Method for eliminating interference of abnormal protein in ABO blood group identification and application thereof
By treating plasma samples with tricarboxyethylphosphine solution, the disulfide bonds of abnormal proteins are broken, solving the problem of inconsistency between forward and reverse typing caused by abnormal protein interference in ABO blood typing, and achieving rapid, safe and accurate blood typing.
CN122409272APending Publication Date: 2026-07-17SHANGHAI LANWEI MEDICAL LAB CO LTD
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Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SHANGHAI LANWEI MEDICAL LAB CO LTD
- Filing Date
- 2026-04-21
- Publication Date
- 2026-07-17
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Figure CN122409272A_ABST
Abstract
本发明公开了一种消除ABO血型鉴定中异常蛋白干扰的方法及其应用。所述方法包括：将三羧乙基膦溶液与待检血浆样本混合处理。本发明首次将三羧乙基膦应用于消除ABO血型鉴定中的异常蛋白干扰，通过三羧乙基膦处理待检血浆，特异性破坏异常蛋白的二硫键，消除其在反定型中引起的非特异性凝集干扰，同时保留正常抗体活性。本发明具有安全性高、效率快、准确性好、成本低等突出优点，适合临床推广使用。
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