Wearable light-regulation cap for skull marrow targeting based on projection positioning of brain function area

Abstract

The application discloses a multifunctional regulation cap type light device based on skull bone marrow-brain function area mapping, and belongs to the technical field of photobiomodulation, transcranial light regulation, neural immune regulation, brain function area positioning and wearable medical device. The device comprises a cap type carrier, a light source array, a function mode selection module, a control unit and a telescopic quasi-direct touch light spot cylinder assembly. After a user selects an emotion, pain, movement, cognition, sleep or visual function irradiation mode through the function mode selection module, the control unit calls corresponding irradiation parameters, irradiation timing and target skull surface projection area, drives the light source unit in the target irradiation partition to work, and keeps the non-target partition light source unit in a closed state. Each light source unit is composed of a telescopic quasi-direct touch light spot cylinder assembly, can adapt to local head curvature through independent telescoping and universal swinging, and can guide light energy to the skull lamella layer in a collimating manner.

Description

Technical Field

[0001] This invention belongs to the field of photobiological regulation, specifically the field of transcranial photomodulation, and more specifically, it is a wearable photomodulation cap for targeted bone marrow targeting based on brain functional area projection localization. Background Technology

[0002] Transcranial photobiological modulation technology involves irradiating the head region with red or near-infrared light to regulate the functional state of brain tissue, meningeal lymphatic vessels, blood vessels, or neural networks. In recent years, it has been widely explored for improving brain functions such as mood, cognition, pain, and sleep. Existing transcranial photobiological modulation devices typically employ helmet-style, cap-style, headband-style, or handheld structures. Their light source arrangements mainly include continuous emitting surfaces, uniform LED grids, a small number of high-power LEDs, or several fixed light source modules. The design focus is often on increasing light penetration depth, expanding the irradiation area, or enhancing the total output power.

[0003] The skull consists of three layers: the outer table, the diploice, and the inner table, with the diploice layer containing bone marrow tissue. The skull diploice bone marrow is adjacent to the dura mater and the central nervous system, and connects with the meningeal immune environment through skull-meningeal pathways, forming a neuroimmunological regulatory interface located superficially beneath the scalp and adjacent to the meninges. However, current transcranial optical devices generally treat the skull merely as a physical barrier for light penetration, optimizing deep penetration with the brain parenchyma as the final target. They fail to structurally design the superficial skull diploice bone marrow as the primary light energy deposition target layer, resulting in a mismatch between light energy distribution and the superficial, discrete, and regionally differentiated distribution characteristics of the diploice bone marrow.

[0004] On the other hand, existing devices mostly employ uniform irradiation of the entire head or fixed-area irradiation, without spatially coding and zoning based on the projection of brain functional areas onto the skull surface. This makes it impossible to implement differentiated zoning irradiation schemes for different brain functional networks such as emotion, pain, movement, cognition, sleep, and vision. In the suture zone, due to the low bone marrow content and different light scattering characteristics compared to the diploic area, uniform irradiation can easily lead to ineffective irradiation or localized heat accumulation; while in areas rich in bone marrow, uniform irradiation may result in insufficient irradiation dose due to energy dispersion.

[0005] Furthermore, existing cap-type irradiation devices typically embed the light source directly within the flexible cap or rigid shell, lacking an optical component that can independently extend and retract, adapt to local skull curvature, limit the beam divergence angle, and provide feedback on the fit. This leads to the following problems: First, individual differences in head shape and local curvature prevent some light sources from fully fitting the scalp, causing the actual light energy dose entering the tissue to deviate from the designed value; second, the divergent beam emitted from exposed LEDs or wide-angle light sources forms a diffuse spot on the scalp surface, with light energy spreading laterally along the superficial layers of the scalp, causing both dose uncertainty in the target area and unintended irradiation of adjacent non-target areas; third, lateral crosstalk between adjacent light sources further weakens spatial irradiation selectivity, making it difficult to meet the requirements for clear spot boundaries in diploic bone marrow targeted irradiation.

