Integrated small animal ECMO device

Abstract

The utility model provides an integrated small animal ECMO device which comprises an integrated platform, a temperature sensor, a heater, a four-channel peristaltic pump, a liquid storage device and an external oxygenator, and a first channel pump is sequentially connected with the liquid storage device and the external oxygenator in series to form a blood input and oxygenation loop; the four-channel peristaltic pump is arranged, the functions of blood oxygenation, water circulation and constant temperature are integrated, waterway circulation is formed through the humidity control unit, the third channel pump and the fourth channel pump, a blood pipeline is wrapped by a heating water bath, the liquid temperature is monitored in real time, the liquid constant temperature is ensured, and the dispersity of components is reduced through the integrated design; multifunctional integration is realized, the compound requirements of small animal experiments are met, and the experiment efficiency is improved.

Description

TECHNICAL FIELD

[0001] The utility model relates to medical instrument technical field, especially a kind of integrated small animal ECMO device. BACKGROUND

[0002] At present, extracorporeal membrane oxygenation (ECMO) technology is mainly used for clinical critical patients and large animal models (such as pigs, dogs) life support, but still faces significant technical bottlenecks in small animal (such as mice) experimental models.

[0003] In existing research, the establishment of mouse ECMO model mainly relies on manual operation of intubation technology, and existing devices are temporarily assembled by dispersed components (such as oxygenators, pumps, pipelines), lacking of integrated design, resulting in complex operation and difficulty in maintaining constant blood flow and temperature, low system integration.

[0004] Therefore, the present inventors specially designed an integrated small animal ECMO device, which gave rise to the present case. INVENTION CONTENTS

[0005] To solve the above problems, the technical scheme of the utility model is as follows:

[0006] An integrated small animal ECMO device, comprising:

[0007] An integrated platform having a pump body groove, a tank groove and a water bath groove formed on the surface;

[0008] A wet control unit comprising a temperature sensor and a heater, wherein the temperature sensor is installed inside the tank groove, the probe of the temperature sensor extends below the liquid surface in the water bath groove, the heater is installed in the water bath groove, and the temperature sensor and the heater are electrically connected;

[0009] A four-channel peristaltic pump installed in the pump body groove, wherein the four-channel peristaltic pump has a first-channel pump, a third-channel pump and a fourth-channel pump, and the two ends of the third-channel pump and the fourth-channel pump are respectively connected to the water bath groove through a third hose and a fourth hose;

[0010] A liquid reservoir installed on the outer side wall of the integrated platform, wherein one end of the liquid reservoir is connected to one end of the first-channel pump through a first hose, and the other end of the liquid reservoir is connected to a mouse;

[0011] An external oxygenator installed on the outer side wall of the integrated platform, wherein one end of the external oxygenator is connected to the other end of the first-channel pump through a first hose, and the other end of the external oxygenator is connected to a mouse.

[0012] Preferably, a plurality of liquid inlets and a plurality of liquid outlets are formed between the side wall of the pump body groove and the water bath groove, a plurality of inlets and a plurality of outlets are formed on the side wall of the water bath groove, and the first hose sequentially passes through the inlets, the liquid inlets, the liquid outlets and the outlets.

[0013] Preferably, the third hose and the fourth hose pass through the liquid inlet and the liquid outlet in sequence.

[0014] Preferably, the integrated platform further comprises a liquid supplement device, the liquid supplement device is installed on the outer side wall of the integrated platform, the four-channel peristaltic pump further comprises a second channel pump, one end of the liquid supplement device is connected with one end of the second channel pump through a second hose, and the other end of the liquid supplement device is connected with the mouse, and the other end of the second channel pump is connected with the mouse through a second hose.

[0015] Preferably, inner walls of the liquid inlet, the liquid outlet, the inlet and the outlet are provided with sealing elements, and the sealing elements are in sealing connection with the first hose, the second hose, the third hose and the fourth hose.

