A formula of multi-vitamins and its preparation method

Abstract

This invention relates to the field of sports nutrition food technology, and discloses a multivitamin formula and its preparation method, comprising the following components in parts by weight: 1.8-2.2 parts of mannose oligosaccharide, 1.8-2.2 parts of galacose oligosaccharide, 9-11 parts of xylooligosaccharide, 6.5-7.5 parts of fructooligosaccharide, 8.5-9.5 parts of maltitol, 1.8-2.2 parts of erythritol, 2.8-3.2 parts of galacose-mannan, 1.8-2.2 parts of stachyose, 13-15 parts of inulin, 38-42 parts of resistant dextrin, 0.20-0.24 parts of vitamin C, 0.45-0.55 parts of silicon dioxide, 0.010-0.014 parts of vitamin B1, and vitamin B2. 0.005-0.007 parts, folic acid 0.0009-0.0011 parts, γ-aminobutyric acid 0.45-0.55 parts, tyrosine 3.8-4.2 parts, magnesium lactate 3.8-4.2 parts; This invention forms a complex prebiotic system by simultaneously adding eight kinds of dietary fiber / oligosaccharides: resistant dextrin, inulin, xylooligosaccharide, fructooligosaccharide, galactooligosaccharide, mannose, galactomannan, and stachyose, which comprehensively regulates the intestinal flora and promotes the production of short-chain fatty acids.

Description

Technical Field

[0001] This invention relates to the field of sports nutrition food technology, specifically to a multivitamin formula and its preparation method. Background Technology

[0002] With the development of national fitness and competitive sports, sports nutrition foods have received increasing attention. In endurance sports such as middle- and long-distance running, swimming, cycling, and aerobic exercise, the body consumes a lot of energy, sweats profusely, and loses electrolytes rapidly, while simultaneously increasing the burden on the intestines, easily leading to fatigue, electrolyte imbalances, and intestinal dysfunction. Existing endurance sports nutrition products mainly supplement carbohydrates, electrolytes, and vitamins, but generally suffer from the following shortcomings: First, the types of dietary fiber are limited, making it difficult to comprehensively regulate the intestinal flora; second, vitamins (especially B vitamins and vitamin C) are easily oxidized and degraded during processing and storage; third, the synergistic supplementation of magnesium, amino acids, etc., is insufficient, resulting in limited anti-fatigue effects; and fourth, the simultaneous addition of multiple oligosaccharides easily leads to hygroscopic clumping, affecting product stability and taste. Therefore, this application proposes a multi-component, synergistic, and stable multivitamin formula suitable for endurance athletes, along with its preparation method. Summary of the Invention

[0003] The purpose of this invention is to provide a multivitamin formulation and its preparation method to solve the problems mentioned in the background art.

[0004] According to a first aspect of the present invention, a multivitamin formulation is provided, comprising the following components in parts by weight:

[0005] Oligomannan 1.8-2.2 parts, galactooligosaccharide 1.8-2.2 parts, xylooligosaccharide 9-11 parts, fructooligosaccharide 6.5-7.5 parts, maltitol 8.5-9.5 parts, erythritol 1.8-2.2 parts, galactooligosaccharide 2.8-3.2 parts, stachyose 1.8-2.2 parts, inulin 13-15 parts, resistant dextrin 38-42 parts, vitamin C 0.20-0.24 parts, silicon dioxide 0.45-0.55 parts, vitamin B1 0.010-0.014 parts, vitamin B2 0.005-0.007 parts, folic acid 0.0009-0.0011 parts, γ-aminobutyric acid 0.45-0.55 parts, tyrosine 3.8-4.2 parts, magnesium lactate 3.8-4.2 parts.

[0006] The weight ratio of xylooligosaccharide to inulin is 1:(1.3-1.5), the weight ratio of galactooligosaccharide to mannose is 1:(0.8-1.2), and the weight ratio of γ-aminobutyric acid to tyrosine is 1:(7-9).

[0007] The weight ratio of stachyose, galactomannan and fructooligosaccharides is (1-3):(2-4):(6-8), and the weight ratio of erythritol to maltitol is 1:(3-5).

[0008] The magnesium lactate exists in the form of a dihydrate, and the weight ratio of magnesium lactate to tyrosine is 1:(0.9-1.1).

[0009] The weight ratio of vitamin B1, vitamin B2 and folic acid is (10-14):(5-7):1.

[0010] Among them, vitamin B1 is thiamine hydrochloride, vitamin B2 is riboflavin, and folic acid is (6S)-5-methyltetrahydrofolate calcium.