[0006] In summary, existing transcranial photodynamic therapy devices have significant shortcomings in target layer selection, spatial coding and zoning control, and structural design adapted to shallow discrete target points. Summary of the Invention

[0007] To address the aforementioned technical problems, this invention provides a skull bone marrow-targeted wearable light-modulated cap based on brain functional area projection localization, thereby resolving the issues in the prior art.

[0008] A wearable, light-modulated cap for targeted bone marrow localization based on brain functional area projection includes: A cap-shaped support device, configured to be worn on the subject's head; A light source array is disposed inside the cap-shaped support body, and the light source array includes multiple light source units that correspond to different projection areas of the skull surface. The function mode selection module allows users to select the function illumination mode; The control unit is used to control the light source units in the corresponding target illumination zone to work according to the illumination parameters and illumination sequence, and to keep the light source units in the non-target zone in the off state. The light source unit is configured as a telescopic quasi-direct light spot tube assembly, which includes a universal floating base, a damping telescopic tube, a light source chip, a collimating optical group, an aperture stop, a cylindrical optical isolation wall, a central transparent light-emitting window, a flexible annular fitting lip located on the outer periphery of the central transparent light-emitting window, and a contact sensing structure. The light source unit is fitted to the local scalp through the damping telescopic tube, the universal floating base, and the flexible annular fitting lip, so that the light emitted by the light source unit enters the scalp in a collimated or near-collimated manner and is mainly deposited in the intracranial diploic layer or the area adjacent to the diploic layer.

[0009] Preferably, the light source array is arranged according to 10-10 EEG spatial positioning reference points and in conjunction with the bone suture avoidance area; the bone suture avoidance area is not provided with light source units, or the control unit keeps the light source units in the corresponding area in a closed state in each functional irradiation mode.

[0010] Preferably, the central transparent light-emitting window is located in the central light-transmitting area of ​​the scalp contact end of the telescopic quasi-direct light-transmitting tube assembly, and the flexible annular fitting lip is only arranged around the outer periphery of the central transparent light-emitting window to form an annular pressing contact surface, without obstructing the central light-transmitting area.

[0011] Preferably, the function mode selection module includes at least one of the following: emotion control button, pain control button, motor function control button, cognitive function control button, sleep rhythm control button, and visual function control button.

[0012] Preferably, the function mode selection module stores or recalls the correspondence between the function irradiation mode and the target brain functional area, the target skull surface projection area, the target irradiation zone, the irradiation parameters, and the irradiation timing; the control unit starts the light source unit in the target irradiation zone according to the correspondence, without redetermining the target irradiation zone based on the bonding signal.

[0013] Preferably, the control unit is configured to start the light source unit in the corresponding target irradiation zone according to the target skull surface projection area corresponding to the function irradiation mode after the user selects the function irradiation mode; the contact sensing structure outputs the contact pressure, displacement or capacitance signal to determine whether the light emission permission condition is met, whether to pause irradiation or whether to trigger an alarm, and not to change the target skull surface projection area or the target irradiation zone.

[0014] Preferably, each light source unit or group of light source units is equipped with a temperature sensor and / or a photodetector. The control unit dynamically adjusts the output power, duty cycle, irradiation duration or irradiation interval of the light source unit according to the local temperature, tissue diffuse reflection signal, light output power or optical coupling state.

[0015] Preferably, the light source unit includes at least one of LED, VCSEL, laser diode or OLED light source, and emits red light and / or near-infrared light in the range of 600 to 1100 nanometers; the irradiation parameters include at least one of wavelength, output power, pulse frequency, duty cycle, single irradiation duration, regional irradiation sequence, multi-region synchronous irradiation parameters or multi-region alternating irradiation parameters.

[0016] Compared with the prior art, the present invention has the following beneficial effects: First, a fundamental improvement in target layer selection. This invention uses the skull diploic bone marrow as the primary target layer for photoelectric energy deposition, rather than treating it as a barrier to light penetration. This transforms the device from a single pathway of "penetrating the skull to irradiate the brain parenchyma" to a structured regulatory pathway of "targeting the superficial skull bone marrow-meningeal neuroimmune interface," fundamentally changing the target layer for photoelectric energy delivery.

