A phenolic compound with multi-target neuroprotective activity, a producing strain and application thereof
By isolating phenolic compounds with multi-target activity from Diaporthe searlei fungus, the shortcomings of existing drugs in the treatment of neurodegenerative diseases with single-target inhibitors have been overcome, and the neuroprotective effect of multi-target synergistic therapy has been achieved.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- ZUNYI MEDICAL UNIV ZHUHAI CAMPUS
- Filing Date
- 2026-04-21
- Publication Date
- 2026-07-17
AI Technical Summary
Existing drugs for treating neurodegenerative diseases are mostly single-target inhibitors, which cannot effectively eliminate reactive oxygen species (ROS), cannot improve cholinergic system disorders, and lack multi-target lead molecules with triple activities of antioxidant-MAO inhibition-cholinesterase inhibition.
A novel phenolic compound was isolated from the fungus Diaporthe searlei, exhibiting distinct dual inhibition of monoamine oxidase, selective inhibition of butyrylcholinesterase, and antioxidant activity, serving as a multi-target neuroprotective agent.
This compound exhibits significant multi-target synergistic activity in in vitro models, and is characterized by its novel structure, natural origin, and high safety profile, making it a potential therapeutic agent for neurodegenerative diseases.
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Figure CN122404149A_ABST