[0011] According to a second aspect of the present invention, a method for preparing a formulation of a multivitamin described above is provided, comprising the following steps:

[0012] Step 1: Weigh out the resistant dextrin, inulin, xylooligosaccharide, maltitol, fructooligosaccharide, galactomannan, stachyose, erythritol, galacto-oligosaccharide, and mannose by weight, and put them into the first mixer. Stir at 200-400 rpm for 15-30 minutes under the conditions of temperature 20℃-30℃ and relative humidity ≤40% to obtain the first premix.

[0013] Step 2: Weigh out tyrosine, magnesium lactate, γ-aminobutyric acid, silicon dioxide, vitamin C, vitamin B1, vitamin B2, and folic acid by weight, and put them into the second mixer. Stir at 100-200 rpm for 5-10 minutes under the conditions of temperature 20℃-30℃ and relative humidity ≤40% to obtain the second premix.

[0014] Step 3: Combine the first premix and the second premix, stir at 300-500 rpm for 10-20 minutes, and then pass through an 80-120 mesh sieve to obtain multivitamin powder.

[0015] In step 2, before mixing, vitamin C, vitamin B1, vitamin B2, folic acid and maltodextrin are pre-treated by fluidized bed coating at a weight ratio of 1:1 to obtain embedded microparticles. Then the embedded microparticles are mixed with the remaining components from step 2.

[0016] In step 1, before mixing, xylooligosaccharides and inulin are premixed at a weight ratio of 1:(1.3-1.5) and dried at 30℃-40℃ for 30-60 minutes to reduce the moisture content to ≤3%, and then mixed with the remaining components of step 1.

[0017] The first and second mixers are both three-dimensional motion mixers, and the filling rate during the mixing process is controlled at 40%-60%.

[0018] Compared with the prior art, the beneficial effects of the present invention are:

[0019] 1. This invention forms a complex prebiotic system by simultaneously adding eight kinds of dietary fiber / oligosaccharides: resistant dextrin, inulin, xylooligosaccharide, fructooligosaccharide, galactooligosaccharide, mannose, galactomannan, and stachyose. This system comprehensively regulates the intestinal flora and promotes the production of short-chain fatty acids.

[0020] 2. This invention combines tyrosine and γ-aminobutyric acid in a specific ratio to synergistically relieve exercise-induced central fatigue. At the same time, magnesium lactate provides magnesium ions and lactate ions to buffer the lactic acid produced during exercise and delay muscle soreness.

[0021] 3. This invention uses fluidized bed coating to encapsulate easily oxidized vitamins, effectively reducing oxidative degradation during processing and storage, and improving the product's nutrient retention rate. At the same time, the pre-drying treatment of easily hygroscopic xylooligosaccharides and inulin, combined with the anti-caking effect of silica, improves the moisture absorption and clumping problem of the multi-oligosaccharide system, resulting in a product with good stability, loose texture, and easy reconstitution.

[0022] 4. The present invention adopts a stepwise premixing preparation process, in which components with different properties are premixed separately and then combined and mixed, which ensures the uniformity of the mixing of each micronutrient in the system and the stable product quality. Detailed Implementation

[0023] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0024] Example 1

[0025] A multivitamin formula, comprising the following components by weight:

[0026] Oligomannan 2.0 parts, galactooligosaccharide 2.0 parts, xylooligosaccharide 10.0 parts, fructooligosaccharide 7.0 parts, maltitol 9.0 parts, erythritol 2.0 parts, galactooligosaccharide 3.0 parts, stachyose 2.0 parts, inulin 14.0 parts, resistant dextrin 40.0 parts, vitamin C 0.22 parts, silicon dioxide 0.50 parts, vitamin B1 (thiamine hydrochloride) 0.012 parts, vitamin B2 (riboflavin) 0.006 parts, folic acid ((6S)-5-methyltetrahydrofolate calcium) 0.001 parts, γ-aminobutyric acid 0.50 parts, tyrosine 4.0 parts, magnesium lactate (dihydrate) 4.0 parts.

[0027] Preparation method:

[0028] Step 1: Weigh out the resistant dextrin, inulin, xylooligosaccharide, maltitol, fructooligosaccharide, galactomannan, stachyose, erythritol, galacto-oligosaccharide, and mannose according to the above weight proportions, and put them into a three-dimensional motion mixer. Stir at 300 rpm for 20 minutes at a temperature of 25°C and a relative humidity of 35% to obtain the first premix.

[0029] Step 2: Weigh out tyrosine, magnesium lactate, γ-aminobutyric acid, silicon dioxide, vitamin C, vitamin B1, vitamin B2, and folic acid by weight, and put them into another three-dimensional motion mixer. Stir at 150 rpm for 8 minutes at a temperature of 25°C and a relative humidity of 35% to obtain the second premix.