[0017] Second, the spatial adaptability of the light source arrangement to the target area distribution. This invention establishes a correspondence between the light source distribution and the distribution of the skull diploic bone marrow region, the projection area of ​​the brain functional area on the skull surface, and the suture avoidance area, enabling single-area fixed-point irradiation, multi-area synchronous irradiation, or multi-area alternating irradiation, which is different from the indiscriminate irradiation method of existing uniform LED caps.

[0018] Third, functional mode-driven spatial coding zoning control. This invention triggers a preset spatial coding irradiation program through a functional mode selection module, so that different functional modes such as emotion, pain, movement, cognition, sleep, and vision correspond to their respective target skull regions, irradiation parameter allocations, and irradiation timing schemes, thereby achieving selective matching between functional requirements and irradiation schemes.

[0019] Fourth, the adaptive structure with multi-point independent bonding. This invention constructs each light source unit as a telescopic quasi-direct contact light spot tube assembly, enabling each light spot to have independent telescopic, damped bonding, universal swing angle, circumferential pressing, and bonding feedback capabilities. From a mechanical structure perspective, this ensures reliable bonding between each light source unit and different individuals and different local cranial curvatures.

[0020] Fifth, the structural synergy between beam orientation and crosstalk suppression. This invention, through the combination of collimating optical group, aperture stop, cylindrical optical isolation wall and central transparent exit window, enables the emitted beam to enter the tissue with a limited divergence angle along the local scalp normal direction, reducing the dose uncertainty caused by wide-angle divergent irradiation at the source, while structurally suppressing lateral light crosstalk between adjacent light source units.

[0021] Sixth, a systematic improvement in safety. This invention enhances the safety of the device from three levels: wearing calibration, process monitoring, and dose closed-loop, through multiple safety mechanisms, including target irradiation zone poor fit alarm, non-target zone abnormal contact alarm, forced shutdown of non-target zones, and temperature / diffuse reflection feedback dose correction. Attached Figure Description

[0022] Figure 1 This is a schematic diagram of the overall structure of the hat-shaped lighting device of the present invention; Figure 2 This is a schematic diagram of the relationship between the light source array and the functional projection lighting (gray) on the skull surface of the present invention; Figure 3This is a schematic cross-sectional view of the telescopic quasi-direct photosensitive spot cylinder assembly of the present invention; Figure 4 This is a schematic diagram of the spatial coding illumination control process of the present invention. Detailed Implementation

[0023] The embodiments of the present invention will be described in further detail below with reference to the accompanying drawings and examples. The following examples are for illustrative purposes only and should not be construed as limiting the scope of the invention.

[0024] For ease of description, in this manual, "proximal end" refers to the end closest to the outer support layer of the cap-type carrier, and "distal end" refers to the end closest to the subject's scalp; "target irradiation zone" refers to one or more zones that the control unit determines need to activate the light source unit for irradiation in the current functional irradiation mode; "non-target zone" refers to other zones besides the target irradiation zone.

[0025] Example 1: Overall Structure and Zoning Layout of the Hat-Type Illumination Device like Figure 1 As shown, the present invention provides a multifunctional adjustable cap-type illumination device based on skull bone marrow-brain functional area mapping, mainly comprising: a cap-type carrier 100, a light source array 200, a control unit 400, a function mode selection module 500, and a power supply unit. The cap-type carrier 100 is configured to be detachably worn on the subject's head.

[0026] The cap-shaped support body 100 comprises, from the outside in, an outer support layer, a flexible partition module, and a replaceable flexible fitting pad. The outer support layer maintains the overall shape of the device and provides a mounting base for the light source array 200 and the control unit 400. The flexible partition module, made of medical-grade silicone, supports different target irradiation zones. The edge of the cap-shaped support body 100 has a retractable annular head circumference adjustment strap, which can be stretched or contracted to adapt to different subject head circumference sizes. The flexible partition module internally houses power supply and control signal lines, and divides the cap into several independent flexible partitions through multiple elastic connecting bridges. The partitions can undergo relative displacement and deformation through the elastic connecting bridges, thereby adapting to differences in head shape between individuals. The inner replaceable fitting pad layer cushions wearing pressure and absorbs local sweat, and can be removed and replaced after use.

