Test tube container used in sample analyzer, and sample analyzer

Abstract

The utility model provides a test tube container used in a sample analysis device and the sample analysis device. The test tube container comprises a test tube main body used for containing a reagent, and the reagent is a quality control product or a cleaning solution; the tube cover is used for sealing the tube opening of the test tube main body and comprises a cover main body, puncture flexible glue and a composite film which are connected in sequence, a puncture area is formed at the top of the cover main body, an opening is formed in the puncture area and used for the sample suction needle to penetrate through, the puncture flexible glue covers the opening and is in interference fit with the tube opening of the test tube main body for sealing, and the bottom surface of the puncture flexible glue is welded with the inner layer of the composite film; and the puncture soft rubber is made of TPE (thermoplastic elastomer). According to the test tube container, the opening of the puncture area of the tube cover is sealed by using the puncture soft rubber made of the TPE material, so that the puncture soft rubber does not generate slag falling and hole phenomena due to multiple times of puncture, and the air tightness requirements of multiple times of puncture and multiple times of reverse uniform mixing of a sample suction needle are met; the composite film and the puncture flexible glue are welded together, and the outer layer of the composite film is in contact with the reagent in the tube, so that the compatibility of the tube cover and the reagent in the tube is ensured.

Description

Technical Field

[0001] The utility model relates to the technical field of medical consumables, in particular to a test tube container used in a sample analysis device and the sample analysis device. Background Art

[0002] Medical laboratories need to perform quality control or special cleaning on sample analysis devices, such as blood cell analysis devices. The current common quality control or special cleaning method is to place the test tube containing quality control products or cleaning fluid on the sample tube rack, send it to the sample suction device through the injection device, and use the sample suction needle to take the liquid in the test tube for quality control or special cleaning. Since the quality control products in the test tube can be used for multiple quality control of the instrument, a cleaning procedure requires the sample suction needle to suck the cleaning fluid in the test tube multiple times, so both quality control and special cleaning require multiple punctures of the test tube.

[0003] The existing multiple puncture tube covers on the market often use screw caps or non-screw caps, which are sealed by interference fit between an independent butyl rubber or silicone plug and the mouth of the reagent container, and the tube cover presses the rubber or silicone plug to prevent the rubber or silicone plug from falling out or leaking after multiple punctures. However, the existing tube covers still have many defects, such as:

[0004] 1) The existing soft rubber material that meets the compatibility of reagents is generally butyl rubber, but butyl rubber is prone to falling off after multiple punctures, which poses a risk of needle clogging. Moreover, after multiple punctures, large voids are likely to appear in the middle of the soft rubber, which cannot meet the requirements of sealed storage and inversion mixing of quality control products.

[0005] 2) The soft rubber and the tube cover are independently arranged. When the sample suction needle punctures, the soft rubber is easily displaced by the sample suction needle, which affects the sealing performance of the soft rubber.

[0006] 3) Using silicone to seal the mouth of the reagent container can meet the requirements of multiple punctures, but silicone has poor compatibility with reagents (such as blood quality control products or cleaning fluids), and silicone has poor water vapor resistance. If left for a long time, the reagent is easy to evaporate and the reagent volume is reduced.

[0007] Therefore, a novel test tube container is needed to solve the above-mentioned technical problems. Utility Model Content

[0008] In order to solve the above technical problems, the utility model provides a test tube container used in a sample analysis device and a sample analysis device. The test tube container is suitable for multiple punctures by a sample suction needle.

[0009] The first aspect of the utility model provides a test tube container used in a sample analysis device, which is suitable for multiple punctures by a sample suction needle. The test tube container comprises:

[0010] The test tube body is used to hold reagents, which are quality control products or cleaning solutions;

[0011] The tube cover is connected to the test tube body and is used to seal the tube mouth of the test tube body. The tube cover includes a cover body, a puncture soft glue and a composite film which are connected in sequence. A puncture area is formed on the top of the cover body. An opening is provided at the puncture area for the sample suction needle to pass through. The puncture soft glue covers the opening of the puncture area and is sealed with an interference fit with the tube mouth of the test tube body. The bottom surface of the puncture soft glue is welded to the inner layer of the composite film, wherein the material of the puncture soft glue is TPE.