[0030] Step 3: Combine the first premix and the second premix, stir at 400 rpm for 15 minutes, then pass through a 100-mesh sieve to obtain multivitamin powder, packaged in 21g bags.

[0031] Example 2

[0032] The difference from Example 1 is as follows: 9.5 parts xylooligosaccharide, 13.5 parts inulin, 1.9 parts galactooligosaccharide, 2.1 parts mannose oligosaccharide, 0.48 parts γ-aminobutyric acid (GABA), 4.1 parts tyrosine, and 3.9 parts magnesium lactate. The remaining components and preparation method are the same as in Example 1. The weight ratio of xylooligosaccharide to inulin is 1:1.42, the ratio of galactooligosaccharide to mannose oligosaccharide is 1:1.11, and the ratio of GABA to tyrosine is 1:8.54.

[0033] Example 3

[0034] The difference from Example 1 is that in step 2 of the preparation method, before mixing, vitamin C, vitamin B1, vitamin B2, folic acid, and maltodextrin are pretreated by fluidized bed coating at a weight ratio of 1:1 (inlet air temperature 50°C, coating solution is hydroxypropyl methylcellulose aqueous solution, coating weight gain 20%) to obtain embedded microparticles. These embedded microparticles are then mixed with the remaining components from step 2. The rest is the same as in Example 1.

[0035] Example 4

[0036] The difference from Example 1 is that in step 1 of the preparation method, xylooligosaccharides and inulin are premixed at a weight ratio of 1:1.4 before mixing, and then dried at 35°C for 45 minutes to reduce the moisture content to 2.5%, before being mixed with the remaining components of the first premix. The rest is the same as in Example 1.

[0037] Comparative Example 1

[0038] The difference from Example 1 is that xylooligosaccharides are replaced with an equal amount of resistant dextrin, i.e., 0 parts xylooligosaccharides and 50 parts resistant dextrin, while the remaining components and preparation methods are the same as in Example 1.

[0039] Comparative Example 2

[0040] The difference from Example 1 is that γ-aminobutyric acid and tyrosine are not added, and their weight parts are distributed proportionally to resistant dextrin (increased by 2.0 parts) and inulin (increased by 2.5 parts), while the rest is the same as in Example 1.

[0041] Comparative Example 3

[0042] The difference from Example 1 is that no graded premixing is performed in the preparation method. All components are added to the mixer at once and stirred at 400 rpm for 30 minutes under the same conditions, and then passed through a 100-mesh sieve. The remaining components are the same as in Example 1.

[0043] Experiment Example 1: Endurance Mouse Swimming Experiment;

[0044] Seventy SPF-grade male Kunming mice, weighing 18-22g, were randomly divided into seven groups of ten mice each: a blank control group (gavaged with an equal volume of distilled water), Example 1 group, Example 2 group, Example 3 group, Example 4 group, Comparative Example 1 group, and Comparative Example 2 group. Each experimental group was administered the corresponding test substance by gavage daily, with the dosage converted from the human daily dose of 21g to the mouse equivalent dose (approximately 1.9g / kg body weight), for 14 consecutive days. Thirty minutes after the last administration, the mice were loaded with lead weights equal to 5% of their body weight and placed in a swimming tank at a depth of 30cm and a water temperature of 30±1℃. The time from entry into the water until the mouse's head submerged for 10 seconds and remained submerged was recorded as the weight-bearing swimming time. The results are shown in the table below:

[0045]

[0046] Note: Compared with the blank control group, , Compared with Example 1, #P<0.05.

[0047] As can be seen from the table above, Examples 1-4 of the present invention can significantly prolong the swimming time of mice under load, and have significant anti-fatigue effects. The anti-fatigue effects of Comparative Example 1 and Comparative Example 2 are significantly reduced due to the lack of xylooligosaccharides and the lack of γ-aminobutyric acid and tyrosine. This indicates that the present invention can significantly improve the anti-fatigue effect after endurance exercise through the synergistic effect of specific components and ratios.

[0048] Experiment Example 2: Vitamin Stability Test;

[0049] The multivitamin powders prepared in Examples 1, 3, and 3 were sealed in 21g bags and placed in a constant temperature and humidity chamber at 40℃ and 75% relative humidity for 6 months for accelerated testing. The contents of vitamin C, vitamin B1, vitamin B2, and folic acid were measured at 0, 1, 2, 3, and 6 months (retention rate was calculated with the initial content as 100%). The results are shown in the table below (6-month data):

[0050]

[0051] Note: Compared with Example 1, Compared with Example 3, ##P<0.01.

