Amphotericin b saturated heterocyclic derivative and use thereof

By modifying the structure of amphotericin B, saturated heterocyclic derivatives of amphotericin B were developed, which solved the problems of poor antibacterial activity, high cost and toxic side effects of existing formulations, and provided a more stable and economical antifungal treatment option.

CN122404449APending Publication Date: 2026-07-17WUHAN XIRUI PHARMACEUTICAL TECHNOLOGY CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
WUHAN XIRUI PHARMACEUTICAL TECHNOLOGY CO LTD
Filing Date
2026-01-16
Publication Date
2026-07-17

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Abstract

本发明提供了一种两性霉素B饱和杂环类衍生物及其应用。所述两性霉素衍生物如式（I）所示，本发明的化合物对白色念珠菌、烟曲霉、黄曲霉生长有较好的抑制作用：（I）。
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