Spirulina polypeptide and application thereof in synergistically enhancing immunity with astaxanthin

By combining the COX-2 inhibitory peptide ASYF extracted from spirulina powder with astaxanthin, the side effects of existing COX-2 inhibitors have been resolved, achieving safe and efficient immunomodulatory effects and product stability.

CN122404477APending Publication Date: 2026-07-17BEIJING FORESTRY UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BEIJING FORESTRY UNIVERSITY
Filing Date
2026-06-02
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing COX-2 inhibitors have gastrointestinal and cardiovascular adverse reactions, which limit their clinical application, and there is a lack of safe and effective natural enzyme activity inhibitors to regulate the body's immune status.

Method used

Bioactive peptides were extracted from spirulina powder, and the COX-2 inhibitory peptide ASYF was screened out. It was then combined with astaxanthin and encapsulated with whey protein and carboxymethyl chitosan to form nanoparticles to improve stability and simulate digestive properties.

Benefits of technology

It achieves highly efficient inhibition of COX-2, enhances immunity, reduces side effects, and improves product stability and digestibility.

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Abstract

本发明属于生物技术领域，具体涉及一种环氧合酶‑2抑制肽及其制备方法与应用。本发明将以螺旋藻为原料提取蛋白质，通过生物酶解法制备活性多肽，利用生物信息学分析及实验验证筛选出环氧合酶‑2抑制肽ASYF，对环氧合酶‑2的IC50值达到0.22 ± 0.02 mmol / L（105.38 ± 7.42 μg / mL）。并进一步探究环氧合酶‑2抑制肽ASYF和虾青素AST联用对环氧合酶‑2活性的抑制作用，当ASYF与AST的浓度比为5:4时，复合物ASYF / AST对环氧合酶‑2的协同抑制率为78.62% ± 1.88%，CI为最小值0.36。本发明还提供采用乳清蛋白WP和羧甲基壳聚糖CMCS包埋ASYF / AST的ASYF / AST‑WP / CMCS纳米颗粒，能够有效提升活性物质的稳定性与缓释性能，可将其应用于制备抑制环氧合酶‑2活性产品，又或是在制备增强免疫力产品中。
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