A branched-chain alpha-keto acid decarboxylase mutant and a method for synthesizing cis-cinnamic acid compounds catalyzed by the same
By mutating the amino acid sites of branched α-keto acid decarboxylase, its catalytic performance was optimized, solving the problem of low synthesis efficiency of cis-cinnamic acid compounds in existing technologies. This achieved efficient catalysis and green synthesis, expanding its application in the fields of medicine, food, and cosmetics.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- EAST CHINA UNIV OF SCI & TECH
- Filing Date
- 2026-05-22
- Publication Date
- 2026-07-17
AI Technical Summary
Existing technologies are insufficient for the efficient catalytic synthesis of cis-cinnamic acid compounds, limiting their widespread application in the pharmaceutical, food, and cosmetic fields and the demand for green synthesis.
By mutating specific amino acid sites of branched-chain α-keto acid decarboxylase, a branched-chain α-keto acid decarboxylase mutant was formed, and its catalytic performance, especially its ability to catalyze the synthesis of cis-cinnamic acid compounds, was optimized.
This improved the synthesis efficiency and selectivity of cis-cinnamic acid compounds, expanded their application potential in the pharmaceutical, food, and cosmetic fields, and achieved improvements in green synthesis and resource utilization efficiency.
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Figure CN122405604A_ABST