[0027] The light source array 200 is disposed on the inner surface of the flexible partition module. The light source array 200 includes multiple light source units, which are arranged on the inner side of the cap-type support 100 according to the following principles: (1) Using the international 10-10EEG system spatial positioning reference point as the benchmark, the skull surface projection coordinates of each main electrode site are used as the layout anchor points of the light source unit, so that the position of each light source unit is established in correspondence with the corresponding skull surface projection area.

[0028] (2) In accordance with the principle of avoiding sutures, no light source units are set in the areas where the coronal suture, sagittal suture, chevron suture and squamous suture of the human skull are located; if light source units are set in the above-mentioned suture areas due to the need for regular array arrangement, the control unit 400 is configured to keep the light source units corresponding to the above-mentioned suture areas in a forced off state in all function irradiation modes, so as to avoid ineffective irradiation or local heat accumulation in the suture areas.

[0029] like Figure 2 As shown, each light source unit is divided into multiple functional zones according to its projection position on the skull surface. One or more light source units within the same zone are uniformly driven by the control unit 400 to form a "target illumination zone" to achieve targeted illumination of the projection area on the skull surface of a specific brain functional area.

[0030] Example 2: Specific Structure of Telescopic Quasi-Direct Photosensitive Spot Cylinder Assembly Combination Figure 3 As shown, in this embodiment, each light source unit independently constitutes a telescopic quasi-direct contact light spot tube assembly 300 (hereinafter referred to as "light spot tube assembly"). The light spot tube assembly 300 includes, from the proximal end to the distal end along its axial direction: a universal floating seat 310, a damping telescopic tube 320, a light source chip 330, a collimating optical group 340, an aperture stop 350, a cylindrical optical isolation wall 360, a central transparent light exit window 370, a flexible annular bonding lip 380, and a contact sensing structure 390.

[0031] A omnidirectional floating seat 310 is disposed at the proximal end of the beam tube assembly 300 for connecting the beam tube assembly 300 to the outer support layer of the cap-type carrier 100. The omnidirectional floating seat 310 is a spherical hinge seat, which allows the beam tube assembly 300 to oscillate relative to the cap-type carrier 100 at a predetermined angle, ranging from ±15° to ±30°. This allows the optical axis of the beam tube assembly 300 to adapt to the local curvature of the skull and remain substantially perpendicular to the local scalp surface. In other feasible embodiments, the omnidirectional floating seat 310 may also be a flexible hinge seat or an elastic self-centering seat.

[0032] The damping telescopic cylinder 320 is connected to the distal end of the universal floating seat 310. The damping telescopic cylinder 320 includes an inner cylinder and an outer cylinder coaxially sleeved together, with the inner cylinder capable of sliding axially within the outer cylinder. A spring element and a friction damping sleeve are provided between the outer and inner cylinders. The friction damping sleeve provides a controllable damping force to prevent excessive vibration of the spotlight assembly 300 due to head movement during dynamic use. A limiting step is also provided between the outer and inner cylinders to limit the effective extension and retraction stroke of the damping telescopic cylinder 320. Optionally, a displacement sensor may also be installed within the damping telescopic cylinder 320 to detect the amount of extension and retraction displacement in real time and transmit the displacement signal to the control unit 400.

[0033] The light source chip 330 is fixedly disposed at the far end of the internal cavity of the inner cylinder. The light source chip 330 can be selected from at least one of the following: a self-emissive light-emitting diode, a vertical-cavity surface-emitting laser, a laser diode, an organic light-emitting diode, or a miniature integrated light source module. The light source chip 330 is electrically connected to the control unit 400 and the power supply unit via a flexible circuit board.