[0016] Preferably, the water bath tank is provided with a clamping groove at the bottom and a plurality of pipe sleeves on the side wall.

[0017] Preferably, the outer side wall of the integrated platform is provided with a plurality of oxygenators.

[0018] The technical scheme provided by the utility model has the following beneficial effects:

[0019] The utility model discloses a four-channel peristaltic pump, integrated blood oxygenation, water circulation and constant temperature function, through the wet control unit, third channel pump and fourth channel pump form water circulation, through heating water bath to wrap blood pipeline, real -time monitoring liquid temperature and ensure liquid constant temperature, through integrated design reduces the component dispersivity, realizes multifunctional integration, satisfies the composite demand of small animal experiment, improves the experiment efficiency. DRAWINGS

[0020] The drawings described herein are used to provide further understanding of the utility model and form a part of the utility model, and the illustrative embodiment of the utility model and the description thereof are used to explain the utility model and do not constitute improper limitation on the utility model.

[0021] Among them:

[0022] Figure 1 It is the whole structure schematic view of the utility model;

[0023] Figure 2 It is the internal structure schematic view of the utility model;

[0024] Figure 3 It is the structure schematic view of four-channel peristaltic pump.

[0025] Label explanation:

[0026] 1, integrated platform; 11, pump body groove; 12, tank groove; 13, water bath tank; 131, liquid inlet; 132, liquid outlet; 133, inlet; 134, outlet; 135, card slot; 136, pipe sleeve; 2, temperature sensor; 3, heater; 4, four-channel peristaltic pump; 41, first channel pump; 42, second channel pump; 43, third channel pump; 44, fourth channel pump; 5, liquid reservoir; 6, external oxygenator; 61, oxygenator tray; 7, liquid supplementer. DETAILED DESCRIPTION

[0027] In order to make the technical problems, technical solutions and beneficial effects of the present application more clear, the following will be further described in detail in conjunction with the drawings and examples. It should be understood that the specific examples described herein are only used to explain the present application, and are not used to limit the present application.

[0028] Please refer to Figures 1 to 3 It is an integrated small animal ECMO device as the best embodiment of the present application, comprising:

[0029] The integrated platform 1 is provided with the pump body groove 11, the tank groove 12 and the water bath tank 13 on the surface;

[0030] The wet control unit comprises the temperature sensor 2 and the heater 3, the temperature sensor 2 is installed inside the tank groove 12, the probe of the temperature sensor 2 extends below the liquid level in the water bath tank 13, the heater 3 is installed in the water bath tank 13, and the temperature sensor 2 and the heater 3 are electrically connected; The temperature sensor 2 is installed inside the tank groove 12, and the probe thereof extends below the liquid level in the water bath tank 13, so that the actual temperature of the liquid in the water bath tank 13 can be directly and accurately sensed, and the temperature signal can be fed back to the heater 3 in real time. The heater 3 accurately adjusts the heating power according to the feedback of the temperature sensor 2, realizes accurate control of the liquid temperature in the water bath tank 13, ensures that the liquid temperature is stable in the set range, and provides a stable temperature environment for the blood of the small animal;

[0031] A four-channel peristaltic pump 4 is installed in the pump body groove 11, and the four-channel peristaltic pump 4 has a first channel pump 41, a second channel pump 42, a third channel pump 43, and a fourth channel pump 44. The two ends of the third channel pump 43 and the fourth channel pump 44 are respectively connected with the water bath tank 13 through the third hose and the fourth hose. The provision of the four-channel peristaltic pump 4 provides multiple independent liquid transmission channels. The first channel pump 41 is used to drive the circulation of blood between the liquid reservoir 5, the external oxygenator 6 and the mouse. The second channel pump 42 can be used as a backup or for other auxiliary liquid transmission tasks. The third and fourth channel pumps 44 are responsible for transporting the liquid in the water bath tank 13 to the oxygenator and the liquid reservoir 5, and then returning the backflow liquid to the water bath tank 13. This multi-channel cooperative working mode ensures the efficiency and stability of liquid transmission, and can meet the precise requirements of blood flow rate and flow during the ECMO process of small animals, and improve the oxygenation efficiency and stability of blood return;

[0032] The liquid reservoir 5 is installed on the outer side wall of the integrated platform 1. One end of the liquid reservoir 5 is connected with one end of the first channel pump 41 through the first hose, and the other end of the liquid reservoir 5 is connected with the mouse. The liquid reservoir 5 is used to buffer the blood flow and stabilize the pressure, so as to avoid the impact of pulse flow on the blood vessels of the animal.