[0052] As can be seen from the table above, in Example 3, the retention rate of each vitamin after fluidized bed coating pretreatment was significantly higher than that in Example 1 without coating; while in Comparative Example 3, a one-time mixing process was used without graded premixing and without controlling low humidity conditions, resulting in severe vitamin degradation. The preferred graded premixing and coating process of this invention significantly improves the stability of the product.

[0053] In summary, the multivitamin formula provided by this invention achieves the effects of regulating intestinal flora and relieving exercise fatigue through a specific combination of various oligosaccharides with functional amino acids, vitamins, and minerals. At the same time, the preparation process of encapsulation pretreatment and step-by-step premixing effectively solves the problems of easy moisture absorption and clumping, easy oxidation and easy degradation of vitamins in the multi-oligosaccharide system. The product has good stability and high mixing uniformity, making it suitable for long-term supplementation by endurance athletes.

[0054] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A multivitamin formula, characterized in that, It consists of the following components in parts by weight: Oligomannan 1.8-2.2 parts, galactooligosaccharide 1.8-2.2 parts, xylooligosaccharide 9-11 parts, fructooligosaccharide 6.5-7.5 parts, maltitol 8.5-9.5 parts, erythritol 1.8-2.2 parts, galactooligosaccharide 2.8-3.2 parts, stachyose 1.8-2.2 parts, inulin 13-15 parts, resistant dextrin 38-42 parts, vitamin C 0.20-0.24 parts, silicon dioxide 0.45-0.55 parts, vitamin B1 0.010-0.014 parts, vitamin B2 0.005-0.007 parts, folic acid 0.0009-0.0011 parts, γ-aminobutyric acid 0.45-0.55 parts, tyrosine 3.8-4.2 parts, magnesium lactate 3.8-4.2 parts.

2. The multivitamin formula according to claim 1, characterized in that: The weight ratio of xylooligosaccharide to inulin is 1:(1.3-1.5), the weight ratio of galactooligosaccharide to mannose is 1:(0.8-1.2), and the weight ratio of γ-aminobutyric acid to tyrosine is 1:(7-9).

3. The multivitamin formula according to claim 1, characterized in that: The weight ratio of stachyose, galactomannan and fructooligosaccharides is (1-3):(2-4):(6-8), and the weight ratio of erythritol to maltitol is 1:(3-5).

4. The multivitamin formula according to claim 1, characterized in that: The magnesium lactate exists in the form of a dihydrate, and the weight ratio of magnesium lactate to tyrosine is 1:(0.9-1.1).

5. The multivitamin formula according to claim 1, characterized in that: The weight ratio of vitamin B1, vitamin B2 and folic acid is (10-14):(5-7):

1.

6. The multivitamin formula according to claim 1, characterized in that: The vitamin B1 is thiamine hydrochloride, the vitamin B2 is riboflavin, and the folic acid is (6S)-5-methyltetrahydrofolate calcium.

7. A method for preparing a multivitamin formula according to claims 1-6, characterized in that, Includes the following steps: Step 1: Weigh out the resistant dextrin, inulin, xylooligosaccharide, maltitol, fructooligosaccharide, galactomannan, stachyose, erythritol, galacto-oligosaccharide, and mannose by weight, and put them into the first mixer. Stir at 200-400 rpm for 15-30 minutes under the conditions of temperature 20℃-30℃ and relative humidity ≤40% to obtain the first premix. Step 2: Weigh out tyrosine, magnesium lactate, γ-aminobutyric acid, silicon dioxide, vitamin C, vitamin B1, vitamin B2, and folic acid by weight, and put them into the second mixer. Stir at 100-200 rpm for 5-10 minutes under the conditions of temperature 20℃-30℃ and relative humidity ≤40% to obtain the second premix. Step 3: Combine the first premix and the second premix, stir at 300-500 rpm for 10-20 minutes, and then pass through an 80-120 mesh sieve to obtain multivitamin powder.

8. The method for preparing a multivitamin formula according to claim 7, characterized in that: In step 2, before mixing, vitamin C, vitamin B1, vitamin B2, folic acid and maltodextrin are pre-treated by fluidized bed coating at a weight ratio of 1:1 to obtain embedded microparticles. Then the embedded microparticles are mixed with the remaining components from step 2.

9. The method for preparing a multivitamin formula according to claim 7, characterized in that: In step 1, before mixing, the xylooligosaccharides and inulin are premixed at a weight ratio of 1:(1.3-1.5) and dried at 30℃-40℃ for 30-60 minutes to reduce the moisture content to ≤3%, and then mixed with the remaining components of step 1.

10. The method for preparing a multivitamin formula according to claim 7, characterized in that: Both the first and second mixers are three-dimensional motion mixers, and the filling rate during the mixing process is controlled at 40%-60%.

Images