[0034] The collimating optics group 340 is positioned at the far end of the light-emitting direction of the light source chip 330. The collimating optics group 340 is used to convert the diverging beam emitted by the light source chip 330 into a collimated beam or a near-collimated beam. The collimating optics group 340 can be one or a combination of collimating lenses, total internal reflection lenses, parabolic reflectors, graduated refractive index lenses, microlens arrays, or short-focal-length collimating lenses.

[0035] An aperture stop 350 is positioned on the far-end light-emitting side of the collimating optics group 340. The aperture stop 350 has a central circular through-hole. The aperture stop 350 is used to intercept large-angle off-axis rays and stray rays in the beam emitted from the collimating optics group 340, thus controlling the divergence angle of the emitted beam within a small range. Through the coordinated operation of the collimating optics group 340 and the aperture stop 350, the emitted beam of the beam tube assembly 300 has a limited divergence angle, avoiding the wide-angle divergence illumination problem common in exposed LED light sources.

[0036] A cylindrical optical isolation wall 360 is disposed inside the inner cylinder, extending from the proximal end of the light source chip 330 to the proximal end of the central transparent light-emitting window 370, forming a closed or semi-closed optical path channel. The inner wall of the cylindrical optical isolation wall 360 is provided with a light-absorbing layer and / or a reflective layer. Specifically, the light-absorbing layer can be a black matting layer, and the reflective layer can be a metallic reflective layer, or a composite light-absorbing and reflective layer. The cylindrical optical isolation wall 360 works in conjunction with the aperture stop 350 to effectively suppress off-axis light and lateral crosstalk between adjacent light source units, ensuring that the emitted light energy of each spot tube assembly 300 primarily acts on the local scalp area directly below it.

[0037] A central transparent light-emitting window 370 is located at the center of the distal end face of the beam tube assembly 300. The central transparent light-emitting window 370 is made of a high-transmittance optical material, such as optical glass or polycarbonate. The central transparent light-emitting window 370 forms a central light-passing area for allowing collimated or near-collimated beams to exit and enter the scalp without obstruction.

[0038] The flexible annular fitting lip 380 is only positioned around the outer periphery of the central transparent light-emitting window 370, without obstructing the central light-transmitting area. The flexible annular fitting lip 380 is made of medical-grade silicone. The distal surface of the flexible annular fitting lip 380 protrudes from the distal surface of the central transparent light-emitting window 370, preferentially contacting the scalp and undergoing elastic deformation during wear to form a ring-shaped sealing and pressing contact surface. This annular lip structure can effectively block ambient light and improve light coupling efficiency, while, since it is only positioned around the outer periphery of the light-emitting window, it does not obstruct the emitted light beam at all.

[0039] The contact sensing structure 390 is disposed inside or near the flexible annular fitting lip 380. The contact sensing structure 390 can be one or more combinations of a pressure sensor, a displacement sensor, or a capacitance sensor. The contact sensing structure 390 is signal-connected to the control unit 400 and is used to output a contact signal reflecting the fitting state to the control unit 400.

[0040] Example 3: Specific Implementation of Functional Mode Selection and Spatial Coding Control like Figure 1 and Figure 4 As shown, the function mode selection module 500 is located externally to the cap-type carrier 100 or wirelessly connected to the control unit 400. The function mode selection module 500 includes emotion control buttons, pain control buttons, motor function control buttons, cognitive function control buttons, sleep rhythm control buttons, and visual function control buttons. Each button may have a corresponding indicator light to indicate the currently activated function mode. In other embodiments, the function mode selection module 500 may also be one or more combinations of a knob, a touchscreen, a remote control button, or an application interface installed on a smart mobile terminal.

[0041] The control unit 400 is disposed inside or on the outer surface of the outer support layer of the cap-type carrier 100. The control unit 400 includes a microprocessor with an integrated storage module. The storage module pre-stores a spatial coding table, which defines the correspondence between various functional irradiation modes and target brain functional areas, target skull surface projection areas, target irradiation zones, irradiation parameters, and irradiation timing. The irradiation parameters include, but are not limited to: wavelength, output optical power, power density, energy density, pulse frequency, duty cycle, single irradiation duration, regional irradiation sequence, multi-region synchronous irradiation parameters, and multi-region alternating irradiation parameters.

