toothpaste and preparation method thereof
CN103536515A