[0012] In an optional embodiment, the puncture soft rubber is made of TPO and the cover body is made of PP.

[0013] In an optional embodiment, the cover body and the puncture soft glue are integrally formed by secondary injection molding or two-color injection molding or are welded and sealed.

[0014] In an optional embodiment, the inner layer where the composite film is welded to the puncture soft glue is made of CPP material, and the outer layer of the composite film in contact with the reagent meets the reagent compatibility requirements.

[0015] In an optional embodiment, the tube cover is connected to the test tube body via threads.

[0016] In an optional embodiment, the welding method is ultrasonic welding, thermal welding or laser welding.

[0017] In an optional embodiment, the thickness of the puncture soft glue is 2 to 4 mm.

[0018] In an optional embodiment, the thickness of the composite film is less than 1 mm.

[0019] A second aspect of the present invention provides a sample analysis device, comprising:

[0020] A sample suction device is used to suck the sample in the sample tube or the quality control product or cleaning liquid in the test tube container through a sample suction needle; wherein the test tube container is any one or more of the test tube containers described above.

[0021] In an optional embodiment, the sample analysis device is a blood cell analysis device.

[0022] In an optional embodiment, the sample analysis device further comprises a sample tube mixing gripper, which grasps the sample tube or test tube container in the sample rack through a clamp and performs inversion mixing.

[0023] Compared with the prior art, the test tube container of the utility model utilizes the puncture soft rubber made of TPE material to seal the opening of the puncture area of ​​the tube cover, and has an interference fit with the tube mouth of the test tube body. The puncture soft rubber made of TPE material will not produce debris or holes due to multiple punctures, and can meet the airtightness requirements of multiple punctures and multiple inversions and mixing by the sample suction needle. At the same time, the composite film and the puncture soft rubber are fixed together by welding, and the outer layer of the composite film is in contact with the reagent in the test tube container, which ensures the compatibility of the tube cover and the reagent in the tube, and avoids the problem of reagent volatilization and reagent volume reduction due to long-term storage.

[0024] The above-mentioned technical features can be combined in various technically feasible ways to produce new implementation schemes, as long as the purpose of the present utility model can be achieved. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] The present invention will be described in more detail below based on non-limiting embodiments and with reference to the accompanying drawings, wherein:

[0026] Figure 1 A schematic diagram showing the split structure of the tube cover of the test tube container used in the sample analysis device according to the present utility model is shown;

[0027] Figure 2 Shows Figure 1 A schematic cross-sectional view of the entire tube cover;

[0028] Figure 3 The test tube body of the test tube container used in the sample analysis device according to the present invention is shown;

[0029] Figure 4 shows a schematic structural diagram of a sample analysis device according to the utility model;

[0030] Figure 5 Shows Figure 4 Schematic diagram of the structure of the sample tube mixing gripper of the sample analysis device.

[0031] In the figures, the same components are indicated by the same reference numerals. The figures are not drawn to scale.

[0032] Wherein, the accompanying drawings are marked as follows:

[0033] 1. Tube cover; 11. Cover body; 12. Puncture soft glue; 13. Composite film; 14. Opening; 15. Puncture area;

[0034] 2. Test tube body;

[0035] 100. Sample tube mixing gripper; 101. Clamping claw; 200. Sample rack; 300. Sample injection device; 400. Sample suction device; 500. Sample tube or test tube container. DETAILED DESCRIPTION

[0036] The present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments. It should be noted that, as long as there is no conflict, the various embodiments and features in the various embodiments of the present invention can be combined with each other, and the resulting technical solutions are all within the protection scope of the present invention.

[0037] The parts not described in the present invention can be realized by adopting or drawing on the existing technology.

