A decellularized fish skin yarn with weavability and a preparation method and application thereof

By combining clamping and flattening with freeze-drying technology with rectangular spiral indentation and mechanical twisting, decellularized fish skin matrix was successfully transformed into one-dimensional continuous yarn, solving the problem of limited structural dimensions in existing technologies. This resulted in decellularized fish skin yarn with flexibility and weavability, expanding its application in biomedical textiles.

CN122406436APending Publication Date: 2026-07-17QINGDAO UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
QINGDAO UNIV
Filing Date
2026-04-24
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing technologies struggle to transform decellularized fish skin matrix from a two-dimensional sheet structure into a one-dimensional continuous yarn, and lack weavability, limiting its application in biomedical applications that require high-strength fiber support.

Method used

A continuous strip-shaped fish skin matrix was prepared by using a combination of clamping and freeze-drying technology, and then formed into a weavable decellularized fish skin yarn through rectangular spiral indentation and mechanical twisting processes.

Benefits of technology

It achieves the flexibility and weavability of decellularized fish skin yarn, possesses good biocompatibility and mechanical properties, and is suitable for the processing and application of various biomedical textiles.

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Abstract

本发明公开了一种具有可织性的脱细胞鱼皮纱线及其制备方法和应用，属于生物医用材料技术领域。本发明以罗非鱼皮为原料，经脱细胞处理后，采用多层硬质夹板交替叠置夹持压平，再经冷冻干燥获得平整干态脱细胞鱼皮基质；通过在基质表面制作螺旋连续压痕并沿痕裁剪，得到连续条带，经加捻处理形成纱线，收集、冻干灭菌封装，制得干态可织脱细胞鱼皮纱线。本发明在保留天然细胞外基质结构与生物活性的前提下，实现脱细胞鱼皮由二维片状向一维连续纱线的结构转化，赋予材料优异可织性，可通过编织、机织、针织等工艺加工为生物医用纺织品，适用于组织工程支架、外科缝合线、创面修复敷料及软组织修复等领域，工艺简便、可控性强、易于规模化生产。
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Citation Information

Patent Citations

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