[0042] Control unit 400 is configured to execute the following spatially encoded illumination control logic, refer to Figure 4 : Step 1: Receive the function mode selection signal generated by the function mode selection module 500. For example, when the user presses the emotion control button, the control unit 400 receives the trigger signal corresponding to the "emotion control mode".

[0043] Step 2: Based on the function mode selection signal, retrieve all parameters corresponding to the irradiation mode from the storage module, including the target brain functional area identifier, the coordinates of the target skull surface projection area, the list of light source unit numbers of the target irradiation zone, and the corresponding irradiation parameters and irradiation timing.

[0044] Step 3: Based on the coordinates of the target skull surface projection area, determine the target illumination zone to be activated. Taking the emotion regulation mode as an example, the control unit 400 determines the zone corresponding to the skull surface projection area related to the prefrontal cortex as the target illumination zone, which contains several corresponding light source units.

[0045] Step Four: The control unit 400 only drives the light source units within the target illumination zone to operate according to the corresponding illumination parameters, while simultaneously forcing all light source units in non-target zones to remain off. It is particularly important to emphasize that the target illumination zone determined in Step Four is entirely determined by the function mode selection signal received in Step One. The contact pressure signal, displacement signal, or capacitance signal output by the contact sensing structure 390 is not used to change, recalculate, or redetermine the target illumination zone. In other words, even if a light source unit in a non-target zone detects a contact signal, the control unit 400 maintains its off state; even if individual light source units in the target zone have poor contact, the control unit 400 will not transfer the illumination task to other non-target zones.

[0046] Step 5: During the irradiation process, the control unit 400 continuously receives feedback signals from the contact sensing structure 390, the temperature sensor, and the photodetector. However, the above feedback signals are only used to perform light emission permission judgment, suspend irradiation, trigger alarm, or correct irradiation dose, and are not used as the basis for changing the target irradiation zone.

[0047] Example 4: Closed-loop implementation of fit detection, safety alarm and dose feedback control (a) Light emission permission judgment and fit alarm Before and during step four, the control unit 400 continuously receives contact signals output by the contact sensing structures 390 of each beam tube assembly 300. For each light source unit within the target irradiation zone, the control unit 400 executes the following judgment logic: The contact signal is compared with a preset bonding threshold. When the contact signal reaches or exceeds the preset bonding threshold, the light source unit is determined to meet the light emission permission conditions; when the contact signal is below the preset bonding threshold, the light source unit is determined to have poor bonding.

[0048] If the fit signal of any light source unit in the target illumination zone is lower than a preset threshold, the control unit 400 performs the following operations: (1) suspends the light output of all light source units in the target illumination zone; (2) triggers an alarm structure to emit an audible, vibrating, or display alarm signal to prompt the user to adjust the wearing position; (3) displays the specific location of the poorly fitted light source unit on the optional display screen. After the user readjusts the wearing position, the control unit 400 re-detects the fit signal. When all light source units in the target zone meet the light output permission conditions, the illumination is automatically restored, or the user can manually restore the illumination by pressing the confirmation button.

[0049] (ii) Abnormal contact alarm in non-target zone When the contact sensing structure 390 of the light source unit in the non-target zone detects an abnormal contact signal exceeding a preset threshold, the control unit 400 determines that the hat has shifted overall, the restricted area has been accidentally compressed, or there has been abnormal contact in the non-target zone. In this case, the control unit 400 immediately suspends all illumination and triggers an alarm, prompting the user to re-wear and recalibrate the hat position. Conversely, when no abnormal contact signal is detected by any of the light source units in the non-target zone, the control unit 400 keeps the light source units in the non-target zone switched off.