[0038] The quality control product in a quality control tube of a blood cell analysis device can be used for multiple quality control of the instrument. After each use, it will be stored in a refrigerated device for the next use. Before each puncture and aspiration by the aspirator, the quality control tube needs to be inverted and mixed. Currently, a quality control tube can be repeatedly punctured and used more than 20 times. Performing a special cleaning procedure requires the aspirator to puncture the tube multiple times to absorb the cleaning solution in the tube to clean multiple parts of the instrument or to clean a part multiple times. A cleaning solution tube will be punctured and used several times or even more than ten times.

[0039] After research, it was found that the existing test tube caps for puncture still have multiple defects for at least these two reagents, and thus there is a risk of affecting the accuracy of sample test results. First of all, the existing soft rubber material that meets the reagent compatibility (reagent compatibility: within the specified time, there is almost no physical or chemical reaction with the reagent, and it does not affect the performance of the reagent.) is generally butyl rubber, but butyl rubber is easy to fall off after multiple punctures, and there is a risk of needle blocking, which in turn affects the stability of the instrument and the accuracy of the test results. After multiple punctures, large voids are likely to appear in the middle of the soft rubber, which cannot meet the requirements of sealed storage and inversion mixing of quality control products. Although the existing technology can meet the sealing requirements of multiple punctures by using silicone seals, the compatibility of silicone with reagents (such as blood quality control products or cleaning fluids) is poor, and the water vapor resistance of silicone is poor. If left for a long time, the reagent will evaporate, the amount of reagent will decrease, and it will also affect the original performance of the reagent, and ultimately indirectly affect the accuracy of the test results. Secondly, in the existing test tube cover, the soft rubber or silicone is independently arranged between the tube cover. When the sample suction needle punctures, the soft rubber or silicone is easily displaced by the sample suction needle, which will also affect its sealing performance.

[0040] The first aspect of the utility model proposes a test tube container used in a sample analysis device, which is suitable for multiple punctures by a sample suction needle. The test tube container includes a test tube body 2 and a tube cover 1. The test tube body 2 is used to hold reagents, and the reagents held therein are quality control products or cleaning liquids, which are used to perform quality control or special cleaning on the sample analysis device; the tube cover 1 is connected to the test tube body 2 and is used to seal the tube mouth of the test tube body 2.

[0041] like Figure 1 and Figure 2As shown, the tube cover 1 includes a cover body 11, a puncture soft gel 12 and a composite film 13 connected in sequence. The top of the cover body 11 forms a puncture area 15, and an opening 14 is provided at the puncture area 15 for the sample suction needle to pass through. The material of the puncture soft gel 12 is TPE (thermoplastic elastomer). Among them, the top surface of the puncture soft gel 12 covers the opening 14 of the puncture area 15, and the puncture soft gel 12 and the tube mouth of the test tube body 2 are sealed by interference fit, and the bottom surface of the puncture soft gel 12 is welded to the inner layer of the composite film 13, and the outer layer of the composite film 13 is used to contact with the reagent.

[0042] The tube cover 1 of the test tube container of the utility model utilizes the puncture soft glue 12 made of TPE material without opening to seal the opening 14 of the puncture area 15 at the top of the tube cover 1, and has an interference fit with the tube mouth of the test tube body 2, so as to ensure the sealing effect of the tube cover 1. At the same time, the puncture soft glue 12 made of TPE material will not produce residue or holes due to multiple punctures, and has good water vapor resistance, so as to meet the sealing storage requirements after multiple punctures and the sealing requirements of multiple inversions and mixing.

[0043] In an optional embodiment, the material of the puncture soft glue 12 has the same material component as that of the cover body 11.

[0044] In an optional embodiment, the cover body 11 and the puncture soft gel 12 can be integrally formed by secondary injection molding or two-color injection molding. The cover body 11 and the puncture soft gel 12 are integrally formed by secondary injection molding or two-color injection molding, which can simplify the molding process of the tube cover 1. At the same time, the cover body 11 and the puncture soft gel 12 are injection molded so that the two are an integrated structure, which avoids the displacement of the puncture soft gel 12 due to puncture or multiple punctures by the sample suction needle, and improves the air tightness.

