A method for rhodium-catalyzed reductive dehalogenation reaction regulated by solvent and construction of phenanthridone skeleton
By employing a solvent-controlled rhodium-catalyzed reduction dehalogenation reaction and a method for constructing the phenanthrone skeleton, the complexity of the reduction dehalogenation reaction and the shortcomings of the phenanthrone skeleton construction in existing technologies have been overcome. This method achieves efficient and simple reduction dehalogenation and phenanthrone skeleton synthesis, which is applicable to medicinal chemistry and environmental science.
Patent Information
- Application Number
- CN202610676681.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-05-17
- Publication Date
- 2026-07-17
AI Technical Summary
Existing reductive dehalogenation methods suffer from problems such as the need for external ligands, expensive catalysts, low yields, sensitivity to air, and complex post-processing. Furthermore, existing methods for constructing phenanthrene skeletons require the prior synthesis of substrates and external phosphine ligands.
A solvent-controlled rhodium-catalyzed reduction dehalogenation reaction is employed. By controlling the reaction temperature and time in the presence of a catalyst, a base, and a polar protic solvent, the reduction dehalogenation of the substrate and the construction of the phenanthrene ketone skeleton are achieved. This avoids the use of hydrogen and external phosphine ligands, and the reaction is simple and insensitive to air.
It achieves high yields of reductive dehalogenated products without further purification, simplifies post-processing, expands the substrate range, and is suitable for medicinal chemistry and environmental science under mild conditions.
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