[0050] (III) Temperature Feedback and Thermal Safety Control A temperature sensor is disposed near the central transparent light-emitting window 370 of each light spot tube assembly 300 or on the substrate of the light source chip 330. The temperature sensor is signal-connected to the control unit 400.

[0051] The control unit 400 executes the following temperature grading control logic: when the local temperature reaches or exceeds the first temperature threshold, the output power of the light source unit is automatically reduced; when the local temperature reaches or exceeds the second temperature threshold, the irradiation of the light source unit is automatically suspended until the temperature drops back to a safe range and then resumes; when the local temperature reaches or exceeds the third temperature threshold, a high temperature emergency alarm is triggered and all irradiation is forcibly terminated.

[0052] (iv) Diffuse feedback and dose correction Each beam tube assembly 300 has a photodetector disposed on the inner wall of its cylindrical optical isolation wall 360 or around its central transparent light-emitting window 370. The photodetector is used to receive a portion of the emitted light signal diffusely reflected back from the scalp and skull tissue, and to transmit the diffuse reflection light intensity signal to the control unit 400.

[0053] The control unit 400 dynamically adjusts the output power, pulse duty cycle, single irradiation duration, and irradiation interval duration of the light source unit in each target irradiation zone according to the diffuse reflection light intensity signal, so as to maintain the actual light energy dose deposited in the bone marrow layer of the barrier within a preset range.

[0054] Example 5: Operation and Working Principle of the Device This embodiment describes in detail the operation and usage process of the hat-shaped illumination device of the present invention.

[0055] Wearing procedure: The subject wears the cap-type support 100 on their head and adjusts the retractable annular head circumference adjustment strap to a suitable tightness. During the wearing process, the flexible annular fitting lip 380 of each beam tube assembly 300 preferentially contacts the scalp. Under the pre-pressure of the spring element, the damping telescopic cylinder 320 adaptively retracts axially. At the same time, the universal floating seat 310 drives the beam tube assembly 300 to swing in all directions, so that the optical axis of the central transparent light window 370 is basically perpendicular to the local scalp surface. Finally, each beam tube assembly 300 independently and adaptively fits the curvature surface of the subject's skull.

[0056] Mode selection steps: The subject presses the corresponding button on the function mode selection module 500 according to their own needs. The corresponding indicator light illuminates, indicating that the function mode has been successfully selected.

[0057] Start-up and Irradiation Procedure: After receiving the mode selection signal, the control unit 400 automatically executes steps two to four as described in Example 3. First, a self-test for fit is performed: If a poorly fitted light source unit exists within the target irradiation zone, the control unit 400 triggers an alarm and pauses light emission until the user adjusts the settings and the test is repeated; if all light emission conditions are met, the control unit 400 drives the light source units within the target irradiation zone to begin emitting light according to the called irradiation parameters. The collimated beam exits through the central transparent light-emitting window 370, passes through the scalp, and is primarily deposited in the outer table and diploic layer of the skull. Light source units outside the target zone remain off.

[0058] Irradiation monitoring steps: During irradiation, the control unit 400 monitors the signals from the temperature sensor and photodetector in real time, dynamically adjusting the output power and irradiation sequence to ensure thermal and dose safety. If the temperature or adhesion signal is abnormal at any time, the control unit 400 executes pause, alarm, or power correction according to the logic of Embodiment 4.

[0059] End procedure: After the preset single irradiation duration is reached, the control unit 400 automatically shuts down all light source units and issues an end prompt. The subject unlocks the head circumference adjustment strap and removes the cap-type support 100.

[0060] In summary, the cap-type phototherapy device of the present invention, through the above-mentioned structural design and control logic, precisely delivers light energy to the superficial neuroimmune target of the skull diploic bone marrow, realizing transcranial photobiological modulation based on the functional selectivity, spatial coded nature, and safe closed-loop controllability of the projection of brain functional areas onto the skull surface.

[0061] The embodiments of the present invention are given for the purposes of illustration and description. Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention. Those skilled in the art can make changes, modifications, substitutions and variations to the above embodiments within the scope of the present invention.