[0045] In addition, the cover body 11 and the puncture soft glue 12 can also be connected by welding sealing. The puncture soft glue 12 and the cover body 11 have the same material composition, which can meet the welding requirements of the puncture soft glue 12 and the cover body 11, ensure the firmness of the connection between the two, and also avoid the displacement of the puncture soft glue due to puncture by the sample suction needle or multiple punctures, so that the tube cover can meet the sealing requirements of multiple punctures.

[0046] In an optional embodiment, the cover body 11 is made of PP (polypropylene).

[0047] In an optional embodiment, in order to realize the welding connection between the puncture soft rubber 12 and the cover body 11, the cover body 11 is made of PP polypropylene material, and the puncture soft rubber material can be selected as TPO (thermoplastic polyolefin) material. The TPO material composition includes PP (polypropylene) and EPDM (ethylene propylene diene monomer rubber), which has the same PP material composition as the cover body 11, so it can meet the welding requirements of the puncture soft rubber 12 and the cover body 11, and realize the welding of the puncture soft rubber 12 and the cover body 11.

[0048] In an optional embodiment, since the inner layer of the composite film 13 and the puncture soft glue 12 need to be welded, the inner layer of the composite film 13 preferably has the same composition as the puncture soft glue 12. Optionally, the inner layer of the composite film 13 may be made of CPP (chlorinated polypropylene).

[0049] Since the outer layer of the composite membrane needs to be in contact with reagents (such as quality control products or cleaning solutions), if the reagent compatibility of the outer layer of the composite membrane is poor, it is easy to interact with the reagents in the tube, affecting the reagent effect, and then affecting the test results. Therefore, a material that meets the reagent compatibility requirements is selected. Preferably, the outer layer of the composite membrane is made of PET, which can be compatible with more types of reagents.

[0050] In addition, an intermediate layer may be provided between the inner layer and the outer layer of the composite film 13 as required, such as PVDC that is resistant to volatility and water vapor. Specifically, the material of the intermediate layer may be selected as required and is not limited here.

[0051] In other optional embodiments, the material of the cover body 11 can also be selected as HDPE (high-density polyethylene) material. In order to meet the welding requirements of the puncture soft rubber 12 and the cover body 11, the puncture soft rubber 12 can correspondingly select a soft rubber material with the same composition as the cover body 11.

[0052] In an optional embodiment, the tube cover 1 is connected to the test tube body 2 via threads.

[0053] In an optional embodiment, the cover body 11 and the puncture soft glue 12 are welded by, but not limited to, ultrasonic welding, heat welding, laser welding, etc. Similarly, the puncture soft glue 12 and the composite film 13 are welded by, but not limited to, ultrasonic welding, heat welding, laser welding, etc.

[0054] In an optional embodiment, in order to ensure smoother puncture of the sample aspiration needle and better sealing after multiple punctures, the thickness of the puncture soft glue 12 can be selected to be 2 to 4 mm.

[0055] Furthermore, the thickness of the composite film 13 is less than 1 mm.

[0056] like Figure 4 As shown, the second aspect of the present invention provides a sample analysis device, comprising:

[0057] The sample suction device 400 is used to suck the sample in the sample tube or the quality control product or cleaning liquid in the test tube container through the sample suction needle, wherein the test tube container is the test tube container described in the first aspect of the utility model.

[0058] In an optional embodiment, the sample analysis device of the present invention is a blood cell analysis device, which is used to detect and analyze white blood cells, red blood cells, platelets, etc. in the blood.

[0059] like Figure 4 and Figure 5 As shown, the sample analysis device of the utility model also includes:

[0060] The sample tube mixing gripper 100 grabs the sample tube or test tube container 500 in the sample rack 200 through the clamping claw 101 and performs inversion mixing.