[0033] The external oxygenator 6 is installed on the outer side wall of the integrated platform 1. One end of the external oxygenator 6 is connected with the other end of the first channel pump 41 through the first hose, and the other end of the external oxygenator 6 is connected with the mouse. The external oxygenator 6 adopts a hollow fiber membrane structure to realize the exchange of blood and oxygen. The oxygenated blood is returned to the body by the peristaltic pump.

[0034] The various functional components are arranged in a centralized manner, which makes the operation more convenient. The experimental personnel can quickly complete the connection of the ECMO pipeline, temperature control, pump speed adjustment and other operations on the same platform, which reduces the conversion time and complexity between operation steps, reduces the risk of mistakes caused by complicated operation, and improves the experimental efficiency and success rate.

[0035] Please refer to Figure 1, the side wall of the pump body groove 11 and the water bath groove 13 are provided with a plurality of liquid inlets 131 and a plurality of liquid outlets 132, the side wall of the water bath groove 13 is provided with a plurality of inlets 133 and a plurality of outlets 134, the first hose sequentially passes through the inlets 133, the liquid inlets 131, the liquid outlets 132 and the outlets 134, and the reasonable layout of the liquid inlets 131, the liquid outlets 132, the inlets 133 and the outlets 134 provides a clear and smooth path for the circulation of the liquid between the water bath groove 13 and the external oxygenator 6 and the liquid reservoir 5. The first hose sequentially passes through these openings, so that the liquid can flow smoothly from the water bath groove 13 into the external oxygenator 6 and the liquid reservoir 5, and then return to the water bath groove 13, effectively reducing the resistance and detours in the liquid flow process, improving the efficiency of the liquid circulation, and ensuring that the blood of small animals can flow quickly and stably in the extracorporeal circulation system, thereby better meeting their physiological needs.

[0036] Please refer to Figures 1 to 3 , the third hose and the fourth hose sequentially pass through the liquid inlets 131 and the liquid outlets 132, and the third hose and the fourth hose sequentially pass through the liquid inlets 131 and the liquid outlets 132, so that the liquid is in full contact with the liquid in the water bath groove 13 when entering and leaving the water bath groove 13, increasing the heat exchange time and area. When the liquid enters the water bath groove 13 from the third hose, it exchanges heat with the liquid in the water bath groove 13, quickly reaching the temperature in the water bath groove 13; when the liquid is sent out of the water bath groove 13 by the fourth hose, the liquid contacts the liquid in the water bath groove 13 again, further adjusting the temperature, ensuring that the liquid temperature delivered to the external oxygenator 6 and the liquid reservoir 5 is uniform and stable, providing precise temperature adjustment for the blood of small animals, reducing the influence of temperature fluctuations on the physiological state of the blood. Since the liquid in the third and fourth hoses is fully exchanged when entering and leaving the water bath groove 13, the temperature sensor 2 can more truly reflect the temperature of the liquid in the water bath groove 13 and the temperature of the liquid about to be delivered externally, thereby providing a more accurate feedback signal for the heater 3, enabling it to more accurately adjust the heating power, further optimizing the temperature control performance of the entire system, and ensuring that the body temperature of small animals during ECMO is stable within the physiological range.