Claims

1. A wearable, light-modulated cap for targeted bone marrow localization based on brain functional area projection, characterized in that, include: A cap-shaped support device, configured to be worn on the subject's head; A light source array is disposed inside the cap-shaped support body, and the light source array includes multiple light source units that correspond to different projection areas of the skull surface. The function mode selection module allows users to select the function illumination mode; The control unit is used to control the light source units in the corresponding target illumination zone to work according to the illumination parameters and illumination sequence, and to keep the light source units in the non-target zone in the off state. The light source unit is configured as a telescopic quasi-direct light spot tube assembly, which includes a universal floating base, a damping telescopic tube, a light source chip, a collimating optical group, an aperture stop, a cylindrical optical isolation wall, a central transparent light-emitting window, a flexible annular fitting lip located on the outer periphery of the central transparent light-emitting window, and a contact sensing structure. The light source unit is fitted to the local scalp through the damping telescopic tube, the universal floating base, and the flexible annular fitting lip, so that the light emitted by the light source unit enters the scalp in a collimated or near-collimated manner and is mainly deposited in the intracranial diploic layer or the area adjacent to the diploic layer.

2. The skull and bone marrow targeted wearable light-modulating cap based on brain functional area projection localization as described in claim 1, characterized in that: The light source array is arranged according to 10-10 EEG spatial positioning reference points and in combination with the bone suture avoidance area; no light source unit is set in the bone suture avoidance area, or the control unit keeps the light source unit in the corresponding area in the off state in each functional irradiation mode.

3. The skull and bone marrow targeted wearable light-modulating cap based on brain functional area projection localization as described in claim 1, characterized in that: The central transparent light-emitting window is located in the central light-transmitting area of ​​the scalp contact end of the telescopic quasi-direct light spot tube assembly. The flexible annular fitting lip is only arranged around the outer periphery of the central transparent light-emitting window and forms an annular pressing contact surface, without obstructing the central light-transmitting area.

4. The skull and bone marrow targeted wearable light-modulating cap based on brain functional area projection localization as described in claim 1, characterized in that: The function mode selection module includes at least one of the following: emotion control button, pain control button, motor function control button, cognitive function control button, sleep rhythm control button, and visual function control button.

5. The skull and bone marrow targeted wearable light-modulating cap based on brain functional area projection localization as described in claim 1, characterized in that: The function mode selection module stores or recalls the correspondence between the function irradiation mode and the target brain functional area, the target skull surface projection area, the target irradiation zone, the irradiation parameters, and the irradiation timing; the control unit starts the light source unit in the target irradiation zone according to the correspondence, without redetermining the target irradiation zone based on the bonding signal.

6. The skull and bone marrow targeted wearable light-modulating cap based on brain functional area projection localization as described in claim 1, characterized in that: The control unit is configured to start the light source unit in the corresponding target irradiation zone according to the target skull surface projection area corresponding to the function irradiation mode after the user selects the function irradiation mode; the contact sensing structure outputs the contact pressure, displacement or capacitance signal to determine whether the light emission permission condition is met, whether to pause irradiation or whether to trigger an alarm, and not to change the target skull surface projection area or the target irradiation zone.

7. The skull and bone marrow targeted wearable light-modulating cap based on brain functional area projection localization as described in claim 1, characterized in that: Each light source unit or group of light source units is equipped with a temperature sensor and / or a photodetector. The control unit dynamically adjusts the output power, duty cycle, irradiation duration, or irradiation interval of the light source unit based on local temperature, tissue diffuse reflection signal, light output power, or optical coupling state.

8. The skull and bone marrow targeted wearable light-modulating cap based on brain functional area projection localization as described in claim 1, characterized in that: The light source unit includes at least one of LED, VCSEL, laser diode or OLED light source, and emits red light and / or near-infrared light in the range of 600 to 1100 nanometers; the irradiation parameters include at least one of wavelength, output power, pulse frequency, duty cycle, single irradiation duration, regional irradiation sequence, multi-region synchronous irradiation parameters or multi-region alternating irradiation parameters.

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