[0061] Since the sample analysis device of the utility model includes the above-mentioned test tube container, the sample analysis device of the utility model also has the beneficial effects that can be achieved by the above-mentioned test tube container. The sealing and compatibility of the reagent in the tube can be ensured in the case of multiple punctures and inversion mixing, avoiding the problem of slag falling and holes in the tube after multiple punctures; at the same time, the puncture soft rubber itself has good water vapor resistance, and the composite layer with high compatibility with the reagent contacts the reagent, avoiding the problem of reagent volatilization and reagent volume reduction due to long-term storage.

[0062] Furthermore, the sample analysis device of the present invention may also include:

[0063] The sample introduction device 300 is used to transport the sample rack 200 loaded with sample tubes or test tube containers 500, and transport the sample rack 200 to the sample tube grabbing position of the sample tube mixing gripper 100, or the sample aspiration position of the sample aspiration device 400. The sample tube grabbing position and the sample aspiration position can be the same position or different positions.

[0064] Unless otherwise defined, the technical terms or scientific terms used in this utility model shall have the common meanings understood by people with ordinary skills in the field to which this utility model belongs. The terms "include" or "comprise" and similar words used in this utility model mean that the elements or objects appearing before the word include the elements or objects listed after the word and their equivalents, but do not exclude other elements or objects. "Connect" or "connected" and similar words are not limited to physical or mechanical connections, whether direct or indirect.

[0065] At this point, those skilled in the art should recognize that, although the present invention has been described with reference to preferred embodiments, various modifications may be made thereto and components thereof may be replaced with equivalents without departing from the scope of the present invention. In particular, the various technical features mentioned in the various embodiments may be combined in any manner as long as there is no structural conflict. The present invention is not limited to the specific embodiments disclosed herein, but includes all technical solutions falling within the scope of the claims.

Claims

1. A test tube container used in a sample analysis device, suitable for multiple punctures by a sample suction needle, characterized in that: include: The test tube body is used to hold reagents, which are quality control products or cleaning solutions; The tube cover is connected to the test tube body and is used to seal the tube mouth of the test tube body. The tube cover includes a cover body, a puncture soft glue and a composite film which are connected in sequence. The top of the cover body forms a puncture area. An opening is provided at the puncture area for the sample suction needle to pass through. The puncture soft glue covers the opening of the puncture area and is sealed with an interference fit with the tube mouth of the test tube body. The bottom surface of the puncture soft glue is welded to the inner layer of the composite film, wherein the material of the puncture soft glue is TPE.

2. The test tube container according to claim 1, characterized in that: The material of the puncture soft rubber is TPO, and the cover body is PP.

3. The test tube container according to claim 1, characterized in that: The cover body and the puncture soft rubber are integrally formed by secondary injection molding or two-color injection molding or are welded and sealed.

4. The test tube container according to claim 1, characterized in that: The inner layer where the composite film is welded to the puncture soft glue is made of CPP material, and the outer layer of the composite film in contact with the reagent meets the reagent compatibility requirements.

5. The test tube container according to claim 1, characterized in that: The tube cover is connected to the test tube body through threads.

6. The test tube container according to claim 1 or claim 3, characterized in that: The welding method is ultrasonic welding, thermal welding or laser welding.

7. The test tube container according to claim 1, characterized in that: The thickness of the puncture soft glue is 2 to 4 mm.

8. The test tube container according to claim 1, characterized in that: The thickness of the composite film is less than 1 mm.

9. A sample analysis device, characterized in that: include: A sample suction device, used for puncturing and aspirating the sample in the sample tube and / or the quality control product or cleaning solution in the test tube container through a sample suction needle; wherein the test tube container is the test tube container according to any one of claims 1-8.

10. The sample analysis device according to claim 9, characterized in that: The sample analysis device is a blood cell analysis device.

11. The sample analysis device according to claim 9 or claim 10, characterized in that: The sample analysis device also includes a sample tube mixing gripper, which grabs the sample tube or test tube container in the sample rack through a clamping claw and performs inversion mixing.

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