Polymorphic carbazole derivatives and uses thereof
By providing a pharmaceutical composition of compound A and its polymorphic forms, AHR is directly inhibited, solving the problems of immunosuppression and tumor promotion caused by AHR activation in the prior art, and achieving therapeutic and research effects on related diseases.
Patent Information
- Application Number
- CN202610357767.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Priority Date
- 2019-11-26
- Filing Date
- 2020-11-25
- Publication Date
- 2026-07-17
AI Technical Summary
The lack of effective AHR inhibitors in current technologies means that the immunosuppression and tumor-promoting effects caused by AHR activation cannot be effectively treated.
Provides compound A and its polymorphic forms and pharmaceutically acceptable compositions for the direct inhibition of AHR, including the free base form and salt form of compound A, administered in various physical forms such as solutions, suspensions or solids to treat the associated disease.
Compound A and its compositions can effectively inhibit AHR, reduce the severity of related diseases, study the biological and pathological phenomena of AHR, and be used for in vitro and in vivo evaluation of AHR inhibitors.
Smart Images
Figure CN122404338A_ABST
Abstract
Citation Information
Patent Citations
Indole AHR inhibitors and uses thereof
US10570138B2
Indole AHR inhibitors and uses thereof
US20180327411A1
Methods for treatment of cancer
US8906682B2
Casier à bouteilles
WO024360
Anti-ox40l antibodies
WO2006029879A2