[0037] Specifically, please refer to Figures 1 to 3It also comprises a liquid supplement device 7, which is installed on the outer side wall of the integrated platform 1, one end of the liquid supplement device 7 is connected with one end of the second channel pump 42 through a second hose, the other end of the liquid supplement device 7 is connected with the mouse, the other end of the second channel pump 42 is connected with the mouse through a second hose, the second channel pump 42 is directly connected with the liquid supplement device 7, and the second channel pump 42 is used for supplementing liquid (such as anticoagulant or medicine) in real time, the liquid supplement device 7 is connected with the second channel pump 42 through the second hose, and then connected with the mouse, so that the amount and speed of the supplemented liquid can be accurately controlled. During the ECMO process of the small animal, according to the real-time physiological condition and blood volume change of the mouse, the rotating speed of the second channel pump 42 is adjusted, accurate liquid supplement operation is realized, adverse effects of excessive liquid supplement or insufficient liquid supplement on the mouse are avoided, and the hemodynamic stability of the mouse is helped to be maintained.

[0038] Specifically, please refer to Figures 1 to 3 The inner walls of the plurality of liquid inlet ports 131, liquid outlet ports 132, inlet ports 133 and outlet ports 134 are provided with sealing elements, the sealing elements are sealingly connected with the first hose, the second hose, the third hose and the fourth hose, the sealing elements are closely attached to the hoses, effective sealing barriers are formed, liquid leakage at the interfaces is prevented, the sealing performance of the liquid conveying system of the entire ECMO device is guaranteed, and blood, liquid supplement and water bath liquid and the like are stably and safely conveyed in the pipeline, and circulation interruption or experiment failure caused by liquid leakage is avoided.

[0039] Specifically, please refer to Figure 3 The water bath tank 13 is provided with a plurality of pipe sleeves 136 on the side wall, and the first hose, the second hose, the third hose and the fourth hose can be fixed on the pipe sleeves 136 and the clamping grooves 135 in the water bath tank 13, and the modular clamping grooves 135 and the pipe sleeves 136 are adopted to fix the channel pipelines, so that winding or displacement is avoided.

[0040] Specifically, please refer to Figure 1 The outer side wall of the integrated platform 1 is provided with a plurality of oxygenator trays 61, so that the external oxygenator 6 can be fixed, and falling is prevented.

[0041] The implementation principle of the integrated small animal ECMO device is as follows:

[0042] The blood oxygenation process is as follows: the first channel pump 41 pumps the blood of the mouse into the liquid reservoir 5, and the blood is oxygenated by the external oxygenator 6 and then returned to the body, so that extracorporeal circulation is formed.

[0043] The liquid supplement process is as follows: the second channel pump independently operates, and liquid is supplemented to the circulation system as needed.

[0044] The constant temperature control is as follows: the third channel pump 43 and the fourth channel pump 44 drive water circulation, the main pipeline is wrapped by a heated water bath, and the water temperature is adjusted in real time by a wet control unit, so that the temperature of the blood and the liquid supplement is constant.

[0045] The specific operation process is as follows:

[0046] System pre-start:

[0047] Connect the water circulation pipeline and inject water, and start the wet control unit to preheat to 37 DEG C.

[0048] Install the blood pipeline (first channel pump 41) and the liquid supplement pipeline (second channel pump 42), and ensure that the interface is waterproof and fixed.

[0049] Animal access:

[0050] Through surgical operation, the left atrial cannula is connected to the liquid inlet 131 of the first channel pump 41, and the liquid outlet 132 is connected to the vein or artery.

[0051] Circulation operation:

[0052] Start the first channel pump 41, and adjust the flow rate to the physiological demand of the mouse (such as 2-5 mL / min).

[0053] Start the third channel pump 43 and the fourth channel pump 44 water circulation to maintain constant temperature.

[0054] Supplement liquid as needed through the second channel pump 42, and monitor the blood parameters (such as oxygen saturation) in real time.

[0055] Termination operation:

[0056] Gradually reduce the pump speed, disconnect the animal connection, empty the pipeline and disinfect.

[0057] As described above, the utility model discloses a four-channel peristaltic pump 4, integrates blood oxygenation, water circulation and constant temperature function, forms water circulation through wet control unit, third channel pump 43 and fourth channel pump 44, through the heating water bath package blood pipeline, real-time monitoring liquid temperature and ensuring liquid constant temperature, through the integrated design reduces the component dispersivity, realizes multifunctional integration, satisfies the composite demand of small animal experiment, improves the experimental efficiency, the cooperative control logic of four-channel pump ensures the synchronous operation of blood flow rate, liquid supplement amount and temperature control module.

[0058] The utility model has been described exemplarily above in connection with the drawings, and obviously, the specific implementation of the utility model is not limited by the above mode, as long as various non-essential improvements are adopted by using the method concept and technical scheme of the utility model, or the concept and technical scheme of the utility model are directly applied to other occasions without improvement, all are within the protection scope of the utility model.

Claims

1. An integrated small animal ECMO device, characterized in that, The utility model relates to an integrated platform for mouse blood oxygenation, comprising: an integrated platform (1) having a pump body groove (11), a tank groove (12) and a water bath groove (13) formed on the surface thereof; a wet control unit comprising a temperature sensor (2) and a heater (3), wherein the temperature sensor (2) is installed inside the tank groove (12), the probe of the temperature sensor (2) extends below the liquid level in the water bath groove (13), the heater (3) is installed in the water bath groove (13), and the temperature sensor (2) and the heater (3) are electrically connected; a four-channel peristaltic pump (4) installed in the pump body groove (11), wherein the four-channel peristaltic pump (4) has a first channel pump (41), a third channel pump (43) and a fourth channel pump (44), and the two ends of the third channel pump (43) and the fourth channel pump (44) are respectively connected to the water bath groove (13) through a third hose and a fourth hose; a liquid reservoir (5) installed on the outer side wall of the integrated platform (1), wherein one end of the liquid reservoir (5) is connected to one end of the first channel pump (41) through a first hose, and the other end of the liquid reservoir (5) is connected to a mouse; an external oxygenator (6) installed on the outer side wall of the integrated platform (1), wherein one end of the external oxygenator (6) is connected to the other end of the first channel pump (41) through a first hose, and the other end of the external oxygenator (6) is connected to the mouse.

2. The integrated small animal ECMO device of claim 1, wherein, A plurality of liquid inlets (131) and a plurality of liquid outlets (132) are formed between the side wall of the pump body groove (11) and the water bath groove (13), a plurality of inlets (133) and a plurality of outlets (134) are formed on the side wall of the water bath groove (13), and the first hose sequentially passes through the inlets (133), the liquid inlets (131), the liquid outlets (132) and the outlets (134).

3. The integrated small animal ECMO device of claim 2, wherein, The third hose and the fourth hose sequentially pass through the liquid inlets (131) and the liquid outlets (132).

4. The integrated small animal ECMO device of claim 2, wherein, The utility model also comprises a liquid supplementing device (7), wherein the liquid supplementing device (7) is installed on the outer side wall of the integrated platform (1), the four-channel peristaltic pump (4) further comprises a second channel pump (42), one end of the liquid supplementing device (7) is connected to one end of the second channel pump (42) through a second hose, the other end of the liquid supplementing device (7) is connected to the mouse, and the other end of the second channel pump (42) is connected to the mouse through a second hose.

5. The integrated small animal ECMO device of claim 4, wherein, The inner walls of the liquid inlets (131), the liquid outlets (132), the inlets (133) and the outlets (134) are provided with sealing members, and the sealing members are sealingly connected to the first hose, the second hose, the third hose and the fourth hose.

6. The integrated small animal ECMO device of claim 1, wherein, A clamping groove (135) is installed at the bottom of the water bath groove (13), and a plurality of pipe sleeves (136) are installed on the side wall of the water bath groove (13).

7. The integrated small animal ECMO device of claim 1, wherein, A plurality of oxygenator trays (61) are provided on the outer side wall of the integrated platform (1).

Images